[go: up one dir, main page]

IN2014CN04470A - - Google Patents

Download PDF

Info

Publication number
IN2014CN04470A
IN2014CN04470A IN4470CHN2014A IN2014CN04470A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A IN 4470CHN2014 A IN4470CHN2014 A IN 4470CHN2014A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A
Authority
IN
India
Prior art keywords
ketoreductase polypeptides
preparation
present disclosure
making
methods
Prior art date
Application number
Inventor
Fabien Cabirol
Haibin Chen
Anupam Gohel
Steven J Collier
Derek Smith
Birgit Kosjek
Jacob Janey
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IN2014CN04470A publication Critical patent/IN2014CN04470A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds and polynucleotides vectors host cells and methods of making and using the ketoreductase polypeptides.
IN4470CHN2014 2011-11-18 2012-11-14 IN2014CN04470A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561665P 2011-11-18 2011-11-18
PCT/US2012/065046 WO2013074650A1 (en) 2011-11-18 2012-11-14 Biocatalysts for the preparation of hydroxy substituted carbamates

Publications (1)

Publication Number Publication Date
IN2014CN04470A true IN2014CN04470A (en) 2015-09-04

Family

ID=47295185

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4470CHN2014 IN2014CN04470A (en) 2011-11-18 2012-11-14

Country Status (8)

Country Link
US (8) US9139819B2 (en)
EP (1) EP2780448B1 (en)
CN (2) CN104053771B (en)
HU (1) HUE046089T2 (en)
IL (1) IL232621B (en)
IN (1) IN2014CN04470A (en)
SG (1) SG11201402401TA (en)
WO (1) WO2013074650A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
WO2013062881A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Process for making beta 3 agonists and intermediates
WO2013062878A1 (en) 2011-10-27 2013-05-02 Merck Sharp & Dohme Corp. Process for making beta 3 angonists and intermediates
IN2014CN04470A (en) 2011-11-18 2015-09-04 Codexis Inc
WO2014150633A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
DK2968269T3 (en) 2013-03-15 2019-10-07 Merck Sharp & Dohme PROCEDURE FOR PREPARING BETA-3 AGONISTS AND INTERMEDIATES
WO2016130412A1 (en) * 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN106011095B (en) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 Engineered ketoreductase polypeptide and method for preparing ezetimibe intermediate by using same
IL317220A (en) 2017-06-06 2025-01-01 Urovant Sciences Gmbh Use of vibegron to treat overactive bladder
US12357636B2 (en) 2018-12-05 2025-07-15 Urovant Sciences Gmbh Vibegron for the treatment of overactive bladder symptoms
CN109943543B (en) * 2019-03-28 2020-12-11 上海健康医学院 Alcohol dehydrogenase mutant and preparation method and application thereof
CN114410599B (en) * 2022-01-29 2023-08-18 浙江工业大学 Carbonyl reductase mutant and application thereof in preparation of rosuvastatin chiral intermediate
CN116814569B (en) * 2023-05-30 2025-07-25 华东理工大学 Alcohol dehydrogenase mutant with improved catalytic activity, genetically engineered bacterium and application thereof

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538867A (en) 1988-09-13 1996-07-23 Elf Aquitaine Process for the electrochemical regeneration of pyridine cofactors
JP3155107B2 (en) 1993-01-12 2001-04-09 ダイセル化学工業株式会社 Method for producing optically active 4-halo-3-hydroxybutyrate
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
CN1087725C (en) 1994-03-25 2002-07-17 同位素技术有限公司 Enhancement of the effect of drugs by deuteration
JPH08336393A (en) 1995-04-13 1996-12-24 Mitsubishi Chem Corp Process for producing optically active γ-substituted-β-hydroxybutyric acid ester
FI104465B (en) 1995-06-14 2000-02-15 Valio Oy Protein hydrolyzates for the treatment and prevention of allergies and their preparation and use
US5891685A (en) 1996-06-03 1999-04-06 Mitsubishi Chemical Corporation Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
US6342507B1 (en) 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
ATE314388T1 (en) 1997-10-08 2006-01-15 Isotechnika Inc DEUTERATED AND UNDEUTERATED CYCLOSPORINE ANALOGAS AND THEIR USE AS IMMUNOMODULATING AGENTS
DK1036198T3 (en) 1997-12-08 2013-01-02 California Inst Of Techn Method for Preparation of Polynucleotide and Polypeptide Sequences
US6495023B1 (en) 1998-07-09 2002-12-17 Michigan State University Electrochemical methods for generation of a biological proton motive force and pyridine nucleotide cofactor regeneration
DE19857302C2 (en) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Process for the enantioselective reduction of 3,5-dioxocarboxylic acids, their salts and esters
JP4221100B2 (en) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 Semiconductor device
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
EP1621613B1 (en) 1999-03-11 2009-04-22 Eastman Chemical Company Enzymatic reductions with dihydrogen via metal catalyzed cofactor regeneration
HUP0105331A3 (en) 1999-12-03 2005-10-28 Kaneka Corp Novel carbonyl reductase, gene thereof and method of using the same
EP1272967A2 (en) 2000-03-30 2003-01-08 Maxygen, Inc. In silico cross-over site selection
PL364577A1 (en) 2001-03-22 2004-12-13 Bristol-Myers Squibb Company Stereoselective reduction of substituted acetophenone
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
JP2007502124A (en) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド Improved ketoreductase polypeptides and related polynucleotides
JP2007502114A (en) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド Improved glucose dehydrogenase polypeptides and related polynucleotides
WO2005017141A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
WO2005018579A2 (en) 2003-08-11 2005-03-03 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
JP4394647B2 (en) 2003-12-02 2010-01-06 メルシャン株式会社 Method for producing optically active tetrahydrothiophene derivative and method for crystallizing optically active tetrahydrothiophene-3-ol
US7705036B2 (en) 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
US7393667B2 (en) 2005-05-31 2008-07-01 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
US7820421B2 (en) * 2007-02-08 2010-10-26 Codexis, Inc. Ketoreductases and uses thereof
US20090118130A1 (en) 2007-02-12 2009-05-07 Codexis, Inc. Structure-activity relationships
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
KR101586503B1 (en) 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 Ketoreductase polypeptides for the reduction of acetophenones
EP2203557B1 (en) 2007-09-28 2012-02-29 Codexis, Inc. Ketoreductase polypeptides and uses thereof
HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
PE20091825A1 (en) 2008-04-04 2009-12-04 Merck & Co Inc HYDROXIMETHYL PYRROLIDINES AS AGONISTS OF THE BETA 3 ADRENERGIC RECEPTOR
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US8288131B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8426178B2 (en) 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
SI2329014T1 (en) 2008-08-29 2015-01-30 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3š(5s)-5(4-fluorophenyl)-5-hydroxypentanoylć-4-phenyl-1,3-oxazolidin-2-one
ES2575560T3 (en) 2009-08-19 2016-06-29 Codexis, Inc. Cetorreductase polypeptides to prepare phenylephrine
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
IN2014CN04470A (en) 2011-11-18 2015-09-04 Codexis Inc

Also Published As

Publication number Publication date
US20150344850A1 (en) 2015-12-03
WO2013074650A1 (en) 2013-05-23
US10253303B2 (en) 2019-04-09
CN104053771B (en) 2016-11-09
US10851351B2 (en) 2020-12-01
US20190177702A1 (en) 2019-06-13
US12241093B2 (en) 2025-03-04
US20210071151A1 (en) 2021-03-11
US11713451B2 (en) 2023-08-01
US9422531B2 (en) 2016-08-23
US20160319247A1 (en) 2016-11-03
SG11201402401TA (en) 2014-06-27
HUE046089T2 (en) 2020-01-28
US9803178B2 (en) 2017-10-31
US20140322769A1 (en) 2014-10-30
IL232621B (en) 2019-10-31
EP2780448A1 (en) 2014-09-24
US10100287B2 (en) 2018-10-16
CN104053771A (en) 2014-09-17
US20180010100A1 (en) 2018-01-11
CN106479990A (en) 2017-03-08
US20240018489A1 (en) 2024-01-18
US20180371427A1 (en) 2018-12-27
CN106479990B (en) 2020-09-18
IL232621A0 (en) 2014-06-30
US9139819B2 (en) 2015-09-22
EP2780448B1 (en) 2019-09-11

Similar Documents

Publication Publication Date Title
IN2014CN04470A (en)
ZA201502433B (en) Methods of host cell modification
IL231171A0 (en) Rna engineered t cells for the treatment of cancer
AP3964A (en) Methods of processing lignocellulosic biomass
IN2014CN04586A (en)
IL237898A0 (en) Three-dimeensional cell culturing systems, methods of producing same and uses thereof
MX2013007853A (en) Polypeptides having cellobiohydrolase activity and polynucleotides encoding same.
MX337919B (en) Polypeptides having cellobiohydrolase activity and polynucleotides encoding same.
EP2861612A4 (en) Methods of preparing pluripotent stem cells
PL3070170T3 (en) Fermentation of co2 by using an electrical potential
MX337913B (en) Polypeptides having cellobiohydrolase activity and polynucleotides encoding same.
MX2014004598A (en) Alpha-amylase variants and polynucleotides encoding same.
SG10201510009YA (en) Methods of metabolic targeting cancer cells using chemo- and immunotherapy for treating cancer
MX2014004539A (en) Alpha-amylase variants and polynucleotides encoding same.
ZA201504408B (en) Solution formulations of engineered anti-il-23p19 antibodies
SG10201706813WA (en) Culture medium for proliferating stem cell, which contains sulfated compound
MX2014001594A (en) Polypeptides having cellulase activity and polynucleotides encoding same.
LT2817070T (en) Cosmetic compositions containing cloudberry cell culture preparation
WO2013011062A3 (en) Antagonistic antibodies against oscar
ZA201403104B (en) Process for the preparation of higher alcohols
HK1210436A1 (en) Novel cell compositions and methods
HK40022222B (en) Isolated discogenic cells, methods of using, and methods of preparing same from mammalian tissue
MY166897A (en) Stable compositions and methods for preparing the same
IL229242B (en) Allogeneic tumor cell vaccination
AU2012905250A0 (en) Uses of Bacopa monnieri extract