JOP20190276A1 - طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة - Google Patents
طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرةInfo
- Publication number
- JOP20190276A1 JOP20190276A1 JOP/2019/0276A JOP20190276A JOP20190276A1 JO P20190276 A1 JOP20190276 A1 JO P20190276A1 JO P20190276 A JOP20190276 A JO P20190276A JO P20190276 A1 JOP20190276 A1 JO P20190276A1
- Authority
- JO
- Jordan
- Prior art keywords
- diarrhea
- treatment
- methods
- bile acid
- bowel syndrome
- Prior art date
Links
- 206010012735 Diarrhoea Diseases 0.000 title abstract 9
- 206010049416 Short-bowel syndrome Diseases 0.000 title abstract 4
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title abstract 2
- 239000003613 bile acid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 210000000232 gallbladder Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002271 resection Methods 0.000 title 1
- 210000000813 small intestine Anatomy 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 229920001393 Crofelemer Polymers 0.000 abstract 1
- 206010000059 abdominal discomfort Diseases 0.000 abstract 1
- 238000002192 cholecystectomy Methods 0.000 abstract 1
- 229940047615 crofelemer Drugs 0.000 abstract 1
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical group C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
غير متوفر
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513257P | 2017-05-31 | 2017-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20190276A1 true JOP20190276A1 (ar) | 2019-11-27 |
Family
ID=64455604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2019/0276A JOP20190276A1 (ar) | 2017-05-31 | 2017-06-16 | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11779564B2 (ar) |
| EP (1) | EP3634455B1 (ar) |
| JP (1) | JP7328153B2 (ar) |
| CN (1) | CN110831612A (ar) |
| AU (1) | AU2018275685B2 (ar) |
| CA (1) | CA3065800A1 (ar) |
| DK (1) | DK3634455T3 (ar) |
| ES (1) | ES2985972T3 (ar) |
| FI (1) | FI3634455T3 (ar) |
| IL (1) | IL270985A (ar) |
| JO (1) | JOP20190276A1 (ar) |
| PT (1) | PT3634455T (ar) |
| WO (1) | WO2018222921A1 (ar) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190275A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج اضطراب إسهال خِلقي |
| JOP20190276A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
| JP7669295B2 (ja) | 2019-06-12 | 2025-04-28 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 胆汁酸性下痢を治療する方法 |
| WO2025014912A1 (en) * | 2023-07-10 | 2025-01-16 | Dimerx, Inc. | Treatment of chronic pain or gastrointestinal disorders using buprenorphine dimer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3564370D1 (en) | 1985-08-30 | 1988-09-22 | Nestle Sa | Dietetic product with depurating and antidiarrheal activity and process for its preparation |
| US5211944A (en) | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| SI9011933A (sl) | 1990-10-15 | 1998-06-30 | TANIN SEVNICA Kemična industrija p.o. | Kostanjev taninski ekstrakt, postopek za njegovo pridobivanje in njegova uporaba |
| KR100467532B1 (ko) | 1996-10-16 | 2005-01-24 | 피에스 팔마큐티칼스 인코퍼레이션 | 프로안토시아니딘 중합체로 된 항-설사 장용피 조제물 |
| US7767203B2 (en) * | 1998-08-07 | 2010-08-03 | Ganeden Biotech, Inc. | Methods for the dietary management of irritable bowel syndrome and carbohydrate malabsorption |
| WO2000047062A2 (en) | 1999-02-01 | 2000-08-17 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same |
| US7235573B2 (en) | 2002-09-30 | 2007-06-26 | The Regents Of The University Of California | Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors |
| DE102006018293A1 (de) | 2006-04-20 | 2007-10-25 | Fresenius Kabi Deutschland Gmbh | Pädiatrische Aminosäurelösung zur parenteralen Ernäherung |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| EP2529626B1 (en) | 2006-05-01 | 2017-11-22 | Napo Pharmaceuticals, Inc. | Compositions and methods for treating or preventing colon cancer |
| AU2007248182B2 (en) | 2006-05-01 | 2013-05-23 | Napo Pharmaceuticals, Inc. | Method for treatment of constipation-predominant irritable bowel syndrome |
| CA2727082C (en) * | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| CA2777214A1 (en) * | 2009-10-06 | 2011-04-14 | The Regents Of The University Of California | Methods of treating diseases with proanthocyanidin oligomers such as crofelemer |
| CN103249304B (zh) * | 2010-05-28 | 2015-07-22 | 新视代皮肤科技公司 | 用于治疗瘀伤的组合物和方法 |
| JP6063385B2 (ja) | 2010-10-31 | 2017-01-18 | ナポ ファーマシューティカルズ インコーポレイテッド | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
| CA2832059C (en) * | 2011-04-01 | 2020-07-14 | Ocean Spray Cranberries, Inc. | Inflammation and immunity treatments |
| AU2013370404B2 (en) * | 2012-12-27 | 2017-11-02 | Ngm Biopharmaceuticals, Inc. | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US20180338932A1 (en) | 2015-12-23 | 2018-11-29 | Dmitry Kravtsov | Compositions and methods of treatment for mvid and related diseases |
| EP3405211A4 (en) | 2016-01-21 | 2019-10-09 | Chiasma Inc. | ORAL OCTREOTIDE FOR THE TREATMENT OF DISEASES |
| US11389424B2 (en) | 2017-03-09 | 2022-07-19 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating chemotherapy-induced diarrhea |
| JOP20190275A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج اضطراب إسهال خِلقي |
| JOP20190276A1 (ar) | 2017-05-31 | 2019-11-27 | Napo Pharmaceuticals Inc | طرق وتركيبات لعلاج إسهال الحمض الصفراوي، والإسهال المرتبط باستئصال الأمعاء الدقيقة أو إزالة المرارة، ومتلازمة الأمعاء القصيرة |
| AU2019240293A1 (en) | 2018-03-23 | 2020-10-15 | Vanessa Research, Inc. | Compositions and methods for treating diarrheal diseases |
-
2017
- 2017-06-16 JO JOP/2019/0276A patent/JOP20190276A1/ar unknown
-
2018
- 2018-05-31 CN CN201880043934.XA patent/CN110831612A/zh active Pending
- 2018-05-31 AU AU2018275685A patent/AU2018275685B2/en active Active
- 2018-05-31 CA CA3065800A patent/CA3065800A1/en active Pending
- 2018-05-31 PT PT188089122T patent/PT3634455T/pt unknown
- 2018-05-31 DK DK18808912.2T patent/DK3634455T3/da active
- 2018-05-31 ES ES18808912T patent/ES2985972T3/es active Active
- 2018-05-31 US US16/617,466 patent/US11779564B2/en active Active
- 2018-05-31 WO PCT/US2018/035471 patent/WO2018222921A1/en active Application Filing
- 2018-05-31 JP JP2019566126A patent/JP7328153B2/ja active Active
- 2018-05-31 FI FIEP18808912.2T patent/FI3634455T3/fi active
- 2018-05-31 EP EP18808912.2A patent/EP3634455B1/en active Active
-
2019
- 2019-11-27 IL IL270985A patent/IL270985A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3634455A1 (en) | 2020-04-15 |
| EP3634455A4 (en) | 2021-02-24 |
| FI3634455T3 (fi) | 2024-07-23 |
| US20200121636A1 (en) | 2020-04-23 |
| EP3634455B1 (en) | 2024-07-03 |
| AU2018275685B2 (en) | 2025-04-17 |
| US11779564B2 (en) | 2023-10-10 |
| ES2985972T3 (es) | 2024-11-08 |
| AU2018275685A1 (en) | 2020-01-02 |
| CN110831612A (zh) | 2020-02-21 |
| PT3634455T (pt) | 2024-07-29 |
| DK3634455T3 (da) | 2024-07-29 |
| WO2018222921A1 (en) | 2018-12-06 |
| JP2020522491A (ja) | 2020-07-30 |
| IL270985A (en) | 2020-01-30 |
| CA3065800A1 (en) | 2018-12-06 |
| JP7328153B2 (ja) | 2023-08-16 |
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