IT1145403B - Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie - Google Patents
Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorieInfo
- Publication number
- IT1145403B IT1145403B IT8047580A IT4758080A IT1145403B IT 1145403 B IT1145403 B IT 1145403B IT 8047580 A IT8047580 A IT 8047580A IT 4758080 A IT4758080 A IT 4758080A IT 1145403 B IT1145403 B IT 1145403B
- Authority
- IT
- Italy
- Prior art keywords
- fenyl
- quinolin
- dihydro
- bone
- inflammatory properties
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/007,069 US4232027A (en) | 1979-01-29 | 1979-01-29 | 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8047580A0 IT8047580A0 (it) | 1980-01-11 |
| IT1145403B true IT1145403B (it) | 1986-11-05 |
Family
ID=21724050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8047580A IT1145403B (it) | 1979-01-29 | 1980-01-11 | Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4232027A (it) |
| JP (1) | JPS55102568A (it) |
| DE (1) | DE3003146A1 (it) |
| FR (1) | FR2447376A1 (it) |
| GB (1) | GB2041361B (it) |
| IT (1) | IT1145403B (it) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0024638A1 (en) * | 1979-08-30 | 1981-03-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them |
| JPH03181465A (ja) * | 1989-12-11 | 1991-08-07 | Takeda Chem Ind Ltd | キノリン誘導体 |
| US5650410A (en) * | 1994-03-08 | 1997-07-22 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition containing quinoline or quinazoline derivatives and derivatives therefor |
| JP4794445B2 (ja) * | 2003-09-23 | 2011-10-19 | メルク・シャープ・エンド・ドーム・コーポレイション | キノリンカリウムチャネル阻害剤 |
| PT3558955T (pt) | 2016-12-22 | 2021-10-19 | Amgen Inc | Derivados de benzisotiazol, isotiazolo[3,4-b]piridina, quinazolina, ftalazina, pirido[2,3-d]piridazima e pirido[2,3-d]pirimidina como inibidores de kras g12c para tratamento de cancro de pulmão, pancreático ou colorretal |
| JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
| CN111051306B (zh) | 2017-09-08 | 2023-01-03 | 美国安进公司 | Kras g12c的抑制剂及其使用方法 |
| MA52496A (fr) | 2018-05-04 | 2021-03-10 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| MX2020010836A (es) | 2018-05-04 | 2021-01-08 | Amgen Inc | Inhibidores de kras g12c y métodos para su uso. |
| MA52564A (fr) | 2018-05-10 | 2021-03-17 | Amgen Inc | Inhibiteurs de kras g12c pour le traitement du cancer |
| EP3802535B1 (en) | 2018-06-01 | 2022-12-14 | Amgen, Inc | Kras g12c inhibitors and methods of using the same |
| EP3802537A1 (en) * | 2018-06-11 | 2021-04-14 | Amgen Inc. | Kras g12c inhibitors for treating cancer |
| US11285156B2 (en) | 2018-06-12 | 2022-03-29 | Amgen Inc. | Substituted piperazines as KRAS G12C inhibitors |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| AU2019384118A1 (en) | 2018-11-19 | 2021-05-27 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| MX2021014126A (es) | 2019-05-21 | 2022-01-04 | Amgen Inc | Formas en estado solido. |
| US20240190842A1 (en) * | 2022-11-09 | 2024-06-13 | Accutar Biotechnology Inc. | Substituted quinolinone-8-carbonitrile derivatives having androgen degradation activity and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3210358A (en) * | 1961-08-09 | 1965-10-05 | Geigy Chem Corp | Substituted 4-amino carbostyrils |
| CH471784A (de) * | 1966-01-26 | 1969-04-30 | Bayer Ag | Verfahren zur Herstellung von Carbostyrilderivaten |
| US3763153A (en) * | 1972-02-22 | 1973-10-02 | Squibb & Sons Inc | Benzothiazines |
| US3895006A (en) * | 1974-04-19 | 1975-07-15 | Squibb & Sons Inc | 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones |
| US3994900A (en) * | 1976-01-23 | 1976-11-30 | E. R. Squibb & Sons, Inc. | 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones |
-
1979
- 1979-01-29 US US06/007,069 patent/US4232027A/en not_active Expired - Lifetime
-
1980
- 1980-01-03 GB GB8000160A patent/GB2041361B/en not_active Expired
- 1980-01-11 IT IT8047580A patent/IT1145403B/it active
- 1980-01-28 JP JP923380A patent/JPS55102568A/ja active Pending
- 1980-01-29 FR FR8001874A patent/FR2447376A1/fr not_active Withdrawn
- 1980-01-29 DE DE19803003146 patent/DE3003146A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS55102568A (en) | 1980-08-05 |
| FR2447376A1 (fr) | 1980-08-22 |
| DE3003146A1 (de) | 1980-08-07 |
| GB2041361A (en) | 1980-09-10 |
| IT8047580A0 (it) | 1980-01-11 |
| GB2041361B (en) | 1982-12-08 |
| US4232027A (en) | 1980-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1116820B (it) | Derivati di moranolina con proprieta'farmacologiche | |
| IT1145403B (it) | Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie | |
| IT8024738A0 (it) | Derivati di deformiltilosina e loro preparazione. | |
| IT1101439B (it) | Derivati di 1,3,4,5-tetraidrobenz-indolo e relativo procedimento per fabbricarli | |
| NL191789C (nl) | Acetylaminoalkaansulfonzuurderivaten met farmacologische eigenschappen. | |
| FI802506A (fi) | Anti-inflammatoriska 5-substituerade 2,3-diaryltiofener | |
| IT1140976B (it) | Derivati di alchil-chetoesopiranosidi | |
| IT8047529A0 (it) | Derivati di acido epossisuccinico dotati di proprieta' farmacologiche | |
| IT8020502A0 (it) | Derivati di 9-amminoalchilfluorene ad azione farmaceutica. | |
| MC1357A1 (fr) | Derives de 2,3-indoledione | |
| SE7708642L (sv) | 1,5-disubstituerade pyrrolidoner och forfaranden for framstellning derav | |
| IT1114721B (it) | Derivati di 3,3-dicloro-2-azetidinone ad attivita' anti-infiammatoria | |
| FI802693A (fi) | Antiinflammatoriska 4,5-diaryl-alfa-polyfluoroalkyl-1h-pyrrol-2-metanoler och 1-(4,5-diaryl-1h-pyrrol-2-yl)-polyfluoroalkanoner | |
| IT8024150A0 (it) | Derivati di alovincamone eprocedimento per la loro preparazione. | |
| IT1164906B (it) | Derivati indolici dotati di proprieta' farmacologiche | |
| IT1102751B (it) | Derivati di 2,3-i-cian-pirazina | |
| IT1158700B (it) | Nuovi derivati 1h-1,2,4-triazolici 3,5-disostituiti | |
| IT7950202A0 (it) | Derivati alfa-aril-alfa alfa-bisomega-ammino bisostituiti alchilacetammidici ditati di proprieta'farmacologiche antiaritmia | |
| IT1085538B (it) | Derivati di i 125 immidazol-steroidi | |
| IT1164729B (it) | Derivati carbamoil-piperazinici dotati di attivita' farmaccologica | |
| IT1196401B (it) | Derivati acil-1h-1,2,4-triazolici | |
| IT8020503A0 (it) | Derivati della 1,1'-bifenil-2-ilalchilammina ad azione farmaceutica. | |
| IT7825879A0 (it) | D-omo ossasteroidi aventi proprieta' antinfiammatorie. | |
| IT1113391B (it) | Derivati fenilcicloesanici ad attivita' antidepressiva | |
| IT1128155B (it) | Derivati della 2,5-diimminopirrolina loro preparazione e loro impiego come coloranti |