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IT1240775B - Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. - Google Patents

Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Info

Publication number
IT1240775B
IT1240775B IT47669A IT4766990A IT1240775B IT 1240775 B IT1240775 B IT 1240775B IT 47669 A IT47669 A IT 47669A IT 4766990 A IT4766990 A IT 4766990A IT 1240775 B IT1240775 B IT 1240775B
Authority
IT
Italy
Prior art keywords
acid
carnitine
beta
esters
acyl
Prior art date
Application number
IT47669A
Other languages
English (en)
Other versions
IT9047669A0 (it
IT9047669A1 (it
Inventor
Maria Ornella Tinti
Domenico Misiti
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT9047669A0 publication Critical patent/IT9047669A0/it
Priority to IT47669A priority Critical patent/IT1240775B/it
Priority to ES91830062T priority patent/ES2056620T3/es
Priority to AT91830062T priority patent/ATE107624T1/de
Priority to DE69102560T priority patent/DE69102560T2/de
Priority to EP91830062A priority patent/EP0443996B1/en
Priority to DK91830062.5T priority patent/DK0443996T3/da
Priority to JP3050644A priority patent/JP2930755B2/ja
Publication of IT9047669A1 publication Critical patent/IT9047669A1/it
Application granted granted Critical
Publication of IT1240775B publication Critical patent/IT1240775B/it
Priority to HK98104950A priority patent/HK1005868A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT47669A 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma. IT1240775B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT47669A IT1240775B (it) 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
EP91830062A EP0443996B1 (en) 1990-02-23 1991-02-21 Esters of (R)(-)-carnitine and acyl (R)(-)-carnitines with beta-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration, liver proteolysis and for the treatment of coma
AT91830062T ATE107624T1 (de) 1990-02-23 1991-02-21 Ester von (r)(-)-carnitin und acyl (r)(-)- carnitin mit beta-hydroxybuttersäure und diese enthaltende pharmazeutische zusammensetzungen zur inhibierung von neuronaler degeneration, leberproteolyse und zur behandlung von koma.
DE69102560T DE69102560T2 (de) 1990-02-23 1991-02-21 Ester von (R)(-)-Carnitin und Acyl (R)(-)-Carnitin mit Beta-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration, Leberproteolyse und zur Behandlung von Koma.
ES91830062T ES2056620T3 (es) 1990-02-23 1991-02-21 Esteres de (r) (-)-carnitina y acil (r) (-)-carnitinas con acido beta hidroxibutirico y composiciones farmaceuticas que las contienen para inhibir la degeneracion neuronal, proteolisis de higado y para el tratamiento de coma.
DK91830062.5T DK0443996T3 (da) 1990-02-23 1991-02-21 Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma
JP3050644A JP2930755B2 (ja) 1990-02-23 1991-02-22 （Ｒ）（−）−カルニチンおよびアシル−（Ｒ）（−）カルニチンとβ−ヒドロキシ酪酸とのエステル
HK98104950A HK1005868A1 (en) 1990-02-23 1998-06-05 Esters of (r)(-)-carnitine and acyl (r)(-)-carnitines with beta-hydroxybutryric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration liver proteolysis and for the treatment of coma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47669A IT1240775B (it) 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Publications (3)

Publication Number Publication Date
IT9047669A0 IT9047669A0 (it) 1990-02-23
IT9047669A1 IT9047669A1 (it) 1991-08-24
IT1240775B true IT1240775B (it) 1993-12-17

Family

ID=11261785

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47669A IT1240775B (it) 1990-02-23 1990-02-23 Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Country Status (8)

Country Link
EP (1) EP0443996B1 (it)
JP (1) JP2930755B2 (it)
AT (1) ATE107624T1 (it)
DE (1) DE69102560T2 (it)
DK (1) DK0443996T3 (it)
ES (1) ES2056620T3 (it)
HK (1) HK1005868A1 (it)
IT (1) IT1240775B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254135B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1254136B (it) * 1992-01-16 1995-09-08 Sigma Tau Ind Farmaceuti Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
CN1315473C (zh) * 1997-03-17 2007-05-16 英国技术集团国际有限公司 治疗组合物
US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
AU2001257451A1 (en) * 2000-05-01 2001-11-12 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism
HUE040002T2 (hu) 2006-04-03 2019-02-28 Accera Inc Ketogén vegyületek alkalmazása korfüggõ memóriazavar kezelésére
CN1995010B (zh) * 2006-12-29 2012-12-12 辽宁科硕营养科技有限公司 一种合成丙酰左旋肉碱盐酸盐的方法
PT2650379E (pt) 2007-07-31 2016-01-13 Accera Inc Utilização de testagem genómica e compostos cetogénicos para o tratamento de função cognitiva reduzida
EP2303036A1 (en) 2008-07-03 2011-04-06 Accera, Inc. Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
CN112341331B (zh) * 2019-08-07 2023-04-07 辽宁科硕营养科技股份有限公司 一种3-羟基丁酸盐及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) * 1980-03-06 1986-11-05 Sigma Tau Ind Farmaceuti Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.

Also Published As

Publication number Publication date
HK1005868A1 (en) 1999-01-29
DK0443996T3 (da) 1994-07-25
ES2056620T3 (es) 1994-10-01
DE69102560T2 (de) 1994-10-13
IT9047669A0 (it) 1990-02-23
ATE107624T1 (de) 1994-07-15
EP0443996A1 (en) 1991-08-28
EP0443996B1 (en) 1994-06-22
DE69102560D1 (de) 1994-07-28
IT9047669A1 (it) 1991-08-24
JP2930755B2 (ja) 1999-08-03
JPH0597785A (ja) 1993-04-20

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940113