IT1314204B1 - Complessi di rutenio con elevata attivita' antitumorale - Google Patents
Complessi di rutenio con elevata attivita' antitumoraleInfo
- Publication number
- IT1314204B1 IT1314204B1 IT1999MI002256A ITMI992256A IT1314204B1 IT 1314204 B1 IT1314204 B1 IT 1314204B1 IT 1999MI002256 A IT1999MI002256 A IT 1999MI002256A IT MI992256 A ITMI992256 A IT MI992256A IT 1314204 B1 IT1314204 B1 IT 1314204B1
- Authority
- IT
- Italy
- Prior art keywords
- ruthenium complexes
- complexes
- high anti
- ruthenium
- tumoral activity
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000003303 ruthenium Chemical class 0.000 abstract 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- 230000002001 anti-metastasis Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002256A IT1314204B1 (it) | 1999-10-28 | 1999-10-28 | Complessi di rutenio con elevata attivita' antitumorale |
| ES00975930T ES2200967T3 (es) | 1999-10-28 | 2000-10-26 | Complejos de rutenio (ii) con gran actividad antitumoral y antimetastasica. |
| AU13882/01A AU1388201A (en) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) complexes with high antitumoral and antimetastatic activities |
| JP2001533141A JP4570833B2 (ja) | 1999-10-28 | 2000-10-26 | 抗腫瘍活性及び抗転移活性を有するルテニウム（ｉｉ）錯体 |
| EP00975930A EP1228077B1 (en) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) complexes with high antitumoral and antimetastatic activities |
| PCT/EP2000/010566 WO2001030789A1 (en) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) complexes with high antitumoral and antimetastatic activities |
| DE60003328T DE60003328T2 (de) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) komplexe mit hoher antitumor und antimetastatischer wirkung |
| AT00975930T ATE242779T1 (de) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) komplexe mit hoher antitumor und antimetastatischer wirkung |
| CA002389171A CA2389171A1 (en) | 1999-10-28 | 2000-10-26 | Ruthenium (ii) complexes with high antitumoral and antimetastatic activities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002256A IT1314204B1 (it) | 1999-10-28 | 1999-10-28 | Complessi di rutenio con elevata attivita' antitumorale |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI992256A0 ITMI992256A0 (it) | 1999-10-28 |
| ITMI992256A1 ITMI992256A1 (it) | 2001-04-28 |
| IT1314204B1 true IT1314204B1 (it) | 2002-12-06 |
Family
ID=11383866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999MI002256A IT1314204B1 (it) | 1999-10-28 | 1999-10-28 | Complessi di rutenio con elevata attivita' antitumorale |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1228077B1 (it) |
| JP (1) | JP4570833B2 (it) |
| AT (1) | ATE242779T1 (it) |
| AU (1) | AU1388201A (it) |
| CA (1) | CA2389171A1 (it) |
| DE (1) | DE60003328T2 (it) |
| ES (1) | ES2200967T3 (it) |
| IT (1) | IT1314204B1 (it) |
| WO (1) | WO2001030789A1 (it) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1253156A3 (en) * | 1992-04-03 | 2004-01-07 | California Institute Of Technology | High activity ruthenium or osmium metal carbene complexes for olefin metathesis reactions and synthesis and application thereof |
| JPH0789855A (ja) * | 1993-09-24 | 1995-04-04 | Toagosei Co Ltd | 抗腫瘍剤 |
| IT1284101B1 (it) * | 1996-07-02 | 1998-05-08 | Sigea Srl | Sali di complessi anionici di ru(iii), utili in terapia come agenti antimetastatici e antineoplastici |
| DE69819501T2 (de) * | 1997-06-27 | 2004-09-23 | Ciba Speciality Chemicals Holding Inc. | Ruthenium und osmiumcarbenkatalysatoren |
-
1999
- 1999-10-28 IT IT1999MI002256A patent/IT1314204B1/it active
-
2000
- 2000-10-26 JP JP2001533141A patent/JP4570833B2/ja not_active Expired - Fee Related
- 2000-10-26 DE DE60003328T patent/DE60003328T2/de not_active Expired - Lifetime
- 2000-10-26 WO PCT/EP2000/010566 patent/WO2001030789A1/en active IP Right Grant
- 2000-10-26 AT AT00975930T patent/ATE242779T1/de not_active IP Right Cessation
- 2000-10-26 CA CA002389171A patent/CA2389171A1/en not_active Abandoned
- 2000-10-26 EP EP00975930A patent/EP1228077B1/en not_active Expired - Lifetime
- 2000-10-26 AU AU13882/01A patent/AU1388201A/en not_active Abandoned
- 2000-10-26 ES ES00975930T patent/ES2200967T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2389171A1 (en) | 2001-05-03 |
| JP2003512470A (ja) | 2003-04-02 |
| EP1228077B1 (en) | 2003-06-11 |
| JP4570833B2 (ja) | 2010-10-27 |
| EP1228077A1 (en) | 2002-08-07 |
| ATE242779T1 (de) | 2003-06-15 |
| DE60003328T2 (de) | 2004-04-29 |
| AU1388201A (en) | 2001-05-08 |
| DE60003328D1 (de) | 2003-07-17 |
| ES2200967T3 (es) | 2004-03-16 |
| WO2001030789A1 (en) | 2001-05-03 |
| ITMI992256A0 (it) | 1999-10-28 |
| ITMI992256A1 (it) | 2001-04-28 |
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