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IT1234508B - Derivati eparinici e procedimento per la loro preparazione - Google Patents

Derivati eparinici e procedimento per la loro preparazione

Info

Publication number
IT1234508B
IT1234508B IT8803504A IT350488A IT1234508B IT 1234508 B IT1234508 B IT 1234508B IT 8803504 A IT8803504 A IT 8803504A IT 350488 A IT350488 A IT 350488A IT 1234508 B IT1234508 B IT 1234508B
Authority
IT
Italy
Prior art keywords
heparin derivatives
heparin
heparins
hemorrhagic
activity
Prior art date
Application number
IT8803504A
Other languages
English (en)
Other versions
IT8803504A0 (it
Inventor
Silvano Piani
Gian Franco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Marinella Fantuz
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IT8803504A0 publication Critical patent/IT8803504A0/it
Priority to IT8803504A priority Critical patent/IT1234508B/it
Priority to ES89109030T priority patent/ES2012748T3/es
Priority to DE68917040T priority patent/DE68917040T2/de
Priority to EP89109030A priority patent/EP0347588B1/en
Priority to AT89109030T priority patent/ATE109164T1/de
Priority to DE198989109030T priority patent/DE347588T1/de
Priority to NZ229212A priority patent/NZ229212A/xx
Priority to ZA893882A priority patent/ZA893882B/xx
Priority to AU35128/89A priority patent/AU611028C/en
Priority to US07/357,548 priority patent/US5010063A/en
Priority to IL90411A priority patent/IL90411A/xx
Priority to CA000602338A priority patent/CA1309402C/en
Priority to KR1019890007930A priority patent/KR960015110B1/ko
Priority to PT90817A priority patent/PT90817B/pt
Priority to DK198902850A priority patent/DK173818B1/da
Priority to FI892850A priority patent/FI94534C/fi
Priority to NO892366A priority patent/NO174259C/no
Priority to JP1148211A priority patent/JPH0739442B2/ja
Priority to IE176289A priority patent/IE64830B1/xx
Priority to GR90300018T priority patent/GR900300018T1/el
Application granted granted Critical
Publication of IT1234508B publication Critical patent/IT1234508B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
IT8803504A 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione IT1234508B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione
ES89109030T ES2012748T3 (es) 1988-06-10 1989-05-19 Nuevos derivados de heparina y procedimiento para su preparacion.
DE68917040T DE68917040T2 (de) 1988-06-10 1989-05-19 Heparinderivate und Verfahren zu deren Herstellung.
EP89109030A EP0347588B1 (en) 1988-06-10 1989-05-19 Heparin derivatives and process for their preparation
AT89109030T ATE109164T1 (de) 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung.
DE198989109030T DE347588T1 (de) 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung.
NZ229212A NZ229212A (en) 1988-06-10 1989-05-22 Heparin derivatives and preparation
ZA893882A ZA893882B (en) 1988-06-10 1989-05-23 New heparin derivatives and process for their preparation
AU35128/89A AU611028C (en) 1988-06-10 1989-05-24 New heparin derivatives and process for their preparation
IL90411A IL90411A (en) 1988-06-10 1989-05-26 Heparin derivatives and process for their preparation
US07/357,548 US5010063A (en) 1988-06-10 1989-05-26 Heparin derivatives and process for their preparation
CA000602338A CA1309402C (en) 1988-06-10 1989-06-09 Heparin derivatives and process for their preparation
KR1019890007930A KR960015110B1 (ko) 1988-06-10 1989-06-09 새로운 헤파린 유도체 및 그 제조방법
PT90817A PT90817B (pt) 1988-06-10 1989-06-09 Processo para a preparacao de novos derivados de heparina
DK198902850A DK173818B1 (da) 1988-06-10 1989-06-09 Heparinderivat
FI892850A FI94534C (fi) 1988-06-10 1989-06-09 Menetelmä uusien hepariinijohdannaisten valmistamiseksi
NO892366A NO174259C (no) 1988-06-10 1989-06-09 Fremgangsmåte til fremstilling av heparinderivater
JP1148211A JPH0739442B2 (ja) 1988-06-10 1989-06-09 新規ヘパリン誘導体およびその製造法
IE176289A IE64830B1 (en) 1988-06-10 1989-06-12 New heparin derivatives and process for their preparation
GR90300018T GR900300018T1 (en) 1988-06-10 1991-06-07 Heparin derivatives and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IT8803504A0 IT8803504A0 (it) 1988-06-10
IT1234508B true IT1234508B (it) 1992-05-19

Family

ID=11108618

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione

Country Status (18)

Country Link
US (1) US5010063A (it)
EP (1) EP0347588B1 (it)
JP (1) JPH0739442B2 (it)
KR (1) KR960015110B1 (it)
AT (1) ATE109164T1 (it)
CA (1) CA1309402C (it)
DE (2) DE68917040T2 (it)
DK (1) DK173818B1 (it)
ES (1) ES2012748T3 (it)
FI (1) FI94534C (it)
GR (1) GR900300018T1 (it)
IE (1) IE64830B1 (it)
IL (1) IL90411A (it)
IT (1) IT1234508B (it)
NO (1) NO174259C (it)
NZ (1) NZ229212A (it)
PT (1) PT90817B (it)
ZA (1) ZA893882B (it)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5232040A (en) * 1990-07-12 1993-08-03 Lanxide Technology Company, Lp Method for reducing metal content of self-supporting composite bodies and articles formed thereby
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
CA2235223A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
CA2272317C (en) * 1996-11-27 2001-01-30 Rhone-Poulenc Rorer Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-xa activity and a platelet aggregation antagonist compound
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) * 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
CA2643162C (en) * 1999-04-23 2018-01-02 Massachusetts Institute Of Technology Polymer identification, compositional analysis and sequencing, based on property comparison
BR0012202A (pt) * 1999-06-30 2002-04-02 Hamilton Civic Hospitals Res Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh
AU4351201A (en) * 2000-03-08 2001-09-17 Massachusetts Inst Technology Heparinase iii and uses thereof
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2420890A1 (en) * 2000-09-08 2002-03-14 Hamilton Civic Hospitals Research Development, Inc. Antithrombotic compositions
DK1319183T3 (da) * 2000-09-12 2009-05-18 Massachusetts Inst Technology Fremgangsmåder og produkter relateret til heparin med lav molekylvægt
CA2423469A1 (en) * 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
AU2003225724A1 (en) 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CA2974062C (en) * 2010-09-14 2018-07-17 Fuso Pharmaceutical Industries, Ltd. High purity heparin and production method therefor
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A4 (en) 2020-07-14 2024-07-31 Optimvia, LLC METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863235A (en) * 1958-07-05 1961-03-22 Roussel Uclaf Improvements in or relating to organic compounds related to heparin
US3016331A (en) * 1960-01-28 1962-01-09 Ormonoterapia Richter Spa Purification of heparin
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
FI94534C (fi) 1995-09-25
KR960015110B1 (ko) 1996-10-28
DK285089D0 (da) 1989-06-09
DE347588T1 (de) 1990-05-23
DE68917040D1 (de) 1994-09-01
EP0347588A1 (en) 1989-12-27
PT90817B (pt) 1994-11-30
NZ229212A (en) 1991-02-26
CA1309402C (en) 1992-10-27
IE64830B1 (en) 1995-09-06
IE891762L (en) 1989-12-10
PT90817A (pt) 1989-12-29
NO892366D0 (no) 1989-06-09
DK285089A (da) 1989-12-11
ATE109164T1 (de) 1994-08-15
NO174259B (no) 1993-12-27
FI892850A (fi) 1989-12-11
IL90411A0 (en) 1990-01-18
IL90411A (en) 1993-05-13
IT8803504A0 (it) 1988-06-10
US5010063A (en) 1991-04-23
NO174259C (no) 1994-04-06
ES2012748A4 (es) 1990-04-16
NO892366L (no) 1989-12-11
DE68917040T2 (de) 1995-01-12
JPH0739442B2 (ja) 1995-05-01
AU611028B2 (en) 1991-05-30
KR910000771A (ko) 1991-01-30
FI94534B (fi) 1995-06-15
AU3512889A (en) 1989-12-14
ZA893882B (en) 1990-02-28
EP0347588B1 (en) 1994-07-27
FI892850A0 (fi) 1989-06-09
GR900300018T1 (en) 1991-06-07
DK173818B1 (da) 2001-11-19
ES2012748T3 (es) 1994-10-16
JPH0264102A (ja) 1990-03-05

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940606