IS7377A - Þíasól go oxasól afleiður sem stilla PPAR virkni - Google Patents

Þíasól go oxasól afleiður sem stilla PPAR virkni

Info

Publication number: IS7377A
Authority: IS; Iceland
Prior art keywords: thiazole; adjust; oxazole derivatives; ppar activity; ppar
Prior art date: 2002-03-07

Application number

IS7377A

Other languages

English (en)

Inventor

Cheng Xue-Min

Ouano Erasga Noe

Frederick Filzen Gary

George Geyer Andrew

Lee Chitase

Kalidas Trivedi Bharat

Original Assignee

Warner-Lambert Company Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-07

Filing date

2004-07-29

Publication date

2004-07-29

2004-07-29 Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc

2004-07-29 Publication of IS7377A publication Critical patent/IS7377A/is

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/26—Radicals substituted by sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Obesity (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

IS7377A 2002-03-07 2004-07-29 Þíasól go oxasól afleiður sem stilla PPAR virkni IS7377A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36240202P	2002-03-07	2002-03-07
PCT/IB2003/000708 WO2003074050A1 (en)	2002-03-07	2003-02-24	Thiazole and oxazole derivatives which modulate ppar activity

Publications (1)

Publication Number	Publication Date
IS7377A true IS7377A (is)	2004-07-29

Family

ID=27789157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7377A IS7377A (is)	2002-03-07	2004-07-29	Þíasól go oxasól afleiður sem stilla PPAR virkni

Country Status (29)

Country	Link
US (1)	US20030207924A1 (is)
EP (1)	EP1482935B1 (is)
JP (1)	JP2005528348A (is)
KR (1)	KR20040091693A (is)
AP (1)	AP2004003124A0 (is)
AR (1)	AR038881A1 (is)
AT (1)	ATE405260T1 (is)
AU (1)	AU2003206059A1 (is)
BR (1)	BR0308277A (is)
CA (1)	CA2478520A1 (is)
CO (1)	CO5601012A2 (is)
DE (1)	DE60323060D1 (is)
EA (1)	EA200400943A1 (is)
EC (1)	ECSP045285A (is)
ES (1)	ES2310650T3 (is)
HN (1)	HN2003000090A (is)
IS (1)	IS7377A (is)
MA (1)	MA27181A1 (is)
MX (1)	MXPA04007564A (is)
NO (1)	NO20044242L (is)
OA (1)	OA12780A (is)
PA (1)	PA8567801A1 (is)
PE (1)	PE20030989A1 (is)
PL (1)	PL372969A1 (is)
TN (1)	TNSN04168A1 (is)
TW (1)	TW200305403A (is)
UY (1)	UY27695A1 (is)
WO (1)	WO2003074050A1 (is)
ZA (1)	ZA200406068B (is)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6833380B2 (en)	2002-03-07	2004-12-21	Warner-Lambert Company, Llc	Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) *	2002-04-05	2005-04-05	Warner-Lambert Company	Compounds that modulate PPAR activity and methods for their preparation
US7244763B2 (en) *	2003-04-17	2007-07-17	Warner Lambert Company Llc	Compounds that modulate PPAR activity and methods of preparation
SI1638551T1 (sl) *	2003-05-19	2012-04-30	Irm Llc	Imunosupresivne spojine in sestavki
MY150088A (en)	2003-05-19	2013-11-29	Irm Llc	Immunosuppressant compounds and compositions
CN1946666A (zh)	2004-02-27	2007-04-11	埃姆艮股份有限公司	用于治疗代谢性疾病的化合物、药物组合物和方法
WO2005105736A1 (en)	2004-05-05	2005-11-10	Novo Nordisk A/S	Novel compounds, their preparation and use
DE602005024384D1 (de)	2004-05-05	2010-12-09	High Point Pharmaceuticals Llc	Neue verbindungen, ihre herstellung und verwendung
US7456164B2 (en)	2004-05-07	2008-11-25	Pfizer, Inc	3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
AU2012200214B2 (en) *	2004-05-14	2013-10-24	Emisphere Technologies, Inc.	Compounds and compositions for delivering active agents
WO2005115383A2 (en) *	2004-05-25	2005-12-08	Metabolex, Inc.	Substituted triazoles as modulators of ppar and methods of their preparation
WO2005115384A2 (en) *	2004-05-25	2005-12-08	Metabolex, Inc.	Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
CN101193876B (zh) *	2005-05-07	2011-05-11	财团法人首尔大学校产学协力财团	制备PPARδ的配体的方法和用于制备该配体的中间化合物
US7465804B2 (en) *	2005-05-20	2008-12-16	Amgen Inc.	Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
JP5052511B2 (ja)	2005-06-30	2012-10-17	ハイポイントファーマシューティカルズ，エルエルシー	Ｐｐａｒデルタ活性化因子としてのフェノキシ酢酸
US8153694B2 (en) *	2005-07-29	2012-04-10	Takeda Pharmaceutical Company Limited	Cyclopropanecarboxylic acid compound
AU2006291234A1 (en)	2005-09-14	2007-03-22	Amgen Inc.	Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
CN103224477A (zh)	2005-12-22	2013-07-31	高点制药有限责任公司	作为PPAR-δ活化剂的苯氧基乙酸
JP2009132620A (ja) *	2006-03-07	2009-06-18	Astellas Pharma Inc	フェニルチアゾール誘導体
WO2007101864A2 (en)	2006-03-09	2007-09-13	High Point Pharmaceuticals, Llc	Compounds that modulate ppar activity, their preparation and use
CA2662305C (en)	2006-09-07	2012-04-17	Amgen Inc.	Heterocyclic gpr40 modulators
CA2662242C (en)	2006-09-07	2012-06-12	Amgen Inc.	Benzo-fused compounds for use in treating metabolic disorders
EP2139843B1 (en)	2007-04-16	2013-12-25	Amgen, Inc	Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
BRPI0818253A2 (pt)	2007-10-10	2015-04-07	Amgen Inc	Moduladores de gpr40 bifenil substituídos
CA2708391A1 (en) *	2007-12-13	2009-06-25	Sri International	Ppar-delta ligands and methods of their use
CN101945848A (zh)	2007-12-20	2011-01-12	英维沃医药有限公司	四取代的苯
US8450522B2 (en)	2008-03-06	2013-05-28	Amgen Inc.	Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
JP5551707B2 (ja)	2008-10-15	2014-07-16	アムジエン・インコーポレーテツド	スピロ環ｇｐｒ４０調節因子
EP2540711A4 (en) *	2010-02-25	2014-01-22	Snu R&Db Foundation	SELENAZOLE DERIVATIVE HAVING A LIGAND THAT ACTIVATES THE ACTIVATED RECEPTOR OF PEROXISOME PROLIFERATION (PPAR), ITS PREPARATION METHOD AND THE USE OF CHEMICAL COMPOUNDS
EP3043789B1 (en)	2013-09-09	2020-07-08	vTv Therapeutics LLC	Use of a ppar-delta agonists for treating muscle atrophy
WO2023147309A1 (en)	2022-01-25	2023-08-03	Reneo Pharmaceuticals, Inc.	Use of ppar-delta agonists in the treatment of disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5859051A (en) *	1996-02-02	1999-01-12	Merck & Co., Inc.	Antidiabetic agents
CZ53699A3 (cs) *	1996-08-19	1999-07-14	Japan Tobacco Inc.	Deriváty propionové kyseliny a jejich použití
GB9914977D0 (en) *	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
EP1345916A1 (en) *	2000-12-20	2003-09-24	Glaxo Group Limited	Substituted oxazoles and thiazoles as hppar alpha agonists
GB0031107D0 (en) *	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
GB0111523D0 (en) *	2001-05-11	2001-07-04	Glaxo Group Ltd	Chemical compounds
MXPA03010903A (es) *	2001-06-07	2004-02-17	Lilly Co Eli	Moduladores de receptores activados por el proliferador de peroxisomas.

2002
- 2002-12-20 US US10/324,148 patent/US20030207924A1/en not_active Abandoned
2003
- 2003-02-24 DE DE60323060T patent/DE60323060D1/de not_active Expired - Fee Related
- 2003-02-24 AP APAP/P/2004/003124A patent/AP2004003124A0/en unknown
- 2003-02-24 CA CA002478520A patent/CA2478520A1/en not_active Abandoned
- 2003-02-24 PL PL03372969A patent/PL372969A1/xx not_active Application Discontinuation
- 2003-02-24 JP JP2003572567A patent/JP2005528348A/ja not_active Abandoned
- 2003-02-24 EP EP03702943A patent/EP1482935B1/en not_active Expired - Lifetime
- 2003-02-24 MX MXPA04007564A patent/MXPA04007564A/es active IP Right Grant
- 2003-02-24 AT AT03702943T patent/ATE405260T1/de not_active IP Right Cessation
- 2003-02-24 ES ES03702943T patent/ES2310650T3/es not_active Expired - Lifetime
- 2003-02-24 AU AU2003206059A patent/AU2003206059A1/en not_active Abandoned
- 2003-02-24 EA EA200400943A patent/EA200400943A1/ru unknown
- 2003-02-24 WO PCT/IB2003/000708 patent/WO2003074050A1/en active IP Right Grant
- 2003-02-24 BR BR0308277-6A patent/BR0308277A/pt not_active IP Right Cessation
- 2003-02-24 KR KR10-2004-7013951A patent/KR20040091693A/ko not_active Application Discontinuation
- 2003-02-24 OA OA1200400232A patent/OA12780A/en unknown
- 2003-02-27 PA PA20038567801A patent/PA8567801A1/es unknown
- 2003-03-04 PE PE2003000210A patent/PE20030989A1/es not_active Application Discontinuation
- 2003-03-05 AR ARP030100737A patent/AR038881A1/es unknown
- 2003-03-06 HN HN2003000090A patent/HN2003000090A/es unknown
- 2003-03-06 UY UY27695A patent/UY27695A1/es not_active Application Discontinuation
- 2003-03-06 TW TW092104790A patent/TW200305403A/zh unknown
2004
- 2004-07-29 IS IS7377A patent/IS7377A/is unknown
- 2004-07-29 ZA ZA200406068A patent/ZA200406068B/en unknown
- 2004-08-24 CO CO04082302A patent/CO5601012A2/es not_active Application Discontinuation
- 2004-08-30 MA MA27839A patent/MA27181A1/fr unknown
- 2004-09-03 TN TNP2004000168A patent/TNSN04168A1/fr unknown
- 2004-09-07 EC EC2004005285A patent/ECSP045285A/es unknown
- 2004-10-06 NO NO20044242A patent/NO20044242L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20030207924A1 (en)	2003-11-06
AR038881A1 (es)	2005-02-02
EP1482935B1 (en)	2008-08-20
JP2005528348A (ja)	2005-09-22
PE20030989A1 (es)	2003-11-29
PA8567801A1 (es)	2003-11-12
CO5601012A2 (es)	2006-01-31
EA200400943A1 (ru)	2005-02-24
ATE405260T1 (de)	2008-09-15
CA2478520A1 (en)	2003-09-12
AP2004003124A0 (en)	2004-09-30
PL372969A1 (en)	2005-08-08
ZA200406068B (en)	2005-09-06
TW200305403A (en)	2003-11-01
MA27181A1 (fr)	2005-01-03
HN2003000090A (es)	2004-05-05
OA12780A (en)	2006-07-07
KR20040091693A (ko)	2004-10-28
WO2003074050A1 (en)	2003-09-12
EP1482935A1 (en)	2004-12-08
BR0308277A (pt)	2004-12-28
AU2003206059A1 (en)	2003-09-16
DE60323060D1 (de)	2008-10-02
NO20044242L (no)	2004-10-06
MXPA04007564A (es)	2004-11-10
TNSN04168A1 (fr)	2007-03-12
ECSP045285A (es)	2004-10-26
ES2310650T3 (es)	2009-01-16
UY27695A1 (es)	2003-10-31

Publication	Publication Date	Title
IS7377A (is)	2004-07-29	Þíasól go oxasól afleiður sem stilla PPAR virkni
IS7399A (is)	2004-08-12	Þíasól og oxasól afleiður sem stilla PPAR virkni
PL372123A1 (en)	2005-07-11	Thiazole derivatives
ATE391505T1 (de)	2008-04-15	Benzothiazole derivative
DE60329601D1 (de)	2009-11-19	Benzothiazolderivate mit beta-2-adrenorezeptor-agonistenwirkung
PL3002283T3 (pl)	2017-10-31	Pochodne tiazolu
IS7429A (is)	2004-08-30	Efnasambönd sem stilla PPAR virkni og aðferðir til framleiðslu þeirra
HK1104543A1 (en)	2008-01-18	Thiazole derivative
DK1206472T3 (da)	2004-01-12	Oxazol- og thiazolderivater som neutrophinproduktions/sekretionsfremmende middel
DE60334944D1 (de)	2010-12-23	Schreitroboter
IS7711A (is)	2005-02-24	Ný oxasól og þíasól efnasambönd sem umbreytingar vaxtaþátta (TGF) hindrar
DK1398328T3 (da)	2010-03-08	Hydroxyalkyl stivelsesderivater
DE102004002416B8 (de)	2017-04-13	Knickarmroboter
ATE478870T1 (de)	2010-09-15	Spiroindolinpiperidinderivate
ATE460418T1 (de)	2010-03-15	Heterocyclocarboxamidderivate
DE60330372D1 (de)	2010-01-14	Indol-3-schwefelderivate
ATE376831T1 (de)	2007-11-15	Nicotin- oder isonicotin benzothiazole derivaten
DK2248807T3 (da)	2013-08-26	N-Phenyl-2-pyrimidinaminderivater
AU2003302763A8 (en)	2004-07-14	Insecticidal aminothiazole derivatives
NO20025978D0 (no)	2002-12-12	Benzotiazol-derivater
DE60307512D1 (de)	2006-09-21	3h-chinazoline -4-on derivaten
ITPD20020133A1 (it)	2003-11-24	Letto particolarmente articolato
FI20020942A (fi)	2003-11-21	Menetelmä tärkkelyksen käsittelemiseksi
ATE309242T1 (de)	2005-11-15	Benzothiazole
DE50306277D1 (de)	2007-02-22	4-alkyl-/4-alkenyl-/4-alkinylmethyl/-1-arylcyclohexylamin-derivate