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IT1213252B - New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame - Google Patents

New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame

Info

Publication number
IT1213252B
IT1213252B IT2387684A IT2387684A IT1213252B IT 1213252 B IT1213252 B IT 1213252B IT 2387684 A IT2387684 A IT 2387684A IT 2387684 A IT2387684 A IT 2387684A IT 1213252 B IT1213252 B IT 1213252B
Authority
IT
Italy
Prior art keywords
alpha
aspartyl
phenylalanine
esp
ester
Prior art date
Application number
IT2387684A
Other languages
Italian (it)
Other versions
IT8423876A0 (en
Inventor
Martino Finotto
Original Assignee
Farchemia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farchemia Spa filed Critical Farchemia Spa
Publication of IT8423876A0 publication Critical patent/IT8423876A0/en
Priority to IT2387684A priority Critical patent/IT1213252B/en
Priority to FI852731A priority patent/FI852731L/en
Priority to DE198585108846T priority patent/DE170148T1/en
Priority to US06/755,063 priority patent/US4642367A/en
Priority to EP85108846A priority patent/EP0170148A3/en
Priority to ES545333A priority patent/ES8608538A1/en
Priority to DK329685A priority patent/DK329685A/en
Priority to KR1019850005468A priority patent/KR880000224B1/en
Priority to NO853039A priority patent/NO853039L/en
Application granted granted Critical
Publication of IT1213252B publication Critical patent/IT1213252B/en

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Abstract

Alpha-haloacyl-alpha -L-aspertyl-L-phenylalanine alkyl esters of formula (I) are new; where R = 1-5C alkyl, esp., Me; R' = H or 1-4C opt. branched alkyl; and Hal = Cl, Br or I. New prepn. of alpha-L-aspartyl -L-phenylalanine alkyl esters of formula (II) comprises reacting (I) with thiourea, cyanic acid salts, thiocyanic acid salts, dithiocarbamic acid salts, guanidine, 1,2-ethanedi-thiol, cysteamine, ethanolamine, ethylenediamine, 1,2-diaminobenzene 1,2-dimercaptobenzene, pyrocatechol or o-aminophenol. Process is pref. in a protic solvent, esp. lower alcohol and/or water, pref. at pH 0-8 and pref. at 20-80 deg.C.
IT2387684A 1984-08-01 1984-12-04 New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame IT1213252B (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT2387684A IT1213252B (en) 1984-12-04 1984-12-04 New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame
FI852731A FI852731L (en) 1984-08-01 1985-07-10 FOERFARANDE FOER FRAMSTAELLNING AV ALFA-L-ASPARTYL-L-FENYLALANINALKYLESTRAR.
EP85108846A EP0170148A3 (en) 1984-08-01 1985-07-15 Process for the preparation of alfa-l-aspartyl-l-phenylalanine alkyl esters
US06/755,063 US4642367A (en) 1984-08-01 1985-07-15 Process for the preparation of alfa-L-aspartyl-L-phenyl-alanine alkyl esters
DE198585108846T DE170148T1 (en) 1984-08-01 1985-07-15 METHOD FOR PRODUCING ALPHA-L-ASPARTYL-L-PHENYLALANINE ALKYL ESTERS.
ES545333A ES8608538A1 (en) 1984-08-01 1985-07-18 Process for the preparation of alfa-L-aspartyl-L-phenylalanine alkyl esters.
DK329685A DK329685A (en) 1984-08-01 1985-07-19 METHOD OF PREPARING ALFA-L-ASPARTYL-L-PHENYLALANINAL COOLESTERS
KR1019850005468A KR880000224B1 (en) 1984-08-01 1985-07-30 Process for preparing alpha-L-aspartyl-L-phenylalanine alkyl ester
NO853039A NO853039L (en) 1984-08-01 1985-07-31 METHOD OF PREPARING ALFA-L-ASPARTYL-L-PHENYLALANINE ALKYL ESTERS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2387684A IT1213252B (en) 1984-12-04 1984-12-04 New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame

Publications (2)

Publication Number Publication Date
IT8423876A0 IT8423876A0 (en) 1984-12-04
IT1213252B true IT1213252B (en) 1989-12-14

Family

ID=11210578

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2387684A IT1213252B (en) 1984-08-01 1984-12-04 New alpha-halo:acyl-alpha-L-aspartyl-L-phenylalanine alkyl ester(s) - and use in prepn. of aspartyl-phenylalanine ester(s) esp. aspartame

Country Status (1)

Country Link
IT (1) IT1213252B (en)

Also Published As

Publication number Publication date
IT8423876A0 (en) 1984-12-04

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