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ITMI20061802A1 - Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio - Google Patents

Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio

Info

Publication number
ITMI20061802A1
ITMI20061802A1 IT001802A ITMI20061802A ITMI20061802A1 IT MI20061802 A1 ITMI20061802 A1 IT MI20061802A1 IT 001802 A IT001802 A IT 001802A IT MI20061802 A ITMI20061802 A IT MI20061802A IT MI20061802 A1 ITMI20061802 A1 IT MI20061802A1
Authority
IT
Italy
Prior art keywords
sulfossonus
ilides
methylen
epoxidation
steroids
Prior art date
Application number
IT001802A
Other languages
English (en)
Inventor
Marco Alpegiani
Fabio Benedetti
Cinzia Botta
Walter Cabri
Manuela Rodriquez
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Priority to IT001802A priority Critical patent/ITMI20061802A1/it
Priority to EP07018400A priority patent/EP1903051A3/en
Priority to US11/858,976 priority patent/US20080076915A1/en
Publication of ITMI20061802A1 publication Critical patent/ITMI20061802A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
IT001802A 2006-09-22 2006-09-22 Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio ITMI20061802A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT001802A ITMI20061802A1 (it) 2006-09-22 2006-09-22 Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio
EP07018400A EP1903051A3 (en) 2006-09-22 2007-09-19 Epoxidation of 17-oxo-15,16-methylene steroids with sulfoxonium ylides
US11/858,976 US20080076915A1 (en) 2006-09-22 2007-09-21 Epoxidation of 17-oxo-15,16-Methylene Steroids with Sulfoxonium Ylides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001802A ITMI20061802A1 (it) 2006-09-22 2006-09-22 Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio

Publications (1)

Publication Number Publication Date
ITMI20061802A1 true ITMI20061802A1 (it) 2008-03-23

Family

ID=38972943

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001802A ITMI20061802A1 (it) 2006-09-22 2006-09-22 Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio

Country Status (3)

Country Link
US (1) US20080076915A1 (it)
EP (1) EP1903051A3 (it)
IT (1) ITMI20061802A1 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009059765A3 (en) * 2007-11-08 2009-10-15 Chorisis S.R.L. Process for the preparation of drospirenone

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2265629B1 (en) * 2008-03-05 2015-06-24 Evestra, Inc. Bismethylene-17 carbolactones and related uses
DE102008026793A1 (de) * 2008-06-02 2009-12-03 Bayer Schering Pharma Aktiengesellschaft C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate
US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
WO2011000535A2 (de) * 2009-07-01 2011-01-06 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. K Verfahren zur herstellung von drospirenon
DE102009031908B4 (de) * 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus 15-Hydroxyandrostendion
DE102009031907B4 (de) * 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Androstendion
DE102009038972A1 (de) * 2009-08-23 2011-06-30 Heyl Chemisch-pharmazeutische Fabrik GmbH & Co. KG, 14167 Verfahren zur Herstellung von Drospirenon aus 6,7,15,16-Dimethylenandrost-4-en-3,17-dion
DE102009031909B4 (de) * 2009-07-01 2017-02-09 Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. Kg Verfahren zur Herstellung von Drospirenon aus Prasteron
US8921346B2 (en) * 2010-03-16 2014-12-30 Taizhou Taifa Pharmaceuticals Co., Ltd. Preparation method of drospirenone
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
CN102964411B (zh) * 2012-12-03 2015-04-22 华中药业股份有限公司 一种雄甾-4,6-二烯-17α-甲基-17β-醇-3-酮的合成方法
CN111892638A (zh) * 2020-04-24 2020-11-06 浙江朗华制药有限公司 甾体化合物、坎利酮以及螺内酯的合成工艺
CN114874280A (zh) * 2022-06-29 2022-08-09 梯尔希（南京）药物研发有限公司 一种屈螺酮杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2349023A1 (de) * 1973-09-26 1975-04-10 Schering Ag Neue d-homo-steroide
DE3306554A1 (de) * 1983-02-22 1984-08-23 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 3-((delta)(pfeil hoch)4(pfeil hoch)-3-ketosteroid-17(alpha)-yl)-propionsaeurelactonen
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
CN100480256C (zh) * 2006-06-21 2009-04-22 上海迪赛诺医药发展有限公司 合成曲螺酮的方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009059765A3 (en) * 2007-11-08 2009-10-15 Chorisis S.R.L. Process for the preparation of drospirenone

Also Published As

Publication number Publication date
EP1903051A2 (en) 2008-03-26
EP1903051A3 (en) 2008-06-25
US20080076915A1 (en) 2008-03-27

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