IT1406151B1 - Procedimento per la preparazione di fosinopril e suoi intermedi - Google Patents
Procedimento per la preparazione di fosinopril e suoi intermediInfo
- Publication number
- IT1406151B1 IT1406151B1 ITMI2010A002249A ITMI20102249A IT1406151B1 IT 1406151 B1 IT1406151 B1 IT 1406151B1 IT MI2010A002249 A ITMI2010A002249 A IT MI2010A002249A IT MI20102249 A ITMI20102249 A IT MI20102249A IT 1406151 B1 IT1406151 B1 IT 1406151B1
- Authority
- IT
- Italy
- Prior art keywords
- fosinopril
- intermediates
- procedure
- preparation
- Prior art date
Links
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 title 1
- 229960002490 fosinopril Drugs 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3241—Esters of arylalkanephosphinic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A002249A IT1406151B1 (it) | 2010-12-06 | 2010-12-06 | Procedimento per la preparazione di fosinopril e suoi intermedi |
| US13/286,421 US20120142939A1 (en) | 2010-12-06 | 2011-11-01 | Process for the preparation of fosinopril and intermediates thereof |
| EP11190979A EP2460808A1 (en) | 2010-12-06 | 2011-11-28 | Process for the preparation of fosinopril and intermediates thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A002249A IT1406151B1 (it) | 2010-12-06 | 2010-12-06 | Procedimento per la preparazione di fosinopril e suoi intermedi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI20102249A1 ITMI20102249A1 (it) | 2012-06-07 |
| IT1406151B1 true IT1406151B1 (it) | 2014-02-14 |
Family
ID=43736905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI2010A002249A IT1406151B1 (it) | 2010-12-06 | 2010-12-06 | Procedimento per la preparazione di fosinopril e suoi intermedi |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20120142939A1 (it) |
| EP (1) | EP2460808A1 (it) |
| IT (1) | IT1406151B1 (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20130434A1 (it) * | 2013-03-21 | 2014-09-22 | Dipharma Francis Srl | Sintesi di un intermedio utile nella preparazione di un composto a struttura fosfinica |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4337201A (en) | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4912231A (en) | 1987-06-15 | 1990-03-27 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-phenyl-L-proline derivatives |
| US4873356A (en) | 1987-09-30 | 1989-10-10 | E. R. Squibb & Sons, Inc. | Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby |
| US4937355A (en) | 1989-01-17 | 1990-06-26 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-substituted-dl-proline derivatives |
| US5008399A (en) | 1990-01-19 | 1991-04-16 | E. R. Squibb & Sons, Inc. | Diastereoselective preparation of phosphinate esters |
| IT1394407B1 (it) * | 2009-05-25 | 2012-06-15 | Dipharma Francis Srl | Procedimento per la preparazione di fosinopril e suoi intermedi |
-
2010
- 2010-12-06 IT ITMI2010A002249A patent/IT1406151B1/it active
-
2011
- 2011-11-01 US US13/286,421 patent/US20120142939A1/en not_active Abandoned
- 2011-11-28 EP EP11190979A patent/EP2460808A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI20102249A1 (it) | 2012-06-07 |
| US20120142939A1 (en) | 2012-06-07 |
| EP2460808A1 (en) | 2012-06-06 |
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