IT1203600B - Solid phase deca:peptide synthesis - Google Patents
Solid phase deca:peptide synthesisInfo
- Publication number
- IT1203600B IT1203600B IT23121/85A IT2312185A IT1203600B IT 1203600 B IT1203600 B IT 1203600B IT 23121/85 A IT23121/85 A IT 23121/85A IT 2312185 A IT2312185 A IT 2312185A IT 1203600 B IT1203600 B IT 1203600B
- Authority
- IT
- Italy
- Prior art keywords
- deca
- solid phase
- tryptophyl
- peptide synthesis
- removal
- Prior art date
Links
- 238000010647 peptide synthesis reaction Methods 0.000 title 1
- 239000007790 solid phase Substances 0.000 title 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The decapeptide (D-trp6)-LHRH (L-pyroglutamyl-L-histidyl-L-tryptophyl- L-seryl-L-tyrosyl-D-tryptophyl- L-leucyl-L-arginyl-L-propyl glycinamide). (I) is prepd. on a benzhydryl aminic resin support by sequential condensation of protected amino acids. The removal of the protection from lateral chains and removal of the peptide from the support, is effected by means of HF at low and at high concentration. The protecting gps. are OH of serine-benzyl; OH of tyrosine- 2,6-dichloro benzyl; guanidine of arginine - tosyl; indole of L- and D-tryprophan -formyl; and pi nitrogen of histidine imidazole - benzyloxy methyl.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23121/85A IT1203600B (en) | 1985-12-06 | 1985-12-06 | Solid phase deca:peptide synthesis |
| BE0/216439A BE904458A (en) | 1985-12-06 | 1986-03-21 | NEW PROCESS FOR THE PREPARATION OF (D-TRP6)-LHRH AND BENZHYDRYLAMINIC RESIN AND PEPTIDE COMPLEX. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23121/85A IT1203600B (en) | 1985-12-06 | 1985-12-06 | Solid phase deca:peptide synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8523121A0 IT8523121A0 (en) | 1985-12-06 |
| IT1203600B true IT1203600B (en) | 1989-02-15 |
Family
ID=11204012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT23121/85A IT1203600B (en) | 1985-12-06 | 1985-12-06 | Solid phase deca:peptide synthesis |
Country Status (2)
| Country | Link |
|---|---|
| BE (1) | BE904458A (en) |
| IT (1) | IT1203600B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03005678A (en) * | 2000-12-22 | 2003-10-06 | Kinerton Ltd | Process for the synthesis of a peptide having a tryptophan residue. |
-
1985
- 1985-12-06 IT IT23121/85A patent/IT1203600B/en active
-
1986
- 1986-03-21 BE BE0/216439A patent/BE904458A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8523121A0 (en) | 1985-12-06 |
| BE904458A (en) | 1986-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0910571T3 (en) | Novel antiangiogenic peptides, coding polynucleotides, and methods of inhibiting angiogenesis | |
| Penke et al. | Solid-phase synthesis of peptide amides on a polystyrene support using fluorenylmethoxycarbonyl protecting groups | |
| HUP0000492A3 (en) | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds | |
| EP0123950A3 (en) | Intermediates for thymosin alpha 1 and desacetylthymosin alpha 1 | |
| ATE99698T1 (en) | PEPTIDES. | |
| HUP9801990A2 (en) | Peptide and method of obtaining it | |
| AU7505294A (en) | Kininogen inhibitors | |
| NO940299D0 (en) | peptide having organelle protective activity | |
| CA2221865A1 (en) | Bradykinin analogs as selective thrombin inhibitors | |
| ES488382A1 (en) | Dipeptide (pyro)Glu-His(Dnp)-OH and process for the preparation of LH-RH and of analogs of LH-RH using the said dipeptide. | |
| DE69321324D1 (en) | LIQUID PHASE SYNTHESIS OF PEPTIDES AND PEPTIDE DERIVATIVES | |
| IT1203600B (en) | Solid phase deca:peptide synthesis | |
| Franzén et al. | Synthesis, properties, and use of N in-Boc-tryptophan derivatives | |
| SG46623A1 (en) | A process for purifying 1-[n-((s)-ethoxycarbonyl-3-phenylpropyl)-n-triflu oroacetyl]-l-lysyl-l-proline (ethylester of lisinopril(tra) | |
| ES2101809T3 (en) | SYNTHESIS OF PEPTIDES IN SOLID PHASE. | |
| IS5064A (en) | Medicinal preparations which include granular analogues suitable for lyophilization | |
| GB1508681A (en) | Synthesis of peptides | |
| NZ215282A (en) | Peptide amino alcohol, renin and acid protease inhibitors, preparation and pharmaceutical composition | |
| DE3586936D1 (en) | Peptide. | |
| DE69227517D1 (en) | PRODUCTION OF PEPTIDE AMIDES | |
| NZ334486A (en) | Preparation of purified (poly) peptides utilising a cleavable amino acid inserted into the polypeptide chain during synthesis | |
| CAPASSO et al. | Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline‐3‐carboxylic acid at position 2 | |
| ATE82984T1 (en) | INHIBITING PEPTIDES. | |
| NZ511747A (en) | Regulatory/unfolding peptides of ezrin | |
| Otsuka et al. | The synthesis and biological activities of a hexadecapeptide corresponding to a modified sequence in the corticotropin structure |