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IT201600130729A1 - Processo per la produzione degli intermedi del delmopinolo - Google Patents

Processo per la produzione degli intermedi del delmopinolo

Info

Publication number
IT201600130729A1
IT201600130729A1 IT102016000130729A IT201600130729A IT201600130729A1 IT 201600130729 A1 IT201600130729 A1 IT 201600130729A1 IT 102016000130729 A IT102016000130729 A IT 102016000130729A IT 201600130729 A IT201600130729 A IT 201600130729A IT 201600130729 A1 IT201600130729 A1 IT 201600130729A1
Authority
IT
Italy
Prior art keywords
delmopinol
intermediates
production
delmopinol intermediates
Prior art date
Application number
IT102016000130729A
Other languages
English (en)
Inventor
Faveri Carla De
Mariano Stivanello
Original Assignee
Lundbeck Pharmaceuticals Italy S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck Pharmaceuticals Italy S P A filed Critical Lundbeck Pharmaceuticals Italy S P A
Priority to IT102016000130729A priority Critical patent/IT201600130729A1/it
Priority to PCT/EP2017/083804 priority patent/WO2018115116A1/en
Priority to ES17822275T priority patent/ES2909566T3/es
Priority to DK17822275.8T priority patent/DK3558952T3/da
Priority to US16/472,476 priority patent/US11384056B2/en
Priority to EP17822275.8A priority patent/EP3558952B1/en
Publication of IT201600130729A1 publication Critical patent/IT201600130729A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/42—Platinum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C21/00—Acyclic unsaturated compounds containing halogen atoms
    • C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
    • C07C21/04—Chloro-alkenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C21/00—Acyclic unsaturated compounds containing halogen atoms
    • C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
    • C07C21/17—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds containing iodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT102016000130729A 2016-12-23 2016-12-23 Processo per la produzione degli intermedi del delmopinolo IT201600130729A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT102016000130729A IT201600130729A1 (it) 2016-12-23 2016-12-23 Processo per la produzione degli intermedi del delmopinolo
PCT/EP2017/083804 WO2018115116A1 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol intermediates
ES17822275T ES2909566T3 (es) 2016-12-23 2017-12-20 Método para la fabricación de delmopinol y de sus intermedios
DK17822275.8T DK3558952T3 (da) 2016-12-23 2017-12-20 Fremgangsmåde til fremstillingen af delmopinol og mellemprodukter deraf
US16/472,476 US11384056B2 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol intermediates
EP17822275.8A EP3558952B1 (en) 2016-12-23 2017-12-20 Method for the manufacturing of delmopinol and of its intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000130729A IT201600130729A1 (it) 2016-12-23 2016-12-23 Processo per la produzione degli intermedi del delmopinolo

Publications (1)

Publication Number Publication Date
IT201600130729A1 true IT201600130729A1 (it) 2018-06-23

Family

ID=58609882

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000130729A IT201600130729A1 (it) 2016-12-23 2016-12-23 Processo per la produzione degli intermedi del delmopinolo

Country Status (6)

Country Link
US (1) US11384056B2 (it)
EP (1) EP3558952B1 (it)
DK (1) DK3558952T3 (it)
ES (1) ES2909566T3 (it)
IT (1) IT201600130729A1 (it)
WO (1) WO2018115116A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600130538A1 (it) * 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione del delmopinolo
CN115315231B (zh) 2020-01-31 2024-03-22 优福斯特服务股份有限公司 制备地莫匹醇及其盐的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007057681A1 (en) * 2005-11-17 2007-05-24 Sinclair Pharmaceuticals Limited Process for the preparation of delmopinol and derivatives thereof
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2008139170A2 (en) * 2007-05-09 2008-11-20 Sinclair Pharmaceuticals Limited Transdermal and transmucosal drug delivery enhancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439011B (sv) 1980-03-21 1985-05-28 Ferrosan Ab Morfolinoforeningar, kompositioner innehallande dessa och anvendning derav
US4565695A (en) * 1983-01-27 1986-01-21 The United States Of America As Represented By The Secretary Of Agriculture Synthetic pheromone 10-methyl-2-tridecanone and its use in controlling the southern corn rootworm and related diabroticites
AU631648B2 (en) 1989-05-24 1992-12-03 Biosurface Pharma Ab Preparation of substituted isoxazolidines and isoxazolines as intermediates for delmopinol
GB0509437D0 (en) 2005-05-09 2005-06-15 Sinclair Pharmaceuticals Ltd Method
GB0515138D0 (en) 2005-07-22 2005-08-31 Sinclair Pharmaceuticals Acne treatment
GB0604018D0 (en) 2006-02-28 2006-04-05 Sinclair Pharmaceuticals Ltd Method
JP5671453B2 (ja) * 2009-04-28 2015-02-18 中外製薬株式会社 スピロイミダゾロン誘導体
GB201105162D0 (en) 2011-03-28 2011-05-11 Lane Jonathan Improved deodorant formulations
IT201600130538A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione del delmopinolo
IT201600130642A1 (it) 2016-12-23 2018-06-23 Lundbeck Pharmaceuticals Italy S P A Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007057681A1 (en) * 2005-11-17 2007-05-24 Sinclair Pharmaceuticals Limited Process for the preparation of delmopinol and derivatives thereof
WO2007091009A2 (en) * 2006-02-07 2007-08-16 Sinclair Pharmaceuticals Limited Preparation of delmopinol
WO2008139170A2 (en) * 2007-05-09 2008-11-20 Sinclair Pharmaceuticals Limited Transdermal and transmucosal drug delivery enhancers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JEAN KOSSANYI ET AL: "Insect chemistry. Application of the norrish type-I reaction to the synthesis of propylure, the sexual pheromone of pectinophora gossypiella saunders.", TETRAHEDRON LETTERS, vol. 14, no. 36, 1 January 1973 (1973-01-01), pages 3459 - 3462, XP055373545, DOI: 10.1016/S0040-4039(01)86942-2 *
MYRSINA, R. A.; SEMENYUK, N. L., UKRAINSKII KHIMICHESKII ZHURNAL (RUSSIAN EDITION), vol. 41, 1975, pages 1068 - 1070, XP009194442 *

Also Published As

Publication number Publication date
DK3558952T3 (da) 2022-03-21
US20210130307A1 (en) 2021-05-06
EP3558952B1 (en) 2022-02-09
ES2909566T3 (es) 2022-05-09
US11384056B2 (en) 2022-07-12
WO2018115116A1 (en) 2018-06-28
EP3558952A1 (en) 2019-10-30

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