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IN2015DN01967A - - Google Patents

Info

Publication number
IN2015DN01967A
IN2015DN01967A IN1967DEN2015A IN2015DN01967A IN 2015DN01967 A IN2015DN01967 A IN 2015DN01967A IN 1967DEN2015 A IN1967DEN2015 A IN 1967DEN2015A IN 2015DN01967 A IN2015DN01967 A IN 2015DN01967A
Authority
IN
India
Prior art keywords
antibody
compared
reduced immunogenicity
anti tnf
reference antibody
Prior art date
Application number
Other languages
English (en)
Inventor
Fiona A Harding
Olivia Jennifer Razo
Original Assignee
Abbvie Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Biotherapeutics Inc filed Critical Abbvie Biotherapeutics Inc
Publication of IN2015DN01967A publication Critical patent/IN2015DN01967A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/525Tumor necrosis factor [TNF]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IN1967DEN2015 2012-09-19 2013-09-18 IN2015DN01967A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261703170P 2012-09-19 2012-09-19
PCT/US2013/060480 WO2014047222A2 (fr) 2012-09-19 2013-09-18 Procédés d'identification d'anticorps ayant une immunogénicité réduite

Publications (1)

Publication Number Publication Date
IN2015DN01967A true IN2015DN01967A (fr) 2015-08-14

Family

ID=49304336

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1967DEN2015 IN2015DN01967A (fr) 2012-09-19 2013-09-18

Country Status (28)

Country Link
US (1) US9279016B2 (fr)
EP (2) EP3211006A3 (fr)
JP (1) JP2015537190A (fr)
KR (1) KR20150056788A (fr)
CN (1) CN104704000A (fr)
AU (1) AU2013318147B2 (fr)
BR (1) BR112015005857A2 (fr)
CA (1) CA2885422A1 (fr)
CY (1) CY1118893T1 (fr)
DK (1) DK2897978T3 (fr)
ES (1) ES2621285T3 (fr)
HK (1) HK1211306A1 (fr)
HR (1) HRP20170937T1 (fr)
HU (1) HUE032569T2 (fr)
IL (1) IL237833A0 (fr)
IN (1) IN2015DN01967A (fr)
LT (1) LT2897978T (fr)
MX (1) MX2015003541A (fr)
NZ (1) NZ705606A (fr)
PL (1) PL2897978T3 (fr)
PT (1) PT2897978T (fr)
RS (1) RS56093B1 (fr)
RU (1) RU2648141C2 (fr)
SG (1) SG11201502094TA (fr)
SI (1) SI2897978T1 (fr)
SM (1) SMT201700255T1 (fr)
TW (1) TWI519646B (fr)
WO (1) WO2014047222A2 (fr)

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CN106478802B (zh) * 2016-10-11 2019-08-09 浙江省人民医院 TNF-α蛋白B细胞表位,含此表位的多抗原肽及应用
EP3558363A1 (fr) 2016-12-21 2019-10-30 Amgen Inc. Formulations d'anticorps anti-tnf alpha
JP7473339B2 (ja) * 2017-03-07 2024-04-23 エフ. ホフマン-ラ ロシュ アーゲー 代替の抗原特異的抗体変異体を発見するための方法
TW202039554A (zh) * 2018-12-19 2020-11-01 瑞士商諾華公司 抗TNF-α抗體
CN114401988A (zh) * 2019-07-09 2022-04-26 国家生物技术研究所公司 具有降低的免疫原性的抗体
EP4037699A1 (fr) 2019-09-30 2022-08-10 SciRhom GmbH Liants protéiques à des épitopes d'irhom2
FR3104582A1 (fr) * 2019-12-17 2021-06-18 Commissariat A L'energie Atomique Et Aux Energies Alternatives Variants de l’adalimumab au potentiel immunogène réduit
CN113125714B (zh) * 2019-12-31 2023-06-16 科美博阳诊断技术(上海)有限公司 一种人类免疫缺陷病毒抗体检测试剂盒及其应用
WO2021147642A1 (fr) * 2020-01-20 2021-07-29 Bio-Thera Solutions, Ltd. Procédés, modèles et systèmes liés à l'immunogénicité d'anticorps
KR102568430B1 (ko) * 2020-11-16 2023-08-24 바디텍메드(주) 항 약물 항체의 신속 검출 방법
EP4301778A1 (fr) 2021-03-01 2024-01-10 SciRhom GmbH Anticorps humanisés contre irhom2
WO2022207652A1 (fr) 2021-03-29 2022-10-06 Scirhom Gmbh Méthodes de traitement utilisant des liants protéiques pour des épitopes irhom2
WO2022214664A1 (fr) 2021-04-09 2022-10-13 Philogen S.P.A. Mutant amélioré d'interféron-gamma
WO2024023246A1 (fr) 2022-07-28 2024-02-01 Philogen S.P.A. Anticorps se liant à pd1
WO2024033362A1 (fr) 2022-08-08 2024-02-15 Atb Therapeutics Anticorps humanisés dirigés contre cd79b

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Also Published As

Publication number Publication date
NZ705606A (en) 2018-05-25
HUE032569T2 (en) 2017-09-28
DK2897978T3 (en) 2017-05-15
KR20150056788A (ko) 2015-05-27
EP3211006A2 (fr) 2017-08-30
CN104704000A (zh) 2015-06-10
CY1118893T1 (el) 2018-01-10
HRP20170937T1 (hr) 2017-11-03
AU2013318147A1 (en) 2015-03-19
SG11201502094TA (en) 2015-04-29
EP2897978A2 (fr) 2015-07-29
MX2015003541A (es) 2015-10-26
US9279016B2 (en) 2016-03-08
PL2897978T3 (pl) 2017-08-31
JP2015537190A (ja) 2015-12-24
CA2885422A1 (fr) 2014-03-27
RU2015111671A (ru) 2016-11-10
IL237833A0 (en) 2015-05-31
WO2014047222A3 (fr) 2014-10-23
RU2648141C2 (ru) 2018-03-22
WO2014047222A2 (fr) 2014-03-27
PT2897978T (pt) 2017-05-22
RS56093B1 (sr) 2017-10-31
EP2897978B1 (fr) 2017-03-22
WO2014047222A9 (fr) 2014-06-26
SI2897978T1 (sl) 2017-05-31
EP3211006A3 (fr) 2017-11-08
HK1211306A1 (en) 2016-05-20
ES2621285T3 (es) 2017-07-03
US20140227251A1 (en) 2014-08-14
TW201418469A (zh) 2014-05-16
AU2013318147B2 (en) 2018-01-04
SMT201700255T1 (it) 2017-07-18
LT2897978T (lt) 2017-06-12
BR112015005857A2 (pt) 2017-08-08
TWI519646B (zh) 2016-02-01

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