IT202100027086A1 - PORTABLE REGULATOR FOR THE TREATMENT OR PREVENTION OF AN INFECTION OR DISEASE CAUSED BY A VIRUS - Google Patents

Description

DESCRIPTION

Attached to patent application for INDUSTRIAL INVENTION having as title

?Portable dispenser for the treatment or prevention of an infection or pathology caused by a virus?

The object of the present invention is a portable dispenser as well as? a portable kit comprising such a dispenser configured to deliver a composition for use in the treatment or prevention of an infection or pathology caused by a pathogen transmittable through the respiratory tract in an individual.

Since when, January 11, 2020,? Once the genetic sequence of the SARS-CoV-2 virus was published, scientists, industries and other organizations around the world collaborated to develop safe and effective vaccines against COVID-19 as soon as possible.

According to the overview of the World Health Organization? (WHO), as of 22 January 2021, there were 237 candidate vaccines under development, of which 173 in the pre-clinical phase and 64 in the clinical phase (16 of the latter in phase 3).

Some vaccines are made using the same technology (or ?platform?) as vaccines currently in use, others are made using new approaches or approaches used in the development of vaccines against SARS and Ebola. The goal of all these vaccines is? that of producing an immune response in order to neutralize the virus and prevent infection of the cells. The main platforms used are the following: inactivated viral vaccines, live attenuated vaccines, recombinant protein vaccines, viral vector vaccines, DNA vaccines and RNA vaccines.

However, vaccines are very effective in avoiding severe symptoms of COVID-19 and minimizing the chances of of contagion, but they are not a therapy for the disease. In fact, numerous antiviral molecules are also being studied that could be used in the therapy of COVID-19, such as, for example, monoclonal antibodies or specific antiviral drugs against SARS-CoV-2.

Furthermore, other strategies are being developed to stop the pandemic. For example, in Italy? testing of a nasal spray to be applied in patients with the first symptoms of COVID-19 has begun. The spray? an aqueous washing solution that contains 0.005% hypochlorous acid, an antimicrobial substance also produced by the cells of our immune system, made stable and pure. The results of preliminary in vitro and in vivo tests, recently published, have shown that the hypochlorous acid-based nasal spray eliminates Sars-Cov-2 in less than a minute without irritating the mucous membranes of the nose and throat.

Therefore, ? still very much felt the need? to develop new drugs and/or new strategies for the prevention and treatment of the COVID-19 disease.

In particular, ? still strongly felt the need? to develop new strategies for the prevention and treatment of COVID-19 disease that are accessible in the most accessible way? convenient and immediate for the patient.

Typically, in fact, in the case of treatment of the disease, the patient can being forced to wait a significant amount of time before being able to receive adequate healthcare treatment. Furthermore, the patient's stay within the healthcare facility, in addition to being risky and unpleasant for the patient himself, entails a further series of disadvantages such as, for example, the possible saturation of dedicated places in the healthcare facility or the financial burden that results from the patient's prolonged stay.

As regards the prevention strategies adopted by individuals in order to protect themselves from possible infections and/or pathologies of the respiratory system, and in particular from the SARS-CoC-2 virus, they mostly concern personal protective equipment, such as masks, or hygiene procedures, such as correct hand washing using soap and water using alcohol-based sanitizing solutions.

These strategies, however, are incapable of eliminating viruses or pathogens already entered the respiratory system.

In this context, the technical task underlying the present invention is? that of proposing a dispenser to release a composition for use in the treatment or prevention of an infection or pathology caused by a pathogen transmittable through the respiratory tract in an individual as well as? a kit comprising such a dispenser which overcomes the above-mentioned drawbacks of the prior art.

In particular, ? The purpose of the present invention is to provide a dispenser for delivering a composition for use in the treatment or prevention of an infection or pathology caused by a pathogenic agent transmissible through the respiratory tract in an individual as well as? a kit including this dispenser which can be easily used even by non-specialised personnel and/or by the patient himself.

Further purpose of the present invention? that of making a dispenser available to deliver a composition for use in the treatment or prevention of an infection or pathology caused by a pathogen transmittable through the respiratory tract in an individual as well as a kit including such a dispenser that is easily and conveniently transportable, especially by the user himself. Further purpose of the present invention? that of making a dispenser available to deliver a composition for use in the treatment or prevention of an infection or pathology caused by a pathogen transmittable through the respiratory tract in an individual as well as a kit including such a dispenser that is economically accessible to the individual himself.

The specified technical task and the specified purposes are substantially achieved by a portable dispenser comprising a charging module, a dispensing module and a power supply module, in which each of the modules includes at least one mechanical connection interface arranged at one end. and configured for a reversible connection to at least one adjacent module.

According to an example, the charging module has a containment volume comprising a composition in liquid form comprising ethyl alcohol in a concentration between 60% and 90% w/w and at least one solvent for use in the treatment or prevention of an infection or pathology caused by a virus in an individual.

With the term ?ethyl alcohol? or ?ethanol? we mean an alcohol with the formula CH3-CH2-OH.

According to an example, the solvent can? include sterile water.

According to a further example, the solvent can? include sterile ozonated water.

According to a further example, the solvent can? include ozonated water.

According to a further example, the composition can? furthermore include at least one antiviral drug and/or an anti-inflammatory and/or an antipyretic and/or an antibiotic.

Advantageously, this composition can be taken either by an individual with a blood oxygen saturation within normal limits or by an individual with a blood oxygen saturation below normal limits. Advantageously, the administration of the aforementioned composition allows the complete destruction of a virus in the respiratory tract.

According to an example, the charging module can? be a containment body that can be coupled, in use, at least to the dispensing module and can be filled with the composition in a non-use configuration.

According to a further example, the charging module can? be a disposable bottle of the composition that can? be coupled directly to the dispensing module.

Regardless of the nature of the charging module, the containment volume can present a volume between 1.5 ml and 20 ml. According to an example, the containment volume has a volume of 5 ml.

According to a further example, the containment volume has a volume of 3 ml.

The dispensing module, connected or connectable to the charging module, is configured to receive the composition in liquid form and dispense it in the form of microparticles via a dispensing element. In use, the dispensing element is in fluid communication with the containment volume.

According to an example, the dispensing element can be shaped so as to administer said composition in the form of microparticles having a size between 0.1 and 6 ?m.

Advantageously, thanks to the administration of microparticles with a size between 0.1 and 6 ?m,? It is possible to reach the lower respiratory tract, i.e. the pulmonary alveoli, where a virus can nestle. The administration of the composition? capable of destroying a virus, in particular a respiratory virus, such as SARS-CoV-2.

According to an example, the dispensing module can? include a nebulizer while the dispensing element can? be a speaker.

According to a further example, the dispensing module can? include an electrical resistance configured to vaporize the composition while the dispensing element can? be a suction mouthpiece. The power supply module, connected or electrically connectable to the dispensing module, is equipped with an electric battery to electrically power the dispensing module.

According to an example, the electric battery of the power module can? be a rechargeable electric battery.

According to a further example, the electric battery of the power module can? be a supercapacitor.

The power module can? furthermore comprising a receiving portion, electrically connected to the electric battery and configured for reversible coupling with a connector suitable for recharging the electric battery.

Advantageously, the portable dispenser can be easily transported and used by even non-specialized personnel and by the patient himself. Furthermore, this dispenser is economically accessible.

Furthermore, the specified technical task and the specified purposes are substantially achieved by a portable kit including the aforementioned dispenser and a plurality of of refills of the aforementioned composition.

Further characteristics and advantages of the present invention will appear clear from the indicative, and therefore non-limiting, description of this dispenser and this kit, as illustrated in the attached drawings in which:

- figure 1 shows a schematic view of a first embodiment of a dispenser configured to deliver a composition for use in the treatment or prevention of an infection or pathology caused by a pathogenic agent transmissible through the respiratory tract in an individual in accordance with the present invention;

- figure 2 shows a schematic view of a second exemplary embodiment of a dispenser configured to deliver a composition for use in the treatment or prevention of an infection or pathology caused by a pathogenic agent transmissible through the respiratory tract in an individual in accordance with the present invention; - figures 3A and 3B respectively show possible embodiments of the dispenser;

- figure 4 shows a charge of the aforementioned composition.

With reference to the attached figures, with the numerical reference 1 ? Overall, a portable dispenser configured to release a composition comprising ethyl alcohol in a concentration between 60% and 90% w/w and at least one solvent for use in the treatment or prevention of an infection or pathology has been indicated caused by a pathogen that can be transmitted through the respiratory tract in an individual.

In this description, with the term ?ethyl alcohol? or ?ethanol? we mean an alcohol with the formula CH3-CH2-OH.

With the expression ?respiratory virus? we mean a virus that is inhaled and transmitted through the respiratory tract

In particular, with the expression ?respiratory virus? we mean one of an influenza virus, a parainfluenza virus, respiratory syncytial virus, a rhinovirus, a virus of the Coronaviridae family, an adenovirus and a mycobacterium. In other words, the pathogen can be transmitted through the respiratory tract. be a virus of the Coronaviridae family, preferably chosen between SARS-CoV, MERS-CoV and SARS-CoV-2, even more so? preferably? SARS-CoV-2.

Also?, with the term ?infection? we mean a process characterized by the penetration and multiplication of viruses in living tissues. The concept of infection is not identical with that of infectious disease or pathology since it there are cases of infection without any morbid phenomenon, i.e. asymptomatic individuals carrying the pathogen. Essentially, as illustrated in figures 1 and 2, the dispenser 1 comprises a charging module 10, a dispensing module 20 and a power module 30, wherein each of said modules 10, 20, 30 comprises at least one communication interface mechanical connection arranged at its own end? and configured for a reversible connection to at least one adjacent module 10, 20, 30.

The charging module 10 has a containment volume ?V? comprising a composition in liquid form comprising ethyl alcohol in a concentration of between 60% and 90% w/w and at least one solvent for use in the treatment or prevention of an infection or pathology caused by a virus in an individual.

Advantageously, this composition can be taken either by an individual with a blood oxygen saturation within normal limits or by an individual with a blood oxygen saturation below normal limits.

Advantageously, the administration of the aforementioned composition allows the complete destruction of a virus in the respiratory tract.

According to an example, the concentration of ethyl alcohol in the composition is ? between 60 and 85% w/w, even more? preferably between 70 and 80% w/w. According to a further example, the concentration of ethyl alcohol in the composition is ? of 74-75% w/w.

According to a further aspect, regardless of the concentration of ethyl alcohol present in the composition, the solvent can includes water.

According to an example, the solvent comprises sterile water.

According to a further example, the solvent comprises sterile ozonated water.

According to a further example, the solvent comprises ozonated water. Advantageously, this type of solvent further contributes to improving the effectiveness of the composition.

According to a further aspect of the present invention, the composition can furthermore include at least one antiviral drug and/or an anti-inflammatory and/or an antipyretic and/or an antibiotic.

According to a further aspect, the composition can? furthermore include at least one flavoring agent, preferably chosen from: vanilla, mint, tobacco, lavender, coffee, lemon, orange, pistachio, cocoa, hazelnut, almond, grape, melon, berries, coconut, kiwi and combinations thereof. Advantageously, in this way, the assumption of the composition is made more pleasant.

According to a further aspect, the composition can? further comprise a smoking agent such as for example vegetable glycerin and/or propylene glycol. Advantageously, in this way, the user? able to control the operation of dispenser 1 during its operation.

The dispensing module 20, connected or connectable to the charging module 10, is configured to receive the composition in liquid form and dispense it in the form of microparticles via a dispensing element. In use, the dispensing element is in fluid communication with the containment volume ?V?.

Preferably, but not in a restrictive manner, the dispensing element 1 can? be shaped so as to administer the composition in the form of microparticles having a size between 0.1 and 6 ?m. Advantageously, thanks to the administration of microparticles with a size between 0.1 and 6 ?m,? It is possible to reach the lower respiratory tract, i.e. the pulmonary alveoli, where a virus can nestle. The administration of the composition? capable of destroying a virus, in particular a respiratory virus, such as SARS-CoV-2.

The power supply module 30, connected or electrically connectable to the delivery module 20, is equipped with an energy accumulator to electrically power the dispensing module 20.

Preferably, the energy accumulator of the power module 30? a rechargeable energy accumulator and the power module 30 includes a receiving portion 31, electrically connected to the energy accumulator, configured for reversible coupling with a connector suitable for recharging the energy accumulator.

According to one embodiment, the energy accumulator comprises an electric battery, preferably a rechargeable electric battery. In this embodiment, the receiving portion 31, electrically connected to the electric battery, is configured for reversible coupling with a connector suitable for recharging the rechargeable electric battery. The connector, not shown, can? be a standardized hot swap connector or a USB connector.

According to a further embodiment, the energy accumulator comprises a supercapacitor accumulator.

In this embodiment, the receiving portion 31, electrically connected to the supercapacitor battery, is configured for reversible coupling with a connector suitable for recharging the supercapacitor accumulator. The connector, not shown, can? be a standardized hot swap connector or a USB connector.

According to a further aspect, the power supply module 30 includes an interface apparatus 32 to determine the operation of the dispenser 1.

In detail, figures 2 and 3B show a first exemplary and therefore non-limiting embodiment of the dispenser 1, and in particular of the dispensing module 20 and the charging module 10.

In this embodiment, the dispensing module 20 includes a nebulizer for the composition, in particular of the ultrasonic type, while the dispensing element is a speaker 22.

The 22 speaker can? understand a piezoelectric atomizer.

The dispensing module 20, in use, is electrically connected to the power supply module 30.

In particular, the dispensing module 20, in use, is placed between the supply module 30 and the charging module 10.

The charging module 10 includes a bottle having a neck 14 while the dispensing module 20 has a recess 23 counter-shaped to the neck 14 of the bottle and configured to at least partially accommodate the neck 14 of the bottle.

In use, the containment volume ?V? results in fluid communication with the diffuser 22 through the neck 14 and a duct 24.

In particular, the neck 14 of the bottle and the recess 23 have reciprocal threaded clamping members in such a way as to define a reversible and stable coupling.

Furthermore, can it? a watertight seal ring should be provided (not shown in the attached figures), in order to improve the coupling between the neck 14 of the bottle and the recess 23.

In this description, with the term ?bottle? can you? meaning a containment body that can be filled with the composition in a non-use configuration in which the charging module 10 is detached from the dispensing module 20.

Also?, in this description, with the term ?bottle? can you? mean a bottle ?F? disposable containing a certain quantity? of the composition.

Preferably, the charging module 10 can? include a ?F? bottle disposable containing the composition and having a containment volume between 3 ml and 20 ml, preferably 5 ml.

In the embodiment of figures 2 and 3B, the dispensing module 20 together with the bottle ?F? disposable define a first dispensing block 200.

On a functional level, the ?F? sealed for single use and place dispenser 1 in a non-use configuration. Remove the cap from the ?F? bottle. disposable and matches the neck 14 of the ?F? bottle disposable to the recess 23 of the dispensing module 20, defining the coupling of the two bodies, obtaining a configuration of use. Naturally, during use, the ?F? is connected to the dispensing module 20 in such a way as to feed it with the composition.

This embodiment is particularly advantageous due to its simplicity. of use. Furthermore, this embodiment turns out to be particularly advantageous since it it is not necessary to carry out cleaning operations on the charging module 10 given that the bottle ?F? disposable is thrown away once the contents of the composition are finished.

Alternatively, if the charging module 10 turns out to be a containment body, a generic bottle comprising the composition is prepared and the dispenser 1 is placed in a non-use condition. The cap is removed from the bottle and the composition is poured into the charging module 10. Subsequently, the charging module 10 is coupled to the dispensing module 20 obtaining the usage configuration.

Advantageously, this embodiment of the dispenser 1 can can also be used for sanitizing parts of the user's body, such as hands or face, as well as? of objects.

Figures 1 and 3A show a second exemplary and therefore non-limiting embodiment of the dispenser 1, and in particular of the dispensing module 20 and the charging module 10.

In this embodiment, the dispensing module 20 includes an electrical resistance configured to vaporize the composition while the dispensing element is a suction mouthpiece 21.

In particular, in use, the electrical resistance is at least partially inserted into the containment volume ?V? so as to be at least partially in contact with the composition.

The charging module 10 is, in use, interposed between the supply module 30 and the dispensing module 20. Furthermore, the charging module 10 has a containment volume ?V? between 1 ml and 10 ml, preferably 2 ml or 3 ml.

According to a further aspect, the charging module 10 can? be at least partially transparent in such a way as to make the quantity visible? of the composition within the containment volume ?V?. Can you? for example, a window 11 should be provided.

According to a further aspect, the charging module 10 can? be a rechargeable 10 charge module once the composition is finished.

Functionally, in this embodiment, a composition refill is arranged (where this composition refill may include a generic bottle containing the composition or a disposable "F" bottle of composition) and the dispenser 1 is arranged in the non-return configuration. use, or in a configuration in which the dispensing element is decoupled from the charging module 10. Once the bottle has been opened and the composition has been poured into the containment volume ?V? of the charging module 10, the dispensing element is coupled to the charging module 10, obtaining the usage configuration. Alternatively, the charging module 10 can? be a disposable 10 charge module. Functionally, in this embodiment, a disposable charging module 10 is provided and a power supply module 30 and a dispensing module 20 are provided in the non-use configuration. Subsequently, the three modules 10, 20, 30 are coupled, obtaining the usage configuration.

According to a further aspect, if the charging module 10 is a rechargeable charging module 10, the dispensing module 20 can be at least partially integral with the charging module 10.

In other words, resistance can? be irreversibly fixed inside the containment volume ?V? of the charging module 10. Also, the dispensing element can? be reversibly coupled to the charging module 10. Alternatively, the dispensing module 20 can? be shaped so as to be an integral block including the resistance and the delivery element.

In the embodiment of Figures 1 and 3A, regardless of whether or not the dispensing module 20 is integral with the charging module 10, the dispensing module 20 and the charging module 10 jointly define a second dispensing block 100.

According to an aspect of the present invention, the first dispensing block 200 and the second dispensing block 100 are interchangeable.

In other words, the first dispensing block 200 and the second dispensing block 100 have the same mechanical interface for reversible coupling with the supply module 30.

Advantageously, this characteristic, how will it be? better outlined later in this description, it allows the first and second dispensing blocks 200, 100 to be interchanged while maintaining the same supply module 30.

Does the present invention also concern? a portable dispensing kit comprising a portable dispenser 1 as previously described and a plurality of of refills of the aforementioned composition.

According to an example, the kit includes a feeding module 30, a dispensing module 20 equipped with a nebulizer and a plurality of of composition refills. In particular, these refills of the composition include a plurality? of ?F? bottles single use. In other words, according to this example, the kit is configured to operate via the power supply module 30 and the first dispensing block 200.

According to a further example, the kit includes a power supply module 30, a delivery module 20 equipped with an electrical resistance and a plurality of of composition refills. In other words, according to this example, the kit is configured to operate via the power supply module 30 and the second dispensing block 100.

According to a further example, the kit includes a power supply module 30, a delivery module 20 equipped with a nebulizer, a delivery module 20 equipped with the electrical resistance and a plurality of of composition refills. In other words, according to this example, the kit can? operate both with the first dispensing block 200 and with the second dispensing block 100, which are coupled alternately to the supply module 30.

The composition refills can include a plurality? of ?F? bottles single use.

The composition refills can include a plurality? of disposable charging modules 10 as previously described with reference to the embodiment of figures 1 and 3A.

The kit guarantees easy and precise use and, at the same time, allows the user to use the regulator 1 in a plurality? of different situations and operating conditions.

According to an example, plurality? of refills of the aforementioned composition can? understand a plurality? of refills presenting the same quantity of composition and/or the same composition in terms of quantity? of concentration of ethyl alcohol, of quantity? and composition of the solvent and/or quantity? and composition of additives.

According to a further example, plurality? of refills of the aforementioned composition can? understand a plurality? of refills presenting a different quantity of composition and/or a different composition in terms of quantity? of concentration of ethyl alcohol, of quantity? and composition of the solvent and/or quantity? and composition of additives.

According to a further example, plurality? of refills of the aforementioned composition can? include a first set of refills presenting the same quantity of composition and/or the same composition in terms of quantity? of concentration of ethyl alcohol, of quantity? and composition of the solvent and/or quantity? and composition of additives and at least a second set of refills presenting a different quantity of composition and/or a different composition in terms of quantity? of concentration of ethyl alcohol, of quantity? and composition of the solvent and/or quantity? and composition of additives from refills of the first set.

Advantageously, in this way, the user has a kit capable of being extremely versatile.

The present invention achieves the proposed objectives, overcoming the drawbacks complained of in the prior art.

Claims (16)

1. Portable dispenser (1) including: - a charge module (10) presenting a containment volume (V) comprising a composition in liquid form comprising ethyl alcohol in a concentration between 60% and 90% w/w and at least one solvent for use in the treatment or in the prevention of an infection or disease caused by a virus in an individual, - a dispensing module (20), connected or connectable to said charging module (10) and configured to receive said composition in liquid form and dispense it in the form of microparticles via a dispensing element; in use, said dispensing element being in fluid communication with said containment volume (V); - a power supply module (30), connected or electrically connectable to said dispensing module (20) and equipped with an energy accumulator to electrically power said dispensing module (20); wherein each of said modules (10, 20, 30) comprises at least one mechanical connection interface arranged at one end and configured for a reversible connection to at least one adjacent module (10, 20, 30). 2. Portable dispenser (1) according to claim 1, wherein said dispensing element is? shaped so as to administer said composition in the form of microparticles having a size between 0.1 and 6 ?m. 3. Portable dispenser (1) according to claim 1 or 2, wherein the energy accumulator of said power module (30) is an energy accumulator of the rechargeable type and in which said power supply module (30) includes a receiving portion (31), electrically connected to said energy accumulator, configured for reversible coupling with a connector suitable for recharging said energy accumulator. 4. Portable dispenser (1) according to claim 2 or 3, wherein said energy accumulator comprises an electric battery and/or a supercapacitor accumulator. 5. Portable dispenser (1) according to any of the previous claims, wherein said containment volume (V) has a volume between 1 ml and 20 ml. 6. Portable dispenser (1) according to any of the preceding claims 2 to 4, wherein said dispensing module (20) comprises a nebulizer for said composition, preferably an ultrasonic nebulizer, and wherein said dispensing element is a diffuser (22), preferably a piezoelectric atomizer. 7. Portable dispenser (1) according to claim 6, in which said charging module (10) includes a bottle having a neck (14) and in which said dispensing module (20) has a recess (23) contoured to said neck (14) and configured to at least partially accommodate said package (14); preferably said recess (23) and said neck (14) have reciprocal threaded clamping members. 8. Portable dispenser (1) according to claim 7, wherein said charging module (10) is a disposable bottle (F) containing a certain quantity? of that composition. 9. Portable dispenser (1) according to any one of claims 6 to 8, wherein said dispensing module (20) is, in use, interposed between said power module (30) and said charging module (10). 10. Portable dispenser (1) according to any of the preceding claims 2 to 5, wherein said dispensing module (20) comprises an electrical resistance configured to vaporize said composition and wherein said dispensing element is? a suction mouthpiece (21). 11. Portable dispenser (1) according to claim 10, wherein, in use, said electrical resistance is at least partially inserted in said containment volume (V) of said charging module (10) so as to be at least partially in contact with said composition. 12. Portable dispenser (1) according to claim 10 or 11, wherein said charging module (10) is, in use, interposed between said power module (30) and said dispensing module (20); 13. Portable dispenser (1) according to any one of the preceding claims, wherein said solvent comprises sterile water, sterile ozonated water and/or ozonated water. 14. Dispenser (1) according to any one of the previous claims, wherein said composition comprises at least an antiviral drug and/or an anti-inflammatory and/or an antipyretic and/or an antibiotic. 15. Portable dispensing kit including: - one (1) portable dispenser according to one or more? of the previous claims; - a plurality? of refills containing said composition. 16. Portable kit according to claim 15, wherein said plurality? of refills includes a plurality? of disposable bottles (F) containing the composition.