[go: up one dir, main page]

IT1237798B - Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). - Google Patents

Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).

Info

Publication number
IT1237798B
IT1237798B IT02207589A IT2207589A IT1237798B IT 1237798 B IT1237798 B IT 1237798B IT 02207589 A IT02207589 A IT 02207589A IT 2207589 A IT2207589 A IT 2207589A IT 1237798 B IT1237798 B IT 1237798B
Authority
IT
Italy
Prior art keywords
amino
propandiols
fenyl
stereo
reversal process
Prior art date
Application number
IT02207589A
Other languages
English (en)
Other versions
IT8922075A0 (it
Inventor
Marco Villa
Claudio Giordano
Silvia Cavicchioli
Silvio Levi
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT8922075A0 publication Critical patent/IT8922075A0/it
Priority to IT02207589A priority Critical patent/IT1237798B/it
Priority to AT90119803T priority patent/ATE116957T1/de
Priority to EP90119803A priority patent/EP0423705B1/en
Priority to DE69015956T priority patent/DE69015956T2/de
Priority to ES90119803T priority patent/ES2066931T3/es
Priority to DK90119803.6T priority patent/DK0423705T3/da
Priority to JP2283237A priority patent/JP2852801B2/ja
Priority to US07/599,881 priority patent/US5202484A/en
Priority to US07/992,747 priority patent/US5284966A/en
Application granted granted Critical
Publication of IT1237798B publication Critical patent/IT1237798B/it
Priority to US08/127,506 priority patent/US5401852A/en
Priority to GR950400833T priority patent/GR3015686T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT02207589A 1989-10-20 1989-10-20 Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r). IT1237798B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT02207589A IT1237798B (it) 1989-10-20 1989-10-20 Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
ES90119803T ES2066931T3 (es) 1989-10-20 1990-10-16 Procedimiento para la inversion estereoquimica de los (2s,3s)-2-amino-3-fenil-1,3-propanodioles en sus (2r,3r)-enantiomeros.
EP90119803A EP0423705B1 (en) 1989-10-20 1990-10-16 Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
DE69015956T DE69015956T2 (de) 1989-10-20 1990-10-16 Verfahren zur stereochemischen Inversion von (2S,3S)-2-Amino-3-phenyl-1,3-Propandiolen in ihre (2R,3R)-Enantiomere.
AT90119803T ATE116957T1 (de) 1989-10-20 1990-10-16 Verfahren zur stereochemischen inversion von (2s,3s)-2-amino-3-phenyl-1,3-propandiolen in ihre (2r,3r)-enantiomere.
DK90119803.6T DK0423705T3 (da) 1989-10-20 1990-10-16 Fremgangsmåde til stereokemisk inversion af (2S,3 S)-2-amino-3-phenyl-1,3-propandioler til deres tilsvarende (2R,3R)-enantiomerer
JP2283237A JP2852801B2 (ja) 1989-10-20 1990-10-19 （２ｓ，３ｓ）―２―アミノ―３―フェニル―１，３―プロパンジオールから（２ｒ，３ｒ）―鏡像異性体への変換方法
US07/599,881 US5202484A (en) 1989-10-20 1990-10-19 Process for the stereochemical inversion of (2s,3s)-2-amino-3-phenyl-1,3-propanediols into their (2r,3r) enantiomers
US07/992,747 US5284966A (en) 1989-10-20 1992-12-18 Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
US08/127,506 US5401852A (en) 1989-10-20 1993-09-28 Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
GR950400833T GR3015686T3 (en) 1989-10-20 1995-04-04 Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02207589A IT1237798B (it) 1989-10-20 1989-10-20 Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).

Publications (2)

Publication Number Publication Date
IT8922075A0 IT8922075A0 (it) 1989-10-20
IT1237798B true IT1237798B (it) 1993-06-17

Family

ID=11191106

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02207589A IT1237798B (it) 1989-10-20 1989-10-20 Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).

Country Status (9)

Country Link
US (3) US5202484A (it)
EP (1) EP0423705B1 (it)
JP (1) JP2852801B2 (it)
AT (1) ATE116957T1 (it)
DE (1) DE69015956T2 (it)
DK (1) DK0423705T3 (it)
ES (1) ES2066931T3 (it)
GR (1) GR3015686T3 (it)
IT (1) IT1237798B (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5243056A (en) * 1983-06-02 1993-09-07 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoro propane derivatives
NZ240319A (en) * 1990-10-25 1994-10-26 Schering Corp Preparation of florfenicol and its analogs from oxazoline derivatives
IT1249048B (it) 1991-02-21 1995-02-11 Zambon Spa Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
IT1271800B (it) * 1994-12-27 1997-06-09 Zambon Spa Processo di preparazione degli enantiomeri dell'acido 2- (2-fluoro- 4-bifenil) propionico
EP1614672B1 (en) * 2003-04-04 2010-09-22 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences An amino alcohol ligand and its use in preparation of chiral proparglic tertiary alkohols and tertiary amines via enantioselective additon reaction
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
MX2008003187A (es) * 2005-09-07 2008-03-18 Schering Plough Ltd Un procedimiento mejorado para preparar compuestos de aminodiol protegidos con oxazodilina, utiles como intermediarios para el florfenicol.
US7975794B2 (en) * 2005-09-28 2011-07-12 Simmons, Inc. Suspension for tracked vehicles
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
RU2010106607A (ru) * 2007-07-25 2011-08-27 Интервет Интернэшнл Б.В. (Nl) Способ получения оксазолидин- и оксазолидинонаминодиолов
CN106278964B (zh) * 2016-07-31 2018-01-16 浙江润康药业有限公司 氟苯尼考的制备方法
CN108017549A (zh) * 2017-12-07 2018-05-11 南通常佑药业科技有限公司 一种1-芳基-2-氨基-1,3-丙二醇盐酸盐衍生物的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2483885A (en) * 1949-02-12 1949-10-04 Parke Davis & Co Nitrophenyl acyl amido alkane diols
US2538763A (en) * 1949-02-12 1951-01-23 Parke Davis & Co Phenylaminopropandiols
US2699451A (en) * 1950-11-08 1955-01-11 Parke Davis & Co Process for the production of organic amino diol derivatives
US2721207A (en) * 1952-11-01 1955-10-18 Parke Davis & Co Process for the production of amino diols and intermediate products utilized in said process
US2717268A (en) * 1952-12-16 1955-09-06 Parke Davis & Co Process for preparing phenyldichloro-acetamidopropanediols
US2744136A (en) * 1953-02-16 1956-05-01 Du Pont Amides of sulfonylserinophenones
US2742500A (en) * 1953-12-22 1956-04-17 Du Pont Resolution of phenylaminopropanediols and intermediates
US2759970A (en) * 1956-05-09 1956-08-21 Sterling Drug Inc Acylamidoaceto-mercaptophenones
US3962271A (en) * 1974-03-04 1976-06-08 Tenneco Chemicals, Inc. Monocyclic polyoxymethyleneoxazolidines and biocidal compositions containing same
US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
EP0677511A3 (en) * 1983-06-02 1996-07-24 Zambon Spa Intermediates for the production of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
US5105009A (en) * 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
IT1164387B (it) * 1983-08-05 1987-04-08 Zambon Spa Derivati n-sostituiti dell'1-(4'-alchilsulfonilfenil)-2-ammino-1,3-propandiolo
IT1164389B (it) * 1983-08-05 1987-04-08 Zambon Spa Derivati n-sostituiti dell'1-(4'-alchiltiofenil)-2-ammino-1,3-propandiolo
US4782163A (en) * 1984-10-05 1988-11-01 Smithkline Beckman Corporation 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
US4723986A (en) * 1986-05-19 1988-02-09 Stauffer Chemical Company Herbicidal oxazolidines and methods of use

Also Published As

Publication number Publication date
EP0423705A3 (en) 1992-05-06
GR3015686T3 (en) 1995-07-31
IT8922075A0 (it) 1989-10-20
DK0423705T3 (da) 1995-03-27
DE69015956D1 (de) 1995-02-23
ES2066931T3 (es) 1995-03-16
EP0423705A2 (en) 1991-04-24
US5401852A (en) 1995-03-28
ATE116957T1 (de) 1995-01-15
US5202484A (en) 1993-04-13
DE69015956T2 (de) 1995-06-08
JP2852801B2 (ja) 1999-02-03
JPH03188050A (ja) 1991-08-16
US5284966A (en) 1994-02-08
EP0423705B1 (en) 1995-01-11

Similar Documents

Publication Publication Date Title
IT1237798B (it) Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
BR9609450A (pt) Processo para a purificação óptica de preparações enriquecidas enanciomericamente e composto
RU94036748A (ru) Церамиды, способ их получения, композиция на их основе и способ гидратирующей обработки кожи или волос
PT90845A (pt) Processo para a preparacao de novos enantiomeros do citalopram e de composicoes farmaceuticas que os contem
BR9405687A (pt) Processo químico utilizável na produção de taxol análogos de taxol e seus intermediários e produto
ATE195973T1 (de) Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
BR9404842A (pt) Compostos,processo para sua preparação e formulação farmacêutica
CA2044491A1 (fr) Nouveau procede de preparation industrielle du 4-chloro 3-sulfamoyl n-(2,3-dihydro 2-methyl 1h-indol -1-yl) benzamide
PT90584A (pt) Processo de preparacao de agentes diureticos de glutaramidas enantiomericas
BR9401156A (pt) Processo para a produção de um composto de alcoxiiminoacetamida
IT1226300B (it) Processo per la preparazione di intermedi per la sintesi del diltiazem.
ATE176783T1 (de) Verfahren zur herstellung von urethangruppen enthaltende bisoxazolidinen
DE59009951D1 (de) Verfahren zur Herstellung von Zwischenprodukten und zur Synthese von N-(2-Hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine.
ES2021058B3 (es) Procedimiento para la sintesis de una azetidinona quiral.
BR9402461A (pt) Aminopeptidase; processo para sua preparação e processo para a preparação de uma proteína recombinante do tipe não cultivado
NO940113L (no) Syntese av 2-fenyl-substituerte 1,3-propandioler
MX170707B (es) Procedimiento para la produccion discontinua de l-carnitina por transformacion microbiologica de crotonobetaina y gama-butirobetaina
DE3587252D1 (de) Keten-s,s,-acetalderivate, verfahren zu ihrer herstellung und methode zur heilung von mykose unter verwendung dieser derivate.
IT1295376B1 (it) Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
DE3871862D1 (de) Thiophenverbindungen und deren herstellung.
IT1271469B (it) Processo per la preparazione di 5-ammino-2,2-dialchil-1,3 diossani
DE3869361D1 (de) Annaeherung zur herstellung von natuerlicher vitamin e verwendender asymetrischer synthese.
DE59605316D1 (de) Verfahren zur herstellung von beta-amino-alpha-hydroxycarbonsäuren und deren derivaten
IT9021071A0 (it) Processo di preparazione di intermedi utili per la sintesi del probucolo
PT98444A (pt) Processo para a preparacao de um novo antibiotico, balimicina, e de composicoes farmaceuticas que o contem

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940929