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IT1249063B - Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva - Google Patents

Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva

Info

Publication number
IT1249063B
IT1249063B ITMI911445A ITMI911445A IT1249063B IT 1249063 B IT1249063 B IT 1249063B IT MI911445 A ITMI911445 A IT MI911445A IT MI911445 A ITMI911445 A IT MI911445A IT 1249063 B IT1249063 B IT 1249063B
Authority
IT
Italy
Prior art keywords
acid
phospholipidic
derivatives
immunosoppressive
activity
Prior art date
Application number
ITMI911445A
Other languages
English (en)
Inventor
Alberta Leon
Gunnter Kirschner
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Priority to ITMI911445A priority Critical patent/IT1249063B/it
Publication of ITMI911445A0 publication Critical patent/ITMI911445A0/it
Priority to CA002069367A priority patent/CA2069367A1/en
Priority to EP92108832A priority patent/EP0516034A1/en
Priority to KR1019920008970A priority patent/KR920021151A/ko
Priority to JP4160115A priority patent/JPH07173064A/ja
Publication of ITMI911445A1 publication Critical patent/ITMI911445A1/it
Application granted granted Critical
Publication of IT1249063B publication Critical patent/IT1249063B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Viene descritto un nuovo impiego terapeutico come immunosoppressori di derivati fosfolipidici aventi formula generale (I) (FORMULA I) in cui A = H, -(CH2)nOH-(CH2)n -O-CO-R (con n =1,2); B= (FORMULA) con la limitazione che quando A = -(CH2)n-O-CO-R, m = 1, 2; Y = serina o inositolo e in cui i gruppi R, uguali o diversi fra loro, sono radicali di acidi della serie alifatica, aromatica, aralifatica, aliciclica o eterociclica con la condizione che almeno un gruppo R è sempre il radicale di un acido grasso monoinsaturo o poliinsaturo, preferibilmente scelto nel gruppo costituito dall'acido palmitoleico, acido oleico, acido linoleico, acido linoleico, acido arachidonico.
ITMI911445A 1991-05-28 1991-05-28 Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva IT1249063B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI911445A IT1249063B (it) 1991-05-28 1991-05-28 Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
CA002069367A CA2069367A1 (en) 1991-05-28 1992-05-25 Pharmaceutical compositions with immunosuppresive properties
EP92108832A EP0516034A1 (en) 1991-05-28 1992-05-26 Pharmaceutical compositions with immunosuppresive properties
KR1019920008970A KR920021151A (ko) 1991-05-28 1992-05-27 면역억제특성을 갖는 약제학적 조성물을 제조하기 위한 인지질 유도체의 용도
JP4160115A JPH07173064A (ja) 1991-05-28 1992-05-28 免疫抑制特性を有する製薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911445A IT1249063B (it) 1991-05-28 1991-05-28 Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva

Publications (3)

Publication Number Publication Date
ITMI911445A0 ITMI911445A0 (it) 1991-05-28
ITMI911445A1 ITMI911445A1 (it) 1992-11-28
IT1249063B true IT1249063B (it) 1995-02-11

Family

ID=11359991

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911445A IT1249063B (it) 1991-05-28 1991-05-28 Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva

Country Status (5)

Country Link
EP (1) EP0516034A1 (it)
JP (1) JPH07173064A (it)
KR (1) KR920021151A (it)
CA (1) CA2069367A1 (it)
IT (1) IT1249063B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2368656A1 (en) * 2002-01-21 2003-07-21 Vasogen Ireland Limited Receptor-ligand pairing for anti-inflammatory response
AU2003266884A1 (en) * 2002-09-16 2004-04-30 Vasogen Ireland Limited Accelerating recovery from trauma
TW201209267A (en) * 2010-08-31 2012-03-01 rui-wen Wang Out-pushing door/window frame
CN113662948B (zh) * 2021-09-10 2022-10-11 中国海洋大学 磷脂及其衍生物在制备改善系统性红斑狼疮制品中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE452466B (sv) * 1983-03-24 1987-11-30 Paul Gunnar Embring Blandning av vattenlosliga 3-fosfatidylestrar och kolin, sett att framstella denna och ett rektalt administrerbart preparat for tomning av grovtarm
EP0229128B1 (de) * 1985-07-03 1990-05-30 Cl Pharma Aktiengesellschaft Glycero-3(2)-phospho-l-serinderivate und diese enthaltende pharmazeutischen präparate
IT1230140B (it) * 1989-05-03 1991-10-14 Fidia Spa Derivati della serina, loro processo di preparazione e impiego in terapia umana
FR2649322A1 (fr) * 1989-07-04 1991-01-11 Natura Medica Laboratoires Complexes biodisponibles d'acide (alpha)-linolenique, extraits de plantes en contenant et compositions pharmaceutiques les incorporant

Also Published As

Publication number Publication date
JPH07173064A (ja) 1995-07-11
ITMI911445A0 (it) 1991-05-28
ITMI911445A1 (it) 1992-11-28
EP0516034A1 (en) 1992-12-02
KR920021151A (ko) 1992-12-18
CA2069367A1 (en) 1992-11-29

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970530