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IT1313587B1 - Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound - Google Patents

Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound

Info

Publication number
IT1313587B1
IT1313587B1 ITMI991724A IT1313587B1 IT 1313587 B1 IT1313587 B1 IT 1313587B1 IT MI991724 A ITMI991724 A IT MI991724A IT 1313587 B1 IT1313587 B1 IT 1313587B1
Authority
IT
Italy
Prior art keywords
new
preparation
citalopram
compound
antidepressant
Prior art date
Application number
Other languages
Italian (it)
Inventor
Asta Leone Dall
Umberto Casazza
Original Assignee
Norpharma S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norpharma S P A filed Critical Norpharma S P A
Publication of ITMI991724A0 publication Critical patent/ITMI991724A0/en
Priority to IT99MI001724 priority Critical patent/IT1313587B1/en
Priority to US09/830,109 priority patent/US6365747B1/en
Priority to EP99950506A priority patent/EP1123284B1/en
Priority to CZ20011418A priority patent/CZ299920B6/en
Priority to EA200100457A priority patent/EA002977B1/en
Priority to IL14234699A priority patent/IL142346A0/en
Priority to DE69904853T priority patent/DE69904853T2/en
Priority to SK535-2001A priority patent/SK285719B6/en
Priority to CA002291134A priority patent/CA2291134C/en
Priority to BRPI9915158-8A priority patent/BR9915158B1/en
Priority to JP2000577159A priority patent/JP3892667B2/en
Priority to KR10-2001-7004889A priority patent/KR100411505B1/en
Priority to AT99950506T priority patent/ATE230738T1/en
Priority to PL347189A priority patent/PL199423B1/en
Priority to AU63260/99A priority patent/AU746665B2/en
Priority to DK99950506T priority patent/DK1123284T3/en
Priority to NZ510858A priority patent/NZ510858A/en
Priority to PCT/DK1999/000576 priority patent/WO2000023431A1/en
Priority to CN99812369A priority patent/CN1129592C/en
Priority to HU0104128A priority patent/HU228576B1/en
Priority to SI9930214T priority patent/SI1123284T1/en
Priority to ES99950506T priority patent/ES2189502T3/en
Priority to ARP990105305A priority patent/AR018693A1/en
Publication of ITMI991724A1 publication Critical patent/ITMI991724A1/en
Priority to IS5911A priority patent/IS2256B/en
Priority to NO20011936A priority patent/NO327038B1/en
Priority to BG105457A priority patent/BG64704B1/en
Priority to HK02103712.9A priority patent/HK1042297B/en
Application granted granted Critical
Publication of IT1313587B1 publication Critical patent/IT1313587B1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

Preparation (A) of citalopram comprises dehydrating new oxazoline compounds or thermally cleaving new thiazoline compounds. Preparation (A) of citalopram of formula (I) or its enantiomers or salts comprises treating an oxazoline compound of formula (IV) with a dehydration agent, or (when X = S), thermally cleaving the thiazoline ring, or treating in the presence of a radical initiator and optionally converting the free base or its acid addition salt to a salt. [Image] X : O or S; R 1>-R 3>H or 1-6C alkyl; R 4>H, 1-6C alkyl, carboxy or its precursor or CR 1>R 2> or CR 3>R 4>3-6C spiro-cycloalkane. Independent claims are included for the following: (1) new compounds of formula (VIII), (IX) and (IV) and (2) citalopram (I) prepared as above. [Image] ACTIVITY : Antidepressant. MECHANISM OF ACTION : None given.
IT99MI001724 1998-10-20 1999-08-02 Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound IT1313587B1 (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
IT99MI001724 IT1313587B1 (en) 1999-08-02 1999-08-02 Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound
AU63260/99A AU746665B2 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
DK99950506T DK1123284T3 (en) 1998-10-20 1999-10-19 Process for the preparation of citalopram
CZ20011418A CZ299920B6 (en) 1998-10-20 1999-10-19 Process for preparing citalopram
EA200100457A EA002977B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
IL14234699A IL142346A0 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
DE69904853T DE69904853T2 (en) 1998-10-20 1999-10-19 METHOD FOR PRODUCING CITALOPRAM
SK535-2001A SK285719B6 (en) 1998-10-20 1999-10-19 Method for preparation of citalopram and intermediates
CA002291134A CA2291134C (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
BRPI9915158-8A BR9915158B1 (en) 1998-10-20 1999-10-19 a method for preparing citalopram, and compounds of formula viii, ix and iv, or any of their enantiomers and acid addition salts thereof.
JP2000577159A JP3892667B2 (en) 1998-10-20 1999-10-19 Citalopram manufacturing method
KR10-2001-7004889A KR100411505B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
AT99950506T ATE230738T1 (en) 1998-10-20 1999-10-19 METHOD FOR PRODUCING CITALOPRAM
PL347189A PL199423B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
US09/830,109 US6365747B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
PCT/DK1999/000576 WO2000023431A1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
SI9930214T SI1123284T1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
NZ510858A NZ510858A (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
CN99812369A CN1129592C (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
HU0104128A HU228576B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
EP99950506A EP1123284B1 (en) 1998-10-20 1999-10-19 Method for the preparation of citalopram
ES99950506T ES2189502T3 (en) 1998-10-20 1999-10-19 METHOD FOR THE PREVENTION OF CITALOPRAM.
ARP990105305A AR018693A1 (en) 1998-10-20 1999-10-20 METHOD FOR THE PREPARATION OF CITALOPRAM AND INTERMEDIATE COMPOUNDS FOR USE IN THIS METHOD.
IS5911A IS2256B (en) 1998-10-20 2001-03-30 Method for producing citalopram
NO20011936A NO327038B1 (en) 1998-10-20 2001-04-19 Process for the preparation of citalopram
BG105457A BG64704B1 (en) 1998-10-20 2001-04-20 Method for the preparation of citalopram
HK02103712.9A HK1042297B (en) 1998-10-20 2002-05-16 Method for the preparation of citalopram

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT99MI001724 IT1313587B1 (en) 1999-08-02 1999-08-02 Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound

Publications (3)

Publication Number Publication Date
ITMI991724A0 ITMI991724A0 (en) 1999-08-02
ITMI991724A1 ITMI991724A1 (en) 2001-02-02
IT1313587B1 true IT1313587B1 (en) 2002-09-09

Family

ID=11383475

Family Applications (1)

Application Number Title Priority Date Filing Date
IT99MI001724 IT1313587B1 (en) 1998-10-20 1999-08-02 Preparation of citalopram used as antidepressant by dehydrating new oxazoline compound or thermally cleaving new thiazoline compound

Country Status (1)

Country Link
IT (1) IT1313587B1 (en)

Also Published As

Publication number Publication date
ITMI991724A1 (en) 2001-02-02
ITMI991724A0 (en) 1999-08-02

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