IN2015MN00436A - - Google Patents

Info

Publication number: IN2015MN00436A
Authority: IN; India
Prior art keywords: sequence; protein; contiguous nucleotides; bont; nucleic acid
Prior art date: 2012-10-31

Application number

Other languages

English (en)

Inventor

Aimee Cossins

Matthew Beard

Original Assignee

Syntaxin Ltd

Ipsen Biopharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-10-31

Filing date

2013-10-31

Publication date

2015-09-04

2013-10-31 Application filed by Syntaxin Ltd, Ipsen Biopharm Ltd filed Critical Syntaxin Ltd

2015-09-04 Publication of IN2015MN00436A publication Critical patent/IN2015MN00436A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IN436MUN2015 2012-10-31 2013-10-31 IN2015MN00436A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB201219602A GB201219602D0 (en)	2012-10-31	2012-10-31	Recombinant clostridium botulinum neurotoxins
PCT/GB2013/052845 WO2014068317A1 (fr)	2012-10-31	2013-10-31	Neurotoxines recombinantes de clostridium botulinum

Publications (1)

Publication Number	Publication Date
IN2015MN00436A true IN2015MN00436A (fr)	2015-09-04

Family

ID=47358958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN436MUN2015 IN2015MN00436A (fr)	2012-10-31	2013-10-31

Country Status (26)

Country	Link
US (1)	US10030238B2 (fr)
EP (3)	EP3673914B1 (fr)
JP (2)	JP2019068823A (fr)
KR (2)	KR102264478B1 (fr)
CN (2)	CN104755098A (fr)
AR (2)	AR093309A1 (fr)
AU (3)	AU2013340610B2 (fr)
BR (1)	BR112015005384A2 (fr)
CA (1)	CA2885519A1 (fr)
DK (2)	DK2914282T3 (fr)
EA (1)	EA201590794A8 (fr)
ES (2)	ES2662402T3 (fr)
GB (1)	GB201219602D0 (fr)
HU (2)	HUE036764T2 (fr)
IL (1)	IL237623B (fr)
IN (1)	IN2015MN00436A (fr)
MX (2)	MX367080B (fr)
NO (1)	NO2914282T3 (fr)
NZ (1)	NZ705575A (fr)
PL (2)	PL2914282T3 (fr)
PT (2)	PT2914282T (fr)
SG (2)	SG10201701140WA (fr)
TW (3)	TW202012622A (fr)
UA (1)	UA118837C2 (fr)
WO (1)	WO2014068317A1 (fr)
ZA (1)	ZA201501449B (fr)

Families Citing this family (16)

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GB201219602D0 (en) *	2012-10-31	2012-12-12	Syntaxin Ltd	Recombinant clostridium botulinum neurotoxins
TWI725963B (zh) *	2015-03-26	2021-05-01	哈佛大學校長及研究員協會	工程化之肉毒桿菌神經毒素
WO2017063743A1 (fr)	2015-10-14	2017-04-20	Merz Pharma Gmbh & Co. Kgaa	Améliorations apportées à la thérapie par ultrasons de tissu atteint de photovieillissement
RU2743746C2 (ru)	2016-03-02	2021-02-25	Мерц Фарма Гмбх Энд Ко. Кгаа	Композиция, содержащая ботулинический токсин
EP3263710A1 (fr) *	2016-07-01	2018-01-03	Ipsen Biopharm Limited	Production de neurotoxines clostridiales activées
EP3504226A1 (fr)	2016-08-24	2019-07-03	President and Fellows of Harvard College	Neurotoxine botulique manipulée
AU2017327369A1 (en)	2016-09-13	2019-05-02	Allergan, Inc.	Stabilized non-protein Clostridial toxin compositions
US11952601B2 (en)	2017-06-20	2024-04-09	Merz Pharma Gmbh & Co. Kgaa	Recombinant botulinum toxin with increased duration of effect
EP3649143B1 (fr)	2017-07-06	2022-08-31	Merz Pharma GmbH & Co. KGaA	Nouvelles neurotoxines botuliques recombinantes présentant une durée d'effet accrue
EP3694489A4 (fr)	2017-10-11	2021-06-30	Illustris Pharmaceuticals, Inc.	Procédés et compositions à administration topique
CA3083083A1 (fr) *	2018-01-29	2019-08-01	Ipsen Biopharm Limited	Neurotoxines botuliques de clivage de snare non neuronales
US11707510B2 (en) *	2018-02-16	2023-07-25	Preclinics Discovery Gmbh	Nucleic acid-based botulinum neurotoxin for therapeutic use
GB201815844D0 (en)	2018-09-28	2018-11-14	Ipsen Biopharm Ltd	Therapeutic & comestic uses of botulinum neurotoxin serotype e
GB202011055D0 (en)	2020-07-17	2020-09-02	Ipsen Bioinnovation Ltd	Treatment of post-operative pain
GB202015618D0 (en)	2020-10-01	2020-11-18	Ipsen Biopharm Ltd	Method for producing beta-trypsin
CN115819526A (zh) *	2022-12-02	2023-03-21	海雅美生物技术(珠海)有限公司	一种重组肉毒杆菌神经毒素及其制备方法和应用

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US6967088B1 (en) *	1995-03-16	2005-11-22	Allergan, Inc.	Soluble recombinant botulinum toxin proteins
NZ308772A (en) *	1995-05-17	1999-04-29	Du Pont	Recombinant baculovirus insecticides
EP1119626B1 (fr)	1998-07-10	2008-01-02	U.S. Army Medical Research Institute of Infectious Diseases	Vaccin a base de neurotoxine botulinique
CN1214114C (zh)	1999-08-25	2005-08-10	阿勒根公司	可活化的重组神经毒素
US7374896B2 (en)	2001-08-28	2008-05-20	Allergan, Inc.	GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US20110111483A1 (en) *	2004-06-30	2011-05-12	Allergan, Inc.	Optimizing Expression of Active Botulinum Toxin Type E
WO2006011966A1 (fr) *	2004-06-30	2006-02-02	Allergan, Inc.	Optimisation d'expression de toxine botulinum active de type e
US7514088B2 (en) *	2005-03-15	2009-04-07	Allergan, Inc.	Multivalent Clostridial toxin derivatives and methods of their use
GB2416122A (en) *	2004-07-12	2006-01-18	Ipsen Ltd	Botulinum neurotoxin composition
DE102004043009A1 (de) *	2004-09-06	2006-03-23	Toxogen Gmbh	Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
DE102005002978B4 (de)	2005-01-21	2013-04-25	Merz Pharma Gmbh & Co. Kgaa	Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
JP4913074B2 (ja) *	2005-03-03	2012-04-11	アラーガン、インコーポレイテッド	動物由来産物不含方法およびボツリヌス毒素を精製するための方法
AU2006339490B2 (en) *	2005-09-19	2011-12-08	Allergan, Inc.	Clostridial toxin activatable clostridial toxins
US20070218084A1 (en) *	2005-12-30	2007-09-20	Fondazione Pierfranco E Luisa Mariani- Onlus	Method for the Mapping of the Epileptogenic Focus in the Pre-Surgical Evaluation of Patients with Intractable Epilepsy
JP2009543558A (ja) *	2006-07-11	2009-12-10	アラーガン、インコーポレイテッド	増強した転位置能力および増強したターゲティング活性を有する改変クロストリジウム毒素
EP2178905B1 (fr) *	2007-07-26	2013-11-06	Allergan, Inc.	Procédés d'activation de toxines clostridiales
EP3067049A1 (fr) *	2008-12-10	2016-09-14	Allergan, Inc.	Compositions pharmaceutiques comprenant toxine de clostridium
GB0903006D0 (en) *	2009-02-23	2009-04-08	Syntaxin Ltd	Modified non-cytotoxic proteases
WO2010120766A1 (fr) *	2009-04-14	2010-10-21	Mcw Research Foundation, Inc.	Neurotoxine botulinique remaniée
CN102753681A (zh) *	2009-12-16	2012-10-24	阿勒根公司	包含整合型蛋白酶裂解位点-结合结构域的经过修饰的梭菌毒素
WO2012112434A1 (fr)	2011-02-14	2012-08-23	Allergan, Inc.	Procédé permettant d'inhiber la formation de vaisseaux sanguins aberrants au moyen d'endopeptidases reciblées
GB201219602D0 (en) *	2012-10-31	2012-12-12	Syntaxin Ltd	Recombinant clostridium botulinum neurotoxins
GB201407525D0 (en) *	2014-04-29	2014-06-11	Syntaxin Ltd	Manufacture of recombinant clostridium botulinum neurotoxins
EP3504226A1 (fr) *	2016-08-24	2019-07-03	President and Fellows of Harvard College	Neurotoxine botulique manipulée

2012
- 2012-10-31 GB GB201219602A patent/GB201219602D0/en not_active Ceased
2013
- 2013-10-31 UA UAA201502159A patent/UA118837C2/uk unknown
- 2013-10-31 BR BR112015005384A patent/BR112015005384A2/pt not_active Application Discontinuation
- 2013-10-31 SG SG10201701140WA patent/SG10201701140WA/en unknown
- 2013-10-31 TW TW108125708A patent/TW202012622A/zh unknown
- 2013-10-31 CA CA2885519A patent/CA2885519A1/fr not_active Abandoned
- 2013-10-31 DK DK13811605.8T patent/DK2914282T3/en active
- 2013-10-31 EA EA201590794A patent/EA201590794A8/ru unknown
- 2013-10-31 IN IN436MUN2015 patent/IN2015MN00436A/en unknown
- 2013-10-31 DK DK17201198.3T patent/DK3326644T3/da active
- 2013-10-31 WO PCT/GB2013/052845 patent/WO2014068317A1/fr active Application Filing
- 2013-10-31 TW TW107110108A patent/TWI673361B/zh not_active IP Right Cessation
- 2013-10-31 KR KR1020207026658A patent/KR102264478B1/ko active Active
- 2013-10-31 AU AU2013340610A patent/AU2013340610B2/en not_active Ceased
- 2013-10-31 HU HUE13811605A patent/HUE036764T2/hu unknown
- 2013-10-31 PT PT138116058T patent/PT2914282T/pt unknown
- 2013-10-31 CN CN201380047542.8A patent/CN104755098A/zh active Pending
- 2013-10-31 PT PT172011983T patent/PT3326644T/pt unknown
- 2013-10-31 EP EP20153122.5A patent/EP3673914B1/fr active Active
- 2013-10-31 NZ NZ705575A patent/NZ705575A/en not_active IP Right Cessation
- 2013-10-31 ES ES13811605.8T patent/ES2662402T3/es active Active
- 2013-10-31 PL PL13811605T patent/PL2914282T3/pl unknown
- 2013-10-31 HU HUE17201198A patent/HUE048802T2/hu unknown
- 2013-10-31 SG SG11201502372SA patent/SG11201502372SA/en unknown
- 2013-10-31 AR ARP130103981A patent/AR093309A1/es active IP Right Grant
- 2013-10-31 CN CN201910795176.3A patent/CN110499321A/zh active Pending
- 2013-10-31 TW TW102139558A patent/TWI626307B/zh not_active IP Right Cessation
- 2013-10-31 PL PL17201198T patent/PL3326644T3/pl unknown
- 2013-10-31 NO NO13811605A patent/NO2914282T3/no unknown
- 2013-10-31 KR KR1020157010099A patent/KR102188539B1/ko active Active
- 2013-10-31 MX MX2015005156A patent/MX367080B/es active IP Right Grant
- 2013-10-31 US US14/427,234 patent/US10030238B2/en active Active
- 2013-10-31 EP EP13811605.8A patent/EP2914282B1/fr active Active
- 2013-10-31 EP EP17201198.3A patent/EP3326644B1/fr active Active
- 2013-10-31 ES ES17201198T patent/ES2788199T3/es active Active
2015
- 2015-03-03 ZA ZA2015/01449A patent/ZA201501449B/en unknown
- 2015-03-08 IL IL237623A patent/IL237623B/en active IP Right Grant
- 2015-04-23 MX MX2019009222A patent/MX2019009222A/es unknown
2018
- 2018-05-21 AU AU2018203556A patent/AU2018203556B2/en not_active Ceased
- 2018-12-10 JP JP2018230980A patent/JP2019068823A/ja not_active Ceased
2019
- 2019-12-26 AR ARP190103867A patent/AR117738A2/es unknown
2020
- 2020-02-05 JP JP2020017612A patent/JP2020078321A/ja active Pending
- 2020-09-30 AU AU2020244481A patent/AU2020244481A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN104755098A (zh)	2015-07-01
MX2019009222A (es)	2019-11-21
SG10201701140WA (en)	2017-04-27
GB201219602D0 (en)	2012-12-12
PT3326644T (pt)	2020-05-29
EP3673914A1 (fr)	2020-07-01
EA201590794A8 (ru)	2016-01-29
HUE048802T2 (hu)	2020-08-28
CN110499321A (zh)	2019-11-26
DK3326644T3 (da)	2020-05-11
US20150247139A1 (en)	2015-09-03
AU2013340610B2 (en)	2018-02-22
KR102264478B1 (ko)	2021-06-15
PL2914282T3 (pl)	2018-07-31
TWI673361B (zh)	2019-10-01
AU2018203556B2 (en)	2020-08-20
DK2914282T3 (en)	2018-02-26
TW201435084A (zh)	2014-09-16
NZ705575A (en)	2019-08-30
WO2014068317A1 (fr)	2014-05-08
EP2914282B1 (fr)	2017-12-20
IL237623A0 (en)	2015-04-30
EP2914282A1 (fr)	2015-09-09
MX367080B (es)	2019-08-05
JP2019068823A (ja)	2019-05-09
AR117738A2 (es)	2021-08-25
TWI626307B (zh)	2018-06-11
AU2020244481A1 (en)	2020-10-29
PT2914282T (pt)	2018-03-13
UA118837C2 (uk)	2019-03-25
PL3326644T3 (pl)	2020-08-24
TW201825680A (zh)	2018-07-16
KR102188539B1 (ko)	2020-12-09
SG11201502372SA (en)	2015-05-28
BR112015005384A2 (pt)	2017-08-08
AU2013340610A1 (en)	2015-03-19
AR093309A1 (es)	2015-05-27
EP3326644A1 (fr)	2018-05-30
EP3673914B1 (fr)	2021-10-27
ZA201501449B (en)	2016-08-31
MX2015005156A (es)	2015-09-23
ES2662402T3 (es)	2018-04-06
HUE036764T2 (hu)	2018-07-30
KR20150094590A (ko)	2015-08-19
HK1208359A1 (en)	2016-03-04
TW202012622A (zh)	2020-04-01
ES2788199T3 (es)	2020-10-20
EP3326644B1 (fr)	2020-03-04
IL237623B (en)	2019-05-30
US10030238B2 (en)	2018-07-24
JP2020078321A (ja)	2020-05-28
NO2914282T3 (fr)	2018-05-19
AU2018203556A1 (en)	2018-06-07
EA201590794A1 (ru)	2015-08-31
KR20200110470A (ko)	2020-09-23
CA2885519A1 (fr)	2014-05-08

Publication	Publication Date	Title
IN2015MN00436A (fr)	2015-09-04
UA116980C2 (uk)	2018-06-11	Полінуклеотид, який кодує 5-енолпірувілшикімат-3-фосфатсинтазу, та його використання в наданні рослині стійкості до гліфосату
MX2013007853A (es)	2013-07-30	Polipeptidos que tienen actividad de celobiohidrolasa y polinucleotidos que codifican los mismos.
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MX2018010529A (es)	2022-01-25	Composiciones y metodos para la produccion y administracion de acido ribonucleico.
MX379251B (es)	2025-03-11	Producción mejorada de derivados de ácidos grasos.
MX337984B (es)	2016-03-30	Variantes de alfa amilasa y polinucleotidos que codifican la misma.
MX366912B (es)	2019-07-30	Producción de vacuna recombinante en e. coli mediante conjugación enzimática.
AR092712A1 (es)	2015-04-29	Una proteina con actividad cetosa 3-epimerasa
EA201291024A1 (ru)	2013-11-29	Композиции эндорибонуклеаз и способы их использования
MX2013003681A (es)	2013-11-20	Ácidos nucleicos manipulados y métodos de uso de los mismos.
MX337913B (es)	2016-03-28	Polipeptidos que tienen actividad celobiohidrolasa y polinucleotidos que codifican los mismos.
MX2014004598A (es)	2014-05-27	Variantes de alfa-amilasa y polinucleotidos que codifican las mismas.
MX354704B (es)	2018-03-16	Variantes de alfa-amilasa y polinucleotidos que codifican las mismas.
EA201401041A1 (ru)	2015-03-31	Наночастицы дуально дериватизованного хитозана и способы их получения и применения для переноса генов in vivo
NZ729980A (en)	2020-01-31	Genes involved in noscapine production
MX2015000312A (es)	2015-04-10	Polipeptidos que tienen actividad lipasa y polinucleotidos que los codifican.
BR112017020690A2 (pt)	2018-06-26	produção livre de células de ácido ribonucleico
MY182946A (en)	2021-02-05	Production of organic acids by fermentation at low ph
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