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ITMO20090309A1 - Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione - Google Patents

Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione

Info

Publication number
ITMO20090309A1
ITMO20090309A1 IT000309A ITMO20090309A ITMO20090309A1 IT MO20090309 A1 ITMO20090309 A1 IT MO20090309A1 IT 000309 A IT000309 A IT 000309A IT MO20090309 A ITMO20090309 A IT MO20090309A IT MO20090309 A1 ITMO20090309 A1 IT MO20090309A1
Authority
IT
Italy
Prior art keywords
liofilization
monitoring
primary drying
drying
primary
Prior art date
Application number
IT000309A
Other languages
English (en)
Inventor
Antonello A Barresi
Davide Fissore
Roberto Pisano
Original Assignee
Telstar Technologies S L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telstar Technologies S L filed Critical Telstar Technologies S L
Priority to ITMO2009A000309A priority Critical patent/IT1397930B1/it
Priority to EP10814744.8A priority patent/EP2516948B1/en
Priority to DK10814744.8T priority patent/DK2516948T3/da
Priority to US13/518,445 priority patent/US9170049B2/en
Priority to CN201080063408.3A priority patent/CN102753923B/zh
Priority to ES10814744.8T priority patent/ES2471016T3/es
Priority to PCT/IB2010/056011 priority patent/WO2011077390A2/en
Publication of ITMO20090309A1 publication Critical patent/ITMO20090309A1/it
Application granted granted Critical
Publication of IT1397930B1 publication Critical patent/IT1397930B1/it

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
ITMO2009A000309A 2009-12-23 2009-12-23 Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione. IT1397930B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMO2009A000309A IT1397930B1 (it) 2009-12-23 2009-12-23 Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.
EP10814744.8A EP2516948B1 (en) 2009-12-23 2010-12-22 Method for monitoring primary drying of a freeze-drying process
DK10814744.8T DK2516948T3 (da) 2009-12-23 2010-12-22 Fremgangsmåde til overvågning af primær tørring i en frysetørringsproces
US13/518,445 US9170049B2 (en) 2009-12-23 2010-12-22 Method for monitoring primary drying of a freeze-drying process
CN201080063408.3A CN102753923B (zh) 2009-12-23 2010-12-22 用来监视冻干过程的初级干燥的方法
ES10814744.8T ES2471016T3 (es) 2009-12-23 2010-12-22 Método de control de secado principal de un proceso de secado por congelación
PCT/IB2010/056011 WO2011077390A2 (en) 2009-12-23 2010-12-22 Method for monitoring primary drying of a freeze-drying process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMO2009A000309A IT1397930B1 (it) 2009-12-23 2009-12-23 Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.

Publications (2)

Publication Number Publication Date
ITMO20090309A1 true ITMO20090309A1 (it) 2011-06-24
IT1397930B1 IT1397930B1 (it) 2013-02-04

Family

ID=42536411

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMO2009A000309A IT1397930B1 (it) 2009-12-23 2009-12-23 Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.

Country Status (7)

Country Link
US (1) US9170049B2 (it)
EP (1) EP2516948B1 (it)
CN (1) CN102753923B (it)
DK (1) DK2516948T3 (it)
ES (1) ES2471016T3 (it)
IT (1) IT1397930B1 (it)
WO (1) WO2011077390A2 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1397930B1 (it) * 2009-12-23 2013-02-04 Telstar Technologies S L Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.
JP5827178B2 (ja) * 2012-06-05 2015-12-02 北越紀州製紙株式会社 セルロース多孔質体及びその製造方法
ES2661246T3 (es) 2013-11-27 2018-03-28 Laboratorio Reig Jofre S.A. Método para controlar la calidad de un proceso de liofilización
US20150226617A1 (en) * 2014-02-12 2015-08-13 Millrock Technology, Inc Using in-process heat flow and developing transferable protocols for the monitoring, control and characerization of a freeze drying process
US10266292B2 (en) 2015-01-22 2019-04-23 Neptune Research, Llc Carriers for composite reinforcement systems and methods of use
WO2018194925A1 (en) * 2017-04-21 2018-10-25 Mks Instruments, Inc. End point detection for lyophilization
EP3775740B1 (en) * 2018-04-10 2025-07-30 IMA Life North America Inc. Freeze drying process and equipment health monitoring
US10914717B2 (en) 2018-05-09 2021-02-09 Mks Instruments, Inc. Method and apparatus for partial pressure detection
US11287185B1 (en) 2020-09-09 2022-03-29 Stay Fresh Technology, LLC Freeze drying with constant-pressure and constant-temperature phases
WO2023286137A1 (ja) * 2021-07-12 2023-01-19 株式会社アルバック 凍結乾燥装置及び凍結乾燥方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780964A (en) * 1987-11-30 1988-11-01 Fts Systems, Inc. Process and device for determining the end of a primary stage of freeze drying
WO1995030118A1 (fr) * 1994-05-03 1995-11-09 Institut National De La Recherche Agronomique Procede et dispositif de controle de la lyophilisation sous vide
US6971187B1 (en) * 2002-07-18 2005-12-06 University Of Connecticut Automated process control using manometric temperature measurement
WO2007115965A1 (en) * 2006-04-10 2007-10-18 F. Hoffmann-La Roche Ag Apparatus for monitoring freeze-drying process
EP1903291A1 (en) * 2006-09-19 2008-03-26 Ima-Telstar S.L. Method and system for controlling a freeze drying process
WO2008042408A2 (en) * 2006-10-03 2008-04-10 Wyeth Lyophilization methods and apparatuses

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2994132A (en) 1956-08-22 1961-08-01 Neumann Karlheinz Freeze drying apparatus
FR1286002A (fr) 1961-01-17 1962-03-02 Usifroid Procédé pour la régulation des opérations de congélation-dessication et installation pour sa mise en oeuvre
US3266169A (en) * 1962-10-31 1966-08-16 Hupp Corp Vacuum freeze drying apparatus
DE1604803A1 (de) * 1962-03-01 1971-01-07 Carlo Barbareschi Verfahren zur kontinuierlichen Absorbierung und Beseitigung von Wasserdampf oder anderen Loesungsmitteln durch Verdampfung oder Sublimation bei niedriger Temperatur unter Vakuum
AU4658296A (en) * 1995-01-20 1996-08-07 Freezedry Specialties, Inc. Freeze dryer
DE19719398A1 (de) * 1997-05-07 1998-11-12 Amsco Finn Aqua Gmbh Verfahren zur Steuerung eines Gefriertrocknungsprozesses
US6226997B1 (en) 1999-12-07 2001-05-08 Cryo-Cell International, Inc. Method and device for maintaining temperature integrity of cryogenically preserved biological samples
SE0001453D0 (sv) * 2000-04-19 2000-04-19 Astrazeneca Ab Method of monitoring a freeze drying process
JP4179881B2 (ja) 2000-12-06 2008-11-12 エーザイ株式会社 凍結乾燥ケークの抵抗を測定するためのシステム及び方法
NL1020603C2 (nl) * 2002-05-15 2003-11-18 Tno Werkwijze voor het drogen van een product met behulp van een regeneratief adsorbens.
US20060208191A1 (en) * 2005-01-07 2006-09-21 Kessler William J System for monitoring a drying process
ITTO20060270A1 (it) * 2006-04-11 2007-10-12 Torino Politecnico Ottimazione e controllo del processo di liofilizzazione di prodotti farmaceutici
EP2148158B1 (en) * 2008-07-23 2011-11-02 Telstar Technologies, S.L. Method for monitoring the secondary drying in a freeze-drying process
US8528225B2 (en) * 2009-12-11 2013-09-10 Wyssmont Company Inc. Apparatus and method for continuous lyophilization
IT1397930B1 (it) * 2009-12-23 2013-02-04 Telstar Technologies S L Metodo per monitorare l'essiccamento primario di un processo di liofilizzazione.
US8689460B2 (en) * 2010-09-28 2014-04-08 Baxter International Inc. Optimization of nucleation and crystallization for lyophilization using gap freezing
US8898928B2 (en) * 2012-10-11 2014-12-02 Lam Research Corporation Delamination drying apparatus and method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780964A (en) * 1987-11-30 1988-11-01 Fts Systems, Inc. Process and device for determining the end of a primary stage of freeze drying
WO1995030118A1 (fr) * 1994-05-03 1995-11-09 Institut National De La Recherche Agronomique Procede et dispositif de controle de la lyophilisation sous vide
US6971187B1 (en) * 2002-07-18 2005-12-06 University Of Connecticut Automated process control using manometric temperature measurement
WO2007115965A1 (en) * 2006-04-10 2007-10-18 F. Hoffmann-La Roche Ag Apparatus for monitoring freeze-drying process
EP1903291A1 (en) * 2006-09-19 2008-03-26 Ima-Telstar S.L. Method and system for controlling a freeze drying process
WO2008042408A2 (en) * 2006-10-03 2008-04-10 Wyeth Lyophilization methods and apparatuses

Also Published As

Publication number Publication date
US9170049B2 (en) 2015-10-27
ES2471016T3 (es) 2014-06-25
WO2011077390A3 (en) 2011-08-18
IT1397930B1 (it) 2013-02-04
EP2516948A2 (en) 2012-10-31
DK2516948T3 (da) 2014-06-30
WO2011077390A2 (en) 2011-06-30
CN102753923B (zh) 2015-03-04
CN102753923A (zh) 2012-10-24
US20130006546A1 (en) 2013-01-03
EP2516948B1 (en) 2014-03-19

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