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IT1299563B1 - ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS - Google Patents

ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS

Info

Publication number
IT1299563B1
IT1299563B1 IT98RM000476A ITRM980476A IT1299563B1 IT 1299563 B1 IT1299563 B1 IT 1299563B1 IT 98RM000476 A IT98RM000476 A IT 98RM000476A IT RM980476 A ITRM980476 A IT RM980476A IT 1299563 B1 IT1299563 B1 IT 1299563B1
Authority
IT
Italy
Prior art keywords
nanocrystalline
dentine
materials
remineralisation
apatite
Prior art date
Application number
IT98RM000476A
Other languages
Italian (it)
Inventor
Giovanni Dolci
Romano Mongiorgi
Carlo Prati
Giovanni Valdre
Original Assignee
Giovanni Dolci
Romano Mongiorgi
Carlo Prati
Giovanni Valdre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giovanni Dolci, Romano Mongiorgi, Carlo Prati, Giovanni Valdre filed Critical Giovanni Dolci
Priority to IT98RM000476A priority Critical patent/IT1299563B1/en
Publication of ITRM980476A0 publication Critical patent/ITRM980476A0/en
Priority to AU51919/99A priority patent/AU5191999A/en
Priority to EP99936957A priority patent/EP1098623A2/en
Priority to CA002338021A priority patent/CA2338021A1/en
Priority to PCT/IT1999/000224 priority patent/WO2000003747A2/en
Publication of ITRM980476A1 publication Critical patent/ITRM980476A1/en
Application granted granted Critical
Publication of IT1299563B1 publication Critical patent/IT1299563B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/52—Cleaning; Disinfecting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/54—Filling; Sealing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A61K6/75—Apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Landscapes

  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Birds (AREA)
  • Dental Preparations (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Biocompatible nanocrystalline materials based on apatite with high specific surface properties, having average size of the crystallites comprised between 0.5 and 200 nm and possible lattice deformations and/or defects, are proposed for use in the fields of dentistry and dental hygiene, in particular for the production of preparations, solutions, toothpastes and materials for the remineralisation of enamel and dentine and for the treatment of dentine hypersensitivity. The apatite-based nanostructured materials appear to possess specific physico-chemical properties connected to their nanocrystalline and defective nature, such as the remarkable surface chemical reactivity and the hygroscopicity, which allow the material to recrystallise as a result of the metastable character of the nanocrystalline system, to be used for the remineralisation of enamel and dentine. In addition, they possess the most suitable grain sizes to easily and deeply penetrate mechanically within the dentinal tubules, and also cause it to cement the internal surface thereof, both by swelling and by readily reacting with the natural tissues.
IT98RM000476A 1998-07-17 1998-07-17 ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS IT1299563B1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT98RM000476A IT1299563B1 (en) 1998-07-17 1998-07-17 ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS
AU51919/99A AU5191999A (en) 1998-07-17 1999-07-16 Odontostomatologic use of apatite-based nanostructured materials
EP99936957A EP1098623A2 (en) 1998-07-17 1999-07-16 Odontostomatologic use of apatite-based nanostructured materials
CA002338021A CA2338021A1 (en) 1998-07-17 1999-07-16 Odontostomatologic use of apatite-based nanostructured materials
PCT/IT1999/000224 WO2000003747A2 (en) 1998-07-17 1999-07-16 Odontostomatologic use of apatite-based nanostructured materials

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98RM000476A IT1299563B1 (en) 1998-07-17 1998-07-17 ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS

Publications (3)

Publication Number Publication Date
ITRM980476A0 ITRM980476A0 (en) 1998-07-17
ITRM980476A1 ITRM980476A1 (en) 2000-01-17
IT1299563B1 true IT1299563B1 (en) 2000-03-16

Family

ID=11406050

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98RM000476A IT1299563B1 (en) 1998-07-17 1998-07-17 ODONTOSTOMATOLOGICAL USE OF NANOSTRUCTURED APATITIC BASED MATERIALS

Country Status (5)

Country Link
EP (1) EP1098623A2 (en)
AU (1) AU5191999A (en)
CA (1) CA2338021A1 (en)
IT (1) IT1299563B1 (en)
WO (1) WO2000003747A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19930335A1 (en) * 1999-07-02 2001-01-18 Henkel Kgaa Composite materials made from calcium compounds and protein components
CN1106861C (en) 2000-05-19 2003-04-30 清华大学 Preparation method of nanometer phase calcium-phosphorus salt/collagen/polylactic acid bone composite material
DE10028975B4 (en) * 2000-06-16 2005-06-30 Henkel Kgaa Compositions for the treatment of tooth and / or bone tissue
JP2004511320A (en) * 2000-10-16 2004-04-15 ユニバーシテイ・オブ・サウス・カロライナ Biocompatible cement containing reactive calcium phosphate nanoparticles and methods of making and using said cement
DE10063945A1 (en) * 2000-12-20 2002-07-04 Henkel Kgaa Remineralizing dental adhesive film
US6921544B2 (en) * 2001-03-06 2005-07-26 Rutgers, The State University Magnesium-substituted hydroxyapatites
US20040101494A1 (en) 2002-11-26 2004-05-27 Scott Douglas Craig Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth
US7156911B2 (en) 2004-05-17 2007-01-02 3M Innovative Properties Company Dental compositions containing nanofillers and related methods
US7090721B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Use of nanoparticles to adjust refractive index of dental compositions
US7090722B2 (en) 2004-05-17 2006-08-15 3M Innovative Properties Company Acid-reactive dental fillers, compositions, and methods
US7649029B2 (en) 2004-05-17 2010-01-19 3M Innovative Properties Company Dental compositions containing nanozirconia fillers
DE102004025030A1 (en) * 2004-05-18 2005-12-15 S&C Polymer Silicon- und Composite-Spezialitäten GmbH Nano-apatite fillers containing curable restorative materials
EP1846325A4 (en) 2005-01-04 2010-04-21 Univ Rutgers HYDROXYAPATITIS OF REGULABLE DIMENSIONS AND MORPHOLOGY
DE102005027813A1 (en) * 2005-06-15 2006-12-28 Henkel Kgaa Remineralizing oral and dental care and cleaning products
US8287914B2 (en) 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
WO2007137606A1 (en) * 2006-05-30 2007-12-06 Coswell S.P.A. Biologicallly active nanoparticles of a carbonate-substituted hydroxyapatite, process for their preparation and compositions incorporating the same
EP2409677A4 (en) * 2009-03-19 2013-02-13 Britesmilejapan Co Ltd Tooth surface repairing material
EP2493686A4 (en) 2009-10-26 2015-09-09 Univ Rutgers HYDROXYAPATITIS WITH CONTROLLABLE DIMENSION AND MORPHOLOGY
WO2012159645A1 (en) 2011-05-26 2012-11-29 Coswell S.P.A. Dental care products comprising carbonate-substituted fluoro-hydroxyapatite particles
EP2591825A1 (en) * 2011-11-08 2013-05-15 PeGoMa B.V. Composition for the treatment of teeth, and use
JP5973585B2 (en) * 2011-11-08 2016-08-23 コスウェル・エス・ペー・アーＣｏｓｗｅｌｌ Ｓ．Ｐ．Ａ． Dental care products containing biomimetic hydroxyapatite particles with a lactoferrin functionalized surface
GB201202341D0 (en) * 2012-02-10 2012-03-28 Periproducts Ltd Multicomponent oral care compostion
WO2014027887A2 (en) 2012-08-13 2014-02-20 Matthew Scott Spaid Teeth whitening composition
US9962319B2 (en) 2013-09-30 2018-05-08 Kuraray Noritake Dental Inc. One-component-type dentinal tubule sealant
ITMI20132003A1 (en) 2013-11-29 2015-05-30 Perfetti Van Melle Spa CONFETTER PRODUCTS WITH CALCIUM PHOSPHATE
GB2554484B (en) * 2016-04-14 2021-07-07 M B Lloyd Ltd A dental formulation for the treatment of tooth sensitivity
RU2627624C1 (en) * 2016-10-06 2017-08-09 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Means for teeth hard tissue remineralization
CN113260592A (en) 2018-12-27 2021-08-13 白石钙新加坡有限公司 Hydroxyapatite particles
CN116251230B (en) * 2023-01-30 2024-07-16 重庆大学 Preparation method of biomimetic mineralized enamel for constructing unstable amorphous calcium phosphate clusters by atomization method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3872862T2 (en) * 1987-12-28 1993-01-14 Asahi Optical Co Ltd COMPOSITION FOR PRODUCING A HARDENABLE CALCIUM PHOSPHATE-LIKE MATERIAL AND METHOD FOR PRODUCING SUCH A MATERIAL.
IT1271874B (en) * 1994-03-07 1997-06-09 Massimo Minozzi ADDITION OF HYDROXYAPATITE, CA10 (PO4) 6 (OH) 2, ULTRAMICRONIZED, HAUM, DIAMETER OF MICROCRYSTALS: OR, 2 - 1, OR MICRON, RANGE 70% TO THE VARIOUS TYPES OF CANAL CONCRETE FOR THE FINAL FILLING OF THE ROOT CANALS OF THE TOOTH .
JP4040705B2 (en) * 1996-01-24 2008-01-30 株式会社サンギ Oral composition
IT1288038B1 (en) * 1996-04-30 1998-09-10 Flametal S P A PROCEDURE FOR THE PREPARATION OF HYDROXYAPATITE COATINGS
EP0832636B1 (en) * 1996-09-30 2003-11-19 DeguDent GmbH Polymerisable dental material and use of apatite fillers in the dental material
DK0936929T3 (en) * 1996-10-16 2004-11-08 Etex Corp Process for the preparation of weak crystalline calcium phosphate and methods for its use

Also Published As

Publication number Publication date
AU5191999A (en) 2000-02-07
ITRM980476A1 (en) 2000-01-17
ITRM980476A0 (en) 1998-07-17
WO2000003747A2 (en) 2000-01-27
WO2000003747A3 (en) 2000-05-11
CA2338021A1 (en) 2000-01-27
EP1098623A2 (en) 2001-05-16

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