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IT1201511B - Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono - Google Patents

Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Info

Publication number
IT1201511B
IT1201511B IT23373/85A IT2337385A IT1201511B IT 1201511 B IT1201511 B IT 1201511B IT 23373/85 A IT23373/85 A IT 23373/85A IT 2337385 A IT2337385 A IT 2337385A IT 1201511 B IT1201511 B IT 1201511B
Authority
IT
Italy
Prior art keywords
methyl
hydrogen
group
formula
citoprotective
Prior art date
Application number
IT23373/85A
Other languages
English (en)
Other versions
IT8523373A0 (it
Inventor
Giancarlo Sporletti
Pietro Cremonesi
Monique Sarret
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of IT8523373A0 publication Critical patent/IT8523373A0/it
Priority to IT23373/85A priority Critical patent/IT1201511B/it
Priority to EP86117895A priority patent/EP0230037B1/en
Priority to US06/944,949 priority patent/US4789681A/en
Priority to AT86117895T priority patent/ATE61347T1/de
Priority to ES86117895T priority patent/ES2020508B3/es
Priority to JP61306184A priority patent/JPS62158249A/ja
Priority to DE8686117895T priority patent/DE3677943D1/de
Priority to CA000526235A priority patent/CA1284646C/en
Application granted granted Critical
Publication of IT1201511B publication Critical patent/IT1201511B/it
Priority to GR91400552T priority patent/GR3001879T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT23373/85A 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono IT1201511B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono
ES86117895T ES2020508B3 (es) 1985-12-23 1986-12-22 Derivados citoprotectores utiles para enfermedades isquemicas, su preparacion y composiciones que los contienen.
US06/944,949 US4789681A (en) 1985-12-23 1986-12-22 Cytoprotective guanidine derivatives useful in ischemic diseases
AT86117895T ATE61347T1 (de) 1985-12-23 1986-12-22 Zytoprotektive derivate zur anwendung bei ischaemischen erkrankungen, ihre herstellung und sie enthaltende zusammensetzungen.
EP86117895A EP0230037B1 (en) 1985-12-23 1986-12-22 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them
JP61306184A JPS62158249A (ja) 1985-12-23 1986-12-22 抗虚血剤およびその製法
DE8686117895T DE3677943D1 (de) 1985-12-23 1986-12-22 Zytoprotektive derivate zur anwendung bei ischaemischen erkrankungen, ihre herstellung und sie enthaltende zusammensetzungen.
CA000526235A CA1284646C (en) 1985-12-23 1986-12-23 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them
GR91400552T GR3001879T3 (en) 1985-12-23 1991-04-29 Cytoprotective derivatives useful in ischemic diseases, their preparation and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Publications (2)

Publication Number Publication Date
IT8523373A0 IT8523373A0 (it) 1985-12-23
IT1201511B true IT1201511B (it) 1989-02-02

Family

ID=11206518

Family Applications (1)

Application Number Title Priority Date Filing Date
IT23373/85A IT1201511B (it) 1985-12-23 1985-12-23 Derivati citoprotettivi in patologie a base ischemica,loro preparazione e composizioni che li cntengono

Country Status (9)

Country Link
US (1) US4789681A (it)
EP (1) EP0230037B1 (it)
JP (1) JPS62158249A (it)
AT (1) ATE61347T1 (it)
CA (1) CA1284646C (it)
DE (1) DE3677943D1 (it)
ES (1) ES2020508B3 (it)
GR (1) GR3001879T3 (it)
IT (1) IT1201511B (it)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770623A (en) * 1989-09-13 1998-06-23 Board Of Regents, The University Of Texas System Argine antagonists for inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
GB8929076D0 (en) * 1989-12-22 1990-02-28 Scras Treatment of shock by blocking agents of edrf effect or formation
US5710324A (en) * 1990-02-26 1998-01-20 Merrell Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
US5318992A (en) * 1990-02-26 1994-06-07 Merrell Dow Pharmaceuticals Inc. Inhibitors of nitric oxide biosynthesis
CA2036770C (en) * 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5585402A (en) * 1992-12-23 1996-12-17 Glaxo Wellcome Inc. Nitric oxide synthase inhibitors
AU6950294A (en) * 1993-05-14 1994-12-12 Amira, Inc. Treating body parts susceptible to ischemia using creatine analogs
GB9312761D0 (en) * 1993-06-21 1993-08-04 Wellcome Found Amino acid derivatives
DE793646T1 (de) 1994-11-23 1999-12-30 Pharmacia & Upjohn Co., Kalamazoo Carboxylierte aminoguanidine zum behandlung von insulin-unabhängigem diabetes mellitus
WO1996018607A1 (fr) * 1994-12-12 1996-06-20 Chugai Seiyaku Kabushiki Kaisha Derive d'aniline inhibant la synthase du monoxyde d'azote
DE19544686A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19544685A1 (de) * 1995-11-30 1997-06-05 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1997044324A1 (en) 1996-05-21 1997-11-27 Pharmacia & Upjohn Company Aminoguanidine carboxylate lactams for the treatment of non-insulin-dependent diabetes mellitus
AU5854799A (en) * 1998-08-25 2000-03-14 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Novel treatment of neurodegenerative diseases
CA2587444C (en) * 2004-11-12 2013-09-10 Ucl Business Plc Guanidine derivatives as inhibitors of ddah
CN109593052B (zh) * 2018-11-20 2021-04-20 首都医科大学 用于诊断和治疗的放射性精氨酸衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195303B (de) * 1964-04-16 1965-06-24 Bayer Ag Verfahren zur Herstellung von tetracyclischen und pentacyclischen Triterpenamidino-hydrazonen
US3576844A (en) * 1966-10-13 1971-04-27 Sumitomo Chemical Co N-alkoxycarbonyl-aminoalkyl guanidines
FR2390954A1 (fr) * 1976-10-13 1978-12-15 Choay Sa Nouvelles guanylhydrazones, leurs procedes de preparation et medicaments les contenant
IT1127322B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici
IT1127321B (it) * 1979-12-28 1986-05-21 Italfarmaco Spa Composizione farmaceutiche aventi specifiche proprieta' terapeutiche nei confronti dell'edema polmonare acuto,di alcuni stati di shock e dell'iperfibrinolisi
US4499068A (en) * 1982-08-26 1985-02-12 Johnson & Johnson Products, Inc. Oral compositions comprising NG -alkyl derivatives of arginine
US4477429A (en) * 1982-08-26 1984-10-16 Johnson & Johnson Products, Inc. Oral compositions comprising N.sup.α -alkyl derivatives of arginine

Also Published As

Publication number Publication date
ES2020508B3 (es) 1991-08-16
JPS62158249A (ja) 1987-07-14
IT8523373A0 (it) 1985-12-23
DE3677943D1 (de) 1991-04-11
GR3001879T3 (en) 1992-11-23
EP0230037A1 (en) 1987-07-29
ATE61347T1 (de) 1991-03-15
CA1284646C (en) 1991-06-04
EP0230037B1 (en) 1991-03-06
US4789681A (en) 1988-12-06

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