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IT1294325B1 - Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici - Google Patents

Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici

Info

Publication number
IT1294325B1
IT1294325B1 IT97MI001940A ITMI971940A IT1294325B1 IT 1294325 B1 IT1294325 B1 IT 1294325B1 IT 97MI001940 A IT97MI001940 A IT 97MI001940A IT MI971940 A ITMI971940 A IT MI971940A IT 1294325 B1 IT1294325 B1 IT 1294325B1
Authority
IT
Italy
Prior art keywords
conjugates
zinc
preparation
phthalocyanins
diagnostic
Prior art date
Application number
IT97MI001940A
Other languages
English (en)
Inventor
Gabrio Roncucci
Donata Dei
Filippis Maria Paola De
Lia Fantetti
Ilaria Masini
Barbara Cosimelli
Giulio Jori
Original Assignee
Molteni L E C Dei Fratelli Ali
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI001940A priority Critical patent/IT1294325B1/it
Application filed by Molteni L E C Dei Fratelli Ali filed Critical Molteni L E C Dei Fratelli Ali
Priority to AT98115036T priority patent/ATE506057T1/de
Priority to DK98115036.0T priority patent/DK0906758T3/da
Priority to PT98115036T priority patent/PT906758E/pt
Priority to DE69842227T priority patent/DE69842227D1/de
Priority to ES98115036T priority patent/ES2365383T3/es
Priority to EP98115036A priority patent/EP0906758B1/en
Priority to CA002245066A priority patent/CA2245066C/en
Priority to US09/133,618 priority patent/US5965598A/en
Publication of ITMI971940A1 publication Critical patent/ITMI971940A1/it
Application granted granted Critical
Publication of IT1294325B1 publication Critical patent/IT1294325B1/it
Priority to CY20111100697T priority patent/CY1111832T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IT97MI001940A 1997-08-14 1997-08-14 Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici IT1294325B1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT97MI001940A IT1294325B1 (it) 1997-08-14 1997-08-14 Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici
DK98115036.0T DK0906758T3 (da) 1997-08-14 1998-08-11 Zink-phthalocyaniner og tilsvarende konjugater, deres frembingelse og anvendelse i fotodynamisk terapi og som diagnostiske midler
PT98115036T PT906758E (pt) 1997-08-14 1998-08-11 Zinco-ftalocianinas e correspondentes conjugados, sua preparação e uso em terapia fotodinâmica e como agentes de diagnóstico&
DE69842227T DE69842227D1 (de) 1997-08-14 1998-08-11 Zink-Phthalocyanine und deren Konjugate, ihre Herstellung und Verwendung in der photodynamischen Therapie und als Diagnostika
AT98115036T ATE506057T1 (de) 1997-08-14 1998-08-11 Zink-phthalocyanine und deren konjugate, ihre herstellung und verwendung in der photodynamischen therapie und als diagnostika
ES98115036T ES2365383T3 (es) 1997-08-14 1998-08-11 Ftalocianinas de cinc y conjugados correspondientes, sus preparaciones y uso en terapia fotodinámica y como agentes de diagnóstico.
EP98115036A EP0906758B1 (en) 1997-08-14 1998-08-11 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents
CA002245066A CA2245066C (en) 1997-08-14 1998-08-12 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents
US09/133,618 US5965598A (en) 1997-08-14 1998-08-13 Zinc-phthalocyanines and corresponding conjugates, their preparation and use in photodynamic therapy and as diagnostic agents
CY20111100697T CY1111832T1 (el) 1997-08-14 2011-07-15 Φθαλοκυανινες ψευδαργυρου και τα αντιστοιχα συζυγη, η παρασκευη αυτων και η χρηση στην φωτοδυναμικη θεραπεια και ως διαγνωστικοι παραγοντες

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001940A IT1294325B1 (it) 1997-08-14 1997-08-14 Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici

Publications (2)

Publication Number Publication Date
ITMI971940A1 ITMI971940A1 (it) 1999-02-14
IT1294325B1 true IT1294325B1 (it) 1999-03-24

Family

ID=11377772

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001940A IT1294325B1 (it) 1997-08-14 1997-08-14 Zinco-ftalocianine e relativi coniugati, preparazione e uso nella terapia fotodinamica e come diagnostici

Country Status (10)

Country Link
US (1) US5965598A (it)
EP (1) EP0906758B1 (it)
AT (1) ATE506057T1 (it)
CA (1) CA2245066C (it)
CY (1) CY1111832T1 (it)
DE (1) DE69842227D1 (it)
DK (1) DK0906758T3 (it)
ES (1) ES2365383T3 (it)
IT (1) IT1294325B1 (it)
PT (1) PT906758E (it)

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US6609014B1 (en) 1999-04-14 2003-08-19 Qlt Inc. Use of PDT to inhibit intimal hyperplasia
EP1229937B1 (en) * 1999-11-17 2007-11-07 QLT Inc. Use of pdt to inhibit intimal hyperplasia
US7122568B1 (en) 1999-11-17 2006-10-17 Qlt, Inc. Use of low-dose PDT to inhibit restenosis
CA2394891A1 (en) * 1999-12-08 2001-06-14 Michael John Cook Substituted phthalocyanines and their precursors
DE60008354T2 (de) 2000-06-15 2004-12-09 L. Molteni & C. dei Fratelli Alitti Società di Esercizio S.p.A. Substituierte Metallphthalocyaninen, ihre Herstellung und Verwendung
ES2289099T3 (es) * 2001-01-05 2008-02-01 Seung-Yong Lee Compuestos a base de complejos de metal paramagnetico con ftalocianina y agente de contraste que los comprende.
CN100351255C (zh) * 2001-03-21 2007-11-28 L.摩尔特尼公司和阿立提兄弟贸易公司股份公司 金属取代的非中心对称型酞菁类似物,其制备方法以及在光动力治疗和体内诊断中的用途
GB0113899D0 (en) 2001-06-07 2001-08-01 Photocure Asa Photodynamic therapy lamp
IL161650A0 (en) 2001-10-29 2004-09-27 Molteni & C Dei Flii Alittisoc Separation of regioisomers of metal phthalocyanines
SI1356813T1 (sl) * 2002-04-25 2006-02-28 Molteni & C Protibakterijske sestave, vsebujoce analogone kovinskega ftalocianina
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
ITFI20030063A1 (it) * 2003-03-11 2004-09-12 Molteni & C Metallo ftalocianine boronate, loro preparazione, composizioni
CA2541385C (en) * 2003-09-05 2013-11-19 The Ohio State University Research Foundation Nanoparticulate probe for in vivo monitoring of tissue oxygenation
US8066973B2 (en) * 2003-09-05 2011-11-29 The Ohio State University Research Foundation Nanoparticulate probe for in vivo monitoring of tissue oxygenation
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US7153956B2 (en) 2004-08-09 2006-12-26 Silverbrook Research Pty Ltd Cyanine dye having multifunctional peripheral groups
ITFI20050093A1 (it) * 2005-05-05 2006-11-06 Molteni & C Processo per la preparazione di cloruri di derivati ftalocianinici comprendenti almeno un gruppo ammonio quaternario
ITFI20050092A1 (it) 2005-05-05 2006-11-06 Molteni & C Derivati ftalocianinici, processo per la loro preparazione, composizioni farmaceutiche che li contengono e loro uso
CN101212987B (zh) * 2005-06-29 2011-02-02 阿利提兄弟有限公司L.莫太尼公司 自杀菌产品
EP1904060B1 (en) * 2005-06-29 2011-06-01 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio Societa' Per Azioni Use of phthalocyanine derivates for the non-photodynamic treatment of diseases
US8741264B2 (en) 2005-06-29 2014-06-03 Molteni Therapeutics S.R.L. Self-sterilizing products
WO2007009101A2 (en) * 2005-07-14 2007-01-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tetraazaporphyrin-based compounds and their uses
JP5066417B2 (ja) * 2006-09-27 2012-11-07 株式会社日本触媒 フタロシアニン化合物およびその製造方法
US7645875B2 (en) * 2006-12-19 2010-01-12 Xerox Corporation Colorant compounds
EP2072584B1 (de) * 2007-12-17 2011-05-11 ILFORD Imaging Switzerland GmbH Phthalocyanin-Farbstoffe, ihre Herstellung und Verwendung
IT1395907B1 (it) * 2009-07-30 2012-11-02 Molteni E C Dei Flii Alitti Societa Di Esercizio Spa L Derivato ftalocianinico costituito da una miscela di quattro isomeri
ITFI20110166A1 (it) * 2011-08-05 2013-02-06 Molteni & C Nuovi fotosensibilizzanti ad uso terapeutico.
KR101385196B1 (ko) 2012-05-17 2014-04-14 주식회사 유니크메디케어 광 조사를 이용한 광감각제―펩타이드를 유효성분으로 포함하는 발모 개선 또는 촉진용 조성물 및 이를 이용한 방법
CN102702210B (zh) * 2012-06-01 2014-09-10 福州大学 含哌嗪乙氧基修饰基团的酞菁金属配合物的应用
CN102675325B (zh) * 2012-06-01 2014-06-25 福州大学 含哌嗪乙氧基修饰基团的酞菁金属配合物及其制备方法
CN102755647A (zh) * 2012-07-23 2012-10-31 中国科学院福建物质结构研究所 五聚赖氨酸酞菁锌在制备杀菌药物中的应用
SG10201804772UA (en) 2013-12-06 2018-07-30 Agency Science Tech & Res Method of imaging living tissue
CN103772397B (zh) * 2014-01-25 2016-02-24 福州大学 一类哌嗪修饰的酞菁配合物及其制备方法
CN105363031B (zh) * 2014-09-01 2019-04-02 北京贵千金医药科技有限公司 α-(8-喹啉氧基)单取代酞菁锌治疗银屑病的用途
EP3553062A1 (en) * 2018-04-09 2019-10-16 Chemical Intelligence Limited Antimicrobial and anticancer cationic phthalocyanine compounds
CN113518627A (zh) * 2019-03-06 2021-10-19 莫尔泰尼治疗有限责任公司 包含酞菁光敏剂的局部制剂
CN112028901B (zh) * 2020-10-16 2021-06-01 福州大学 十六铵基修饰的酞菁及其制备方法与作为光动力药物的应用
KR20230096017A (ko) * 2020-11-24 2023-06-29 후지필름 가부시키가이샤 착색 조성물, 경화물, 컬러 필터, 고체 촬상 소자, 화상 표시 장치, 및, 화합물

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US4961755A (en) * 1987-12-29 1990-10-09 Ciba-Geigy Corporation Coated active substances: dye coated with polyethylene oxide-propylene oxide or with ethoxylated stearyldi phenyloxyethyl diethylenetriamine
US5446141A (en) * 1988-04-01 1995-08-29 Mitsui Toatsu Chemicals, Incorporated Alkylphthalocyanine near-infrared absorbers and recording/display materials using the same
US5192788A (en) * 1988-05-23 1993-03-09 Georgia State University Foundation, Inc. Porphyrin antiviral compositions
US5109016A (en) * 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
JP3129030B2 (ja) * 1993-06-04 2001-01-29 東洋インキ製造株式会社 銅フタロシアニン顔料組成物の製造方法
GB9317881D0 (en) * 1993-08-27 1993-10-13 Secr Defence Photosensitizers
JP3830993B2 (ja) * 1995-08-23 2006-10-11 株式会社興人 水溶性金属フタロシアニン誘導体を担持した消臭抗菌材

Also Published As

Publication number Publication date
DK0906758T3 (da) 2011-07-11
ITMI971940A1 (it) 1999-02-14
CA2245066C (en) 2009-10-20
US5965598A (en) 1999-10-12
CA2245066A1 (en) 1999-02-14
EP0906758B1 (en) 2011-04-20
EP0906758A1 (en) 1999-04-07
PT906758E (pt) 2011-07-29
CY1111832T1 (el) 2015-10-07
ES2365383T3 (es) 2011-10-03
ATE506057T1 (de) 2011-05-15
DE69842227D1 (de) 2011-06-01

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