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IT1404145B1 - Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi - Google Patents

Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Info

Publication number
IT1404145B1
IT1404145B1 ITMI2010A002404A ITMI20102404A IT1404145B1 IT 1404145 B1 IT1404145 B1 IT 1404145B1 IT MI2010A002404 A ITMI2010A002404 A IT MI2010A002404A IT MI20102404 A ITMI20102404 A IT MI20102404A IT 1404145 B1 IT1404145 B1 IT 1404145B1
Authority
IT
Italy
Prior art keywords
enzymes
degradation
compositions
heat
hyaluronic acid
Prior art date
Application number
ITMI2010A002404A
Other languages
English (en)
Inventor
Stefano Togni
Carlo Vernasca
Andrea Maria Giori
Original Assignee
Altergon Sa
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ITMI2010A002404A priority Critical patent/IT1404145B1/it
Application filed by Altergon Sa, Indena Spa filed Critical Altergon Sa
Priority to PCT/EP2011/073079 priority patent/WO2012089537A1/en
Priority to CN2011800628689A priority patent/CN103314047A/zh
Priority to KR1020137016624A priority patent/KR20130132503A/ko
Priority to AU2011351661A priority patent/AU2011351661A1/en
Priority to US13/976,113 priority patent/US20140094430A1/en
Priority to BR112013018745A priority patent/BR112013018745A2/pt
Priority to JP2013546659A priority patent/JP2014506876A/ja
Priority to RU2013129206/05A priority patent/RU2013129206A/ru
Priority to CA2823052A priority patent/CA2823052A1/en
Priority to EP11799424.4A priority patent/EP2658914A1/en
Publication of ITMI20102404A1 publication Critical patent/ITMI20102404A1/it
Application granted granted Critical
Publication of IT1404145B1 publication Critical patent/IT1404145B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
ITMI2010A002404A 2010-12-27 2010-12-27 Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi IT1404145B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI2010A002404A IT1404145B1 (it) 2010-12-27 2010-12-27 Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi
CN2011800628689A CN103314047A (zh) 2010-12-27 2011-12-16 对热或酶的降解作用稳定的透明质酸组合物
KR1020137016624A KR20130132503A (ko) 2010-12-27 2011-12-16 열 또는 효소의 분해 효과에 대해 안정화된 히알루론산 조성물
AU2011351661A AU2011351661A1 (en) 2010-12-27 2011-12-16 Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
PCT/EP2011/073079 WO2012089537A1 (en) 2010-12-27 2011-12-16 Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
US13/976,113 US20140094430A1 (en) 2010-12-27 2011-12-16 Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
BR112013018745A BR112013018745A2 (pt) 2010-12-27 2011-12-16 composições de ácido hialurônico estabilizadas contra o efeito de degradação de calor ou de enzimas
JP2013546659A JP2014506876A (ja) 2010-12-27 2011-12-16 熱または酵素の分解作用に対して安定化されたヒアルロン酸組成物
RU2013129206/05A RU2013129206A (ru) 2010-12-27 2011-12-16 Композиции гиалуроновой кислоты, стабилизированные против разрушающего действия тепла или ферментов
CA2823052A CA2823052A1 (en) 2010-12-27 2011-12-16 Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
EP11799424.4A EP2658914A1 (en) 2010-12-27 2011-12-16 Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A002404A IT1404145B1 (it) 2010-12-27 2010-12-27 Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Publications (2)

Publication Number Publication Date
ITMI20102404A1 ITMI20102404A1 (it) 2012-06-28
IT1404145B1 true IT1404145B1 (it) 2013-11-15

Family

ID=43737057

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2010A002404A IT1404145B1 (it) 2010-12-27 2010-12-27 Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Country Status (11)

Country Link
US (1) US20140094430A1 (it)
EP (1) EP2658914A1 (it)
JP (1) JP2014506876A (it)
KR (1) KR20130132503A (it)
CN (1) CN103314047A (it)
AU (1) AU2011351661A1 (it)
BR (1) BR112013018745A2 (it)
CA (1) CA2823052A1 (it)
IT (1) IT1404145B1 (it)
RU (1) RU2013129206A (it)
WO (1) WO2012089537A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1402382B1 (it) † 2010-09-09 2013-09-04 Ibsa Inst Biochimique Sa Complessi cooperativi ibridi di acido ialuronico
ITMI20130221A1 (it) * 2013-02-18 2014-08-19 Novagenit S R L Formulazione a base di polisaccaridi biocompatibili e biodegradabili da impiegare in chirurgia
TW201609145A (zh) * 2013-12-25 2016-03-16 參天製藥股份有限公司 注射劑及形成緩釋（ｄｅｐｏｔ）之方法
KR102336699B1 (ko) 2015-02-23 2021-12-08 주식회사 파마리서치 소듐 2-메르캅토에탄 설포네이트를 함유하는 히알루론산의 분해억제제 및 이를 포함하는 조성물
KR102329495B1 (ko) 2015-02-23 2021-11-24 주식회사 파마리서치 소듐 2-메르캅토에탄 설포네이트를 삼투압 조절제로서 함유하는 생체투여 또는 미용성형용 생분해성 고분자 조성물
IL280109B2 (en) * 2018-07-18 2024-08-01 Atg 20 S R L Composition comprising glycyrrhizin and cosmetic and pharmaceutical uses thereof
IT202100013787A1 (it) * 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
CN113831551B (zh) * 2021-10-13 2023-04-21 江苏集萃新型药物制剂技术研究所有限公司 水基分散体系

Family Cites Families (14)

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JP3807782B2 (ja) * 1995-06-22 2006-08-09 ライオン株式会社 ヒアルロニダーゼ阻害剤
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
JPH1180004A (ja) * 1997-09-01 1999-03-23 Kanebo Ltd ヒアルロン酸分解阻害剤、ヒアルロン酸異常分解疾患改善・治療剤、及び歯肉炎防止剤、並びに乾燥肌又は荒れ肌防止剤
DE60221227T2 (de) * 2002-04-30 2008-01-31 Sifi S.P.A., Lavinaio-Aci Xanthangummi enthaltende reepithelialisierende pharmazeutische Zubereitungen
JP2003342166A (ja) * 2002-05-29 2003-12-03 Japan Science & Technology Corp 眼内疾患用製剤
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
AU2003206922A1 (en) * 2003-02-19 2004-09-09 Aventis Pharmaceuticals Holdings Inc. Composition and method for intradermal soft tissue augmentation
US7262179B2 (en) * 2003-05-28 2007-08-28 Bristol-Myers Squibb Company Wound care compositions
US8288362B2 (en) * 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
ITPD20060202A1 (it) * 2006-05-22 2007-11-23 Univ Degli Studi Trieste Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5254572B2 (ja) * 2007-06-22 2013-08-07 エステー株式会社 精製カラギーナン及びその製造方法
US20090087569A1 (en) * 2007-09-27 2009-04-02 Fenchem Enterprises Ltd. Methods for Preparing Highly Stable Hyaluronic Acid
ITRM20070510A1 (it) * 2007-10-02 2009-04-03 Rmfa Trading S A Composizioni oftalmiche a base di polisaccaride del seme di tamarindo e acido ialuronico.
WO2010070655A1 (en) * 2008-12-15 2010-06-24 Council Of Scientific & Industrial Research A transparent xyloglucan/chitosan gel and a process for the preparation thereof

Also Published As

Publication number Publication date
WO2012089537A1 (en) 2012-07-05
ITMI20102404A1 (it) 2012-06-28
AU2011351661A1 (en) 2013-07-11
US20140094430A1 (en) 2014-04-03
KR20130132503A (ko) 2013-12-04
RU2013129206A (ru) 2015-01-10
EP2658914A1 (en) 2013-11-06
CN103314047A (zh) 2013-09-18
BR112013018745A2 (pt) 2016-10-25
CA2823052A1 (en) 2012-07-05
JP2014506876A (ja) 2014-03-20

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