[go: up one dir, main page]

IN2014CN00961A - - Google Patents

Info

Publication number
IN2014CN00961A
IN2014CN00961A IN961CHN2014A IN2014CN00961A IN 2014CN00961 A IN2014CN00961 A IN 2014CN00961A IN 961CHN2014 A IN961CHN2014 A IN 961CHN2014A IN 2014CN00961 A IN2014CN00961 A IN 2014CN00961A
Authority
IN
India
Prior art keywords
compounds
intended
lsd1
methods
compositions
Prior art date
Application number
Inventor
Hariprasad Vankayalapati
Venkataswamy Sorna
Steve L Warner
David J Bearss
Sunil Sharma
Bret Stephens
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Publication of IN2014CN00961A publication Critical patent/IN2014CN00961A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

In one aspect the invention relates to substituted (E) N (1 phenylethylidene)benzohydrazide analogs derivatives thereof and related compounds which are useful as inhibitors of lysine specific histone demethylase including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
IN961CHN2014 2011-08-15 2012-08-15 IN2014CN00961A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161523801P 2011-08-15 2011-08-15
PCT/US2012/050948 WO2013025805A1 (en) 2011-08-15 2012-08-15 Substituted (e)-n'-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhiitors

Publications (1)

Publication Number Publication Date
IN2014CN00961A true IN2014CN00961A (en) 2015-04-10

Family

ID=47715455

Family Applications (1)

Application Number Title Priority Date Filing Date
IN961CHN2014 IN2014CN00961A (en) 2011-08-15 2012-08-15

Country Status (26)

Country Link
US (2) US8987335B2 (en)
EP (1) EP2744330B1 (en)
JP (1) JP6122006B2 (en)
KR (1) KR101983537B1 (en)
CN (1) CN103929960B (en)
AU (1) AU2012296639B2 (en)
BR (1) BR112014003382B1 (en)
CA (1) CA2843609C (en)
CY (1) CY1123345T1 (en)
DK (1) DK2744330T3 (en)
EA (1) EA026389B1 (en)
ES (1) ES2821548T3 (en)
HK (1) HK1200052A1 (en)
HR (1) HRP20201433T1 (en)
HU (1) HUE050962T2 (en)
IL (1) IL230728A (en)
IN (1) IN2014CN00961A (en)
LT (1) LT2744330T (en)
MX (1) MX356486B (en)
PL (1) PL2744330T3 (en)
PT (1) PT2744330T (en)
SG (1) SG2014009609A (en)
SI (1) SI2744330T1 (en)
SM (1) SMT202000551T1 (en)
WO (1) WO2013025805A1 (en)
ZA (1) ZA201400881B (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266838B2 (en) 2011-08-15 2016-02-23 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
CN107434803B (en) 2012-10-02 2020-05-05 吉利德科学公司 Inhibitors of histone demethylases
ES2670864T3 (en) * 2013-02-27 2018-06-01 Gilead Sciences, Inc. Histone Demethylase Inhibitors
JP6320506B2 (en) * 2013-03-12 2018-05-09 セルジーン クオンティセル リサーチ，インク． Histone demethylase inhibitor
ES2739814T3 (en) * 2013-06-19 2020-02-04 Univ Utah Res Found Compounds of (3- (5-Chloro-2-hydroxyphenyl) -1-benzoyl-1H-pyrazole substituted as histone demethylase inhibitors
SMT201900620T1 (en) 2014-02-13 2020-01-14 Incyte Corp Cyclopropylamines as lsd1 inhibitors
EP3392244A1 (en) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
PL3105218T3 (en) 2014-02-13 2020-03-31 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US10807944B2 (en) 2014-04-04 2020-10-20 University Of Florida Research Foundation, Inc. HDAC inhibitor compounds and methods of treatment
WO2015188130A1 (en) * 2014-06-05 2015-12-10 The University Of Kansas Marmelin analogs and methods of use in cancer treatment
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
AR101692A1 (en) 2014-08-27 2017-01-04 Epitherapeutics Aps COMPOUNDS AND METHODS TO INHIBIT HISTONES DEMETILASAS
EP2993175A1 (en) 2014-09-05 2016-03-09 IEO - Istituto Europeo di Oncologia Srl Thienopyrroles as histone demethylase inhibitors
CN106146361A (en) * 2015-03-16 2016-11-23 四川大学 Indenes-1-subunit sulfonyl benzoyl hydrazine derivant and its production and use
ES2757948T3 (en) 2015-04-03 2020-04-30 Incyte Corp Heterocyclic compounds as LSD1 inhibitors
KR20180011331A (en) 2015-06-12 2018-01-31 오리존 지노믹스 에스.에이. Biomarkers associated with LSDl inhibitors and uses thereof
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
AU2016306555B2 (en) 2015-08-12 2021-01-28 Incyte Holdings Corporation Salts of an LSD1 inhibitor
WO2017157825A1 (en) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinations of lsd1 inhibitors for use in the treatment of solid tumors
EP3430015A1 (en) 2016-03-16 2019-01-23 Oryzon Genomics, S.A. Methods to determine kdm1a target engagement and chemoprobes useful therefor
IL262488B (en) 2016-04-22 2022-08-01 Incyte Corp Formulations of an lsd1 inhibitor
EP3246330A1 (en) 2016-05-18 2017-11-22 Istituto Europeo di Oncologia S.r.l. Imidazoles as histone demethylase inhibitors
US11427543B2 (en) 2016-07-19 2022-08-30 The General Hospital Corporation Compounds for targeting cancer stem cells
EP3535414A1 (en) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Pharmacodynamic biomarkers for personalized cancer care using epigenetic modifying agents
EP3535420A1 (en) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Biomarkers for determining responsiveness to lsd1 inhibitors
WO2018106984A1 (en) 2016-12-09 2018-06-14 Constellation Pharmaceuticals, Inc. Markers for personalized cancer treatment with lsd1 inhibitors
CN106831489B (en) * 2017-03-23 2018-04-17 郑州大学 Tranylcypromine acylhydrazone, preparation method and applications
SI3661510T1 (en) 2017-08-03 2025-03-31 Oryzon Genomics, S.A. Methods of treating behavior alterations
EP3668877B1 (en) 2017-08-18 2024-05-01 Istituto Europeo di Oncologia S.r.l. Indole derivatives as histone demethylase inhibitors
WO2019068326A1 (en) 2017-10-05 2019-04-11 Université D'aix-Marseille Lsd1 inhibitors for the treatment and prevention of cardiomyopathies
ES2910071T3 (en) 2018-03-08 2022-05-11 Incyte Corp Aminopyrazine diol compounds as PI3K-Y inhibitors
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
CN109793742A (en) * 2019-03-04 2019-05-24 四川大学华西医院 A pharmaceutical compound application
CN109758442B (en) * 2019-03-20 2021-08-17 武汉大学 Application of diarylhydrazide compounds in the preparation of anti-influenza virus drugs
CA3130638A1 (en) 2019-03-20 2020-09-24 Oryzon Genomics, S.A. Methods of treating borderline personality disorder
EP3941465A1 (en) 2019-03-20 2022-01-26 Oryzon Genomics, S.A. Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
CN114341366A (en) 2019-07-05 2022-04-12 奥莱松基因组股份有限公司 Biomarkers and methods for personalized treatment of small cell lung cancer using KDM1A inhibitors
WO2022020804A1 (en) * 2020-07-24 2022-01-27 Salarius Pharmaceuticals Llc Methods of inhibiting lysine-specific demethylase 1 (lsd-1)
EP3964204A1 (en) 2020-09-08 2022-03-09 Université d'Aix-Marseille Lsd1 inhibitors for use in the treatment and prevention of fibrosis of tissues
BR112023020554A2 (en) 2021-04-08 2023-12-05 Oryzon Genomics Sa LSD1 INHIBITOR COMBINATIONS FOR THE TREATMENT OF MYELOID CANCERS
WO2023217758A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
WO2023217784A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
CN116077661B (en) * 2022-08-22 2024-09-27 沈阳药科大学 Use of KDM1A inhibitors in the preparation of drugs for treating DNMT3A gene-deficient cancers
WO2024110649A1 (en) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070464A2 (en) * 2001-01-22 2002-09-12 Arpida Ag Hydrazones and their therapeutic use
JP2002302472A (en) * 2001-01-31 2002-10-18 Meiji Seika Kaisha Ltd Maillard reaction inhibitor
EP1649852A1 (en) 2003-07-16 2006-04-26 Institute of Medicinal Molecular Design, Inc. Chromatosis remedies
WO2006136008A1 (en) 2005-05-24 2006-12-28 University Health Network Salicylic acid hydrazones as inhibitors of the erk mapkinase pathway and for the treatment of cancer
TW200800145A (en) * 2005-08-26 2008-01-01 Dekk Tec Inc Hydrazone agents to treat cutaneous lesions
JP2009514878A (en) 2005-11-03 2009-04-09 レッドポイント バイオ コーポレイション Hydrazine derivatives and uses thereof
US8338464B2 (en) 2006-11-30 2012-12-25 Albert Einstein College Of Medicine Of Yeshiva University Small molecule inhibitors of BCL6
US8193168B2 (en) 2007-02-02 2012-06-05 Redpoint Bio Corporation Use of a TRPM5 inhibitor to regulate insulin and GLP-1 release
BRPI0809498A2 (en) * 2007-04-02 2014-09-23 Inst Oneworld Health CFTR INHIBITOR COMPOUNDS AND THEIR USES
EP2195029A2 (en) * 2007-08-24 2010-06-16 Oryzon Genomics SA Treatment and prevention of neurodegenerative diseases
AR070898A1 (en) * 2008-03-18 2010-05-12 Solvay Pharm Bv ARILSULFONIL PIRAZOLIN CARBOXAMIDINE DERIVATIVES AS 5-HT6 ANTAGONISTS
JP2011526925A (en) 2008-07-01 2011-10-20 ザカロン ファーマシューティカルズ，インク． Heparan sulfate inhibitor
US20120010075A1 (en) * 2009-01-14 2012-01-12 Dow Agrosciences Llc Synergistic fungicidal compositions including hydrazone derivatives and copper
US20110189306A1 (en) * 2010-01-13 2011-08-04 Norbert Kartner COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES

Also Published As

Publication number Publication date
NZ621078A (en) 2015-10-30
KR101983537B1 (en) 2019-05-29
SMT202000551T1 (en) 2020-11-10
IL230728A0 (en) 2014-03-31
IL230728A (en) 2017-05-29
PL2744330T3 (en) 2020-12-14
CA2843609A1 (en) 2013-02-21
CN103929960B (en) 2016-08-17
EP2744330A1 (en) 2014-06-25
US8987335B2 (en) 2015-03-24
ES2821548T3 (en) 2021-04-26
MX356486B (en) 2018-05-30
CA2843609C (en) 2020-12-08
ZA201400881B (en) 2015-07-29
BR112014003382A2 (en) 2017-11-21
SI2744330T1 (en) 2020-11-30
BR112014003382B1 (en) 2022-03-15
EP2744330A4 (en) 2015-03-25
JP6122006B2 (en) 2017-04-26
KR20140077887A (en) 2014-06-24
MX2014001842A (en) 2014-07-24
EA201490453A1 (en) 2014-09-30
HRP20201433T1 (en) 2020-12-11
EP2744330B1 (en) 2020-07-15
LT2744330T (en) 2020-10-26
AU2012296639A1 (en) 2014-03-06
HK1200052A1 (en) 2015-07-31
HUE050962T2 (en) 2021-01-28
DK2744330T3 (en) 2020-09-07
CN103929960A (en) 2014-07-16
JP2014527531A (en) 2014-10-16
US20150150864A1 (en) 2015-06-04
AU2012296639B2 (en) 2016-06-09
US9555024B2 (en) 2017-01-31
SG2014009609A (en) 2014-05-29
WO2013025805A1 (en) 2013-02-21
US20140094445A1 (en) 2014-04-03
EA026389B1 (en) 2017-04-28
PT2744330T (en) 2020-10-01
CY1123345T1 (en) 2022-03-24

Similar Documents

Publication Publication Date Title
IN2014CN00961A (en)
WO2014194280A8 (en) Novel suicidal lsd1 inhibitors targeting sox2-expressing cancer cells
CY1122556T1 (en) SUBSTITUTED N-PHENYLPYRIMIDINE-2-AMINE ANALOGS AS AXL KINASE INHIBITORS
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
WO2013170072A3 (en) Compounds for the treatment of neurological disorders
WO2012118563A3 (en) 6-alkyl-n-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mglur5 negative allosteric modulators and methods of making and using the same
EA201890086A1 (en) 1,4-substituted derivatives of piperidine
EA201691401A1 (en) INDASOLIC COMPOUNDS AS IRAK4 INHIBITORS
AR084433A1 (en) FAAH INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA201691428A1 (en) BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS
EA201391230A1 (en) COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
MX2013009393A (en) Chroman - spirocyclic piperidine amides as modulators of ion channels.
CL2016003301A1 (en) Substituted amino- (pyridine-4-carboxylic acid) derivative compounds, histone demethylase inhibitors; pharmaceutical composition, comprising them, useful in the treatment of cancer, such as prostate, breast, bladder, lung and / or melanoma cancer.
CA2818187C (en) Bromodomain inhibitors and uses thereof
MX2013008902A (en) Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels.
MX2009013169A (en) Benzamide mglur5 positive allosteric modulators and methods of making and using same.
MX350862B (en) Piperidinyl naphthylacetic acids.
MX2014014253A (en) Novel ring-substituted n-pyridinyl amides as kinase inhibitors.
CL2013003484A1 (en) Compounds derived from n- (4-morpholin-2-yl) phenyl) -1h-pyrazole- (3 or 5) -carboxamide or n- (4-piperidin-3-yl) phenyl) -1h-pyrazole- (3 or 5) -carboxamide related to receptors associated with taar1; preparation procedure; Pharmaceutical composition and use in the treatment and / or prophylaxis of diseases such as depression, bipolar disorder, Alzheimer's and Parkinson's, among others.
PE20150224A1 (en) NAMPT INHIBITORS
ECSP14030538A (en) BRIDGE HEAD CYCLIC ETHER DGAT1 INHIBITORS
EA201490152A1 (en) TRPM8 ANTAGONISTS AND THEIR APPLICATION IN TREATMENT
MD20160105A2 (en) 2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
EP2575461A4 (en) SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5-POSITIVE ALLOSTERIC MODULATORS
WO2013006734A8 (en) Substituted 4-phenoxyphenol analogs as modulators of proliferating cell nuclear antigen activity