[go: up one dir, main page]

IT1212983B - Fabbricazione ed espressione di geni strutturali - Google Patents

Fabbricazione ed espressione di geni strutturali

Info

Publication number
IT1212983B
IT1212983B IT8367481A IT6748183A IT1212983B IT 1212983 B IT1212983 B IT 1212983B IT 8367481 A IT8367481 A IT 8367481A IT 6748183 A IT6748183 A IT 6748183A IT 1212983 B IT1212983 B IT 1212983B
Authority
IT
Italy
Prior art keywords
expression
manufacture
structural genes
genes
structural
Prior art date
Application number
IT8367481A
Other languages
English (en)
Other versions
IT8367481A0 (it
Inventor
Yitzhak Stabinsky
Original Assignee
Applied Molecular Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23481109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1212983(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Applied Molecular Genetics Inc filed Critical Applied Molecular Genetics Inc
Publication of IT8367481A0 publication Critical patent/IT8367481A0/it
Application granted granted Critical
Publication of IT1212983B publication Critical patent/IT1212983B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT8367481A 1982-05-06 1983-05-04 Fabbricazione ed espressione di geni strutturali IT1212983B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/375,493 US4652639A (en) 1982-05-06 1982-05-06 Manufacture and expression of structural genes

Publications (2)

Publication Number Publication Date
IT8367481A0 IT8367481A0 (it) 1983-05-04
IT1212983B true IT1212983B (it) 1989-12-07

Family

ID=23481109

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8367481A IT1212983B (it) 1982-05-06 1983-05-04 Fabbricazione ed espressione di geni strutturali

Country Status (8)

Country Link
US (1) US4652639A (it)
EP (1) EP0108787B1 (it)
JP (1) JPH0789934B2 (it)
CA (1) CA1266628A (it)
DE (1) DE3381438D1 (it)
IL (1) IL68491A (it)
IT (1) IT1212983B (it)
WO (1) WO1983004029A1 (it)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
US6018030A (en) 1986-11-04 2000-01-25 Protein Polymer Technologies, Inc. Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
WO1989009780A1 (en) * 1988-04-15 1989-10-19 Chemical Industry Institute Of Toxicology Site-specific tritium-labeled oligodeoxynucleotides
US5594113A (en) 1988-06-23 1997-01-14 Associates Of Cape Cod, Inc. Endotoxin binding and neutralizing protein and uses thereof
US5268276A (en) * 1988-09-16 1993-12-07 Jan Holmgren Recombinant systems for expression of cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
EP0364275B1 (en) * 1988-10-13 1995-05-31 Fujisawa Pharmaceutical Co., Ltd. D-amino acid oxidase
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5766939A (en) * 1989-05-05 1998-06-16 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5849881A (en) * 1989-05-05 1998-12-15 Baylor College Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
US6100054A (en) * 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
JP2527035B2 (ja) * 1989-06-16 1996-08-21 東洋紡績株式会社 クレアチニン・アミドヒドロラ―ゼをコ―ドする遺伝子を含有するｄｎａ断片、該ｄｎａ断片を有する組換えベクタ―及び該組換えベクタ―を有する形質転換体、並びにクレアチニン・アミドヒドロラ―ゼの製造方法
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686569A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5795868A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5627262A (en) * 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
US5227293A (en) * 1989-08-29 1993-07-13 The General Hospital Corporation Fusion proteins, their preparation and use
US5358857A (en) * 1989-08-29 1994-10-25 The General Hospital Corp. Method of preparing fusion proteins
IL95495A (en) * 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use
DK16490D0 (da) * 1990-01-19 1990-01-19 Novo Nordisk As Enzym
IL97311A0 (en) * 1990-02-23 1992-05-25 Lilly Co Eli Vectors and compounds for expression of glycosylation mutants of human protein c
US5322785A (en) * 1990-04-26 1994-06-21 New England Biolabs, Inc. Purified thermostable DNA polymerase obtainable from thermococcus litoralis
US5352778A (en) * 1990-04-26 1994-10-04 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5500363A (en) * 1990-04-26 1996-03-19 New England Biolabs, Inc. Recombinant thermostable DNA polymerase from archaebacteria
US5756334A (en) * 1990-04-26 1998-05-26 New England Biolabs, Inc. Thermostable DNA polymerase from 9°N-7 and methods for producing the same
US5670350A (en) * 1990-08-20 1997-09-23 Novartis Finance Corporation Genomic DNA encoding a pseudomonas global transcriptional activation element and its use in activating gene expression
US5244796A (en) * 1990-10-12 1993-09-14 Syracuse University Cloned leuconostoc mesenteroides glucose-6-phosphate dehydrogenase genes and method of making glucose-6-phospate dehydrogenase
ATE158816T1 (de) * 1990-11-26 1997-10-15 Genetics Inst Expression von pace in wirtszellen und verfahren zu dessen verwendung
EP0507723A1 (en) * 1991-04-02 1992-10-07 Novo Nordisk A/S Xylanase, corresponding recombinant DNA sequence, xylanase containing agent, and use of the agent
US5876985A (en) * 1991-04-25 1999-03-02 Board Of Regents, The University Of Texas System Methods and compositions for the preparation of recombinant Trichomonas vaginalis proteins and peptides
DE4117747A1 (de) * 1991-05-30 1992-12-03 Bayer Ag Kaffeoyl-coa 3-o-methyltransferase-gene
DE4208277A1 (de) * 1992-03-13 1993-09-16 Bosch Gmbh Robert Verkehrsrundfunkempfaenger
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
DK42092D0 (it) * 1992-03-27 1992-03-27 Novo Nordisk As
ZA932568B (en) * 1992-04-24 1993-11-12 Baylor College Midecine A Non Production of recombinant human lactoferrin
US5621089A (en) * 1992-05-27 1997-04-15 Novo Nordisk Biotech, Inc. Nucleic acid constructs for the production of a Bacillus alkaline protease
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
US7008783B1 (en) 1992-09-22 2006-03-07 Maruha Corporation Gene encoding chondroitinase ABC and uses therefor
US6824777B1 (en) 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
US6107046A (en) * 1992-10-09 2000-08-22 Orion Corporation Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US5484727A (en) * 1992-10-14 1996-01-16 Trustees Of Dartmouth College Cloned gene encoding acylcoenzyme A: cholesterol acyltransferase (ACAT)
WO1994012645A2 (en) * 1992-11-25 1994-06-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education cDNA CLONE FOR HUMAN INDUCIBLE NITRIC OXYDE SYNTHASE AND PROCESS FOR PREPARING SAME
US5712366A (en) * 1993-05-25 1998-01-27 The United States Of America As Represented By The Secretary Of The Army Fabrication of nanoscale materials using self-assembling proteins
DK72593D0 (da) * 1993-06-18 1993-06-18 Symbicom Ab Rekombinant protein
US6653442B1 (en) 1993-07-20 2003-11-25 Intrabiotics Pharmaceuticals, Inc. Protegrins
US6159936A (en) * 1993-07-20 2000-12-12 The Regents Of The University Of California Compositions and methods for treating and preventing microbial and viral infections
US5804558A (en) * 1993-07-20 1998-09-08 University Of California Protegrins
US5693486A (en) * 1993-07-20 1997-12-02 Intrabiotics DNA sequences encoding protegrins and protegrin analogs and their use in recombinant methods of producing protegrins
US5616485A (en) * 1993-12-23 1997-04-01 Cangene Corporation Streptomyces proteases and improved streptomyces strains for expression of peptides and polypeptides
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
JP3198842B2 (ja) * 1994-03-24 2001-08-13 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸合成酵素およびそれをコードするｄｎａ
US5795737A (en) * 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US5786464C1 (en) * 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
US5741898A (en) * 1994-09-22 1998-04-21 Hanley; Kathleen Marie DNA sequence encoding nicotiana squalene synthetase
JP2938352B2 (ja) * 1994-09-30 1999-08-23 オリエンタル酵母工業株式会社 組換え人マトリライシンの製造方法
EP1353952B1 (en) 1994-11-14 2007-04-11 Ludwig Institute For Cancer Research Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy
IT1275909B1 (it) * 1995-03-07 1997-10-24 Mirella Pilone Frammento di dna codificante d-amminoacido ossidasi
US5646025A (en) * 1995-05-05 1997-07-08 Novo Nordisk A/S Scytalidium catalase gene
US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
JP3709422B2 (ja) * 1995-07-21 2005-10-26 昌 清水 ニトリラーゼ遺伝子発現に関わる調節因子およびその遺伝子
AU7289496A (en) * 1995-10-18 1997-05-07 Ciba-Geigy Ag Nucleotide sequences coding for mevalonate pyrophosphate decarboxylase
US5994306A (en) * 1995-11-22 1999-11-30 Intrabiotics Pharmaceuticals, Inc. Fine-tuned protegrins
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
US6114148C1 (en) * 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
US6110668A (en) * 1996-10-07 2000-08-29 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Gene synthesis method
EP1015576B1 (en) * 1997-09-16 2005-05-04 Egea Biosciences, LLC Method for the complete chemical synthesis and assembly of genes and genomes
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
NZ511408A (en) * 1998-10-09 2004-04-30 Licentia Ltd Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
JP2002533124A (ja) * 1998-12-31 2002-10-08 カイロン コーポレイション Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
ATE384795T1 (de) 1998-12-31 2008-02-15 Novartis Vaccines & Diagnostic Modifizierte hiv env polypeptide
EP1141314A2 (en) * 1998-12-31 2001-10-10 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US6107460A (en) 1999-03-01 2000-08-22 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use thereof
US8137906B2 (en) * 1999-06-07 2012-03-20 Sloning Biotechnology Gmbh Method for the synthesis of DNA fragments
EP1287010A1 (en) 2000-06-02 2003-03-05 Blue Heron Biotechnology, Inc. Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides
JP2004533228A (ja) 2001-01-19 2004-11-04 エジー バイオサイエンシーズ， インコーポレイテッド 標的ポリペプチドをコードするポリヌクレオチドのコンピューターに従うアセンブリ
US7164992B1 (en) 2001-03-22 2007-01-16 Blue Heron Biotechnology, Inc. Method and system for polynucleotide synthesis
AU2002316578A1 (en) * 2001-08-31 2003-03-18 Chiron Corporation Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
EP1314783B1 (de) * 2001-11-22 2008-11-19 Sloning BioTechnology GmbH Nukleinsäure-Linker und deren Verwendung in der Gensynthese
KR101161819B1 (ko) * 2004-04-22 2012-07-03 테일크리스 바이오쎄러퓨틱스 아이엔씨. 재조합적으로 변형된 플라스민
CN101918548B (zh) 2007-11-29 2013-10-16 泰勒克里斯生物治疗学公司 重组修饰的纤溶酶
US9115352B2 (en) * 2008-03-31 2015-08-25 Sloning Biotechnology Gmbh Method for the preparation of a nucleic acid library
KR20160110544A (ko) * 2008-06-04 2016-09-21 그리폴스 테라퓨틱스 인코포레이티드 플라스민의 제조를 위한 조성물, 방법 및 키트
HUE025670T2 (en) 2009-03-03 2016-04-28 Grifols Therapeutics Inc A method for producing plasminogen
PL2499165T3 (pl) 2009-11-13 2017-04-28 Grifols Therapeutics Inc. Preparaty zawierające czynnik von willenbranda (vwf) oraz sposoby, zestawy i zastosowania z nim powiązane
WO2011150168A1 (en) 2010-05-28 2011-12-01 Gen9, Inc. Methods and devices for in situ nucleic acid synthesis
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
EP2768607B1 (en) 2011-09-26 2021-08-18 Thermo Fisher Scientific GENEART GmbH Multiwell plate for high efficiency, small volume nucleic acid synthesis
WO2013093760A2 (en) 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
WO2013130487A2 (en) 2012-02-29 2013-09-06 Duke University Novel oxidoreductases for enantioselective reactions
US10563240B2 (en) 2013-03-14 2020-02-18 Life Technologies Corporation High efficiency, small volume nucleic acid synthesis
LT3229959T (lt) 2014-12-09 2019-08-26 Life Technologies Corporation Didelio efektyvumo nukleorūgščių sintezė mažame tūryje
EP3359669B1 (en) 2015-10-06 2020-05-13 Pierce Biotechnology, Inc. Devices and methods for producing proteins
WO2024132094A1 (en) 2022-12-19 2024-06-27 Thermo Fisher Scientific Geneart Gmbh Retrieval of sequence-verified nucleic acid molecules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225784A (en) * 1976-06-17 1980-09-30 Smith Kline Instruments, Inc. Covalently bound biological substances to plastic materials and use in radioassay
US4140662A (en) * 1977-03-25 1979-02-20 Ortho Diagnostics, Inc. Attachment of proteins to inert particles
US4366246A (en) * 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
US4322499A (en) * 1978-12-22 1982-03-30 The Regents Of The University Of California Adrenocorticotropin-lipotropin precursor gene
US4293652A (en) * 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4350764A (en) * 1980-03-10 1982-09-21 The Regents Of The University Of California Microbiological synthesis of beta endorphin
DK339781A (da) * 1980-08-05 1982-02-06 Searle & Co Syntetisk gen
US4403036A (en) * 1980-12-02 1983-09-06 University Of Iowa Research Foundation Genetic reagents for generating plasmids containing multiple copies of DNA segments
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
EP0107710A4 (en) * 1982-05-06 1985-02-28 Applied Molecular Genetics Inc PRODUCTION AND EXPRESSION OF GENES FOR CALCITONIN AND ITS POLYPEPTIDE ANALOGS.
EP0108132A1 (en) * 1982-05-06 1984-05-16 Applied Molecular Genetics Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof

Also Published As

Publication number Publication date
EP0108787A4 (en) 1986-11-07
IL68491A (en) 1990-07-26
IL68491A0 (en) 1983-07-31
JPH0789934B2 (ja) 1995-10-04
WO1983004029A1 (en) 1983-11-24
CA1266628A (en) 1990-03-13
DE3381438D1 (de) 1990-05-17
EP0108787A1 (en) 1984-05-23
EP0108787B1 (en) 1990-04-11
US4652639A (en) 1987-03-24
IT8367481A0 (it) 1983-05-04
JPS59501096A (ja) 1984-06-28

Similar Documents

Publication Publication Date Title
IT1212983B (it) Fabbricazione ed espressione di geni strutturali
IT8367500A0 (it) Fabbricazione ed espressione di grossi geni strutturali
IT1212984B (it) Fabbricazione ed espressione di geni per l urogastrone e suoi analoghi polipeptidici
IT1131393B (it) Espressione microbica di geni quasi-sintetici
JPS54125987A (en) Vmos metha structure and method of fabricating same
DE2967061D1 (en) Preparation of fluoro-substituted benzodioxoles and benzodioxanes
FI834345A0 (fi) Substituerade tetrapeptider
JPS5557550A (en) Manufacture of diphenylmethanedicarbamate and polymethylenepolyphenylcarbamate
DK64782A (da) Hudelektrode og fremgangsmaade ved fremstilling deraf
BE878174A (fr) Wandbekleding of vloerbekleding
IT1144705B (it) Produzione ottimale di polipeptidi con impiego di geni fusionati
TR20622A (tr) 4-halometilpiridinlerin eterleri
JPS5535079A (en) Manufacture of alkylthiomethylphenol and arylthiomethylphenol
IT1212981B (it) Fabbricazione ed espressione di geni per la calcitonina e suoi analoghi polipeptidici
FI813527L (fi) Foerbaettrade makrolidantibiotika
BE875293A (fr) Nouveaux agents anti-salissures et application desdits agents
IT1110830B (it) Struttura di grigliato
IT1173654B (it) Impiego di colecalciferol-derivati
IT8349471A0 (it) Preparazione di acqua ossigenata
TR22560A (tr) Sulfonilguanidinopirimidin tuerevleri
DE3361290D1 (de) Preparation of cyanobenzoic-acid esters
JPS54150814A (en) Connecting structure of deal and section
JPS57109974A (en) Self-label having high exfoliating property and manufacture of said self-label
IT1097754B (it) Preparazione di 2-alchil-semicarbazoni e di 2-alchil-carbalcossi-idrazoni
IT1125592B (it) Immidazolil-etossi-derivati di piridin-5-metanoli e di chinolin-3-metanoli

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970514