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IT1193665B - Proteins corresponding to diphtheria toxin for vaccine prodn. - Google Patents

Proteins corresponding to diphtheria toxin for vaccine prodn.

Info

Publication number
IT1193665B
IT1193665B IT19462/83A IT1946283A IT1193665B IT 1193665 B IT1193665 B IT 1193665B IT 19462/83 A IT19462/83 A IT 19462/83A IT 1946283 A IT1946283 A IT 1946283A IT 1193665 B IT1193665 B IT 1193665B
Authority
IT
Italy
Prior art keywords
diphtheria toxin
prodn
vaccine
proteins corresponding
pref
Prior art date
Application number
IT19462/83A
Other languages
Italian (it)
Other versions
IT8319462A0 (en
IT8319462A1 (en
Inventor
Rino Rappuoli
Original Assignee
Sclavo Inst Sieroterapeut
Slavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo Inst Sieroterapeut, Slavo Spa filed Critical Sclavo Inst Sieroterapeut
Publication of IT8319462A0 publication Critical patent/IT8319462A0/en
Priority to IT19462/83A priority Critical patent/IT1193665B/en
Priority to CH286/84A priority patent/CH660375A5/en
Priority to CA000446410A priority patent/CA1212642A/en
Priority to US06/575,335 priority patent/US4925792A/en
Priority to NL8400365A priority patent/NL192208C/en
Priority to LU85197A priority patent/LU85197A1/en
Priority to FR8401863A priority patent/FR2540516B1/en
Priority to ES529698A priority patent/ES8505408A1/en
Priority to DE3404434A priority patent/DE3404434C2/en
Priority to JP59020118A priority patent/JPH0789950B2/en
Priority to BE0/212355A priority patent/BE898864A/en
Publication of IT8319462A1 publication Critical patent/IT8319462A1/en
Application granted granted Critical
Publication of IT1193665B publication Critical patent/IT1193665B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • C12R2001/16—Corynebacterium diphtheriae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Method comprises cultivation of a microorganism of the Corynebacterium diphtheriae family having two mutant phages (bacterophages) carrying coding for the protein corresp. to the diphtheria toxin and integrated in non-tandem mode into their chromosomes. The cultivation is effected in a neutral liq. nutritive medium contg. 0.05-0.5 pref. 0.1, micrograms/ml of iron ions, at 30-40 pref. 37-37 deg.C, under aerobic conditions.
IT19462/83A 1983-02-08 1983-02-08 Proteins corresponding to diphtheria toxin for vaccine prodn. IT1193665B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT19462/83A IT1193665B (en) 1983-02-08 1983-02-08 Proteins corresponding to diphtheria toxin for vaccine prodn.
CH286/84A CH660375A5 (en) 1983-02-08 1984-01-23 PROCEDURE FOR THE PRODUCTION OF PROPHINES RELATED TO DIPHTERIC TOXIN.
CA000446410A CA1212642A (en) 1983-02-08 1984-01-31 Process for producing proteins correlated with the diphtheric toxin
US06/575,335 US4925792A (en) 1983-02-08 1984-01-31 Process for producing proteins correlated with the diphtheric toxin
NL8400365A NL192208C (en) 1983-02-08 1984-02-06 Method for preparing diphtheria toxin related proteins.
FR8401863A FR2540516B1 (en) 1983-02-08 1984-02-07 PROCESS FOR PRODUCING PROTEINS CORRESPONDING TO DIPHTERIC TOXIN
LU85197A LU85197A1 (en) 1983-02-08 1984-02-07 PROCESS FOR PRODUCING PROTEINS CORRESPONDING TO DIPHTERIC TOXIN
ES529698A ES8505408A1 (en) 1983-02-08 1984-02-07 Process for producing proteins correlated with the diphtheric toxin
DE3404434A DE3404434C2 (en) 1983-02-08 1984-02-08 Process for the production of proteins that correspond to the diphtheria toxin
JP59020118A JPH0789950B2 (en) 1983-02-08 1984-02-08 Method for producing protein having immunological cross-reactivity with diphtheria toxin
BE0/212355A BE898864A (en) 1983-02-08 1984-02-08 PROCESS FOR PRODUCING PROTEINS CORRESPONDING TO DIPHTERIC TOXIN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19462/83A IT1193665B (en) 1983-02-08 1983-02-08 Proteins corresponding to diphtheria toxin for vaccine prodn.

Publications (3)

Publication Number Publication Date
IT8319462A0 IT8319462A0 (en) 1983-02-08
IT8319462A1 IT8319462A1 (en) 1984-08-08
IT1193665B true IT1193665B (en) 1988-07-21

Family

ID=11158221

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19462/83A IT1193665B (en) 1983-02-08 1983-02-08 Proteins corresponding to diphtheria toxin for vaccine prodn.

Country Status (2)

Country Link
BE (1) BE898864A (en)
IT (1) IT1193665B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160711B2 (en) 2001-08-06 2007-01-09 Degussa Ag Coryneform bacteria which produce chemical compounds I

Also Published As

Publication number Publication date
IT8319462A0 (en) 1983-02-08
BE898864A (en) 1984-08-08
IT8319462A1 (en) 1984-08-08

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980225