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IT1126216B - Composti 1-fenil-2,3,4,5-tetraidro-1h-3-benz azepinici trisostituiti e metodo di loro preparazione - Google Patents

Composti 1-fenil-2,3,4,5-tetraidro-1h-3-benz azepinici trisostituiti e metodo di loro preparazione

Info

Publication number
IT1126216B
IT1126216B IT29708/77A IT2970877A IT1126216B IT 1126216 B IT1126216 B IT 1126216B IT 29708/77 A IT29708/77 A IT 29708/77A IT 2970877 A IT2970877 A IT 2970877A IT 1126216 B IT1126216 B IT 1126216B
Authority
IT
Italy
Prior art keywords
azepinic
tetraidro
fenyl
benz
trisubstituted
Prior art date
Application number
IT29708/77A
Other languages
English (en)
Original Assignee
Smithkline Corp
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp, Smithkline Beckman Corp filed Critical Smithkline Corp
Application granted granted Critical
Publication of IT1126216B publication Critical patent/IT1126216B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
IT29708/77A 1976-11-17 1977-11-15 Composti 1-fenil-2,3,4,5-tetraidro-1h-3-benz azepinici trisostituiti e metodo di loro preparazione IT1126216B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/742,965 US4160765A (en) 1976-11-17 1976-11-17 Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (1)

Publication Number Publication Date
IT1126216B true IT1126216B (it) 1986-05-14

Family

ID=24986959

Family Applications (1)

Application Number Title Priority Date Filing Date
IT29708/77A IT1126216B (it) 1976-11-17 1977-11-15 Composti 1-fenil-2,3,4,5-tetraidro-1h-3-benz azepinici trisostituiti e metodo di loro preparazione

Country Status (37)

Country Link
US (1) US4160765A (it)
JP (3) JPS5363335A (it)
AR (1) AR224495A1 (it)
AT (1) AT362379B (it)
AU (1) AU509754B2 (it)
BE (1) BE860774A (it)
BG (1) BG30019A3 (it)
CA (1) CA1092107A (it)
CH (1) CH635079A5 (it)
CS (1) CS219333B2 (it)
CY (1) CY1246A (it)
DD (1) DD133563A5 (it)
DE (1) DE2751258A1 (it)
DK (1) DK156057C (it)
ES (1) ES464044A1 (it)
FI (1) FI67374C (it)
FR (1) FR2371430A1 (it)
GB (1) GB1595502A (it)
HU (1) HU176709B (it)
IE (1) IE46087B1 (it)
IL (1) IL53377A (it)
IN (1) IN150172B (it)
IT (1) IT1126216B (it)
LU (1) LU78513A1 (it)
MX (1) MX4682E (it)
MY (1) MY8500382A (it)
NL (2) NL185563C (it)
NO (1) NO147029C (it)
PH (2) PH13611A (it)
PL (1) PL109672B1 (it)
PT (1) PT67260B (it)
RO (1) RO72905A (it)
SE (1) SE436646B (it)
SG (1) SG31784G (it)
SU (1) SU976847A3 (it)
YU (1) YU40490B (it)
ZA (1) ZA775910B (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
ZA792044B (en) * 1978-05-08 1980-05-28 Scherico Ltd Substituted 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof,and pharmaceutical compositions containing them
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
DE3065940D1 (en) * 1979-07-10 1984-01-26 Smithkline Beckman Corp Synergistic antihypertensive compositions
US4285938A (en) * 1979-10-11 1981-08-25 Smithkline Corporation 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4328153A (en) * 1980-07-17 1982-05-04 Smith Kline Corporation Dopaminergic benzazepines
ATE15762T1 (de) * 1981-12-08 1985-10-15 Smithkline Beckman Corp Pharmazeutische zusammensetzungen mit gehalt an 7,8-dihydroxy-1-(hydroxy-phenyl)-2,3,4,5tetrahydro-1h-3-benzazepin-derivaten und an einem beta-adrenergischen blocker.
US4705862A (en) * 1984-10-05 1987-11-10 Smithkline Beckman Corporation Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines
US4782163A (en) * 1984-10-05 1988-11-01 Smithkline Beckman Corporation 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
KR20010113006A (ko) * 2000-06-15 2001-12-24 주정호 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20030051728A1 (en) 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
EP1625336B9 (en) 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Use of a layer of solid fuel, method for producing such a layer and associated heating unit
GB0412314D0 (en) * 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
EP1725517A2 (en) * 2005-01-24 2006-11-29 Sicor Inc. Process for the preparation of fenoldopam mesylate
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
CN103172565A (zh) * 2011-12-22 2013-06-26 四川科伦药物研究有限公司 一种手性菲诺多泮的拆分方法
WO2019152873A1 (en) 2018-02-02 2019-08-08 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
CH498122A (de) * 1968-02-09 1970-10-31 Geigy Ag J R Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
DE1695844C3 (de) * 1967-02-21 1980-01-17 Scherico Ltd., Luzern (Schweiz) l-Phenyl-23,43-tetrahydro-lH^benzazepin-Derivate und sie enthaltende pharmazeutische Zusammensetzungen
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives

Also Published As

Publication number Publication date
DD133563A5 (de) 1979-01-10
AU509754B2 (en) 1980-05-22
HU176709B (en) 1981-04-28
GB1595502A (en) 1981-08-12
FI67374C (fi) 1985-03-11
DE2751258C2 (it) 1990-01-04
NL7712567A (nl) 1978-05-19
SE7712944L (sv) 1978-05-18
JPS6225658B2 (it) 1987-06-04
IN150172B (it) 1982-04-07
NO147029B (no) 1982-10-11
BE860774A (fr) 1978-05-16
IE46087B1 (en) 1983-02-23
NL185563C (nl) 1990-05-16
JPS6125697B2 (it) 1986-06-17
PH14740A (en) 1981-11-20
CH635079A5 (de) 1983-03-15
JPS58113153A (ja) 1983-07-05
ES464044A1 (es) 1978-08-01
AR224495A1 (es) 1981-12-15
MX4682E (es) 1982-07-28
CS219333B2 (en) 1983-03-25
NO773901L (no) 1978-05-19
JPS6366808B2 (it) 1988-12-22
NO147029C (no) 1983-01-19
BG30019A3 (en) 1981-03-16
YU40490B (en) 1986-02-28
IE46087L (en) 1978-05-17
JPS5363335A (en) 1978-06-06
IL53377A (en) 1982-09-30
JPS62155218A (ja) 1987-07-10
CA1092107A (en) 1980-12-23
AT362379B (de) 1981-05-11
ZA775910B (en) 1978-05-30
YU270777A (en) 1983-02-28
DK500477A (da) 1978-05-18
RO72905A (ro) 1981-11-04
FR2371430B1 (it) 1980-06-27
DK156057B (da) 1989-06-19
SG31784G (en) 1985-03-08
NL185563B (nl) 1989-12-18
PL109672B1 (en) 1980-06-30
DE2751258A1 (de) 1978-06-01
NL930026I2 (nl) 1993-11-01
DK156057C (da) 1989-11-13
FI67374B (fi) 1984-11-30
MY8500382A (en) 1985-12-31
CY1246A (en) 1984-08-31
NL930026I1 (nl) 1993-06-01
PH13611A (en) 1980-08-05
ATA816377A (de) 1980-10-15
SE436646B (sv) 1985-01-14
FI773448A (fi) 1978-05-18
AU3062677A (en) 1979-05-24
LU78513A1 (it) 1978-03-20
IL53377A0 (en) 1978-01-31
SU976847A3 (ru) 1982-11-23
PL202177A1 (pl) 1978-09-25
PT67260B (en) 1979-04-18
PT67260A (en) 1977-12-01
US4160765A (en) 1979-07-10
FR2371430A1 (fr) 1978-06-16

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Legal Events

Date Code Title Description
ITCP Complementary protection certificate

Free format text: CCP 396

MEDM Supplementary protection certificate for pharmaceutical products: withdrawal of spc application

Free format text: CCP 509, 19951009; SMITHKLINE BEECHAM CORPORATION

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 396, 19920630; SMITHKLINE BEECHAM CORPORATION

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19941130