[go: up one dir, main page]

IN2014CN04037A - - Google Patents

Download PDF

Info

Publication number
IN2014CN04037A
IN2014CN04037A IN4037CHN2014A IN2014CN04037A IN 2014CN04037 A IN2014CN04037 A IN 2014CN04037A IN 4037CHN2014 A IN4037CHN2014 A IN 4037CHN2014A IN 2014CN04037 A IN2014CN04037 A IN 2014CN04037A
Authority
IN
India
Prior art keywords
sbhprovided
dihydropyrazino
isotopologues
methoxycyclohexyl
hydroxypropan
Prior art date
Application number
Inventor
Mahmoud S Assaf
Terrence Joseph Connolly
Angela Joubert James
Kevin Joseph Klopfer
William Wei Hwa Leong
Anil Menon
Amanda Nicole Miklos
Original Assignee
Signal Pharm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of IN2014CN04037A publication Critical patent/IN2014CN04037A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

tran)SbHProvided herein are compositions of 7 (6 (2 hydroxypropan 2 yl)pyridin 3 yl) l (( 4 methoxycyclohexyl) 3 4 dihydropyrazino[2 3 ]pyrazin 2( 1) one solid forms isotopologues and metabolites thereof and methods of their use for the treatment of a disease disorder or condition.
IN4037CHN2014 2011-12-02 2012-11-30 IN2014CN04037A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161566109P 2011-12-02 2011-12-02
US201261647288P 2012-05-15 2012-05-15
US201261653439P 2012-05-31 2012-05-31
US201261670419P 2012-07-11 2012-07-11
PCT/US2012/067172 WO2013082344A1 (en) 2011-12-02 2012-11-30 Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use

Publications (1)

Publication Number Publication Date
IN2014CN04037A true IN2014CN04037A (en) 2015-10-23

Family

ID=47324465

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4037CHN2014 IN2014CN04037A (en) 2011-12-02 2012-11-30

Country Status (24)

Country Link
US (1) US9403829B2 (en)
EP (1) EP2785325B1 (en)
JP (2) JP6076370B2 (en)
KR (1) KR102040997B1 (en)
CN (1) CN104093398B (en)
AU (1) AU2012304276B2 (en)
BR (1) BR112014013332B1 (en)
CA (2) CA3125862A1 (en)
CO (1) CO6990726A2 (en)
EA (1) EA026390B1 (en)
EC (1) ECSP14007473A (en)
ES (1) ES2694413T3 (en)
HK (1) HK1202052A1 (en)
IL (1) IL232827B (en)
IN (1) IN2014CN04037A (en)
MX (1) MX363034B (en)
MY (1) MY169749A (en)
NI (1) NI201400052A (en)
PE (1) PE20141696A1 (en)
PH (2) PH12014501230A1 (en)
SG (2) SG10201604558SA (en)
UA (1) UA114496C2 (en)
WO (1) WO2013082344A1 (en)
ZA (1) ZA201403865B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX373925B (en) 2011-10-19 2020-07-10 Signal Pharm Llc CANCER TREATMENT WITH TOR KINASE INHIBITORS.
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
NZ630467A (en) 2013-01-16 2017-02-24 Signal Pharm Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
WO2014172436A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
EP2986298A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Treatment of cancer with dihydropyrazino-pyrazines
CN111166751A (en) 2013-04-17 2020-05-19 西格诺药品有限公司 Pharmaceutical formulations, procedures, solid forms and methods of use of the compounds
SG10201708111YA (en) 2013-04-17 2017-11-29 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
EP2986299B1 (en) 2013-04-17 2023-03-29 Signal Pharmaceuticals, LLC 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one for treating glioblastoma multiforme
WO2014172429A1 (en) * 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer
US9358232B2 (en) 2013-04-17 2016-06-07 Signal Pharmaceuticals, Llc Methods for treating cancer using TOR kinase inhibitor combination therapy
MX374749B (en) 2013-04-17 2025-03-06 Signal Pharm Llc COMBINATION THERAPY INCLUDING A TOR KINASE INHIBITOR AND A CYTIDINE ANALOGUE TO TREAT CANCER.
CN113831345A (en) 2013-05-29 2021-12-24 西格诺药品有限公司 Pharmaceutical compositions of dihydropyrazinopyrazine compounds, solid forms thereof and their use
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
JP2017511367A (en) 2014-04-16 2017-04-20 シグナル ファーマシューティカルズ，エルエルシー 1-ethyl-7- (2-methyl-6- (1H-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino [2,3-b] pyrazine-2 Solid forms comprising (1H) -one and coforms, compositions thereof and methods of use
WO2015160882A1 (en) * 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
WO2015160868A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Methods for treating cancer using tor kinase inhibitor combination therapy
US9623028B2 (en) 2014-07-14 2017-04-18 Signal Pharmaceuticals, Llc Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
MX2019015731A (en) * 2017-06-22 2020-08-03 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection.
CN112409399B (en) * 2019-08-20 2022-06-28 德琪(浙江)医药科技有限公司 Preparation method of drug intermediate compound

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507866A (en) 1967-08-08 1970-04-21 Merck & Co Inc 1h - imidazo(4,5-b)pyrazin - 2 - one and processes for their preparation
US3567725A (en) 1968-11-20 1971-03-02 Merck & Co Inc Process for preparation of 1h-imidazo-(4,5-b)pyrazin-2-ones
US4317909A (en) 1980-03-24 1982-03-02 Sterling Drug Inc. Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones
US4294837A (en) 1980-03-28 1981-10-13 Sterling Drug Inc. 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]pyridine-2-thiones and their cardiotonic use
US4294836A (en) 1980-03-24 1981-10-13 Sterling Drug Inc. 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use
US4309537A (en) 1980-03-28 1982-01-05 Sterling Drug Inc. Production of imidazo[4,5-b]pyridin-2-ones or thiones
GB8709448D0 (en) 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
JPS63275582A (en) 1987-05-02 1988-11-14 Naade Kenkyusho:Kk Production of 1-aminoimidazo(4,5-b)pyridine derivative
DD262026A1 (en) 1987-07-10 1988-11-16 Akad Wissenschaften Ddr PROCESS FOR PREPARING 4-SUBSTITUTED 6- (PYRID-4-YL) -2,4-DIHYDRO-1H-IMIDAZO [4,5-B] PYRID-2-ONEN
FR2643903A1 (en) 1989-03-03 1990-09-07 Union Pharma Scient Appl NOVEL BENZIMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING SAME, SYNTHESIS INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, IN PARTICULAR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES, AND DUODENIAL ULCERS
US4963561A (en) 1990-02-28 1990-10-16 Sterling Drug Inc. Imidazopyridines, their preparation and use
TW274550B (en) 1992-09-26 1996-04-21 Hoechst Ag
DE19601627A1 (en) 1996-01-18 1997-07-24 Bayer Ag Cyclopentanopyridyl oxazolidinones containing heteroatoms
US6031105A (en) 1996-04-09 2000-02-29 Pfizer Inc Substituted pyridines
DK1017384T3 (en) 1997-09-26 2005-01-31 Zentaris Gmbh Azabenzimidazole-based compounds for modulating serine / threonine protein kinase function
ZA9810490B (en) 1997-12-03 1999-05-20 Dainippon Pharmaceutical Co 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
JP2003146987A (en) 1999-05-31 2003-05-21 Dainippon Pharmaceut Co Ltd 2-arylpurine-9-acetamide derivatives
JP3814125B2 (en) 1999-06-02 2006-08-23 大日本住友製薬株式会社 Pharmaceutical comprising 2-aryl-8-oxodihydropurine derivative
JP2002100363A (en) 2000-09-25 2002-04-05 Mitsubishi Chemicals Corp Battery and lithium secondary battery
JP2002167387A (en) 2000-11-29 2002-06-11 Dainippon Pharmaceut Co Ltd 2- (7,8-dihydro-8-oxo-9H-purin-9-yl) acetic acid derivative
BR0116113A (en) 2000-12-12 2004-08-03 Neurogen Corp Spiro [isobenzofuran-1,4'-piperidin] -3-ones and 3h-spiroisoben-zofuran-1,4'-piperidines
WO2002076954A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
BRPI0212137A2 (en) 2001-09-04 2016-06-28 Boehringer Ingelheim Pharma dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
EP1438048A1 (en) 2001-10-18 2004-07-21 Boehringer Ingelheim Pharmaceuticals Inc. 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors
US7247621B2 (en) 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
MXPA04010983A (en) 2002-05-06 2005-02-14 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis c virus infection.
US20040204420A1 (en) 2002-08-05 2004-10-14 Rana Tariq M. Compounds for modulating RNA interference
CA2502429A1 (en) 2002-10-31 2004-05-21 Amgen Inc. Antiinflammation agents
ATE433967T1 (en) 2003-01-17 2009-07-15 Warner Lambert Co 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION
KR100983462B1 (en) 2003-02-26 2010-09-27 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 Dihydrophteridinone, preparation method thereof and use thereof as medicament
GB2400101A (en) 2003-03-28 2004-10-06 Biofocus Discovery Ltd Compounds capable of binding to the active site of protein kinases
AU2004232308A1 (en) 2003-04-23 2004-11-04 Wyeth Holdings Corporation PEG-wortmannin conjugates
EP2345661A1 (en) 2003-05-30 2011-07-20 Pharmasset, Inc. Modified fluorinated nucleoside analogues
DE602004026053D1 (en) 2003-06-26 2010-04-29 Merck Sharp & Dohme
WO2005120511A1 (en) 2004-06-04 2005-12-22 Icos Corporation Methods for treating mast cell disorders
DE102004029784A1 (en) 2004-06-21 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Novel 2-Benzylaminodihydropteridinones, process for their preparation and their use as medicaments
WO2006001266A1 (en) 2004-06-23 2006-01-05 Banyu Pharmaceutical Co., Ltd. Method for producing 2-arylpurine derivative
GB0420719D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
CN101065016A (en) 2004-09-24 2007-10-31 詹森药业有限公司 Imidazo{4,5-b}pyrazinone inhibitors of protein kinases
US7855205B2 (en) 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
EP1807430B1 (en) 2004-10-29 2014-07-23 Janssen R&D Ireland Hiv inhibiting bicyclic pyrimidine derivatives
SE0403006D0 (en) 2004-12-09 2004-12-09 Biovitrum Ab New compounds
US7767687B2 (en) 2004-12-13 2010-08-03 Biogen Idec Ma Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
DK1853588T3 (en) 2005-02-16 2008-09-15 Astrazeneca Ab Chemical compounds
WO2006091737A1 (en) 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
EP1877388A2 (en) * 2005-02-25 2008-01-16 Kudos Pharmaceuticals Ltd Hydrazinomethyl, hydrazonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents
RU2007140903A (en) 2005-04-05 2009-05-20 Фармакопия, Инк. (Us) PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPRESSION
CA2629714A1 (en) * 2005-11-14 2007-05-24 Ariad Gene Therapeutics, Inc. Administration of an mtor inhibitor to treat patients with cancer
US20090281075A1 (en) 2006-02-17 2009-11-12 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
ES2439590T3 (en) 2006-08-02 2014-01-23 Cytokinetics, Inc. Certain chemical entities, compositions and methods
US20100144738A1 (en) 2006-09-05 2010-06-10 William Bornmann Inhibitors of c-met and uses thereof
CA2662677C (en) 2006-09-05 2016-05-31 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
US7902187B2 (en) 2006-10-04 2011-03-08 Wyeth Llc 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
CL2007002866A1 (en) 2006-10-04 2008-07-04 Pharmacopeia Inc COMPOUNDS DERIVED FROM 6-SUBSTITUTES-2- (BENCIMIDAZOLIL) PURINA AND PURINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND IN THE TREATMENT OF AUTOIMMUNE DISEASES, INFLAMMATORY DISEASE, DISEASE MEDIATED BY M
MX337906B (en) * 2006-10-19 2016-03-28 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors.
BRPI0717773A2 (en) 2006-10-19 2013-11-05 Signal Pharm Llc COMPOUND, PHARMACEUTICAL COMPOSITION, AND METHODS FOR TREATING OR PREVENTING CANCER, AN INFLAMMATORY CONDITION, IMMUNOLOGICAL CONDITION OR METHODOLOGICAL CONDITION, AND FOR INHIBITING A KINASE IN A CELL EXPRESSING DITA KINASE
JP2011507910A (en) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター Methods for changing the lifetime of eukaryotes
US8110578B2 (en) * 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
AU2009324894B2 (en) 2008-11-25 2015-04-09 University Of Rochester MLK inhibitors and methods of use
JP2013508456A (en) * 2009-10-26 2013-03-07 シグナル ファーマシューティカルズ， エルエルシー Methods for synthesizing and purifying heteroaryl compounds
AU2011212927B2 (en) 2010-02-03 2014-10-09 Signal Pharmaceuticals, Llc Identification of LKB1 mutation as a predictive biomarker for sensitivity to TOR kinase inhibitors

Also Published As

Publication number Publication date
SG11201402766UA (en) 2014-06-27
EA201491083A1 (en) 2014-11-28
CA3125862A1 (en) 2013-06-06
JP2015500236A (en) 2015-01-05
PH12015501707B1 (en) 2017-01-16
AU2012304276A1 (en) 2013-06-20
CA2857155A1 (en) 2013-06-06
KR102040997B1 (en) 2019-11-27
MX363034B (en) 2019-03-06
IL232827B (en) 2018-07-31
PE20141696A1 (en) 2014-11-08
MX2014006590A (en) 2014-07-11
CA2857155C (en) 2021-09-21
HK1202052A1 (en) 2015-09-18
IL232827A0 (en) 2014-07-31
CO6990726A2 (en) 2014-07-10
CN104093398A (en) 2014-10-08
MY169749A (en) 2019-05-15
NI201400052A (en) 2015-01-12
US20130142873A1 (en) 2013-06-06
BR112014013332B1 (en) 2022-09-06
KR20140098831A (en) 2014-08-08
EP2785325A1 (en) 2014-10-08
AU2012304276B2 (en) 2015-01-15
JP6076370B2 (en) 2017-02-08
CN104093398B (en) 2017-03-15
UA114496C2 (en) 2017-06-26
SG10201604558SA (en) 2016-07-28
JP2017048227A (en) 2017-03-09
EA201491083A8 (en) 2015-02-27
WO2013082344A1 (en) 2013-06-06
ZA201403865B (en) 2015-11-25
PH12015501707A1 (en) 2017-01-16
US9403829B2 (en) 2016-08-02
ES2694413T3 (en) 2018-12-20
PH12014501230B1 (en) 2014-09-08
PH12014501230A1 (en) 2014-09-08
ECSP14007473A (en) 2015-11-30
BR112014013332A2 (en) 2017-06-13
EP2785325B1 (en) 2018-08-22
NZ625511A (en) 2016-03-31
EA026390B1 (en) 2017-04-28
NZ711123A (en) 2016-06-24

Similar Documents

Publication Publication Date Title
IN2014CN04037A (en)
MX370814B (en) Substituted pyrazolo[3,4-d]pyrimidines and uses thereof.
PH12013502230A1 (en) Multispecific antibodies
TN2013000378A1 (en) Anti - sclerostin antibody crystals and formulations thereof
MX2011007930A (en) Crystalline insulin-conjugates.
AU2010233994A8 (en) Bispecific anti-ErbB-3/anti-c-Met antibodies
TR201813877T4 (en) COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY.
MX2013008850A (en) Compositions and methods for treating cardiovascular diseases.
PH12014502010A1 (en) Bispecific antibodies against human tweak and human il17 and uses thereof
MX2014002053A (en) Anti-mcsp antibodies.
MX355728B (en) Kinase inhibitors.
MX2010006576A (en) Compositions and methods for producing isoprene.
MX355543B (en) Peptidomimetic macrocycles.
EA201391602A1 (en) CONTROLLED EMISSION OF IMMUNODPRESSANTS FROM SYNTHETIC NANO MEDIA
MY178142A (en) Anti-phf-tau antibodies and their uses
WO2015001504A3 (en) Antibody formulations and methods
WO2012173846A3 (en) Peptidomimetic macrocycles
WO2013059530A3 (en) Peptidomimetic macrocycles
WO2012166626A8 (en) Reagents and methods for treating dental disease
PH12014500904B1 (en) Antibody formulations and methods
AU2012209332A8 (en) Methods and compositions for preparing noribogaine from voacangine
IN2014CN03597A (en)
MX370253B (en) Compositions of jasmonate compounds and methods of use.
IN2014CN04050A (en)
WO2013023151A3 (en) Compositions and methods for treating celiac sprue disease