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IT1223334B - Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse - Google Patents

Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse

Info

Publication number
IT1223334B
IT1223334B IT22481/87A IT2248187A IT1223334B IT 1223334 B IT1223334 B IT 1223334B IT 22481/87 A IT22481/87 A IT 22481/87A IT 2248187 A IT2248187 A IT 2248187A IT 1223334 B IT1223334 B IT 1223334B
Authority
IT
Italy
Prior art keywords
preparation
vaccine
immunologically active
antipertox
active polypeptides
Prior art date
Application number
IT22481/87A
Other languages
English (en)
Other versions
IT8722481A0 (it
Inventor
Mariagrazia Pizza
Antonella Bartoloni
Rino Rappuoli
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11196853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1223334(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of IT8722481A0 publication Critical patent/IT8722481A0/it
Priority to IT22481/87A priority Critical patent/IT1223334B/it
Application filed by Sclavo Spa filed Critical Sclavo Spa
Priority to EP88117742A priority patent/EP0322533B1/en
Priority to AT88117742T priority patent/ATE123062T1/de
Priority to DE3853876T priority patent/DE3853876T2/de
Priority to ES88117742T priority patent/ES2072857T3/es
Priority to CA000581889A priority patent/CA1341582C/en
Priority to JP63276322A priority patent/JP2728275B2/ja
Publication of IT1223334B publication Critical patent/IT1223334B/it
Application granted granted Critical
Priority to US08/261,668 priority patent/US6713072B1/en
Priority to US08/261,692 priority patent/US7410646B1/en
Priority to US08/479,626 priority patent/US5889172A/en
Priority to HK192995A priority patent/HK192995A/en
Priority to JP8160348A priority patent/JP2857105B2/ja
Priority to US10/766,560 priority patent/US20050281837A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT22481/87A 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse IT1223334B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT22481/87A IT1223334B (it) 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse
EP88117742A EP0322533B1 (en) 1987-11-02 1988-10-25 Bordetella pertussis toxin with altered toxicity
AT88117742T ATE123062T1 (de) 1987-11-02 1988-10-25 Bordetella pertussis-toxin mit veränderter toxizität.
DE3853876T DE3853876T2 (de) 1987-11-02 1988-10-25 Bordetella pertussis-Toxin mit veränderter Toxizität.
ES88117742T ES2072857T3 (es) 1987-11-02 1988-10-25 Toxina de bordetella pertussis con toxicidad alterada.
CA000581889A CA1341582C (en) 1987-11-02 1988-11-01 Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
JP63276322A JP2728275B2 (ja) 1987-11-02 1988-11-02 免疫活性ポリペプチド及びその製法
US08/261,692 US7410646B1 (en) 1987-11-02 1994-06-17 Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
US08/261,668 US6713072B1 (en) 1987-11-02 1994-06-17 Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
US08/479,626 US5889172A (en) 1987-11-02 1995-06-07 DNA sequences for immunologically active peptides of pertussis toxin
HK192995A HK192995A (en) 1987-11-02 1995-12-21 Bordetella pertussis toxin with altered toxicity
JP8160348A JP2857105B2 (ja) 1987-11-02 1996-06-20 免疫活性ポリペプチド及びその製法
US10/766,560 US20050281837A1 (en) 1987-11-02 2004-01-29 Immunologically active peptides with altered toxicity useful for the preparation of antipertussis vaccine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22481/87A IT1223334B (it) 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse

Publications (2)

Publication Number Publication Date
IT8722481A0 IT8722481A0 (it) 1987-11-02
IT1223334B true IT1223334B (it) 1990-09-19

Family

ID=11196853

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22481/87A IT1223334B (it) 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse

Country Status (9)

Country Link
US (1) US7410646B1 (it)
EP (1) EP0322533B1 (it)
JP (2) JP2728275B2 (it)
AT (1) ATE123062T1 (it)
CA (1) CA1341582C (it)
DE (1) DE3853876T2 (it)
ES (1) ES2072857T3 (it)
HK (1) HK192995A (it)
IT (1) IT1223334B (it)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5244657A (en) * 1987-11-24 1993-09-14 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5332583A (en) * 1987-11-24 1994-07-26 Connaught Laboratories Limited Vaccine containing genetically-detoxified pertussis holotoxin
US5358868A (en) * 1987-11-24 1994-10-25 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
DE69022106T2 (de) * 1989-04-28 1996-02-15 Sclavo Spa Pertussistoxin-Mutanten, dieselbe produzierende Bordetella-Stämme und ihre Verwendung als Vakzin gegen Pertussis.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
US5856122A (en) * 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
GB9908263D0 (en) * 1999-04-13 1999-06-02 Binding Site The Limited Eliciting improved immune responses
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313242D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Pulmonary immunopathology
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
US8956625B2 (en) 2006-09-07 2015-02-17 Glaxosmithkline Biologicals, S.A. Inactivated polio vaccines
JP2010525035A (ja) 2007-05-02 2010-07-22 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
AR077636A1 (es) 2009-07-08 2011-09-14 Abbott Biologicals Bv Vacuna viral y uso de la misma
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
CA2879939A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Novel method
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
CN104918634A (zh) * 2012-10-12 2015-09-16 葛兰素史密丝克莱恩生物有限公司 用于组合疫苗的非交联无细胞百日咳抗原
EP2863943B1 (en) 2013-03-08 2016-07-13 Crucell Holland B.V. Acellular pertussis vaccine
US20160193322A1 (en) 2013-08-05 2016-07-07 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
EP0275689B1 (en) * 1986-12-23 1992-09-02 The Board Of Trustees Of The Leland Stanford Junior University Modified pertussis exotoxin
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin

Also Published As

Publication number Publication date
US7410646B1 (en) 2008-08-12
HK192995A (en) 1995-12-29
DE3853876D1 (de) 1995-06-29
DE3853876T2 (de) 1995-10-05
ATE123062T1 (de) 1995-06-15
JPH01165370A (ja) 1989-06-29
JPH09157293A (ja) 1997-06-17
EP0322533B1 (en) 1995-05-24
JP2728275B2 (ja) 1998-03-18
CA1341582C (en) 2008-10-07
EP0322533A1 (en) 1989-07-05
JP2857105B2 (ja) 1999-02-10
IT8722481A0 (it) 1987-11-02
ES2072857T3 (es) 1995-08-01

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Effective date: 19971125