IN2015DN00886A - - Google Patents
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- Publication number
- IN2015DN00886A IN2015DN00886A IN886DEN2015A IN2015DN00886A IN 2015DN00886 A IN2015DN00886 A IN 2015DN00886A IN 886DEN2015 A IN886DEN2015 A IN 886DEN2015A IN 2015DN00886 A IN2015DN00886 A IN 2015DN00886A
- Authority
- IN
- India
- Prior art keywords
- oxoisoindolin
- morpholinomethyl
- clathrate
- polymorph
- enantiomer
- Prior art date
Links
- IXZOHGPZAQLIBH-UHFFFAOYSA-N 3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N(C2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 IXZOHGPZAQLIBH-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Provided herein are methods of treating, preventing and/or managing cancers, which comprise administering to a patient 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl) piperidine-2,6- dione, or an enantiomer or a mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261681447P | 2012-08-09 | 2012-08-09 | |
| US201261722727P | 2012-11-05 | 2012-11-05 | |
| PCT/US2013/054055 WO2014025960A1 (en) | 2012-08-09 | 2013-08-08 | Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00886A true IN2015DN00886A (en) | 2015-06-12 |
Family
ID=49004013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN886DEN2015 IN2015DN00886A (en) | 2012-08-09 | 2013-08-08 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20140045843A1 (en) |
| EP (2) | EP2882442B1 (en) |
| JP (2) | JP6347782B2 (en) |
| KR (3) | KR102266510B1 (en) |
| CN (4) | CN114366746A (en) |
| AU (1) | AU2013299627C1 (en) |
| BR (1) | BR112015002285B1 (en) |
| CA (1) | CA2881116C (en) |
| CY (1) | CY1124622T1 (en) |
| DK (1) | DK2882442T3 (en) |
| EA (1) | EA029485B1 (en) |
| ES (1) | ES2881220T3 (en) |
| HK (1) | HK1211489A1 (en) |
| HR (1) | HRP20211243T1 (en) |
| HU (1) | HUE056127T2 (en) |
| IL (3) | IL288506B2 (en) |
| IN (1) | IN2015DN00886A (en) |
| LT (1) | LT2882442T (en) |
| MX (1) | MX367869B (en) |
| NI (1) | NI201500012A (en) |
| NZ (1) | NZ628078A (en) |
| PH (1) | PH12015500212A1 (en) |
| PL (1) | PL2882442T3 (en) |
| PT (1) | PT2882442T (en) |
| RS (1) | RS62201B1 (en) |
| SG (3) | SG10202108516PA (en) |
| SI (1) | SI2882442T1 (en) |
| SM (1) | SMT202100457T1 (en) |
| TW (2) | TWI723266B (en) |
| UA (1) | UA116544C2 (en) |
| WO (1) | WO2014025960A1 (en) |
| ZA (1) | ZA201500564B (en) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5645816B2 (en) | 2009-05-25 | 2014-12-24 | 国立大学法人東京工業大学 | Pharmaceutical composition comprising core factor related to proliferation and differentiation of central nerve cell |
| US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| ES2956743T3 (en) | 2010-02-11 | 2023-12-27 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising them and methods of use thereof |
| US9056852B2 (en) | 2011-03-28 | 2015-06-16 | Mei Pharma, Inc. | (Alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
| ES3013301T3 (en) | 2012-06-29 | 2025-04-11 | Celgene Corp | Methods for determining drug efficacy using ikzf3 (aiolos) |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| BR112015005243A2 (en) * | 2012-09-10 | 2017-07-04 | Celgene Corp | Methods For Treating Locally Advanced Breast Cancer |
| US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| US20160313300A1 (en) | 2013-12-06 | 2016-10-27 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| JP6640126B2 (en) | 2014-06-27 | 2020-02-05 | セルジーン コーポレイション | Compositions and methods for inducing conformational changes of cerebrons and other E3 ubiquitin ligases |
| JP2017538104A (en) * | 2014-10-07 | 2017-12-21 | セルジーン コーポレイション | Use of biomarkers to predict clinical sensitivity to cancer treatment |
| EP3352756A1 (en) * | 2015-09-25 | 2018-08-01 | Celgene Corporation | Methods for treating diffuse large b-cell lymphoma and the use of biomarkers as a predictor of responsiveness to drugs |
| WO2017117118A1 (en) | 2015-12-28 | 2017-07-06 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| KR102002581B1 (en) * | 2016-10-04 | 2019-07-22 | 주식회사 종근당 | Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer |
| US20180238886A1 (en) * | 2017-01-31 | 2018-08-23 | Celgene Corporation | Methods for treating hematological cancer and the use of biomarkers as a predictor for responsiveness to treatment compounds |
| AU2018269982B2 (en) * | 2017-05-16 | 2024-06-13 | Biomed Valley Discoveries, Inc. | Compositions and methods for treating cancer with atypical BRAF mutations |
| KR20200009088A (en) | 2017-05-23 | 2020-01-29 | 메이 파마, 아이엔씨. | Combination therapy |
| WO2019006299A1 (en) * | 2017-06-30 | 2019-01-03 | Celgene Corporation | Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-doxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide |
| WO2019014100A1 (en) * | 2017-07-10 | 2019-01-17 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| MA49921A (en) | 2017-08-14 | 2021-05-12 | Mei Pharma Inc | POLYTHERAPY |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| WO2019084434A1 (en) | 2017-10-26 | 2019-05-02 | National University Of Singapore | A new approach for universal monitoring of minimal residual disease in acute myeloid leukemia |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | IRAK joints and used in them |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| AU2019321526A1 (en) * | 2018-08-14 | 2021-03-25 | Mei Pharma, Inc. | Treatment of relapsed follicular lymphoma |
| KR102605291B1 (en) * | 2018-09-07 | 2023-11-23 | 메드샤인 디스커버리 아이엔씨. | Piperidione compounds substituted by tricyclic furan |
| MX2021003842A (en) * | 2018-10-01 | 2021-05-27 | Celgene Corp | COMBINED THERAPY FOR THE TREATMENT OF CANCER. |
| US12263190B2 (en) | 2018-11-08 | 2025-04-01 | Juno Therapeutics, Inc. | Methods and combinations for treatment and T cell modulation |
| CN113423427A (en) | 2018-11-30 | 2021-09-21 | 凯麦拉医疗公司 | IRAK degraders and their uses |
| BR112021019748A2 (en) | 2019-04-05 | 2021-12-07 | Kymera Therapeutics Inc | Stat degraders and their uses |
| AR119715A1 (en) * | 2019-04-12 | 2022-01-05 | Celgene Corp | METHODS TO TREAT NON-HODGKIN'S LYMPHOMA WITH THE USE OF 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORFOLINOAZETIDIN-1-IL)METHYL)BENZYL)AMINO) ISOINDOLIN-1,3-DIONE |
| EA039874B1 (en) * | 2019-06-06 | 2022-03-22 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Composition of pomalidomide for treatment of diseases associated with tumor necrosis factor (tnf) |
| CN114980918A (en) | 2019-11-07 | 2022-08-30 | 朱诺治疗学股份有限公司 | T cell therapy with (S)-3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl] - Combination of piperidine-2,6-diones |
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| AU2020412780A1 (en) | 2019-12-23 | 2022-07-21 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
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| KR20230027082A (en) * | 2020-06-25 | 2023-02-27 | 셀진 코포레이션 | Methods of treating cancer using combination therapy |
| CA3202360A1 (en) | 2020-12-30 | 2022-07-07 | Nello Mainolfi | Irak degraders and uses thereof |
| CA3207049A1 (en) | 2021-02-15 | 2022-08-18 | Jared Gollob | Irak4 degraders and uses thereof |
| CN117715904A (en) | 2021-05-07 | 2024-03-15 | 凯麦拉医疗公司 | CDK2 degraders and their uses |
| KR20240110592A (en) | 2021-10-29 | 2024-07-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | IRAK4 degrader and its synthesis |
| US12091411B2 (en) | 2022-01-31 | 2024-09-17 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2024015618A2 (en) * | 2022-07-15 | 2024-01-18 | St. Jude Children's Research Hospital, Inc. | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione/2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione analogs as modulators of cereblon protein |
| WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
| WO2025076472A1 (en) | 2023-10-06 | 2025-04-10 | Juno Therapeutics, Inc. | Combination therapies with a cell therapy expressing a gprc5d-targeting car and related methods and uses |
| WO2025120113A1 (en) | 2023-12-08 | 2025-06-12 | Celgene Corporation | Therapy for the treatment of multiple myeloma |
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-
2013
- 2013-08-08 HU HUE13751007A patent/HUE056127T2/en unknown
- 2013-08-08 CN CN202110936758.6A patent/CN114366746A/en active Pending
- 2013-08-08 RS RS20210904A patent/RS62201B1/en unknown
- 2013-08-08 EA EA201590345A patent/EA029485B1/en not_active IP Right Cessation
- 2013-08-08 US US13/962,776 patent/US20140045843A1/en not_active Abandoned
- 2013-08-08 MX MX2015001775A patent/MX367869B/en active IP Right Grant
- 2013-08-08 ES ES13751007T patent/ES2881220T3/en active Active
- 2013-08-08 PL PL13751007T patent/PL2882442T3/en unknown
- 2013-08-08 TW TW107117959A patent/TWI723266B/en active
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