ITMI20052515A1 - Formulazione farmaceutica per il trattamento della osteoartrite - Google Patents

Formulazione farmaceutica per il trattamento della osteoartrite

Info

Publication number: ITMI20052515A1
Authority: IT; Italy
Prior art keywords: osteoartrite; treatment; pharmaceutical formulation; salts; mixed
Prior art date: 2005-12-29

Application number

IT002515A

Other languages

English (en)

Inventor

Sergio Rosini

Silvia Trasciatti

Original Assignee

Abiogen Pharma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-29

Filing date

2005-12-29

Publication date

2007-06-30

2005-12-29 Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa

2005-12-29 Priority to IT002515A priority Critical patent/ITMI20052515A1/it

2006-12-21 Priority to JP2008547886A priority patent/JP2009522218A/ja

2006-12-21 Priority to NZ569420A priority patent/NZ569420A/en

2006-12-21 Priority to PL06841087T priority patent/PL1976538T3/pl

2006-12-21 Priority to US12/159,222 priority patent/US20090042833A1/en

2006-12-21 Priority to DK06841087T priority patent/DK1976538T3/da

2006-12-21 Priority to ES06841087T priority patent/ES2333615T3/es

2006-12-21 Priority to CA2646974A priority patent/CA2646974C/en

2006-12-21 Priority to ZA200805598A priority patent/ZA200805598B/xx

2006-12-21 Priority to EP06841087A priority patent/EP1976538B1/en

2006-12-21 Priority to KR1020147021224A priority patent/KR20140107651A/ko

2006-12-21 Priority to HK09103213.6A priority patent/HK1123986B/en

2006-12-21 Priority to DE602006010111T priority patent/DE602006010111D1/de

2006-12-21 Priority to PCT/EP2006/012367 priority patent/WO2007073921A1/en

2006-12-21 Priority to PT06841087T priority patent/PT1976538E/pt

2006-12-21 Priority to SI200630473T priority patent/SI1976538T1/sl

2006-12-21 Priority to AU2006331019A priority patent/AU2006331019B2/en

2006-12-21 Priority to RU2008126108/15A priority patent/RU2414908C2/ru

2006-12-21 Priority to AT06841087T priority patent/ATE446763T1/de

2007-06-30 Publication of ITMI20052515A1 publication Critical patent/ITMI20052515A1/it

2008-06-26 Priority to NO20082848A priority patent/NO340794B1/no

2008-06-26 Priority to KR1020087015583A priority patent/KR101470608B1/ko

2009-12-03 Priority to CY20091101271T priority patent/CY1109541T1/el

2014-09-03 Priority to US14/476,521 priority patent/US9943540B2/en

2018-02-28 Priority to US15/907,300 priority patent/US20180185407A1/en

2019-12-27 Priority to US16/728,378 priority patent/US20200147126A1/en

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 abstract 1
229960002286 clodronic acid Drugs 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
229920002674 hyaluronan Polymers 0.000 abstract 1
229960003160 hyaluronic acid Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicinal Preparation (AREA)

IT002515A 2005-12-29 2005-12-29 Formulazione farmaceutica per il trattamento della osteoartrite ITMI20052515A1 (it)

Priority Applications (25)

Application Number	Priority Date	Filing Date	Title
IT002515A ITMI20052515A1 (it)	2005-12-29	2005-12-29	Formulazione farmaceutica per il trattamento della osteoartrite
HK09103213.6A HK1123986B (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
PCT/EP2006/012367 WO2007073921A1 (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
PL06841087T PL1976538T3 (pl)	2005-12-29	2006-12-21	Preparat farmaceutyczny do leczenia choroby zwyrodnieniowej stawów zawierający kwas klodronowy i kwas hialuronowy
US12/159,222 US20090042833A1 (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
DK06841087T DK1976538T3 (da)	2005-12-29	2006-12-21	Farmaceutisk formulering til behandling af slidgigt indeholdende clodronsyre og hyaluronsyre
ES06841087T ES2333615T3 (es)	2005-12-29	2006-12-21	Formulacion farmaceutica para el tratamiento de artrosis que contiene acido clodronico y acido hialuronico.
CA2646974A CA2646974C (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
ZA200805598A ZA200805598B (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
EP06841087A EP1976538B1 (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
NZ569420A NZ569420A (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
JP2008547886A JP2009522218A (ja)	2005-12-29	2006-12-21	変形性骨関節炎の治療のための医薬処方物
DE602006010111T DE602006010111D1 (de)	2005-12-29	2006-12-21	Pharmazeutische formulierung zur behandlung von osteoarthritis mit clodronsäure und hyaluronsäure
SI200630473T SI1976538T1 (sl)	2005-12-29	2006-12-21	Farmacevtska formulacija za zdravljenje osteoartritisa, ki vsebuje klodronsko kislino in hialuronsko kislino
PT06841087T PT1976538E (pt)	2005-12-29	2006-12-21	Formulação farmacêutica para o tratamento de artrose que contém ácido clodrónico e ácido hialurónico
KR1020147021224A KR20140107651A (ko)	2005-12-29	2006-12-21	클로드론산 및 히알루론산을 포함하는 골관절염 치료용 약학적 제제
AU2006331019A AU2006331019B2 (en)	2005-12-29	2006-12-21	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
RU2008126108/15A RU2414908C2 (ru)	2005-12-29	2006-12-21	Фармацевтическая композиция для лечения остеоартрита, содержащая клодроновую кислоту и гиалуроновую кислоту
AT06841087T ATE446763T1 (de)	2005-12-29	2006-12-21	Pharmazeutische formulierung zur behandlung von osteoarthritis mit clodronsäure und hyaluronsäure
KR1020087015583A KR101470608B1 (ko)	2005-12-29	2008-06-26	클로드론산 및 히알루론산을 포함하는 골관절염 치료용약학적 제제
NO20082848A NO340794B1 (no)	2005-12-29	2008-06-26	Farmasøytisk formulering for behandling av osteoartritt inneholdende klodronsyre og hyaluronsyre
CY20091101271T CY1109541T1 (el)	2005-12-29	2009-12-03	Φαρμακευτικη συνταγοποιηση για την θεραπεια οστεοαρθριτιδας η οποια περιεχει κλοδρονικο οξυ και υαλουρονικο οξυ
US14/476,521 US9943540B2 (en)	2005-12-29	2014-09-03	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
US15/907,300 US20180185407A1 (en)	2005-12-29	2018-02-28	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid
US16/728,378 US20200147126A1 (en)	2005-12-29	2019-12-27	Pharmaceutical formulation for the treatment of osteoarthritis containing clodronic acid and hyaluronic acid

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002515A ITMI20052515A1 (it)	2005-12-29	2005-12-29	Formulazione farmaceutica per il trattamento della osteoartrite

Publications (1)

Publication Number	Publication Date
ITMI20052515A1 true ITMI20052515A1 (it)	2007-06-30

Family

ID=36648609

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT002515A ITMI20052515A1 (it)	2005-12-29	2005-12-29	Formulazione farmaceutica per il trattamento della osteoartrite

Country Status (20)

Country	Link
US (4)	US20090042833A1 (it)
EP (1)	EP1976538B1 (it)
JP (1)	JP2009522218A (it)
KR (2)	KR20140107651A (it)
AT (1)	ATE446763T1 (it)
AU (1)	AU2006331019B2 (it)
CA (1)	CA2646974C (it)
CY (1)	CY1109541T1 (it)
DE (1)	DE602006010111D1 (it)
DK (1)	DK1976538T3 (it)
ES (1)	ES2333615T3 (it)
IT (1)	ITMI20052515A1 (it)
NO (1)	NO340794B1 (it)
NZ (1)	NZ569420A (it)
PL (1)	PL1976538T3 (it)
PT (1)	PT1976538E (it)
RU (1)	RU2414908C2 (it)
SI (1)	SI1976538T1 (it)
WO (1)	WO2007073921A1 (it)
ZA (1)	ZA200805598B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2624842B1 (en) *	2010-10-07	2017-03-15	National Cheng Kung University	Use of hyaluronan for promoting angiogenesis
CN107106613B (zh)	2014-11-07	2021-07-06	胞外体干细胞株式会社	用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物
KR101706642B1 (ko)	2015-02-04	2017-02-17	주식회사 엑소스템텍	연골세포로 분화되고 있는 줄기세포로부터 추출된 엑소좀을 포함하는 연골세포 분화 유도 또는 연골조직 재생용 조성물
IT201600123773A1 (it) *	2016-12-06	2018-06-06	Abiogen Pharma Spa	Composizione per il trattamento dell’osteoartrosi
IT202100023894A1 (it) *	2021-09-16	2023-03-16	Professional Derma Sa	Composizione per utilizzo in campo ortopedico
EP4450062A1 (en) *	2023-04-20	2024-10-23	Abiogen Pharma S.p.A.	Composition for the treatment of osteoarthrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1187828B (it) *	1985-05-24	1987-12-23	Gentili Ist Spa	Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
JP2001253827A (ja) *	2000-02-15	2001-09-18	Pfizer Prod Inc	骨粗鬆症を治療するための組成物および方法
MXPA02010740A (es) *	2000-05-05	2003-03-10	Hoffmann La Roche	Composicion farmaceutica similar al gel para la administracion subcutanea que comprende acidos bisfosfonicos o sus sales.
EP1519744A4 (en) *	2002-05-17	2007-10-03	Wyeth Corp	INJECTABLE SOLID HYALURONIC ACID CARRIER FOR THE ADMISSION OF OSTEOGEN PROTEINS
WO2005105058A1 (en) *	2004-05-04	2005-11-10	Amorepacific Corporation	Sustained-releasing injectable formulation for the treatment or prevention of bone-related diseases comprising bisphorenate-containing polymeric microparticles

2005
- 2005-12-29 IT IT002515A patent/ITMI20052515A1/it unknown
2006
- 2006-12-21 JP JP2008547886A patent/JP2009522218A/ja active Pending
- 2006-12-21 US US12/159,222 patent/US20090042833A1/en not_active Abandoned
- 2006-12-21 WO PCT/EP2006/012367 patent/WO2007073921A1/en active Application Filing
- 2006-12-21 NZ NZ569420A patent/NZ569420A/en unknown
- 2006-12-21 ZA ZA200805598A patent/ZA200805598B/xx unknown
- 2006-12-21 CA CA2646974A patent/CA2646974C/en active Active
- 2006-12-21 EP EP06841087A patent/EP1976538B1/en active Active
- 2006-12-21 PT PT06841087T patent/PT1976538E/pt unknown
- 2006-12-21 AT AT06841087T patent/ATE446763T1/de active
- 2006-12-21 ES ES06841087T patent/ES2333615T3/es active Active
- 2006-12-21 DK DK06841087T patent/DK1976538T3/da active
- 2006-12-21 PL PL06841087T patent/PL1976538T3/pl unknown
- 2006-12-21 RU RU2008126108/15A patent/RU2414908C2/ru active
- 2006-12-21 KR KR1020147021224A patent/KR20140107651A/ko not_active Abandoned
- 2006-12-21 AU AU2006331019A patent/AU2006331019B2/en active Active
- 2006-12-21 DE DE602006010111T patent/DE602006010111D1/de active Active
- 2006-12-21 SI SI200630473T patent/SI1976538T1/sl unknown
2008
- 2008-06-26 NO NO20082848A patent/NO340794B1/no unknown
- 2008-06-26 KR KR1020087015583A patent/KR101470608B1/ko active Active
2009
- 2009-12-03 CY CY20091101271T patent/CY1109541T1/el unknown
2014
- 2014-09-03 US US14/476,521 patent/US9943540B2/en active Active
2018
- 2018-02-28 US US15/907,300 patent/US20180185407A1/en not_active Abandoned
2019
- 2019-12-27 US US16/728,378 patent/US20200147126A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1976538E (pt)	2009-12-07
JP2009522218A (ja)	2009-06-11
US20090042833A1 (en)	2009-02-12
NZ569420A (en)	2010-05-28
HK1123986A1 (en)	2009-07-03
RU2008126108A (ru)	2010-01-10
KR20140107651A (ko)	2014-09-04
US20200147126A1 (en)	2020-05-14
EP1976538A1 (en)	2008-10-08
CA2646974C (en)	2013-06-11
PL1976538T3 (pl)	2010-03-31
RU2414908C2 (ru)	2011-03-27
DE602006010111D1 (de)	2009-12-10
ES2333615T3 (es)	2010-02-24
AU2006331019B2 (en)	2012-03-22
US9943540B2 (en)	2018-04-17
EP1976538B1 (en)	2009-10-28
KR101470608B1 (ko)	2014-12-09
DK1976538T3 (da)	2010-01-11
KR20080082657A (ko)	2008-09-11
CY1109541T1 (el)	2014-08-13
AU2006331019A1 (en)	2007-07-05
ATE446763T1 (de)	2009-11-15
ZA200805598B (en)	2009-11-25
WO2007073921A1 (en)	2007-07-05
AU2006331019A2 (en)	2009-01-22
NO340794B1 (no)	2017-06-19
CA2646974A1 (en)	2007-07-05
US20180185407A1 (en)	2018-07-05
NO20082848L (no)	2008-08-27
US20140371170A1 (en)	2014-12-18
SI1976538T1 (sl)	2010-01-29

Publication	Publication Date	Title
AR047928A1 (es)	2006-03-01	Derivados de tetrahidropiridoindol
NO20075111L (no)	2007-11-16	Farmasoytisk sammensetning
ATE470443T1 (de)	2010-06-15	Indol-1-yl-essigsäurederivate
UY31673A1 (es)	2009-09-30	"derivados heterocíclicos de urea y métodos de uso de los mismos-211"
EA201170772A1 (ru)	2012-03-30	Органические соединения
TW200738659A (en)	2007-10-16	Novel compounds
EA201100691A1 (ru)	2012-02-28	Антагонисты рецепторов лизофосфатидной кислоты
BRPI0515012A (pt)	2008-07-01	substáncia quìmica, composição e formulação farmacêutica, método de tratamento, método de inibição de pelo menos uma enzima que utiliza atp e uso
CY1108794T1 (el)	2014-04-09	Σπειροκυκλικα παραγωγα κυκλοεξανιου
TW200800987A (en)	2008-01-01	Triazolopyridine derivatives as inhibitors of lipases and phospholipases
EA201000436A1 (ru)	2010-10-29	Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью
UY31209A1 (es)	2009-01-30	Uso de homo y copolimeros para la estabilización de formulaciones de principios activos
WO2009109927A3 (en)	2010-02-25	Glp-1 receptor agonists and related active pharmaceutical ingredients for treatment of cancer
PA8720801A1 (es)	2008-11-19	Nuevas combinaciones terapeuticas para el tratamiento de la depresion
TR200806298A2 (tr)	2010-03-22	Farmasötik formülasyon
DK1654253T3 (da)	2007-04-30	Substituerede 3-pyrrolidinindolderivater
CY1109366T1 (el)	2014-07-02	Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
CL2009000246A1 (es)	2009-06-26	Compuestos derivados de 1h-imidazo[4,5-b]piridin-2-ol; moduladores de la contraccion sarcomero; composicion farmaceutica que comprende; kit farmaceutico; y uso en el tratamiento de enfermedades neuromusculares, tales como atrofia, fatiga, claudicacion, en entre otras.
CY1109537T1 (el)	2014-08-13	Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης
EA201190236A1 (ru)	2012-04-30	Новые производные стероидных соединений [3,2-c]пиразолов с глюкокортикоидной активностью
CY1109541T1 (el)	2014-08-13	Φαρμακευτικη συνταγοποιηση για την θεραπεια οστεοαρθριτιδας η οποια περιεχει κλοδρονικο οξυ και υαλουρονικο οξυ
UY29999A1 (es)	2007-07-31	"n-pirazinil-fenilsulfonamidas, procedimientos y compuestos intemedios utilizados en su preparacion, composiciones farmaceuticas que las contienen y aplicaciones"
ATE531703T1 (de)	2011-11-15	Benzochromenderivate
DE602006015837D1 (de)	2010-09-09	Formulierungen von tipifarnib zur intravenösen verabreichung
NO20065898L (no)	2007-02-19	1-heterocyklyl-1,5-dihydro-pyrido[3,2-b]indol-2-oner