ITRM20010688A1 - Composti immunoregolatori. - Google Patents
Composti immunoregolatori.Info
- Publication number
- ITRM20010688A1 ITRM20010688A1 ITRM20010688A ITRM20010688A1 IT RM20010688 A1 ITRM20010688 A1 IT RM20010688A1 IT RM20010688 A ITRM20010688 A IT RM20010688A IT RM20010688 A1 ITRM20010688 A1 IT RM20010688A1
- Authority
- IT
- Italy
- Prior art keywords
- compounds
- sphingosine
- methods
- derivative compounds
- microbicidal
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000004957 immunoregulator effect Effects 0.000 title 1
- 230000003641 microbiacidal effect Effects 0.000 abstract 3
- 102000011420 Phospholipase D Human genes 0.000 abstract 2
- 108090000553 Phospholipase D Proteins 0.000 abstract 2
- -1 sphingosine derivative compounds Chemical class 0.000 abstract 2
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- VDRZDTXJMRRVMF-UONOGXRCSA-N D-erythro-sphingosine Natural products CCCCCCCCCC=C[C@@H](O)[C@@H](N)CO VDRZDTXJMRRVMF-UONOGXRCSA-N 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 230000002979 macrophagic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940124561 microbicide Drugs 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000688 ITRM20010688A1 (it) | 2001-11-21 | 2001-11-21 | Composti immunoregolatori. |
| DE60229660T DE60229660D1 (de) | 2001-11-21 | 2002-11-21 | Verwendung eines sphingosin derivats zur behandlung von mikrobiellen infektionen |
| AT02793332T ATE412406T1 (de) | 2001-11-21 | 2002-11-21 | Verwendung eines sphingosin derivats zur behandlung von mikrobiellen infektionen |
| OA1200400144A OA13138A (en) | 2001-11-21 | 2002-11-21 | Immunoregulator compounds. |
| EP02793332A EP1453494B1 (en) | 2001-11-21 | 2002-11-21 | Use of a sphingosine derivative for the treatment of microbial infections |
| US10/496,497 US8377910B2 (en) | 2001-11-21 | 2002-11-21 | Immunoregulator compounds |
| AU2002358986A AU2002358986A1 (en) | 2001-11-21 | 2002-11-21 | Sphingosine derivative as an immunoregulator compound |
| PCT/IT2002/000740 WO2003045365A2 (en) | 2001-11-21 | 2002-11-21 | Sphingosine derivative as an immunoregulator compound |
| US13/743,516 US9078907B2 (en) | 2001-11-21 | 2013-01-17 | Immunoregulator compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000688 ITRM20010688A1 (it) | 2001-11-21 | 2001-11-21 | Composti immunoregolatori. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITRM20010688A0 ITRM20010688A0 (it) | 2001-11-21 |
| ITRM20010688A1 true ITRM20010688A1 (it) | 2003-05-21 |
Family
ID=11455889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001RM000688 ITRM20010688A1 (it) | 2001-11-21 | 2001-11-21 | Composti immunoregolatori. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8377910B2 (it) |
| EP (1) | EP1453494B1 (it) |
| AT (1) | ATE412406T1 (it) |
| AU (1) | AU2002358986A1 (it) |
| DE (1) | DE60229660D1 (it) |
| IT (1) | ITRM20010688A1 (it) |
| OA (1) | OA13138A (it) |
| WO (1) | WO2003045365A2 (it) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20010688A1 (it) * | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
| GB0513431D0 (en) | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
| WO2014061016A1 (en) * | 2012-10-15 | 2014-04-24 | Yeda Research And Development Co. Ltd. | Use of sphingoid long chain bases and their analogs in treating and preventing bacterial infections |
| EP3259990A1 (en) * | 2016-06-20 | 2017-12-27 | Ceva Sante Animale | Methods for controlling ectoparasites in non-human mammals |
| IL260690A (en) | 2018-07-19 | 2018-12-31 | Yeda Res & Dev | Sphingosine derivatives and their use against pulmonary bacterial infections |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0321287A3 (en) * | 1987-12-18 | 1990-11-22 | City of Hope | Inhibition of lipogenesis |
| US5256641A (en) * | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| US5260288A (en) * | 1992-04-03 | 1993-11-09 | The Biomembrane Institute | Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives |
| WO1995007089A1 (en) * | 1993-09-09 | 1995-03-16 | Imutec Corporation | Immunomodulating compositions from bile |
| US5430169A (en) * | 1994-02-14 | 1995-07-04 | The United States Of America Represented By The Department Of Health And Human Services | Method for preparation of sphingoid bases |
| EP0754053A1 (en) * | 1995-02-03 | 1997-01-22 | Korea Institute of Science and Technology | Novel hemostatic composition |
| WO1998049999A2 (en) * | 1997-05-02 | 1998-11-12 | Gist-Brocades B.V. | Antimicrobial compositions for topical use |
| CA2206047A1 (en) * | 1997-05-23 | 1998-11-23 | Romeo Rang (Deceased) | Immunomodulating compositions for the treatment of viral disorders |
| JPH1180026A (ja) | 1997-09-02 | 1999-03-23 | Yoshitomi Pharmaceut Ind Ltd | 新規免疫抑制剤、その使用方法およびその同定方法 |
| AU9002298A (en) * | 1997-09-11 | 1999-03-29 | Takara Shuzo Co., Ltd. | Sphingosine derivatives and medicinal composition |
| DE19810999A1 (de) | 1998-03-13 | 1999-09-16 | Dermapharm Gmbh | Verwendung von Sphingosin, Sphingosin-1-Phosphat, Sphingosin-1-Phosphat-Derivaten und/oder deren Gemischen zur Behandlung von entzündlichen Hautkrankheiten |
| US6248329B1 (en) | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| FR2823117A1 (fr) * | 2000-11-14 | 2002-10-11 | Pharmascience Lab | Composition pharmaceutique ou cosmetique ainsi que l'utilisation d'au moins un compose actif pour inhiber la migration des cellules de langerhans |
| GB0030700D0 (en) * | 2000-12-15 | 2001-01-31 | European Molecular Biology Lab Embl | Membrane signalling networks |
| WO2002060405A1 (en) * | 2001-01-29 | 2002-08-08 | Cosmoferm B.V. | Veterinary dermatologic composition comprising a sphingoid base and/or a sphingoid base derivative |
| US7064217B2 (en) | 2001-01-30 | 2006-06-20 | University Of Virginia Patent Foundation | Agonists and antagonists of sphingosine-1-phosphate receptors |
| ITRM20010688A1 (it) * | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
| ES2316758T3 (es) | 2002-05-16 | 2009-04-16 | Novartis Ag | Uso de aglutinantes del receptor edg en el cancer. |
| CN100516024C (zh) | 2002-09-13 | 2009-07-22 | 诺瓦提斯公司 | 氨基-丙醇衍生物 |
| EP2251007A3 (en) | 2002-09-24 | 2011-03-23 | Novartis AG | Sphingosine-1-phosphate (S1P) receptor agonists for use in the treatment of demyelinating diseases |
| NL1022443C2 (nl) * | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| EP1638611B1 (en) * | 2003-06-18 | 2012-10-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sphingolipids polyalkylamine conjugates for use in transfection |
| ES2317259T3 (es) * | 2004-06-29 | 2009-04-16 | Jado Technologies Gmbh | Esfingolipidos contra procesos patologicos en baldas lipidicas. |
| GB0513431D0 (en) * | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
-
2001
- 2001-11-21 IT IT2001RM000688 patent/ITRM20010688A1/it unknown
-
2002
- 2002-11-21 AU AU2002358986A patent/AU2002358986A1/en not_active Abandoned
- 2002-11-21 EP EP02793332A patent/EP1453494B1/en not_active Expired - Lifetime
- 2002-11-21 OA OA1200400144A patent/OA13138A/en unknown
- 2002-11-21 WO PCT/IT2002/000740 patent/WO2003045365A2/en not_active Application Discontinuation
- 2002-11-21 DE DE60229660T patent/DE60229660D1/de not_active Expired - Fee Related
- 2002-11-21 AT AT02793332T patent/ATE412406T1/de not_active IP Right Cessation
- 2002-11-21 US US10/496,497 patent/US8377910B2/en active Active
-
2013
- 2013-01-17 US US13/743,516 patent/US9078907B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8377910B2 (en) | 2013-02-19 |
| ITRM20010688A0 (it) | 2001-11-21 |
| EP1453494B1 (en) | 2008-10-29 |
| US9078907B2 (en) | 2015-07-14 |
| AU2002358986A1 (en) | 2003-06-10 |
| DE60229660D1 (de) | 2008-12-11 |
| AU2002358986A8 (en) | 2003-06-10 |
| ATE412406T1 (de) | 2008-11-15 |
| WO2003045365A2 (en) | 2003-06-05 |
| EP1453494A2 (en) | 2004-09-08 |
| US20050009757A1 (en) | 2005-01-13 |
| OA13138A (en) | 2006-12-13 |
| WO2003045365A3 (en) | 2004-03-25 |
| US20130202648A1 (en) | 2013-08-08 |
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