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ITMI922006A0 - Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preprazione - Google Patents

Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preprazione

Info

Publication number
ITMI922006A0
ITMI922006A0 IT92MI2006A ITMI922006A ITMI922006A0 IT MI922006 A0 ITMI922006 A0 IT MI922006A0 IT 92MI2006 A IT92MI2006 A IT 92MI2006A IT MI922006 A ITMI922006 A IT MI922006A IT MI922006 A0 ITMI922006 A0 IT MI922006A0
Authority
IT
Italy
Prior art keywords
prepration
phenylamino
halo
derivatives
procedure
Prior art date
Application number
IT92MI2006A
Other languages
English (en)
Inventor
Jose Antonio Matji
Antonio Alcaide
Original Assignee
Corlay Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corlay Sl filed Critical Corlay Sl
Publication of ITMI922006A0 publication Critical patent/ITMI922006A0/it
Priority to ITMI922006A priority Critical patent/IT1256345B/it
Priority to EP93917596A priority patent/EP0609415B1/en
Priority to UA94005348A priority patent/UA39172C2/uk
Priority to ES93917596T priority patent/ES2093979T3/es
Priority to AT93917596T priority patent/ATE143941T1/de
Priority to RU94046148A priority patent/RU2109009C1/ru
Priority to KR1019940701286A priority patent/KR100269727B1/ko
Priority to CA002120942A priority patent/CA2120942C/en
Priority to US08/211,447 priority patent/US5597847A/en
Priority to DK93917596.4T priority patent/DK0609415T3/da
Priority to JP50582694A priority patent/JP3231042B2/ja
Priority to DE69305322T priority patent/DE69305322T2/de
Priority to PCT/EP1993/001906 priority patent/WO1994004484A1/en
Publication of ITMI922006A1 publication Critical patent/ITMI922006A1/it
Application granted granted Critical
Publication of IT1256345B publication Critical patent/IT1256345B/it
Priority to GR960402711T priority patent/GR3021404T3/el
Priority to HK98106190A priority patent/HK1006967A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ITMI922006A 1992-08-20 1992-08-20 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione IT1256345B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ITMI922006A IT1256345B (it) 1992-08-20 1992-08-20 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
US08/211,447 US5597847A (en) 1992-08-20 1993-07-20 Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation
JP50582694A JP3231042B2 (ja) 1992-08-20 1993-07-20 ２−（２，６−ジ−ハロ−フェニルアミノ）フェニル酢酸の誘導体の硝酸エステルおよびその製造法
ES93917596T ES2093979T3 (es) 1992-08-20 1993-07-20 Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino)fenilacetico y su procedimiento de preparacion.
AT93917596T ATE143941T1 (de) 1992-08-20 1993-07-20 Salpetersäureester von 2-(2,6- dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
RU94046148A RU2109009C1 (ru) 1992-08-20 1993-07-20 Производные 2-(2,6-дигалофениламино)фенилуксусной кислоты и способ их получения
KR1019940701286A KR100269727B1 (ko) 1992-08-20 1993-07-20 2-(2,6-디-할로페닐아미노)페닐아세트산의 유도체의 니트릭에스테르 및 그들의 제조방법
CA002120942A CA2120942C (en) 1992-08-20 1993-07-20 Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino)phenyl-acetic acid and process for their preparation
EP93917596A EP0609415B1 (en) 1992-08-20 1993-07-20 Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation
DK93917596.4T DK0609415T3 (da) 1992-08-20 1993-07-20 Salpetersyreestere af 2-(2,6-di-halogen-phenylamino)phenyleddikesyrederivater og fremgangsmåde til deres fremstilling
UA94005348A UA39172C2 (uk) 1992-08-20 1993-07-20 Похідні 2-(2,6-дигалофеніламіно) фенілоцтової кислоти і спосіб їх одержання
DE69305322T DE69305322T2 (de) 1992-08-20 1993-07-20 Salpetersäureester von 2-(2,6-dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
PCT/EP1993/001906 WO1994004484A1 (en) 1992-08-20 1993-07-20 Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation
GR960402711T GR3021404T3 (en) 1992-08-20 1996-10-21 Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation.
HK98106190A HK1006967A1 (en) 1992-08-20 1998-06-23 Nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI922006A IT1256345B (it) 1992-08-20 1992-08-20 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Publications (3)

Publication Number Publication Date
ITMI922006A0 true ITMI922006A0 (it) 1992-08-20
ITMI922006A1 ITMI922006A1 (it) 1994-02-20
IT1256345B IT1256345B (it) 1995-12-01

Family

ID=11363881

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI922006A IT1256345B (it) 1992-08-20 1992-08-20 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione

Country Status (15)

Country Link
US (1) US5597847A (it)
EP (1) EP0609415B1 (it)
JP (1) JP3231042B2 (it)
KR (1) KR100269727B1 (it)
AT (1) ATE143941T1 (it)
CA (1) CA2120942C (it)
DE (1) DE69305322T2 (it)
DK (1) DK0609415T3 (it)
ES (1) ES2093979T3 (it)
GR (1) GR3021404T3 (it)
HK (1) HK1006967A1 (it)
IT (1) IT1256345B (it)
RU (1) RU2109009C1 (it)
UA (1) UA39172C2 (it)
WO (1) WO1994004484A1 (it)

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WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
RU2145595C1 (ru) * 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
ES2092962B1 (es) * 1995-04-19 1997-07-16 Prodes Sa Esteres nitricos de derivados del acido 2-(2,6-dihalofenilamino) fenilacetoxiacetico y sus procedimientos de preparacion.
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US6043232A (en) * 1997-07-23 2000-03-28 Nitromed, Inc. Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs
US5792758A (en) * 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6355680B1 (en) * 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
JP2000516235A (ja) * 1996-08-16 2000-12-05 ハンドフォース インベストメンツ リミテッド 非潰瘍誘発性の鎮痛／抗炎症クロニキシン誘導体
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
FR2757159B1 (fr) * 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
AU763000B2 (en) 1998-10-30 2003-07-10 Nicox S.A. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1308633B1 (it) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1311923B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
TWI243672B (en) * 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
IT1312115B1 (it) 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
TWI262791B (en) 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
AU782971B2 (en) 1999-12-23 2005-09-15 Nicox S.A. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
SE0102993D0 (sv) * 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
US7211598B2 (en) 2002-06-28 2007-05-01 Nitromed, Inc. Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) * 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
WO2004010945A2 (en) 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
SE0203093D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Uk Ltd New use
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
US8067464B2 (en) 2004-10-04 2011-11-29 Nitromed, Inc. Compositions and methods using apocynin compounds and nitric oxide donors
AR061623A1 (es) 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico

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US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
DE3407507A1 (de) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US5021576A (en) * 1989-10-27 1991-06-04 American Home Products Corporation 2-Anilino phenylacetic acid derivatives

Also Published As

Publication number Publication date
GR3021404T3 (en) 1997-01-31
WO1994004484A1 (en) 1994-03-03
CA2120942C (en) 2005-09-27
DE69305322T2 (de) 1997-02-20
UA39172C2 (uk) 2001-06-15
CA2120942A1 (en) 1994-03-03
DE69305322D1 (de) 1996-11-14
ITMI922006A1 (it) 1994-02-20
ES2093979T3 (es) 1997-01-01
IT1256345B (it) 1995-12-01
KR100269727B1 (ko) 2000-10-16
EP0609415B1 (en) 1996-10-09
HK1006967A1 (en) 1999-03-26
JPH07500355A (ja) 1995-01-12
ATE143941T1 (de) 1996-10-15
US5597847A (en) 1997-01-28
EP0609415A1 (en) 1994-08-10
RU2109009C1 (ru) 1998-04-20
JP3231042B2 (ja) 2001-11-19
DK0609415T3 (da) 1996-11-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970723