IN2013MN01890A - - Google Patents
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- Publication number
- IN2013MN01890A IN2013MN01890A IN1890MUN2013A IN2013MN01890A IN 2013MN01890 A IN2013MN01890 A IN 2013MN01890A IN 1890MUN2013 A IN1890MUN2013 A IN 1890MUN2013A IN 2013MN01890 A IN2013MN01890 A IN 2013MN01890A
- Authority
- IN
- India
- Prior art keywords
- plasma
- factor
- deficient
- coagulation
- factors
- Prior art date
Links
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 3
- 239000003114 blood coagulation factor Substances 0.000 abstract 3
- 230000002950 deficient Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
- 108010094028 Prothrombin Proteins 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 2
- 229940127219 anticoagulant drug Drugs 0.000 abstract 2
- 229910052791 calcium Inorganic materials 0.000 abstract 2
- 239000011575 calcium Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000015271 coagulation Effects 0.000 abstract 2
- 238000005345 coagulation Methods 0.000 abstract 2
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 108010014173 Factor X Proteins 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- 102000009123 Fibrin Human genes 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A method of measuring the combined activity of both and only coagulation factors II and X for the purpose of monitoring anticoagulant therapy and kits for using the method. This is based on the hypothesis that the combined activity of factor II and factor X (FII and FX) more accurately reflects clottability and the antithrombotic effect of VKA anticoagulants in patients than conventional methods (eg PT P&P). The method involves mixing of test plasma from a human to be tested with specially prepared plasma deficient in both and only coagulation factors II and X but with normal levels of other factors (referred to herein as Fiix deficient plasma pr Fiix plasma) in order to correct for any possible deficiency in other coagulation factors than FII and FX in the test sample. By adding a coagulation reagent and calcium the generation of thrombin or fibrin can be measured. Kits of the invention comprise a coagulation reagent calcium and specially made plasma that is deficient in both and only factor II and factor FX. The kit components are suitably lyophilised.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS050010A IS2809B (en) | 2011-03-08 | 2011-03-08 | Method for monitoring anticoagulant therapy |
| PCT/IS2012/050005 WO2012120546A2 (en) | 2011-03-08 | 2012-03-08 | Method for monitoring anticoagulant therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MN01890A true IN2013MN01890A (en) | 2015-09-25 |
Family
ID=46682867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1890MUN2013 IN2013MN01890A (en) | 2011-03-08 | 2012-03-08 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9234902B2 (en) |
| EP (1) | EP2684056B1 (en) |
| CN (1) | CN103534595B (en) |
| DK (1) | DK2684056T3 (en) |
| ES (1) | ES2636318T3 (en) |
| IN (1) | IN2013MN01890A (en) |
| IS (1) | IS2809B (en) |
| RU (1) | RU2607658C2 (en) |
| WO (1) | WO2012120546A2 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11181534B2 (en) | 2014-04-04 | 2021-11-23 | Bloodworks | Routine laboratory and point-of-care (POC) testing for hemostasis |
| WO2015171116A1 (en) * | 2014-05-05 | 2015-11-12 | Haemonetics Corporation | Methodologies and reagents for detecting fibrinolysis and hyperfibrinolysis |
| SE540132C2 (en) * | 2014-05-22 | 2018-04-10 | Zafena Ab | Method of analysis for the determination of anticoagulants in blood or blood plasma |
| CN110822822B (en) | 2014-06-09 | 2021-08-24 | 泰尔茂比司特公司 | Freeze drying |
| JP6871673B2 (en) * | 2015-03-31 | 2021-05-12 | 学校法人東日本学園 | Methods, devices and computer programs for determining blood samples, and blood sample analyzers |
| JP6147945B2 (en) * | 2015-04-24 | 2017-06-14 | 公立大学法人奈良県立医科大学 | Method for evaluating coagulation ability of blood sample, and reagent, reagent kit and apparatus for use in the method |
| WO2017119508A1 (en) * | 2016-01-07 | 2017-07-13 | 藤森工業株式会社 | Blood collection tube, reagent, and method for analyzing blood characteristics using same |
| RU2655302C1 (en) * | 2017-05-15 | 2018-05-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Method for predicting the efficiency of anticoagulant therapy in patients with atrial fibrillation, who have suffered a stroke |
| RU2660706C1 (en) * | 2017-09-26 | 2018-07-09 | федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр профилактической медицины" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ПМ" Минздрава России) | Screening-test of determining coagulation contact way (stokpk) |
| CN111295094A (en) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | Freeze-drying container and method for using freeze-drying container |
| CN109459420B (en) * | 2018-12-29 | 2021-06-04 | 华南师范大学 | Method for detecting di/ferric iron ions in water body |
| JP7495426B2 (en) | 2019-03-14 | 2024-06-04 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | Filling tool for freeze-drying containers, system and method of use |
| CN110361531B (en) * | 2019-08-02 | 2023-04-11 | 天津医科大学总医院 | Experimental method for detecting particle coagulation promoting activity |
| CN114544983A (en) * | 2022-02-28 | 2022-05-27 | 南京可诺医疗技术有限公司 | Preparation method of normal value quality control product for blood coagulation and platelet function analyzer |
| CN114778858A (en) * | 2022-06-23 | 2022-07-22 | 深圳市帝迈生物技术有限公司 | Lupus anticoagulant detection kit |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL238873A (en) * | 1958-05-16 | |||
| US3395210A (en) * | 1964-02-07 | 1968-07-30 | Warner Lambert Pharmaceutical | Lyophilized diagnostic reagent for the determination of blood coagulation factors |
| AT350726B (en) * | 1976-08-30 | 1979-06-11 | Immuno Ag | PROCESS FOR THE PRODUCTION OF A BLOOD CLOTIFYING PREPARATION FROM HUMAN BLOOD PLASMA |
| DE3413311A1 (en) | 1984-04-09 | 1985-10-17 | Behringwerke Ag, 3550 Marburg | REAGENT FOR DETERMINING THROMBOPLASTIN TIME |
| WO1993007491A1 (en) | 1991-10-04 | 1993-04-15 | Board Of Regents Of The University Of Nebraska | A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins |
| US5447440A (en) * | 1993-10-28 | 1995-09-05 | I-Stat Corporation | Apparatus for assaying viscosity changes in fluid samples and method of conducting same |
| US6194394B1 (en) | 1998-07-01 | 2001-02-27 | Sigma-Aldrich Co. | Coagulation controls for prothrombin time (PT) and activated partial thromboplastin time (APTT) assays |
| EP0984280A1 (en) * | 1998-09-03 | 2000-03-08 | Sysmex Corporation | Anticoagulant and hemanalysis method |
| WO2004102202A1 (en) | 2003-05-16 | 2004-11-25 | National Institute For Biological Standards And Control (Nibsc) | Activation mixture |
| WO2005029093A1 (en) * | 2003-09-22 | 2005-03-31 | Haematex Research Pty Limited | Method for detecting procoagulant phospholipid |
| SE0303249D0 (en) * | 2003-12-02 | 2003-12-02 | Inst Polymerutveckling Ab | Hematocrit and analyte concentration determination |
| CN1952169B (en) * | 2005-10-18 | 2010-05-12 | 上海太阳生物技术有限公司 | In-vitro detection diagnosis kit for clinical examination of prothrombin time (PT) |
| CN101221189B (en) * | 2007-01-12 | 2012-08-15 | 上海太阳生物技术有限公司 | External diagnostic reagent kit used for measuring activated partial thromboplastin time |
| CN101526538B (en) * | 2008-03-09 | 2014-04-09 | 上海长岛生物技术有限公司 | Method for preparing liquid porcellanite APTT reagent |
| EP2177624A1 (en) | 2008-10-02 | 2010-04-21 | Siemens Healthcare Diagnostics Products GmbH | Blood coagulation assays |
-
2011
- 2011-03-08 IS IS050010A patent/IS2809B/en unknown
-
2012
- 2012-03-07 US US13/414,112 patent/US9234902B2/en active Active
- 2012-03-08 RU RU2013144950A patent/RU2607658C2/en active
- 2012-03-08 EP EP12748059.8A patent/EP2684056B1/en active Active
- 2012-03-08 DK DK12748059.8T patent/DK2684056T3/en active
- 2012-03-08 WO PCT/IS2012/050005 patent/WO2012120546A2/en active Application Filing
- 2012-03-08 ES ES12748059.8T patent/ES2636318T3/en active Active
- 2012-03-08 IN IN1890MUN2013 patent/IN2013MN01890A/en unknown
- 2012-03-08 CN CN201280021851.3A patent/CN103534595B/en active Active
-
2015
- 2015-12-03 US US14/957,883 patent/US20160108457A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN103534595A (en) | 2014-01-22 |
| IS2809B (en) | 2012-10-15 |
| RU2013144950A (en) | 2015-04-20 |
| DK2684056T3 (en) | 2017-07-10 |
| EP2684056B1 (en) | 2017-05-03 |
| US9234902B2 (en) | 2016-01-12 |
| CN103534595B (en) | 2016-03-09 |
| RU2607658C2 (en) | 2017-01-10 |
| EP2684056A2 (en) | 2014-01-15 |
| US20120231485A1 (en) | 2012-09-13 |
| ES2636318T3 (en) | 2017-10-05 |
| WO2012120546A2 (en) | 2012-09-13 |
| WO2012120546A3 (en) | 2012-11-29 |
| US20160108457A1 (en) | 2016-04-21 |
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