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IT1050304B - 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity - Google Patents

4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity

Info

Publication number
IT1050304B
IT1050304B IT2252175A IT2252175A IT1050304B IT 1050304 B IT1050304 B IT 1050304B IT 2252175 A IT2252175 A IT 2252175A IT 2252175 A IT2252175 A IT 2252175A IT 1050304 B IT1050304 B IT 1050304B
Authority
IT
Italy
Prior art keywords
alkyl
opt
substd
amino
aryl
Prior art date
Application number
IT2252175A
Other languages
Italian (it)
Inventor
E Manghisi
G Fregnan
G Cascio
Original Assignee
Luso Farmaco Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luso Farmaco Inst filed Critical Luso Farmaco Inst
Priority to IT2252175A priority Critical patent/IT1050304B/en
Priority to US05/576,582 priority patent/US4061637A/en
Priority to DE2521104A priority patent/DE2521104C3/en
Priority to CA226,812A priority patent/CA1039725A/en
Priority to ES437624A priority patent/ES437624A1/en
Priority to GB20160/75A priority patent/GB1494560A/en
Priority to BE156349A priority patent/BE829071A/en
Priority to JP50057157A priority patent/JPS5126873A/en
Priority to NL7505642.A priority patent/NL165736C/en
Priority to FR7514979A priority patent/FR2270873B1/fr
Application granted granted Critical
Publication of IT1050304B publication Critical patent/IT1050304B/en

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Abstract

Cpds. of formula (I) are their salts (where Ar = mono- or polycarboxylic aryl opt. substd. by alkyl, CF3, alkoxy, alkenyloxy, alkylenedioxy, halo, alkylthio, nitro, opt. substd amino etc. and is partic. phenyl, lower alkylphenyl, trifluoromethylphenyl, lower alkoxy phenyl di(lower alkyl) aminophyenyl, halophenyl or alkylmercaptphenyl. Alk = 1-3C straight or branched, opt. unstatd. radical -NR1R2 = monosubstd. amino (e.g. monoalkylamino, mono-hydroxyalkylamino, monoarylalkylamino, monoaryloxyalkylamino, mono N,N-dialkylamino-alkyl amino) or disubstd. amino (e.g. N,N,-dialkylamino, N-cycloalkyl-N-alkylamino, N-alkyl-N-arylalkylamino, N-hydrozylakyl-N-alkylamino, N,N-dihydroxyalkylamino, N,N-alkyleneimine, N-N-oxoalkyleneimine, N,N-thioalkyleneimine, N,N-azaaalkyleneimine (opt. substd. on the aza function by alkyl, hydroxyalkyl, arylalkyl or aryl (opt. substd. by halo or alkoxy)). Z = O or SR3 = H, lowre alkyl, free or etherified lower hydroxyalkyl, arylalkyl dialkylaminoalkyl, lowre aliphatic or aromatic acyl or carbamoyl).act on the CNS and cardiovascular system and have antiinflammatory adrenolytic and anti-ulcer activity. They have anti-arrhythmic activity, prevent platelet agglutination, have anti-convulsant, cataleptic and some analgesic activity. They may be administered orally, parenterally or rectally in the usual formations. LD50 ip in mice vary from 100 to >1000mg/kg.
IT2252175A 1974-05-14 1975-04-18 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity IT1050304B (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT2252175A IT1050304B (en) 1975-04-18 1975-04-18 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity
US05/576,582 US4061637A (en) 1974-05-14 1975-05-12 Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
CA226,812A CA1039725A (en) 1974-05-14 1975-05-13 4-aryl-5-aminoalkyl-4-thiazoline-2-ones, their derivatives and processes for their preparation
ES437624A ES437624A1 (en) 1974-05-14 1975-05-13 Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones
DE2521104A DE2521104C3 (en) 1974-05-14 1975-05-13 4-Aryl-5-aminoalkyl-4-thiazolin-2-ones, processes for their preparation and pharmaceutical compositions containing these compounds
GB20160/75A GB1494560A (en) 1974-05-14 1975-05-13 4-aryl-5-aminoalkyl-4-thiazolin-2-ones and their preparation
BE156349A BE829071A (en) 1974-05-14 1975-05-14 4-ARYL-5-AMINDALKYL-4-THIAZOLINE-2-ONES, DERIVATIVES AND METHODS FOR PREPARING THEM
JP50057157A JPS5126873A (en) 1974-05-14 1975-05-14 44 ariiru 55 aminoarukiru 44 chiazorin 22 on oyobi sonojudotainochoseiho
NL7505642.A NL165736C (en) 1974-05-14 1975-05-14 PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION WITH AN ACTION ON THE CENTRAL NERVOUS SYSTEM AND THE CARDIO-VASCULAR SYSTEM AND WITH AN ANTI-INFLAMMATIC ADRENOLYTIC AND ANTI-ULCER PREPARATELY PREPARED PRODUCTION. -2-ONES.
FR7514979A FR2270873B1 (en) 1974-05-14 1975-05-14

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2252175A IT1050304B (en) 1975-04-18 1975-04-18 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity

Publications (1)

Publication Number Publication Date
IT1050304B true IT1050304B (en) 1981-03-10

Family

ID=11197375

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2252175A IT1050304B (en) 1974-05-14 1975-04-18 4-Aryl 5-aminoalkyl 4-thiazoline-2-ones and 2-thiones - CNS depressant and cardiovascular agents having anti-inflammatory, adrenolytic and anti-ulcer activity

Country Status (1)

Country Link
IT (1) IT1050304B (en)

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