ITMI970339A1 - PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRO AND USE OF COLOSTRO FOR HAIR LOSS TREATMENT - Google Patents
PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRO AND USE OF COLOSTRO FOR HAIR LOSS TREATMENT Download PDFInfo
- Publication number
- ITMI970339A1 ITMI970339A1 IT97MI000339A ITMI970339A ITMI970339A1 IT MI970339 A1 ITMI970339 A1 IT MI970339A1 IT 97MI000339 A IT97MI000339 A IT 97MI000339A IT MI970339 A ITMI970339 A IT MI970339A IT MI970339 A1 ITMI970339 A1 IT MI970339A1
- Authority
- IT
- Italy
- Prior art keywords
- colostrum
- colostro
- hair loss
- treatment
- pharmaceutical formulations
- Prior art date
Links
- 201000004384 Alopecia Diseases 0.000 title claims description 23
- 238000011282 treatment Methods 0.000 title claims description 14
- 208000024963 hair loss Diseases 0.000 title claims description 13
- 230000003676 hair loss Effects 0.000 title claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
- 210000003022 colostrum Anatomy 0.000 claims description 18
- 235000021277 colostrum Nutrition 0.000 claims description 18
- 238000009472 formulation Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 241000283073 Equus caballus Species 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 4
- 241000283690 Bos taurus Species 0.000 claims description 3
- 229940103903 medicated shampoo Drugs 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000011418 maintenance treatment Methods 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 2
- 235000008476 powdered milk Nutrition 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 description 10
- 210000004209 hair Anatomy 0.000 description 4
- 230000001052 transient effect Effects 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000003313 weakening effect Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010039587 Scarlet Fever Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/986—Milk; Derivatives thereof, e.g. butter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Descrizione dell'invenzione industriale avente per titolo: "FORMULAZIONI FARMACEUTICHE CONTENENTI COLOSTRO E USO DEL COLOSTRO PER IL TRATTAMENTO DELLA CADUTA DEI CAPELLI" Description of the industrial invention entitled: "PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRUM AND USE OF COLOSTRUM FOR THE TREATMENT OF HAIR LOSS"
La presente invenzione ha per oggetto formulazioni farmaceutiche a base di colostro animale per il trattamento della caduta dei capelli, e l'uso del colostro per il trattamento della caduta dei capelli. The present invention relates to pharmaceutical formulations based on animal colostrum for the treatment of hair loss, and the use of colostrum for the treatment of hair loss.
La caduta dei capelli, o alopecia, è un disturbo che affligge una notevole quantità di popolazione,particolarmente quella maschile. Hair loss, or alopecia, is a disorder that affects a considerable amount of the population, particularly men.
La caduta dei capelli può essere transitoria, dovuta a cause quali stress, affaticamento, malattie (scarlattina, sifilide, ipopituitarismo), trattamenti farmacologici con farmaci chemioterapici o con alte dosi di vitamina A, puerperio. In altri casi invece la caduta, parziale o generale,dei capelli è definitiva. Hair loss can be transient, due to causes such as stress, fatigue, diseases (scarlet fever, syphilis, hypopituitarism), pharmacological treatments with chemotherapy drugs or with high doses of vitamin A, puerperium. In other cases, however, partial or general hair loss is definitive.
L'alopecia più diffusa è quella maschile, sovente a carattere familiare, dovuta a una particolare sensibilità dei follicoli piliferi agli aridrogeni circolanti. The most widespread alopecia is male alopecia, often of a family nature, due to a particular sensitivity of the hair follicles to circulating arhydrogens.
L'alopecia femminile è meno diffusa e meno persistente, tuttavia nelle donne il fenomeno dell'indebolimento dei capelli in seguito a trattamenti estetici quali colorazione, decolorazione, permanente ecc. porta frequentemente a una caduta dei capelli più o meno transitoria e generalizzata. Female alopecia is less widespread and less persistent, however in women the phenomenon of weakening of the hair following aesthetic treatments such as coloring, bleaching, perming, etc. it frequently leads to more or less transient and generalized hair loss.
Altre forme di alopecia sono quella areata, dovuta ad alterazioni funzionali o strutturali dei follicoli piliferi, e quella cicatriziale, dovuta a lesioni provocate da ustioni,dermatiti atrofiche,traumi,ecc. Other forms of alopecia are the aerated one, due to functional or structural alterations of the hair follicles, and the cicatricial one, due to lesions caused by burns, atrophic dermatitis, trauma, etc.
Non esistono attualmente valide terapie per l'alopecia maschile: il trattamento più diffuso è attualmente quello con Minoxidil, un antiipertensivo che viene utilizzato in soluzione al 3%: tuttavia i risultati sono transitori e cessano quando il trattamento è interrotto. Un'altro approccio al problema dell'alopecia maschile è il trapianto di capelli,che dà risultati variabili. There are currently no valid therapies for male alopecia: the most widespread treatment is currently that with Minoxidil, an antihypertensive that is used in a 3% solution: however the results are transient and cease when the treatment is stopped. Another approach to the problem of male alopecia is hair transplantation, which gives variable results.
L'alopecia aerata è trattata con il triamcinolone acetonide, che però non dà sempre risultati duraturi. Aerated alopecia is treated with triamcinolone acetonide, which however does not always give lasting results.
Il trattamento dell'alopecia cicatriziale è volto all'eliminazione dell'agente eziologico (dermatite ecc.). Treatment of scarring alopecia is aimed at eliminating the causative agent (dermatitis, etc.).
Tutti i trattamenti sopra indicati danno risultati variabili, spesso insoddisfacenti e transitori. All the treatments indicated above give variable, often unsatisfactory and transient results.
La presente invenzione ha lo scopo di superare i problemi sopra indicati, mediante l'uso di formulazioni farmaceutiche contenenti colostro equino o bovino o comunque di mammifero, ma preferibilmente equino,per il trattamento della caduta dei capelli. The present invention has the purpose of overcoming the problems indicated above, through the use of pharmaceutical formulations containing equine or bovine or in any case mammalian colostrum, but preferably equine, for the treatment of hair loss.
La presente invenzione, inoltre, ha per oggetto l'uso di colostro equino o bovino o comunque di mammifero, ma preferibilmente equino, per la preparazione di medicamenti per il trattamento della caduta dei capelli, promuovendone la ricrescita. The present invention furthermore relates to the use of equine or bovine or in any case mammalian colostrum, but preferably equine, for the preparation of medicaments for the treatment of hair loss, promoting its regrowth.
La sperimentazione clinica, effettuata su una serie di pazienti affetti da: The clinical trial, carried out on a series of patients suffering from:
- alopecia maschile; - male alopecia;
- alopecia areata; - alopecia areata;
- indebolimento generalizzato dei capelli; - generalized weakening of the hair;
ha mostrato che il trattamento con colostro esercita un'azione efficace sull'arresto della caduta dei capelli e sulla stimolazione della ricrescita dei capelli, combatte l'indebolimento dei bulbi piliferi e rinforza l'attività dei follicoli piliferi. showed that colostrum treatment exerts an effective action on arresting hair loss and stimulating hair regrowth, combating the weakening of the hair bulbs and strengthening the activity of hair follicles.
Le formulazioni farmaceutiche dell'invenzione contengono colostro liquido oppure in polvere, liofilizzato o sprayzzato, ma preferibilmente colostro liquido, in quantità percentuali dal 10 al 20% in peso. The pharmaceutical formulations of the invention contain liquid or powdered colostrum, lyophilized or sprayed, but preferably liquid colostrum, in percentage quantities from 10 to 20% by weight.
Più particolarmente, le formulazioni dell'invenzione sono in forma di gel, lozione, balsamo, crema, unguento ed eventualmente shampoo medicato per il trattamento di mantenimento. More particularly, the formulations of the invention are in the form of gel, lotion, conditioner, cream, ointment and possibly medicated shampoo for the maintenance treatment.
Le formulazioni dell'invenzione vengono preparate secondo tecniche farmaceutiche convenzionali. The formulations of the invention are prepared according to conventional pharmaceutical techniques.
Secondo un ulteriore aspetto dell'invenzione, le formulazioni possono contenere colostro miscelato a latte. According to a further aspect of the invention, the formulations can contain colostrum mixed with milk.
Di seguito vengono riportati alcuni esempi di formulazioni farmaceutiche secondo l'invenzione. Some examples of pharmaceutical formulations according to the invention are reported below.
ESEMPIO 1 EXAMPLE 1
Lozione:100 mi di lozione contengono: Lotion: 100 ml of lotion contain:
- colostro liquido 5 g - liquid colostrum 5 g
- olio di jojoba 0.6 g - jojoba oil 0.6 g
- propileneglicol 25 g - propylene glycol 25 g
- butilidrossianisolo 0,03 g - butylhydroxyanisole 0.03 g
- trietanolammina q.b. a pH 6-8 - triethanolamine to taste at pH 6-8
- profumo 0.15 g - acqua deinineralizzata q.b. a 100 mi ESEMPIO 2 - perfume 0.15 g - deinineralized water to taste at 100 ml EXAMPLE 2
Shampoo medicato:100 mi di shampoo contengono: - colostro 15 g Medicated shampoo: 100 ml of shampoo contain: - 15 g colostrum
- butilidrossianisolo 0,025 - butylated hydroxyanisole 0.025
- trietanolaranina laurilsolfato 30 g - triethanolaranine lauryl sulfate 30 g
- polietileneglicol 15 g - polyethylene glycol 15 g
- profumo q.b. - perfume q.s.
- acqua deionizzata q.b.a 100 mi. - deionized water q.s. to 100 ml.
Claims (7)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000339A IT1290347B1 (en) | 1997-02-18 | 1997-02-18 | PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRO AND USE OF COLOSTRO FOR HAIR LOSS TREATMENT |
| PCT/EP1998/000903 WO1998036759A1 (en) | 1997-02-18 | 1998-02-17 | Pharmaceutical compositions containing colostrum and the use of colostrum for the treatment of hair loss |
| AU67206/98A AU6720698A (en) | 1997-02-18 | 1998-02-17 | Pharmaceutical compositions containing colostrum and the use of colostrum for the treatment of hair loss |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI000339A IT1290347B1 (en) | 1997-02-18 | 1997-02-18 | PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRO AND USE OF COLOSTRO FOR HAIR LOSS TREATMENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI970339A1 true ITMI970339A1 (en) | 1998-08-18 |
| IT1290347B1 IT1290347B1 (en) | 1998-10-22 |
Family
ID=11376056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI000339A IT1290347B1 (en) | 1997-02-18 | 1997-02-18 | PHARMACEUTICAL FORMULATIONS CONTAINING COLOSTRO AND USE OF COLOSTRO FOR HAIR LOSS TREATMENT |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU6720698A (en) |
| IT (1) | IT1290347B1 (en) |
| WO (1) | WO1998036759A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0518552A2 (en) * | 2004-12-24 | 2008-12-30 | Dolphst Pty Ltd | formulation for welfare in humans and method for enhancing the welfare of a human patient |
| CN102698273A (en) * | 2004-12-24 | 2012-10-03 | 都菲斯特股份有限公司 | Formulations and treatments for trichology |
| ITMI20112432A1 (en) * | 2011-12-30 | 2013-07-01 | Bionest Ltd | KIT FOR TREATMENT AND PREVENTION OF ALOPECIA |
| US9492512B2 (en) | 2011-12-30 | 2016-11-15 | Innomed S.A. | Combination of growth factors, cytokines, antibacterial/antiviral factors, stem cell stimulating factors, complement proteins C3A/C4A, and chemotactic factors |
| JP6139562B2 (en) | 2011-12-30 | 2017-05-31 | イノメッド ソシエテ アノニム | Combination of growth factors, cytokines, antibacterial / antiviral factors, stem cell stimulating factors, complement proteins C3A / C4A, immunoglobulins and chemotactic factors |
| US11413321B2 (en) | 2017-12-26 | 2022-08-16 | Hirotaro FUKUOKA | Pharmaceutical composition for use in increasing hair, modifying scalp or skin, healing a wound, promoting osteogenesis, or modifying hair |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4103275C1 (en) * | 1991-02-04 | 1992-04-02 | Dieter 2000 Hamburg De Bliesener | Agent to prevent hair loss due to seborrhoea - contains peptide(s) from mare's milk, acetate, alpha-tocopherol-acetate of retinol |
| ES2102813T3 (en) * | 1993-01-26 | 1997-08-01 | Horse Vitality Ltd | PHARMACEUTICAL AND DERMOCOSMETIC COMPOSITIONS CONTAINING EQUINE COLOSTRY. |
| DE19537297A1 (en) * | 1995-07-07 | 1997-01-09 | Paerson & Co Gmbh & Co | Cosmetic, esp. skin or hair care prods. opt. stabilised with heparin and/or chondroitin sulphate - comprise growth factor prepd. directly from milk and colostrum from cows or mares, opt. in soya and/or protein phospholipid liposome form |
-
1997
- 1997-02-18 IT IT97MI000339A patent/IT1290347B1/en active IP Right Grant
-
1998
- 1998-02-17 AU AU67206/98A patent/AU6720698A/en not_active Abandoned
- 1998-02-17 WO PCT/EP1998/000903 patent/WO1998036759A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998036759A1 (en) | 1998-08-27 |
| AU6720698A (en) | 1998-09-09 |
| IT1290347B1 (en) | 1998-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |