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IT1285790B1 - Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o - Google Patents

Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o

Info

Publication number
IT1285790B1
IT1285790B1 IT96RM000650A ITRM960650A IT1285790B1 IT 1285790 B1 IT1285790 B1 IT 1285790B1 IT 96RM000650 A IT96RM000650 A IT 96RM000650A IT RM960650 A ITRM960650 A IT RM960650A IT 1285790 B1 IT1285790 B1 IT 1285790B1
Authority
IT
Italy
Prior art keywords
hil
defectives
mutants
coding
antagonist activity
Prior art date
Application number
IT96RM000650A
Other languages
English (en)
Inventor
Gennaro Ciliberto
Michel Perricaudet
Isabella Saggio
Rocco Savino
Original Assignee
Angeletti P Ist Richerche Bio
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio, Centre Nat Rech Scient filed Critical Angeletti P Ist Richerche Bio
Priority to IT96RM000650A priority Critical patent/IT1285790B1/it
Priority to EP97945077A priority patent/EP0956300A1/en
Priority to AU46368/97A priority patent/AU718892B2/en
Priority to JP10515469A priority patent/JP2000504592A/ja
Priority to US09/147,948 priority patent/US6475755B2/en
Priority to PCT/IT1997/000231 priority patent/WO1998013383A1/en
Priority to CA002266743A priority patent/CA2266743C/en
Publication of ITRM960650A1 publication Critical patent/ITRM960650A1/it
Application granted granted Critical
Publication of IT1285790B1 publication Critical patent/IT1285790B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
IT96RM000650A 1996-09-24 1996-09-24 Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o IT1285790B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT96RM000650A IT1285790B1 (it) 1996-09-24 1996-09-24 Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o
EP97945077A EP0956300A1 (en) 1996-09-24 1997-09-24 Adenoviral vectors for mutants of human interleukin 6 (hil-6) with hil-6 antagonist activity, pharmaceutical compositions therewith and their uses
AU46368/97A AU718892B2 (en) 1996-09-24 1997-09-24 Adenoviral vectors for mutants of human interleukin 6 (HIL-6) with HIL-6 antagonist activity, pharmaceutical compositions therewith and their uses
JP10515469A JP2000504592A (ja) 1996-09-24 1997-09-24 ヒトインターロイキン６（ｈＩＬ―６）に対するアンタゴニスト活性を有する、ｈＩＬ―６の突然変異体のアデノウイルスベクター、これを有する薬剤組成物およびその使用
US09/147,948 US6475755B2 (en) 1996-09-24 1997-09-24 Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity, pharmaceutical compositions therewith and their uses
PCT/IT1997/000231 WO1998013383A1 (en) 1996-09-24 1997-09-24 Adenoviral vectors for mutants of human interleukin 6 (hil-6) with hil-6 antagonist activity, pharmaceutical compositions therewith and their uses
CA002266743A CA2266743C (en) 1996-09-24 1997-09-24 Adenoviral vectors for mutants of human interleukin 6 (hil-6) with hil-6 antagonist activity, pharmaceutical compositions therewith and their uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96RM000650A IT1285790B1 (it) 1996-09-24 1996-09-24 Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o

Publications (2)

Publication Number Publication Date
ITRM960650A1 ITRM960650A1 (it) 1998-03-24
IT1285790B1 true IT1285790B1 (it) 1998-06-24

Family

ID=11404436

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96RM000650A IT1285790B1 (it) 1996-09-24 1996-09-24 Adenovirus difettivi ricombinanti che codificano per mutanti di interleuchina 6 umana (hil-6) con attivita' antagonista o

Country Status (7)

Country Link
US (1) US6475755B2 (it)
EP (1) EP0956300A1 (it)
JP (1) JP2000504592A (it)
AU (1) AU718892B2 (it)
CA (1) CA2266743C (it)
IT (1) IT1285790B1 (it)
WO (1) WO1998013383A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU750803B2 (en) * 1997-10-29 2002-07-25 University Of Pittsburgh Use of vectors such as adenoviruses and/or adeno associated viruses and/or retroviruses and/or herpes simplex viruses and/or liposomes and/or plasmids as a vehicle for genetic information enabling mammal cells to produce agents for the treatment of bone pathologies
EP1261367B1 (en) 2000-03-06 2005-05-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of interleukin-6 antagonists for the treatment of oestrogen dependent tumours
CN1405312A (zh) * 2001-01-18 2003-03-26 中山卫健生物科技有限公司 一种能特异性杀灭eb病毒相关肿瘤的重组病毒及其构建方法
UA80091C2 (en) * 2001-04-02 2007-08-27 Chugai Pharmaceutical Co Ltd Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
BRPI0416920A (pt) * 2003-11-24 2007-01-23 Canji Inc redução de cicatriz dérmica
TWI603738B (zh) 2010-11-08 2017-11-01 建南德克公司 皮下投予抗－ｉｌ－６受體抗體

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.
FR2718150B1 (fr) 1994-03-29 1996-04-26 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
IT1274782B (it) * 1994-12-14 1997-07-24 Angeletti P Ist Richerche Bio Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130

Also Published As

Publication number Publication date
US6475755B2 (en) 2002-11-05
ITRM960650A1 (it) 1998-03-24
CA2266743A1 (en) 1998-04-02
JP2000504592A (ja) 2000-04-18
AU4636897A (en) 1998-04-17
AU718892B2 (en) 2000-04-20
EP0956300A1 (en) 1999-11-17
WO1998013383A1 (en) 1998-04-02
CA2266743C (en) 2006-03-21
US20020012656A1 (en) 2002-01-31

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