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ITMI20061297A1 - Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi - Google Patents

Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi

Info

Publication number
ITMI20061297A1
ITMI20061297A1 IT001297A ITMI20061297A ITMI20061297A1 IT MI20061297 A1 ITMI20061297 A1 IT MI20061297A1 IT 001297 A IT001297 A IT 001297A IT MI20061297 A ITMI20061297 A IT MI20061297A IT MI20061297 A1 ITMI20061297 A1 IT MI20061297A1
Authority
IT
Italy
Prior art keywords
methylesanoic
carbamylmethyl
pregabalin
synthesis
procedure
Prior art date
Application number
IT001297A
Other languages
English (en)
Inventor
Angelis Bruno De
Antonio Nardi
Annibale Salvi
Original Assignee
Laboratorio Chimico Int Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorio Chimico Int Spa filed Critical Laboratorio Chimico Int Spa
Priority to IT001297A priority Critical patent/ITMI20061297A1/it
Priority to DK07766518.0T priority patent/DK2035368T3/en
Priority to JP2009517463A priority patent/JP5202519B2/ja
Priority to PCT/IB2007/001514 priority patent/WO2008004044A1/en
Priority to CN2007800245632A priority patent/CN101500985B/zh
Priority to US12/306,980 priority patent/US8563775B2/en
Priority to PL07766518T priority patent/PL2035368T3/pl
Priority to PT77665180T priority patent/PT2035368E/pt
Priority to EP07766518.0A priority patent/EP2035368B1/en
Priority to HUE07766518A priority patent/HUE026917T2/en
Priority to CA2656122A priority patent/CA2656122C/en
Priority to SI200731676T priority patent/SI2035368T1/sl
Priority to ES07766518.0T priority patent/ES2542980T3/es
Publication of ITMI20061297A1 publication Critical patent/ITMI20061297A1/it
Priority to HRP20150738TT priority patent/HRP20150738T1/hr
Priority to CY20151100604T priority patent/CY1116498T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT001297A 2006-07-04 2006-07-04 Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi ITMI20061297A1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT001297A ITMI20061297A1 (it) 2006-07-04 2006-07-04 Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi
PT77665180T PT2035368E (pt) 2006-07-04 2007-06-06 Processo para a preparação de ácido (r)-(-)-3- (carbamoilmetil)-5-metil-hexanóico e de pregabalina e síntese dos produtos intermédios
EP07766518.0A EP2035368B1 (en) 2006-07-04 2007-06-06 Process for the preparation of (r)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates
PCT/IB2007/001514 WO2008004044A1 (en) 2006-07-04 2007-06-06 Process for the preparation of (r)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates
CN2007800245632A CN101500985B (zh) 2006-07-04 2007-06-06 (r)-(-)-3-(氨甲酰基甲基)-5-甲基己酸以及普瑞巴林和合成中间体的制备方法
US12/306,980 US8563775B2 (en) 2006-07-04 2007-06-06 Process for the preparation of (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates
PL07766518T PL2035368T3 (pl) 2006-07-04 2007-06-06 Sposób otrzymywania kwasu (R)-(-)-3-(karbamoilometylo)-5-metyloheksanowego i pregabaliny oraz związków pośrednich syntezy
DK07766518.0T DK2035368T3 (en) 2006-07-04 2007-06-06 PROCESS FOR THE PREPARATION OF (R) - (-) - 3- (carbamoylmethyl) -5-methylhexanoic acid and of the pregabalin AND SYNTHETIC INTERMEDIATES
JP2009517463A JP5202519B2 (ja) 2006-07-04 2007-06-06 （ｒ）−（−）−３−（カルバモイルメチル）−５−メチルヘキサン酸及びプレガバリン及び合成中間体の製法
HUE07766518A HUE026917T2 (en) 2006-07-04 2007-06-06 Process for the preparation of (R) - (-) - 3- (carbamoylmethyl) -5-methylhexanoic acid and pregabalin and synthesis intermediates \ t
CA2656122A CA2656122C (en) 2006-07-04 2007-06-06 Process for the preparation of (r)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates
SI200731676T SI2035368T1 (sl) 2006-07-04 2007-06-06 Postopek za pripravo (r)-(-)-3-(karbamoilmetil)-5-metilheksanojske kisline in pregabalina ter sinteznih intermediatov
ES07766518.0T ES2542980T3 (es) 2006-07-04 2007-06-06 Procedimiento para la preparación de ácido (R)-(-)-3-(carbamoilmetil)-5-metilhexanoico y de pregabalina e intermediarios de síntesis
HRP20150738TT HRP20150738T1 (hr) 2006-07-04 2015-07-07 Postupak za pripremu r-(-)-3-(karbamoilmetil)-5-metilheksanske kiseline i pregabalina i sintezu intermedijera
CY20151100604T CY1116498T1 (el) 2006-07-04 2015-07-10 Διεργασια για την παρασκευη (r)-(-)-3-(καρβαμοϋλομεθυλ)-5-μεθυλεξανοϊκου οξεος και πρεγκαμπαλινης και συνθεση ενδιαμεσων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001297A ITMI20061297A1 (it) 2006-07-04 2006-07-04 Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi

Publications (1)

Publication Number Publication Date
ITMI20061297A1 true ITMI20061297A1 (it) 2008-01-05

Family

ID=38669439

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001297A ITMI20061297A1 (it) 2006-07-04 2006-07-04 Procedimento per la preparazione della'acido (r)-(-)-3-(carbamoilmetil)-5-metilesanoico e del pregabalin e intermedi di sintesi

Country Status (15)

Country Link
US (1) US8563775B2 (it)
EP (1) EP2035368B1 (it)
JP (1) JP5202519B2 (it)
CN (1) CN101500985B (it)
CA (1) CA2656122C (it)
CY (1) CY1116498T1 (it)
DK (1) DK2035368T3 (it)
ES (1) ES2542980T3 (it)
HR (1) HRP20150738T1 (it)
HU (1) HUE026917T2 (it)
IT (1) ITMI20061297A1 (it)
PL (1) PL2035368T3 (it)
PT (1) PT2035368E (it)
SI (1) SI2035368T1 (it)
WO (1) WO2008004044A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007012396A (es) 2005-04-06 2007-11-20 Teva Pharma Formas cristalinas de pregabalina.
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
EP1879851B1 (en) 2005-05-10 2010-11-03 Teva Pharmaceutical Industries Ltd Method for the preparation of pregabalin and salts thereof
BRPI0605833A (pt) 2005-05-10 2007-12-18 Teva Pharma pregabalina livre de ácido isobutilglutárico e um processo para sua preparação
US20070043241A1 (en) 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
CA2619472A1 (en) 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
KR20080027880A (ko) 2006-05-24 2008-03-28 테바 파마슈티컬 인더스트리즈 리미티드 Ｒ-(+)-3-(카바모일메틸)-5-메틸헥산산 및 이의 염의 제조방법
WO2008118427A2 (en) 2007-03-22 2008-10-02 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
US20110230666A1 (en) * 2008-06-03 2011-09-22 Shodhana Laboratories Limited process for the separation of enantiomerically pure compounds
WO2014080345A2 (en) * 2012-11-20 2014-05-30 Shasun Pharmaceuticals Limited Improved process for the preparation of pregabalin
CN103626668B (zh) * 2013-11-07 2015-05-20 河北爱弗特精细化工有限责任公司 一种s-构型普瑞巴林的化学拆分制备方法
CN104356016B (zh) * 2014-10-24 2019-08-23 浙江华海药业股份有限公司 一种用回收制备3-异丁基戊二酸单酰胺的方法
CN104710320A (zh) * 2015-03-30 2015-06-17 浙江华海药业股份有限公司 一种制备普瑞巴林的方法
CN105152954B (zh) * 2015-07-22 2020-12-08 浙江华海药业股份有限公司 一种无溶剂回收3-异丁基戊二酸单酰胺的方法
CN109678737B (zh) * 2019-02-18 2021-12-24 常州制药厂有限公司 一种普瑞巴林的制备方法
CN112745240A (zh) * 2021-01-19 2021-05-04 宁波酶赛生物工程有限公司 一种高选择性的普瑞巴林中间体的重结晶方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829719A (ja) * 1981-08-14 1983-02-22 Hiroyuki Nohira 光学活性フエニルグリシノ−ルを用いるキラルカルボン酸の光学分割法
JPS58183669A (ja) * 1982-04-19 1983-10-26 Teikoku Chem Ind Corp Ltd 光学活性なプロピオン酸誘導体の製造方法
JPS6013736A (ja) * 1983-07-01 1985-01-24 Hiroyuki Nohira （±）−２−クロロプロピオン酸の光学分割法
CA2023954C (en) * 1989-10-17 1999-05-04 Hiroyuki Nohira Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid
JPH0753505A (ja) * 1992-10-01 1995-02-28 Hokuriku Seiyaku Co Ltd ベンゼンスルホンアミド誘導体及びその用途
US5616793A (en) 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
SE9904415D0 (sv) 1999-12-03 1999-12-03 Astra Ab New process
EP1295862A4 (en) * 2000-06-28 2005-09-28 Taisho Pharmaceutical Co Ltd INTERMEDIATE PRODUCT AND PROCESS FOR PRODUCING A FLUORINATED CARBOXYLIC ACID DERIVATIVE FROM THE INTERMEDIATE PRODUCT
JP4319847B2 (ja) 2002-02-13 2009-08-26 第一三共株式会社 （１ｓ，２ｓ）−２−フルオロシクロプロパンカルボン酸誘導体の製造方法
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives

Also Published As

Publication number Publication date
ES2542980T3 (es) 2015-08-13
WO2008004044A1 (en) 2008-01-10
HRP20150738T1 (hr) 2015-08-14
EP2035368A1 (en) 2009-03-18
DK2035368T3 (en) 2015-08-24
US20090192331A1 (en) 2009-07-30
EP2035368B1 (en) 2015-05-27
JP2009542615A (ja) 2009-12-03
CN101500985A (zh) 2009-08-05
HUE026917T2 (en) 2016-08-29
SI2035368T1 (sl) 2015-08-31
JP5202519B2 (ja) 2013-06-05
CN101500985B (zh) 2013-04-03
PT2035368E (pt) 2015-09-01
CA2656122A1 (en) 2008-01-10
PL2035368T3 (pl) 2015-10-30
CY1116498T1 (el) 2017-03-15
CA2656122C (en) 2015-05-05
US8563775B2 (en) 2013-10-22

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