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IT1290781B1 - ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES. - Google Patents

ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES.

Info

Publication number
IT1290781B1
IT1290781B1 IT96RM000364A ITRM960364A IT1290781B1 IT 1290781 B1 IT1290781 B1 IT 1290781B1 IT 96RM000364 A IT96RM000364 A IT 96RM000364A IT RM960364 A ITRM960364 A IT RM960364A IT 1290781 B1 IT1290781 B1 IT 1290781B1
Authority
IT
Italy
Prior art keywords
treatment
therapeutic agent
degenerative diseases
active therapeutic
neuronal degenerative
Prior art date
Application number
IT96RM000364A
Other languages
Italian (it)
Inventor
Cinzia Piazza
Vincenzo Politi
Mario Materazzi
Original Assignee
Polifarma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polifarma Spa filed Critical Polifarma Spa
Publication of ITRM960364A0 publication Critical patent/ITRM960364A0/en
Priority to IT96RM000364A priority Critical patent/IT1290781B1/en
Priority to PCT/IT1997/000117 priority patent/WO1997045127A1/en
Priority to BR9709379-3A priority patent/BR9709379A/en
Priority to HU0000124A priority patent/HUP0000124A3/en
Priority to EP97925266A priority patent/EP0914131A1/en
Priority to AU30468/97A priority patent/AU3046897A/en
Priority to CA002255748A priority patent/CA2255748C/en
Priority to JP54197097A priority patent/JP3725172B2/en
Publication of ITRM960364A1 publication Critical patent/ITRM960364A1/en
Application granted granted Critical
Publication of IT1290781B1 publication Critical patent/IT1290781B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT96RM000364A 1996-05-28 1996-05-28 ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES. IT1290781B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT96RM000364A IT1290781B1 (en) 1996-05-28 1996-05-28 ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES.
EP97925266A EP0914131A1 (en) 1996-05-28 1997-05-23 Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
BR9709379-3A BR9709379A (en) 1996-05-28 1997-05-23 Use of uridine, and, composition for the treatment of disorders of the nervous system due to the selective degeneration of neuronal or glial cells in mammals.
HU0000124A HUP0000124A3 (en) 1996-05-28 1997-05-23 Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
PCT/IT1997/000117 WO1997045127A1 (en) 1996-05-28 1997-05-23 Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
AU30468/97A AU3046897A (en) 1996-05-28 1997-05-23 Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
CA002255748A CA2255748C (en) 1996-05-28 1997-05-23 Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
JP54197097A JP3725172B2 (en) 1996-05-28 1997-05-23 A therapeutic agent active in the treatment of neurodegenerative diseases comprising uridine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96RM000364A IT1290781B1 (en) 1996-05-28 1996-05-28 ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES.
US1854396P 1996-05-29 1996-05-29

Publications (3)

Publication Number Publication Date
ITRM960364A0 ITRM960364A0 (en) 1996-05-28
ITRM960364A1 ITRM960364A1 (en) 1997-11-28
IT1290781B1 true IT1290781B1 (en) 1998-12-10

Family

ID=26332100

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96RM000364A IT1290781B1 (en) 1996-05-28 1996-05-28 ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES.

Country Status (4)

Country Link
EP (1) EP0914131A1 (en)
AU (1) AU3046897A (en)
IT (1) IT1290781B1 (en)
WO (1) WO1997045127A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
EP2145627B1 (en) * 1998-07-31 2014-04-16 Massachusetts Institute Of Technology Use of uridine in combination with choline for the treatment of mood and emotional disorders
US7807654B2 (en) 1998-08-31 2010-10-05 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US7915233B1 (en) 1998-08-31 2011-03-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US6472378B2 (en) 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
NZ546060A (en) * 2001-04-30 2006-11-30 Trommsdorff Gmbh & Co Pharmaceutically active drug combination comprising a fatty acid and a uridine compound, and use thereof
US6767202B2 (en) 2001-12-18 2004-07-27 3M Innovative Properties Company Tooling with helical coils for structured surface articles
WO2005112635A2 (en) 2004-05-13 2005-12-01 Massachusetts Institute Of Technology Uridine effects on dopamine release
CN102600199A (en) * 2004-09-15 2012-07-25 麻省理工学院 Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases
EP1974732A4 (en) 2005-11-24 2010-08-11 Univ Hokkaido Nat Univ Corp THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE
WO2009059306A1 (en) 2007-11-02 2009-05-07 Massachusetts Institute Of Technology Uridine dietary supplementation compliance methods and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178044B (en) * 1984-10-09 1987-09-03 Polifarma Spa PHARMACEUTICAL ACTIVE AGENT FOR THE TREATMENT OF CEREBRAL DISEASES BASED ON URIDINE
IT1219667B (en) * 1988-06-21 1990-05-24 Polifarma Spa USE OF URIDINE IN THE PHARMACOLOGICAL TREATMENT OF DISORDERS DUE TO ALTERATED DOPAMINERGIC BALANCE
IT1241984B (en) * 1990-06-13 1994-02-02 Polifarma Spa USE OF URIDINE IN THE PHARMACOLOGICAL TREATMENT OF PERIPHERAL COMPLICATIONS OF DIABETES
JPH05304951A (en) * 1992-04-06 1993-11-19 N T Sci:Kk Culture solution for early embryo and embryonic stem cell

Also Published As

Publication number Publication date
EP0914131A1 (en) 1999-05-12
WO1997045127A1 (en) 1997-12-04
AU3046897A (en) 1998-01-05
ITRM960364A0 (en) 1996-05-28
ITRM960364A1 (en) 1997-11-28

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Legal Events

Date Code Title Description
0001 Granted