JO2257B1 - Erythopietin derivatives - Google Patents
Erythopietin derivativesInfo
- Publication number
- JO2257B1 JO2257B1 JO200096A JOP20000096A JO2257B1 JO 2257 B1 JO2257 B1 JO 2257B1 JO 200096 A JO200096 A JO 200096A JO P20000096 A JOP20000096 A JO P20000096A JO 2257 B1 JO2257 B1 JO 2257B1
- Authority
- JO
- Jordan
- Prior art keywords
- erythropoietin
- poly
- ethylene glycol
- glycoprotein
- group
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 abstract 3
- 108090000394 Erythropoietin Proteins 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 abstract 2
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 2
- 238000006206 glycosylation reaction Methods 0.000 abstract 2
- 102000044890 human EPO Human genes 0.000 abstract 2
- -1 poly(ethylene glycol) Polymers 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000002798 bone marrow cell Anatomy 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 229940105423 erythropoietin Drugs 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- 210000001995 reticulocyte Anatomy 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having at least one free amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to "n" poly(ethylene glycol) groups of the formula -CO-(CH2)x(OCH2CH2)m-OR with the carbonyl of each poly(ethylene glycol) group forming an amide bond with one of said amino groups; wherein R is lower alkyl; x is 2 or 3; m is about 450 to about 900; n is from 1 to 3; ; and n and m are chosen so that the molecular weight of the conjugate minus the erythropoietin glycoprotein is from 20 kilodaltons to 100 kilodaltons.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14225499P | 1999-07-02 | 1999-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO2257B1 true JO2257B1 (en) | 2004-10-07 |
Family
ID=22499186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO200096A JO2257B1 (en) | 1999-07-02 | 2000-06-29 | Erythopietin derivatives |
Country Status (2)
| Country | Link |
|---|---|
| JO (1) | JO2257B1 (en) |
| ZA (1) | ZA200003282B (en) |
-
2000
- 2000-06-29 JO JO200096A patent/JO2257B1/en active
- 2000-06-29 ZA ZA200003282A patent/ZA200003282B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200003282B (en) | 2001-01-02 |
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