IN2014DN07384A - - Google Patents

Info

Publication number: IN2014DN07384A
Authority: IN; India
Prior art keywords: compounds; disclosed; mediated; pyrimidinebased; pyrazolo
Prior art date: 2012-03-09

Application number

Other languages

English (en)

Inventor

Yingzhi Bi

Kenneth Gordon Carson

Giovanni Cianchetta

Michael Alan Green

Godwin Kumi

Alan Main

Yulian Zhang

Glenn Gregory Zipp

Original Assignee

Lexicon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-09

Filing date

2013-03-05

Publication date

2015-04-24

2013-03-05 Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc

2015-04-24 Publication of IN2014DN07384A publication Critical patent/IN2014DN07384A/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

IN7384DEN2014 2012-03-09 2013-03-05 IN2014DN07384A (he)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261608765P	2012-03-09	2012-03-09
PCT/US2013/029056 WO2013134228A1 (en)	2012-03-09	2013-03-05	PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE

Publications (1)

Publication Number	Publication Date
IN2014DN07384A true IN2014DN07384A (he)	2015-04-24

Family

ID=47892052

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN7384DEN2014 IN2014DN07384A (he)	2012-03-09	2013-03-05

Country Status (26)

Country	Link
US (3)	US8946415B2 (he)
EP (1)	EP2834243B1 (he)
JP (1)	JP6418950B2 (he)
KR (1)	KR101965025B1 (he)
CN (1)	CN104302649B (he)
AR (1)	AR090292A1 (he)
AU (1)	AU2013230128B2 (he)
BR (1)	BR112014022000A8 (he)
CA (1)	CA2866143C (he)
DK (1)	DK2834243T3 (he)
ES (1)	ES2676224T3 (he)
HK (1)	HK1201257A1 (he)
HU (1)	HUE038786T2 (he)
IL (1)	IL234486A (he)
IN (1)	IN2014DN07384A (he)
MX (2)	MX345830B (he)
NZ (1)	NZ630721A (he)
PL (1)	PL2834243T3 (he)
PT (1)	PT2834243T (he)
RU (1)	RU2014140735A (he)
SG (1)	SG11201405561RA (he)
TR (1)	TR201808280T4 (he)
TW (1)	TW201341386A (he)
UY (1)	UY34668A (he)
WO (1)	WO2013134228A1 (he)
ZA (1)	ZA201406149B (he)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2676224T3 (es)	2012-03-09	2018-07-17	Lexicon Pharmaceuticals, Inc.	Compuestos a base de pirazolo[1,5-a]pirimidina, composiciones que los comprenden y métodos para usarlos
MX347917B (es)	2012-03-09	2017-05-17	Lexicon Pharmaceuticals Inc	Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
US8901305B2 (en)	2012-07-31	2014-12-02	Bristol-Myers Squibb Company	Aryl lactam kinase inhibitors
CN105121445A (zh)	2013-02-22	2015-12-02	百时美施贵宝公司	作为连接蛋白相关激酶1(AAK1)抑制剂的5H-色烯并[3,4-c]吡啶
TW201542550A (zh) *	2013-09-06	2015-11-16	Lexicon Pharmaceuticals Inc	吡唑并［１，５－ａ］嘧啶基化合物、包含彼之組合物以及使用彼之方法
JP6473146B2 (ja)	2013-10-11	2019-02-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	ピロロトリアジンキナーゼ阻害剤
PL3572416T3 (pl)	2014-01-24	2023-02-27	Turning Point Therapeutics, Inc.	Diarylowe związki makrocykliczne jako modulatory kinaz białkowych
US9932320B2 (en) *	2014-01-31	2018-04-03	Bristol-Myers Squibb Company	Quinoline-based kinase inhibitors
TW201620911A (zh) *	2014-03-17	2016-06-16	雷西肯製藥股份有限公司	銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法
US20170239249A1 (en) *	2014-09-30	2017-08-24	Bristol-Myers Squibb Company	Quinazoline-based kinase inhibitors
FI3233863T3 (fi) *	2014-12-15	2024-07-10	Cmg Pharmaceutical Co Ltd	Fuusioidun renkaan sisältäviä heteroaryyliyhdisteitä ja niiden käyttö trk:n estäjinä
EP3292124B1 (en)	2015-04-10	2019-05-22	Bristol-Myers Squibb Company	6h-isochromeno[3,4-c]pyridines and benzo[c][1,7]naphthyridin-6-(5h)-ones as adaptor associated kinase 1 (aak1) inhibitors
CA2989327A1 (en)	2015-07-02	2017-01-05	Tp Therapeutics, Inc.	Chiral diaryl macrocycles as modulators of protein kinases
ES2979111T3 (es)	2015-07-06	2024-09-24	Turning Point Therapeutics Inc	Polimorfo de macrociclo de diarilo
ES2993492T3 (en)	2015-07-21	2025-01-02	Turning Point Therapeutics Inc	Chiral diaryl macrocycle and use thereof in the treatment of cancer
US10947239B2 (en)	2015-11-02	2021-03-16	Janssen Pharmaceutica Nv	[1,2,4]triazolo[1,5-a]pyrimidin-7-yl compound
US10689400B2 (en)	2016-07-28	2020-06-23	Turning Point Therapeutics, Inc.	Macrocycle kinase inhibitors
CN109937202B (zh)	2016-11-02	2022-12-30	詹森药业有限公司	作为pde2抑制剂的[1,2,4]三唑并[1,5-a]嘧啶化合物
ES2912264T3 (es)	2016-11-02	2022-05-25	Janssen Pharmaceutica Nv	Compuestos de [1,2,4]triazolo[1,5-a]pirimidina como inhibidores de PDE2
EP3535267B1 (en) *	2016-11-02	2020-12-30	Janssen Pharmaceutica NV	[1,2,4]triazolo[1,5-a]pyrimidine derivatives as pde2 inhibitors
TWI808958B (zh)	2017-01-25	2023-07-21	美商特普醫葯公司	涉及二芳基巨環化合物之組合療法
CN117946114A (zh)	2017-07-28	2024-04-30	武田药品工业株式会社	Tyk2抑制剂与其用途
SMT202400343T1 (it)	2017-07-28	2024-11-15	Turning Point Therapeutics Inc	Composti macrociclici e loro usi
PL3724191T3 (pl) *	2017-12-15	2022-04-25	Pyramid Biosciences, Inc.	Pochodne 5-(2-(2,5-difluorofenylo)pirolidyn-1-ylo)-3-(1h-pirazol-1-ilo)pirazolo[1,5-a]pirymidyny i pokrewne związki jako inhibitory kinaz trk do leczenia nowotworu
ES2929467T3 (es)	2017-12-19	2022-11-29	Turning Point Therapeutics Inc	Compuestos macrocíclicos para tratar enfermedades
WO2019120194A1 (zh) *	2017-12-22	2019-06-27	深圳市塔吉瑞生物医药有限公司	一种取代的吡唑并[1,5-a]嘧啶化合物及其药物组合物及用途
WO2019144885A1 (zh)	2018-01-23	2019-08-01	深圳市塔吉瑞生物医药有限公司	取代的吡唑并[1,5-a]嘧啶类的大环化合物
US20220041588A1 (en) *	2018-09-27	2022-02-10	Fochon Pharmaceuticals, Ltd.	Substituted imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine compounds as ret kinase inhibitors
WO2020081508A1 (en) *	2018-10-15	2020-04-23	Nimbus Lakshmi, Inc.	Tyk2 inhibitors and uses thereof
US11730723B2 (en)	2020-04-21	2023-08-22	Lexicon Pharmaceuticals, Inc.	Compounds and methods for treating viral infections
AU2021258128A1 (en) *	2020-04-21	2022-11-03	Lexicon Pharmaceuticals, Inc.	4-(3-(pyridin-3-yl)pyrazolo(1,5-a)pyrimidin-5-yl)piperazine for use in the the treatment of COV-229E or COV-OC43 coronaviruses infections
US11478733B2 (en)	2020-11-24	2022-10-25	Caterpillar Inc.	Filter interlock with tabs mating with a pedestal or a housing

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5464764A (en)	1989-08-22	1995-11-07	University Of Utah Research Foundation	Positive-negative selection methods and vectors
AU2515992A (en)	1991-08-20	1993-03-16	Genpharm International, Inc.	Gene targeting in animal cells using isogenic dna constructs
US6194410B1 (en) *	1998-03-11	2001-02-27	Hoffman-La Roche Inc.	Pyrazolopyrimidine and pyrazolines and process for preparation thereof
JP4847275B2 (ja) *	2005-10-21	2011-12-28	田辺三菱製薬株式会社	ピラゾロ［１，５−ａ］ピリミジン化合物
CN101516885A (zh)	2006-09-29	2009-08-26	诺瓦提斯公司	作为pi3k脂质激酶抑制剂的吡唑并嘧啶类化合物
US20120058997A1 (en) *	2006-11-06	2012-03-08	Supergen, Inc.	Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
EP2300469B1 (en) *	2008-05-13	2015-06-24	Novartis AG	Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors
SG10201900514RA (en) *	2008-10-22	2019-02-27	Array Biopharma Inc	Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
AR077468A1 (es) *	2009-07-09	2011-08-31	Array Biopharma Inc	Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US8865726B2 (en)	2009-09-03	2014-10-21	Array Biopharma Inc.	Substituted pyrazolo[1,5-a]pyrimidine compounds as mTOR inhibitors
EP2523552B1 (en)	2010-01-14	2015-05-13	Merck Sharp & Dohme Corp.	Pyrazolo[1,5-a]pyrimidines as mark inhibitors
EP3409278B8 (en) *	2011-07-21	2020-11-04	Sumitomo Dainippon Pharma Oncology, Inc.	Heterocyclic protein kinase inhibitors
MX347917B (es)	2012-03-09	2017-05-17	Lexicon Pharmaceuticals Inc	Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
ES2676224T3 (es)	2012-03-09	2018-07-17	Lexicon Pharmaceuticals, Inc.	Compuestos a base de pirazolo[1,5-a]pirimidina, composiciones que los comprenden y métodos para usarlos
PL2822555T3 (pl) *	2012-03-09	2018-04-30	Lexicon Pharmaceuticals Inc	Inhibicja związanej z adaptorem kinazy-1 dla leczenia bólu
TW201620911A (zh) *	2014-03-17	2016-06-16	雷西肯製藥股份有限公司	銜接子關聯激酶１之抑制劑、包含其之組成物、及其使用方法

2013
- 2013-03-05 ES ES13710250.5T patent/ES2676224T3/es active Active
- 2013-03-05 MX MX2014010589A patent/MX345830B/es active IP Right Grant
- 2013-03-05 IN IN7384DEN2014 patent/IN2014DN07384A/en unknown
- 2013-03-05 CN CN201380012483.0A patent/CN104302649B/zh active Active
- 2013-03-05 SG SG11201405561RA patent/SG11201405561RA/en unknown
- 2013-03-05 PT PT137102505T patent/PT2834243T/pt unknown
- 2013-03-05 PL PL13710250T patent/PL2834243T3/pl unknown
- 2013-03-05 HU HUE13710250A patent/HUE038786T2/hu unknown
- 2013-03-05 AU AU2013230128A patent/AU2013230128B2/en active Active
- 2013-03-05 EP EP13710250.5A patent/EP2834243B1/en active Active
- 2013-03-05 BR BR112014022000A patent/BR112014022000A8/pt not_active Application Discontinuation
- 2013-03-05 MX MX2017002117A patent/MX381849B/es unknown
- 2013-03-05 US US13/785,355 patent/US8946415B2/en active Active
- 2013-03-05 JP JP2014561024A patent/JP6418950B2/ja active Active
- 2013-03-05 RU RU2014140735A patent/RU2014140735A/ru not_active Application Discontinuation
- 2013-03-05 CA CA2866143A patent/CA2866143C/en active Active
- 2013-03-05 WO PCT/US2013/029056 patent/WO2013134228A1/en active Application Filing
- 2013-03-05 NZ NZ630721A patent/NZ630721A/en unknown
- 2013-03-05 DK DK13710250.5T patent/DK2834243T3/en active
- 2013-03-05 KR KR1020147028071A patent/KR101965025B1/ko active Active
- 2013-03-05 TR TR2018/08280T patent/TR201808280T4/tr unknown
- 2013-03-08 TW TW102108283A patent/TW201341386A/zh unknown
- 2013-03-11 AR ARP130100765A patent/AR090292A1/es unknown
- 2013-03-11 UY UY0001034668A patent/UY34668A/es not_active Application Discontinuation
2014
- 2014-08-21 ZA ZA2014/06149A patent/ZA201406149B/en unknown
- 2014-09-07 IL IL234486A patent/IL234486A/he active IP Right Grant
- 2014-09-11 US US14/483,898 patent/US9403832B2/en active Active
2015
- 2015-02-13 HK HK15101651.1A patent/HK1201257A1/xx unknown
2016
- 2016-07-12 US US15/207,677 patent/US20170129896A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2013230128B2 (en)	2017-08-17
PT2834243T (pt)	2018-08-01
CN104302649B (zh)	2017-06-23
MX381849B (es)	2025-03-13
PL2834243T3 (pl)	2018-09-28
MX2014010589A (es)	2014-09-18
US20170129896A1 (en)	2017-05-11
TR201808280T4 (tr)	2018-07-23
US9403832B2 (en)	2016-08-02
EP2834243B1 (en)	2018-04-25
DK2834243T3 (en)	2018-07-23
WO2013134228A1 (en)	2013-09-12
HUE038786T2 (hu)	2018-11-28
US8946415B2 (en)	2015-02-03
KR20140138864A (ko)	2014-12-04
RU2014140735A (ru)	2016-04-27
TW201341386A (zh)	2013-10-16
CA2866143A1 (en)	2013-09-12
BR112014022000A2 (pt)	2017-06-20
JP2015509535A (ja)	2015-03-30
AU2013230128A1 (en)	2014-09-25
MX345830B (es)	2017-02-17
CN104302649A (zh)	2015-01-21
EP2834243A1 (en)	2015-02-11
ZA201406149B (en)	2016-06-29
US20130253194A1 (en)	2013-09-26
IL234486A (he)	2016-10-31
AR090292A1 (es)	2014-11-05
KR101965025B1 (ko)	2019-04-02
BR112014022000A8 (pt)	2021-06-15
CA2866143C (en)	2020-08-04
SG11201405561RA (en)	2014-10-30
US20150183792A1 (en)	2015-07-02
NZ630721A (en)	2016-12-23
HK1201257A1 (en)	2015-08-28
ES2676224T3 (es)	2018-07-17
JP6418950B2 (ja)	2018-11-07
UY34668A (es)	2013-10-31

Publication	Publication Date	Title
IN2014DN07384A (he)	2015-04-24
MX347917B (es)	2017-05-17	Compuestos a base de imidazo[1,2-b]piridazina, composiciones que los comprenden, y metodos para su uso.
PH12013501758A1 (en)	2013-10-14	Pyrazolo [1,5-a] pyridines as trk inhibitors
NZ626937A (en)	2016-09-30	Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
MX370814B (es)	2020-01-08	Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
PH12015500988B1 (en)	2018-05-25	Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
CA2871471C (en)	2021-06-01	Dna-pk inhibitors
EA024842B9 (ru)	2017-08-31	Соединения в качестве модуляторов протеинкиназы pi3k
PL3808749T3 (pl)	2023-07-10	Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych
WO2014152029A3 (en)	2014-12-31	Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors
TN2013000325A1 (en)	2015-01-20	(1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases
MX2016003456A (es)	2017-05-25	Compuestos aminopirimidina sustituidos y metodos de uso.
PH12014501829A1 (en)	2014-11-10	Bicyclic pyrazinone derivatives
NZ629499A (en)	2016-05-27	Novel 3,5-disubstituted-3h-imidazo[4,5-b]pyridine and 3,5- disubstituted -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
NZ624063A (en)	2016-09-30	Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
MD20150023A2 (ro)	2015-07-31	Piridinone biciclice noi
NZ630170A (en)	2016-03-31	Tetrahydro-quinazolinone derivatives as tank and parp inhibitors
MX2014000964A (es)	2014-03-27	Derivados aza heterociclicos sustituidos.
MX340574B (es)	2016-07-13	Imidazo pirazinas.
WO2014035846A3 (en)	2015-06-25	Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use
UA111520C2 (uk)	2016-05-10	[1,2,4]триазолопіридини і їх застосування як інгібіторів фосфодіестерази