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IN2014DN09826A - - Google Patents

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Publication number
IN2014DN09826A
IN2014DN09826A IN9826DEN2014A IN2014DN09826A IN 2014DN09826 A IN2014DN09826 A IN 2014DN09826A IN 9826DEN2014 A IN9826DEN2014 A IN 9826DEN2014A IN 2014DN09826 A IN2014DN09826 A IN 2014DN09826A
Authority
IN
India
Prior art keywords
psychiatric
schizophrenia
neurodegenerative
mammals
compounds
Prior art date
Application number
Inventor
Amy B Dounay
Jamison B Tuttle
Patrick R Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN2014DN09826A publication Critical patent/IN2014DN09826A/en

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/00—Drugs for disorders of the senses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)

Abstract

Compounds of Formula (I), wherein R1, R 2, X 1, Y1, Z1, and Z2, are as defined herein , and pharmaceutically acceptable salts thereof , are described as useful for the treatment of cognitive deficits associated with schizophrenia and other psychiatric, neurodegenerative and/or neurological disorders in mammals , including humans.
IN9826DEN2014 2012-06-15 2014-11-19 IN2014DN09826A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261660142P 2012-06-15 2012-06-15
PCT/IB2013/054570 WO2013186666A1 (en) 2012-06-15 2013-06-03 Tricyclic compounds as kat ii inhibitors

Publications (1)

Publication Number Publication Date
IN2014DN09826A true IN2014DN09826A (en) 2015-07-31

Family

ID=48875701

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9826DEN2014 IN2014DN09826A (en) 2012-06-15 2014-11-19

Country Status (15)

Country Link
US (1) US20150175603A1 (en)
EP (1) EP2861593A1 (en)
JP (1) JP2015523352A (en)
KR (1) KR20150007352A (en)
CN (1) CN104364253A (en)
AU (1) AU2013276165B2 (en)
BR (1) BR112014030507A2 (en)
CA (1) CA2874400A1 (en)
HK (1) HK1206734A1 (en)
IL (1) IL236241A0 (en)
IN (1) IN2014DN09826A (en)
MX (1) MX2014014808A (en)
RU (1) RU2014146509A (en)
SG (1) SG11201407389QA (en)
WO (1) WO2013186666A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106661017B (en) 2014-04-23 2019-09-24 田边三菱制药株式会社 Bicyclic or tricyclic heterocyclic compounds
CN106349241B (en) * 2015-07-15 2020-04-21 上海翰森生物医药科技有限公司 Triazole derivatives with HSP90 inhibitory activity and preparation method and application thereof
US10793582B2 (en) 2015-10-22 2020-10-06 Mitsubishi Tanabe Pharma Corporation Bicyclic heterocyclic compound
CA3106752A1 (en) 2018-07-20 2020-01-23 Grunenthal Gmbh Substituted triazolo quinoxaline derivatives
CN111196817B (en) * 2018-11-19 2021-06-11 四川大学华西医院 Tricyclic compounds as BRPF1 inhibitors
TWI880049B (en) * 2020-12-04 2025-04-11 美商美國禮來大藥廠 Kras g12c inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2316072B (en) * 1996-08-05 2000-05-10 Pharmacia Spa Pyrrolo[3,2-c]quinoline derivatives
ES2538386T3 (en) * 2009-06-18 2015-06-19 Pfizer Inc. Bicyclic and tricyclic compounds as inhibitors of KAT II
SG190246A1 (en) * 2010-12-01 2013-06-28 Pfizer Kat ii inhibitors

Also Published As

Publication number Publication date
MX2014014808A (en) 2015-02-12
RU2014146509A (en) 2016-08-10
CA2874400A1 (en) 2013-12-19
HK1206734A1 (en) 2016-01-15
SG11201407389QA (en) 2015-02-27
IL236241A0 (en) 2015-02-01
CN104364253A (en) 2015-02-18
BR112014030507A2 (en) 2017-06-27
AU2013276165A1 (en) 2014-11-27
KR20150007352A (en) 2015-01-20
AU2013276165B2 (en) 2015-07-16
WO2013186666A1 (en) 2013-12-19
US20150175603A1 (en) 2015-06-25
EP2861593A1 (en) 2015-04-22
JP2015523352A (en) 2015-08-13

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