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IT1284650B1 - Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia - Google Patents

Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia

Info

Publication number
IT1284650B1
IT1284650B1 IT96RM000360A ITRM960360A IT1284650B1 IT 1284650 B1 IT1284650 B1 IT 1284650B1 IT 96RM000360 A IT96RM000360 A IT 96RM000360A IT RM960360 A ITRM960360 A IT RM960360A IT 1284650 B1 IT1284650 B1 IT 1284650B1
Authority
IT
Italy
Prior art keywords
dementia
pathology
alzheimer
patients
treatment
Prior art date
Application number
IT96RM000360A
Other languages
English (en)
Inventor
Menotti Calvani
Angelico Carta
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM960360A0 publication Critical patent/ITRM960360A0/it
Priority to IT96RM000360A priority Critical patent/IT1284650B1/it
Priority to EP96830532A priority patent/EP0808626A1/en
Priority to TW086102135A priority patent/TW473388B/zh
Priority to KR1019970019692A priority patent/KR970073581A/ko
Priority to ZA9704506A priority patent/ZA974506B/xx
Priority to JP9133289A priority patent/JPH1045582A/ja
Priority to MX9703810A priority patent/MX9703810A/es
Priority to CA002205940A priority patent/CA2205940A1/en
Publication of ITRM960360A1 publication Critical patent/ITRM960360A1/it
Application granted granted Critical
Publication of IT1284650B1 publication Critical patent/IT1284650B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT96RM000360A 1996-05-24 1996-05-24 Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia IT1284650B1 (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT96RM000360A IT1284650B1 (it) 1996-05-24 1996-05-24 Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia
EP96830532A EP0808626A1 (en) 1996-05-24 1996-10-16 Use of acetyl-L-carnitine for the treatment of presenile Alzheimer's disease
TW086102135A TW473388B (en) 1996-05-24 1997-02-21 Pharmaceutical composition comprising a carnitine derivative for treating Alzheimer's disease in early-onset patients
KR1019970019692A KR970073581A (ko) 1996-05-24 1997-05-21 초로기성 알쯔하이머 질환 치료용 카르니틴 유도체 함유 의약품
ZA9704506A ZA974506B (en) 1996-05-24 1997-05-23 Medicament comprising a carnitine derivative for treating Alzheimer's disease in early-onset patients.
JP9133289A JPH1045582A (ja) 1996-05-24 1997-05-23 アルツハイマー病の早期発病患者を治療するためのカルニチン誘導体を含む医薬
MX9703810A MX9703810A (es) 1996-05-24 1997-05-23 Medicamento que comprende un derivado de carnitinapara tratar la enfermedad de alzheimer en pacientes con inicio prematuro.
CA002205940A CA2205940A1 (en) 1996-05-24 1997-05-23 Medicament comprising a carnitine derivative for treating alzheimer's disease in early-onset patients

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96RM000360A IT1284650B1 (it) 1996-05-24 1996-05-24 Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia

Publications (3)

Publication Number Publication Date
ITRM960360A0 ITRM960360A0 (it) 1996-05-24
ITRM960360A1 ITRM960360A1 (it) 1997-11-24
IT1284650B1 true IT1284650B1 (it) 1998-05-21

Family

ID=11404242

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96RM000360A IT1284650B1 (it) 1996-05-24 1996-05-24 Farmaco a base di un derivato della carnitina per il trattamento della demenza di alzheimer in pazienti ad insorgenza precoce della patologia

Country Status (8)

Country Link
EP (1) EP0808626A1 (it)
JP (1) JPH1045582A (it)
KR (1) KR970073581A (it)
CA (1) CA2205940A1 (it)
IT (1) IT1284650B1 (it)
MX (1) MX9703810A (it)
TW (1) TW473388B (it)
ZA (1) ZA974506B (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
US20020006959A1 (en) 2000-05-01 2002-01-17 Henderson Samuel T. Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
ES2645816T3 (es) 2006-04-03 2017-12-07 Accera, Inc. Uso de compuestos cetogénicos para el tratamiento de la alteración de la memoria asociada a la edad
ES2556537T3 (es) 2007-07-31 2016-01-18 Accera, Inc. Uso de ensayo genómico y compuestos cetogénicos para tratamiento de una función cognitiva reducida
US8597640B2 (en) 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US8105809B2 (en) 2008-07-03 2012-01-31 Accera, Inc. Enzymatic synthesis of acetoacetate esters and derivatives
EP2303036A1 (en) 2008-07-03 2011-04-06 Accera, Inc. Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
AU2011267186B2 (en) * 2010-06-16 2017-01-19 Alfasigma S.P.A. Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue
EP2586438A1 (en) 2011-10-28 2013-05-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Compound useful for preventing cognitive deficit disorders in a new born from HIV-seropositive pregnant female who is in treatment with azidothymidine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346107A (en) * 1979-02-12 1982-08-24 Claudio Cavazza Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism
EP0340759A1 (en) * 1988-05-06 1989-11-08 MAGIS FARMACEUTICI S.p.A. Salts of O-mono (di)-acetyl-glycero-mono-(bis)-(di)-phosphates of L-acetyl-carnitine and of L-acetyl carnitine esters

Also Published As

Publication number Publication date
KR970073581A (ko) 1997-12-10
CA2205940A1 (en) 1997-11-24
JPH1045582A (ja) 1998-02-17
TW473388B (en) 2002-01-21
ZA974506B (en) 1997-12-29
EP0808626A1 (en) 1997-11-26
MX9703810A (es) 1998-04-30
ITRM960360A0 (it) 1996-05-24
ITRM960360A1 (it) 1997-11-24

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Legal Events

Date Code Title Description
0001 Granted