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JOP20190246A1 - جسم مضاد أحادي النسيلة لـ pd-l1 - Google Patents

جسم مضاد أحادي النسيلة لـ pd-l1

Info

Publication number
JOP20190246A1
JOP20190246A1 JOP/2019/0246A JOP20190246A JOP20190246A1 JO P20190246 A1 JOP20190246 A1 JO P20190246A1 JO P20190246 A JOP20190246 A JO P20190246A JO P20190246 A1 JOP20190246 A1 JO P20190246A1
Authority
JO
Jordan
Prior art keywords
monoclonal antibody
antibodies
methods
relates
biotechnology
Prior art date
Application number
JOP/2019/0246A
Other languages
English (en)
Inventor
Valery Vladimirovich Solovyev
Iakov Iurevich Ustiugov
Timofey Aleksandrovich Nemankin
Sergei Andreevich Ageev
Yulia Sergeevna Chernykh
Pavel Alekseevich Grebnev
Pavel Andreevich Iakovlev
Aleksei Aleksandrovich Aleksandrov
Andrei Borisovich Ulitin
Viktoriia Mikhailovna Ekimova
Ekaterina Vladimirovna Sofronova
Anna Konstantinovna Vladimirova
Dmitry Valentinovich Morozov
Original Assignee
Biocad Joint Stock Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocad Joint Stock Co filed Critical Biocad Joint Stock Co
Publication of JOP20190246A1 publication Critical patent/JOP20190246A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

الملخص جسم مضاد أحادي النسيلة لـ PD-L1 يتعلق الاختراع الحالي بمجال التكنولوجيا الحيوية ويوفر أجسام مضادة والتي ترتبط على وجه التحديد بـ PD-L1. يتعلق الاختراع أيضاً بـ DNA يقوم بترميز الأجسام المضادة المذكورة، بنواقل تعبير وراثي مقابلة وبطرق لإنتاج الأجسام المضادة المذكورة وطرق للعلاج باستخدامها.
JOP/2019/0246A 2017-04-17 2017-06-16 جسم مضاد أحادي النسيلة لـ pd-l1 JOP20190246A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2017113141A RU2665790C1 (ru) 2017-04-17 2017-04-17 Моноклональное антитело к pd-l1

Publications (1)

Publication Number Publication Date
JOP20190246A1 true JOP20190246A1 (ar) 2019-10-16

Family

ID=63459922

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0246A JOP20190246A1 (ar) 2017-04-17 2017-06-16 جسم مضاد أحادي النسيلة لـ pd-l1

Country Status (21)

Country Link
US (1) US11236167B2 (ar)
EP (1) EP3613770A4 (ar)
JP (2) JP2020516323A (ar)
KR (1) KR102679554B1 (ar)
CN (1) CN111247166B (ar)
AR (1) AR113223A1 (ar)
AU (1) AU2018255132B2 (ar)
BR (1) BR112019021781A2 (ar)
CA (1) CA3060395A1 (ar)
CL (1) CL2019002894A1 (ar)
CO (1) CO2019011458A2 (ar)
EA (1) EA201992206A1 (ar)
JO (1) JOP20190246A1 (ar)
MA (1) MA47221A1 (ar)
NZ (1) NZ758093A (ar)
PE (1) PE20191786A1 (ar)
PH (1) PH12019502298A1 (ar)
RU (1) RU2665790C1 (ar)
UY (1) UY37683A (ar)
WO (1) WO2018194496A2 (ar)
ZA (1) ZA201907065B (ar)

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SG10201913297TA (en) 2015-03-13 2020-02-27 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
AU2018278327B2 (en) 2017-06-01 2023-03-16 Cytomx Therapeutics, Inc. Activatable anti-pdl1 antibodies and methods of use thereof
EA039662B1 (ru) * 2017-10-03 2022-02-24 Закрытое Акционерное Общество "Биокад" Антитела, специфичные к cd47 и pd-l1
CN109929037B (zh) 2019-04-01 2023-03-17 华博生物医药技术（上海）有限公司 针对程序性死亡配体的结合物及其应用
RU2753282C2 (ru) 2019-09-19 2021-08-12 Закрытое Акционерное Общество "Биокад" ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ
WO2022121846A1 (zh) * 2020-12-08 2022-06-16 博际生物医药科技(杭州)有限公司 Pd-l1抗体及其应用
MA63538A1 (fr) * 2021-06-21 2024-09-30 Joint Stock Company "Biocad" Anticorps bispécifique isolé se liant de mani7re spécifique à cd47 et pd-l1
WO2023187460A1 (en) * 2022-04-01 2023-10-05 Mabtree Biologics Ag Human antibody or antigen binding fragment thereof specific against pd-l1 to enhance t-cell function
AR131718A1 (es) 2023-01-30 2025-04-23 Kymab Ltd Anticuerpos

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Also Published As

Publication number Publication date
AR113223A1 (es) 2020-02-19
JP2023081942A (ja) 2023-06-13
MA47221A1 (fr) 2020-04-30
EA201992206A1 (ru) 2020-02-21
WO2018194496A3 (ru) 2019-01-10
ZA201907065B (en) 2020-09-30
RU2665790C1 (ru) 2018-09-04
UY37683A (es) 2018-11-30
CL2019002894A1 (es) 2020-03-13
NZ758093A (en) 2022-09-30
JP7600285B2 (ja) 2024-12-16
US20200369771A1 (en) 2020-11-26
PE20191786A1 (es) 2019-12-24
US11236167B2 (en) 2022-02-01
EP3613770A2 (en) 2020-02-26
CN111247166A (zh) 2020-06-05
CO2019011458A2 (es) 2020-01-17
AU2018255132A2 (en) 2019-11-07
JP2020516323A (ja) 2020-06-11
PH12019502298A1 (en) 2020-07-06
EP3613770A4 (en) 2021-01-27
CA3060395A1 (en) 2019-11-18
KR102679554B1 (ko) 2024-07-01
BR112019021781A2 (pt) 2020-05-05
KR20190140979A (ko) 2019-12-20
AU2018255132B2 (en) 2025-04-17
CN111247166B (zh) 2024-03-26
AU2018255132A1 (en) 2019-10-31
WO2018194496A2 (ru) 2018-10-25

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