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IT1305294B1 - Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari. - Google Patents

Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.

Info

Publication number
IT1305294B1
IT1305294B1 IT1999RM000069A ITRM990069A IT1305294B1 IT 1305294 B1 IT1305294 B1 IT 1305294B1 IT 1999RM000069 A IT1999RM000069 A IT 1999RM000069A IT RM990069 A ITRM990069 A IT RM990069A IT 1305294 B1 IT1305294 B1 IT 1305294B1
Authority
IT
Italy
Prior art keywords
therapy
growth factor
pathologies
nerve growth
ngf
Prior art date
Application number
IT1999RM000069A
Other languages
English (en)
Inventor
Alessandro Lambiase
Original Assignee
Alessandro Lambiase
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999RM000069A priority Critical patent/IT1305294B1/it
Application filed by Alessandro Lambiase filed Critical Alessandro Lambiase
Priority to EP00901331A priority patent/EP1161256B1/en
Priority to DE60027878T priority patent/DE60027878T2/de
Priority to PCT/IT2000/000016 priority patent/WO2000044396A1/en
Priority to US09/890,088 priority patent/US9468665B1/en
Priority to ES00901331T priority patent/ES2264416T3/es
Priority to AT00901331T priority patent/ATE325618T1/de
Priority to PT00901331T priority patent/PT1161256E/pt
Priority to AU21292/00A priority patent/AU2129200A/en
Priority to DK00901331T priority patent/DK1161256T3/da
Publication of ITRM990069A1 publication Critical patent/ITRM990069A1/it
Application granted granted Critical
Publication of IT1305294B1 publication Critical patent/IT1305294B1/it
Priority to CY20061101109T priority patent/CY1106140T1/el
Priority to US13/372,742 priority patent/US9345749B2/en
Priority to US15/264,987 priority patent/US10010586B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT1999RM000069A 1999-01-29 1999-01-29 Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari. IT1305294B1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT1999RM000069A IT1305294B1 (it) 1999-01-29 1999-01-29 Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.
AU21292/00A AU2129200A (en) 1999-01-29 2000-01-21 Use of nerve growth factor for therapy of intraocular tissue pathologies
PCT/IT2000/000016 WO2000044396A1 (en) 1999-01-29 2000-01-21 Use of nerve growth factor for therapy of intraocular tissue pathologies
US09/890,088 US9468665B1 (en) 1999-01-29 2000-01-21 Method of treating intraoccular tissue pathologies with nerve growth factor
ES00901331T ES2264416T3 (es) 1999-01-29 2000-01-21 Uso del factor de crecimiento de los nervios para la preparacion de un medicamento para la terapia de patologias de tejidos intraoculares.
AT00901331T ATE325618T1 (de) 1999-01-29 2000-01-21 Verwendung des nervenwachstumfaktors zur herstellung eines arzneimittels zur behandlung von erkrankungen der innenaugegeweb
EP00901331A EP1161256B1 (en) 1999-01-29 2000-01-21 Use of nerve growth factor for the manufacture of a medicament for therapy of intraocular tissue pathologies
DE60027878T DE60027878T2 (de) 1999-01-29 2000-01-21 Verwendung des nervenwachstumfaktors zur herstellung eines arzneimittels zur behandlung von erkrankungen der innenaugegeweb
DK00901331T DK1161256T3 (da) 1999-01-29 2000-01-21 Anvendelse af nervevækstfaktor til fremstilling af et medikament til terapi af intraokulære vævspatologier
PT00901331T PT1161256E (pt) 1999-01-29 2000-01-21 Utilizacao de factor do crescimento de nervos para o fabrico de um medicamento para terapeutica de patologias do tecido intra-ocular
CY20061101109T CY1106140T1 (el) 1999-01-29 2006-08-08 Χρηση νευρικου αυξητικου παραγοντα για την παρασκευη ενος φαρμακου για την θepαπεια παθολογικων καταστασεων του ενδοφθαλμικου ιστου
US13/372,742 US9345749B2 (en) 1999-01-29 2012-02-14 Method of treating intraoccular tissue pathologies with nerve growth factor
US15/264,987 US10010586B2 (en) 1999-01-29 2016-09-14 Method of treating intraocular tissue pathologies with nerve growth factor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999RM000069A IT1305294B1 (it) 1999-01-29 1999-01-29 Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.

Publications (2)

Publication Number Publication Date
ITRM990069A1 ITRM990069A1 (it) 2000-07-29
IT1305294B1 true IT1305294B1 (it) 2001-05-04

Family

ID=11406408

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999RM000069A IT1305294B1 (it) 1999-01-29 1999-01-29 Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.

Country Status (11)

Country Link
US (3) US9468665B1 (it)
EP (1) EP1161256B1 (it)
AT (1) ATE325618T1 (it)
AU (1) AU2129200A (it)
CY (1) CY1106140T1 (it)
DE (1) DE60027878T2 (it)
DK (1) DK1161256T3 (it)
ES (1) ES2264416T3 (it)
IT (1) IT1305294B1 (it)
PT (1) PT1161256E (it)
WO (1) WO2000044396A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1305294B1 (it) 1999-01-29 2001-05-04 Alessandro Lambiase Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.
EP1589988A2 (en) 2002-12-20 2005-11-02 Neuronicon ApS Modulation of activity of neurotrophins
ITRM20050447A1 (it) * 2005-08-19 2007-02-20 Anabasis S R L Uso del nerve growth factor in collirio nella terapia di patologie del sistema nervoso centrale, quali la malattia di alzheimer e il morbo di parkinson.
HUE031611T2 (en) 2006-12-21 2017-07-28 H Lundbeck As Modulation of Pronurotrophin Activity
IT1396607B1 (it) 2009-11-16 2012-12-14 Hmfra Hungary Ltd Liability Company Preparazioni oftalmiche a base di bdnf (brain-derived neurotrophic factor) e loro uso.
IT202000032423A1 (it) 2020-12-24 2022-06-24 Univ Degli Studi Di Trieste Metodo per la produzione di forme processate proteoliticamente di fattori trofici o fattori di crescita

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE382477C (de) 1923-10-03 Willy Pietzsch Vorrichtung zum Versenken von Schreibmaschinen in Schreibmaschinentischen, bei der die Schreibmaschine in wagerechter Lage nach einem seitlich in anderer Hoehenlage befindlichen Standplatz auf und ab bewegt wird
US4959319A (en) 1985-08-01 1990-09-25 Skelnik Debra L Process of corneal enhancement
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US4973466A (en) * 1988-06-21 1990-11-27 Chiron Ophthalmics, Inc. Wound-healing dressings and methods
DE3827477A1 (de) 1988-08-12 1990-02-22 Biotechnolog Forschung Gmbh Verfahren zur isolierung und zur alleinigen zuechtung von endothelialzellen der menschlichen hornhaut (hcec)
US5260059A (en) 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US5667968A (en) * 1989-08-30 1997-09-16 Regeneron Pharmaceuticals, Inc. Prevention of retinal injury and degeneration by specific factors
US5641479A (en) 1991-02-12 1997-06-24 Richardson-Vicks Inc. Cosmetic compositions comprising an imidazolium derivative and branched polyethylene glycol
US5272135A (en) 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
IT1255657B (it) 1992-05-29 1995-11-09 Colture di tessuto di mucosa congiuntivale differenziata, procedimentoper la loro preparazione e supporti per il loro uso.
US5767079A (en) * 1992-07-08 1998-06-16 Celtrix Pharmaceuticals, Inc. Method of treating ophthalmic disorders using TGF -β
US6063757A (en) * 1995-11-29 2000-05-16 Urso; Richard G. Wound treatment method with nerve growth factor
US5641750A (en) * 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
IT1283911B1 (it) 1996-02-05 1998-05-07 Farmigea Spa Soluzioni oftalmiche viscosizzate con polisaccaridi della gomma di tamarindo
US6299895B1 (en) * 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
BR9712824A (pt) 1996-09-13 1999-12-21 Advanced Medicine Research Ins Composição oftálmica de fator neurotrófico, agente de tratamento de desordem funcional do nervo ótico e método para tratamento de desordem funcional do nervo ótico
JPH10218787A (ja) * 1997-02-06 1998-08-18 Akio Okamoto 神経栄養因子による眼科用組成物
IT1291892B1 (it) * 1997-04-24 1999-01-21 Alessandro Lambiase Uso del nerve growth factor nella conservazione di cornee in coltura, nella produzione di tessuti corneali e congiuntivali in vitro e nella
WO2000007613A1 (fr) 1998-08-05 2000-02-17 Advanced Medicine Research Institute Remedes contenant des facteurs neurotrophiques pour le traitement des lesions cerebrales centrales
DE69923998T2 (de) 1998-12-09 2006-04-27 Chiron Corp., Emeryville Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems
IT1305294B1 (it) 1999-01-29 2001-05-04 Alessandro Lambiase Uso del nerve growth factor nella terapia di patologie a carico deitessuti intraoculari.
US20020009498A1 (en) 1999-11-05 2002-01-24 Guy L. Clifton Methods and compositions for treatment of traumatic brain injury
IL147921A0 (en) 2002-01-31 2002-08-14 Abdulrazik Mohammad A method for treating central nervous system disorders by ocular dosing

Also Published As

Publication number Publication date
US9468665B1 (en) 2016-10-18
US9345749B2 (en) 2016-05-24
PT1161256E (pt) 2006-09-29
US20120142591A1 (en) 2012-06-07
EP1161256B1 (en) 2006-05-10
ATE325618T1 (de) 2006-06-15
ITRM990069A1 (it) 2000-07-29
EP1161256A1 (en) 2001-12-12
ES2264416T3 (es) 2007-01-01
DE60027878D1 (de) 2006-06-14
AU2129200A (en) 2000-08-18
US20170007670A1 (en) 2017-01-12
WO2000044396A1 (en) 2000-08-03
DE60027878T2 (de) 2007-04-19
US10010586B2 (en) 2018-07-03
CY1106140T1 (el) 2011-06-08
DK1161256T3 (da) 2006-09-18

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