JO3383B1 - مثبطات cdc7 - Google Patents
مثبطات cdc7Info
- Publication number
- JO3383B1 JO3383B1 JOP/2014/0067A JOP20140067A JO3383B1 JO 3383 B1 JO3383 B1 JO 3383B1 JO P20140067 A JOP20140067 A JO P20140067A JO 3383 B1 JO3383 B1 JO 3383B1
- Authority
- JO
- Jordan
- Prior art keywords
- cdc7 inhibitors
- cdc7
- inhibitors
- useful
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
يتعلق الاختراع الحالي بتوفير مركبات أيزوإندولينون، أو ملح مقبول صيدليًا منها، والتي تثبِّط CDC7، وبالتالي يمكن أن تكون مفيدة في علاج السرطان.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782798P | 2013-03-14 | 2013-03-14 | |
| US201361789108P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3383B1 true JO3383B1 (ar) | 2019-03-13 |
Family
ID=50382704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2014/0067A JO3383B1 (ar) | 2013-03-14 | 2014-03-04 | مثبطات cdc7 |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9156824B2 (ar) |
| EP (1) | EP2970221B1 (ar) |
| JP (1) | JP6064079B2 (ar) |
| KR (1) | KR101718645B1 (ar) |
| CN (1) | CN105008351B (ar) |
| AP (1) | AP2015008734A0 (ar) |
| AU (1) | AU2014228374B2 (ar) |
| BR (1) | BR112015020466B1 (ar) |
| CA (1) | CA2900773C (ar) |
| CL (1) | CL2015002530A1 (ar) |
| CR (1) | CR20150416A (ar) |
| CY (1) | CY1119199T1 (ar) |
| DK (1) | DK2970221T3 (ar) |
| EA (1) | EA027012B1 (ar) |
| ES (1) | ES2639793T3 (ar) |
| GT (1) | GT201500263A (ar) |
| HK (1) | HK1212696A1 (ar) |
| HR (1) | HRP20171151T1 (ar) |
| HU (1) | HUE033482T2 (ar) |
| IL (1) | IL240962B (ar) |
| JO (1) | JO3383B1 (ar) |
| LT (1) | LT2970221T (ar) |
| ME (1) | ME02805B (ar) |
| MX (1) | MX363438B (ar) |
| MY (1) | MY188145A (ar) |
| NZ (1) | NZ710392A (ar) |
| PE (1) | PE20151654A1 (ar) |
| PH (1) | PH12015502091B1 (ar) |
| PL (1) | PL2970221T3 (ar) |
| PT (1) | PT2970221T (ar) |
| RS (1) | RS56122B1 (ar) |
| SG (1) | SG11201507541PA (ar) |
| SI (1) | SI2970221T1 (ar) |
| TN (1) | TN2015000349A1 (ar) |
| TW (1) | TWI622396B (ar) |
| UA (1) | UA116125C2 (ar) |
| WO (1) | WO2014143601A1 (ar) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201502237RA (en) * | 2012-10-15 | 2015-05-28 | Pfizer Ireland Pharmaceuticals | Process for the preparation of voriconazole and analogues thereof |
| ES2649156T3 (es) | 2013-01-14 | 2018-01-10 | Incyte Holdings Corporation | Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim |
| SMT202000244T1 (it) | 2013-01-15 | 2020-07-08 | Incyte Holdings Corp | Composti di tiazolocarbossammide e piridincarbossammide utili come inibitori di chinasi pim |
| ES2845473T3 (es) | 2013-03-14 | 2021-07-26 | Boehringer Ingelheim Int | (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C |
| TWI627174B (zh) | 2013-03-14 | 2018-06-21 | 比利時商健生藥品公司 | Ｐ２ｘ７調控劑 |
| WO2014152589A1 (en) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | P2x7 modulators |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | Ｐ２ｘ７調節劑 |
| US9040534B2 (en) | 2013-03-14 | 2015-05-26 | Janssen Pharmaceutica Nv | [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
| CA2921959A1 (en) | 2013-08-23 | 2015-02-26 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| JP6592510B2 (ja) | 2014-09-12 | 2019-10-16 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｐ２ｘ７調節因子 |
| AU2015314355B2 (en) | 2014-09-12 | 2019-06-20 | Boehringer Ingelheim International Gmbh | Spirocyclic inhibitors of Cathepsin C |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Ｐｉｍ激酶抑制劑之鹽 |
| TW201718546A (zh) | 2015-10-02 | 2017-06-01 | 英塞特公司 | 適用作pim激酶抑制劑之雜環化合物 |
| ES2845048T3 (es) * | 2016-09-22 | 2021-07-23 | Cancer Research Tech Ltd | Preparación y usos de derivados de pirimidinona |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| CN108383771A (zh) * | 2018-01-08 | 2018-08-10 | 华东师范大学 | 手性3,3-二取代异吲哚啉-1-酮衍生物及其合成方法和应用 |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| US20200102311A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol Lipase Modulators |
| EA202190886A1 (ru) | 2018-09-28 | 2021-09-07 | Янссен Фармацевтика Нв | Модуляторы моноацилглицерин-липазы |
| US20220220125A1 (en) * | 2019-04-16 | 2022-07-14 | Janssen Pharmaceutica Nv | Fused isoindolin-1-one derivatives useful as grk2 inhibitors |
| EP4038070A1 (en) | 2019-09-30 | 2022-08-10 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
| WO2021191359A1 (en) | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| US7576082B2 (en) * | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| ATE545416T1 (de) * | 2006-10-12 | 2012-03-15 | Xenon Pharmaceuticals Inc | Verwendung von spiro-oxindol-verbindungen als therapeutika |
| US8648069B2 (en) * | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| KR20100032886A (ko) * | 2007-06-08 | 2010-03-26 | 아보트 러보러터리즈 | 키나제 억제제로서의 5-헤테로아릴 치환된 인다졸 |
-
2014
- 2014-03-04 JO JOP/2014/0067A patent/JO3383B1/ar active
- 2014-03-05 TW TW103107546A patent/TWI622396B/zh active
- 2014-03-07 AU AU2014228374A patent/AU2014228374B2/en active Active
- 2014-03-07 BR BR112015020466-0A patent/BR112015020466B1/pt active IP Right Grant
- 2014-03-07 NZ NZ710392A patent/NZ710392A/en unknown
- 2014-03-07 WO PCT/US2014/021466 patent/WO2014143601A1/en active Application Filing
- 2014-03-07 LT LTEP14712966.2T patent/LT2970221T/lt unknown
- 2014-03-07 EA EA201591509A patent/EA027012B1/ru not_active IP Right Cessation
- 2014-03-07 MY MYPI2015703062A patent/MY188145A/en unknown
- 2014-03-07 SI SI201430280T patent/SI2970221T1/sl unknown
- 2014-03-07 RS RS20170791A patent/RS56122B1/sr unknown
- 2014-03-07 HU HUE14712966A patent/HUE033482T2/en unknown
- 2014-03-07 DK DK14712966.2T patent/DK2970221T3/en active
- 2014-03-07 PL PL14712966T patent/PL2970221T3/pl unknown
- 2014-03-07 MX MX2015012583A patent/MX363438B/es unknown
- 2014-03-07 CA CA2900773A patent/CA2900773C/en active Active
- 2014-03-07 CN CN201480011202.4A patent/CN105008351B/zh active Active
- 2014-03-07 ES ES14712966.2T patent/ES2639793T3/es active Active
- 2014-03-07 PE PE2015001925A patent/PE20151654A1/es active IP Right Grant
- 2014-03-07 SG SG11201507541PA patent/SG11201507541PA/en unknown
- 2014-03-07 ME MEP-2017-173A patent/ME02805B/me unknown
- 2014-03-07 UA UAA201508675A patent/UA116125C2/uk unknown
- 2014-03-07 PT PT147129662T patent/PT2970221T/pt unknown
- 2014-03-07 US US14/200,141 patent/US9156824B2/en active Active
- 2014-03-07 AP AP2015008734A patent/AP2015008734A0/xx unknown
- 2014-03-07 EP EP14712966.2A patent/EP2970221B1/en active Active
- 2014-03-07 KR KR1020157024644A patent/KR101718645B1/ko not_active Application Discontinuation
- 2014-03-07 JP JP2016500764A patent/JP6064079B2/ja active Active
-
2015
- 2015-08-12 TN TN2015000349A patent/TN2015000349A1/en unknown
- 2015-08-14 CR CR20150416A patent/CR20150416A/es unknown
- 2015-08-31 IL IL240962A patent/IL240962B/en active IP Right Grant
- 2015-09-09 GT GT201500263A patent/GT201500263A/es unknown
- 2015-09-09 CL CL2015002530A patent/CL2015002530A1/es unknown
- 2015-09-14 PH PH12015502091A patent/PH12015502091B1/en unknown
-
2016
- 2016-01-21 HK HK16100636.2A patent/HK1212696A1/zh unknown
-
2017
- 2017-07-27 HR HRP20171151TT patent/HRP20171151T1/hr unknown
- 2017-08-10 CY CY20171100861T patent/CY1119199T1/el unknown
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