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IN2013DE02956A - - Google Patents

Info

Publication number
IN2013DE02956A
IN2013DE02956A IN2956DE2013A IN2013DE02956A IN 2013DE02956 A IN2013DE02956 A IN 2013DE02956A IN 2956DE2013 A IN2956DE2013 A IN 2956DE2013A IN 2013DE02956 A IN2013DE02956 A IN 2013DE02956A
Authority
IN
India
Prior art keywords
osletamivir
imidazothiazolone
amidoalkylation
ramberg
tamiflu
Prior art date
Application number
Inventor
Prataprao Chavan Subhash
Narsing Chavan Prakash
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Priority to EP14811991.0A priority Critical patent/EP3052473B1/en
Priority to JP2016520012A priority patent/JP6474392B2/en
Priority to IN2956DE2013 priority patent/IN2013DE02956A/en
Priority to PCT/IN2014/000645 priority patent/WO2015049700A1/en
Priority to US15/026,376 priority patent/US9522922B2/en
Publication of IN2013DE02956A publication Critical patent/IN2013DE02956A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention discloses an economic, simple, azide and aziridine complexity free process for the synthesis of osletamivir phosphate (Tamiflu) by stereospecific amidoalkylation of imidazothiazolone from easily available L-cysteine via Ramberg-Backlund reaction and Sharpless-Reich protocol.
IN2956DE2013 2013-10-04 2014-10-07 IN2013DE02956A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP14811991.0A EP3052473B1 (en) 2013-10-04 2014-10-07 A process for the preparation of intermediate for the preparation of oseltamivir phosphate
JP2016520012A JP6474392B2 (en) 2013-10-04 2014-10-07 Method for preparing an intermediate for the preparation of oseltamivir phosphate
IN2956DE2013 IN2013DE02956A (en) 2013-10-04 2014-10-07
PCT/IN2014/000645 WO2015049700A1 (en) 2013-10-04 2014-10-07 A process for the preparation of intermediate for the preparation of oseltamivir phosphate
US15/026,376 US9522922B2 (en) 2013-10-04 2014-10-07 Process for the preparation of intermediate for the preparation of oseltamivir phosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2956DE2013 IN2013DE02956A (en) 2013-10-04 2014-10-07

Publications (1)

Publication Number Publication Date
IN2013DE02956A true IN2013DE02956A (en) 2015-04-10

Family

ID=52023584

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2956DE2013 IN2013DE02956A (en) 2013-10-04 2014-10-07

Country Status (5)

Country Link
US (1) US9522922B2 (en)
EP (1) EP3052473B1 (en)
JP (1) JP6474392B2 (en)
IN (1) IN2013DE02956A (en)
WO (1) WO2015049700A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110506045B (en) * 2017-04-12 2023-01-13 帝斯曼知识产权资产管理有限公司 Process for preparing imidazothiazolone compounds
WO2018233562A1 (en) * 2017-06-20 2018-12-27 广东东阳光药业有限公司 Method for preparing oseltamivir and isomer thereof
US10385010B1 (en) * 2018-03-28 2019-08-20 Georgia State University Research Foundation, Inc. Expedient synthesis of oseltamivir and related compounds via direct olefin diazidation-diamidation reaction
CN111349059B (en) * 2018-12-20 2023-03-31 中国科学院上海药物研究所 Preparation method of chiral epoxy compound
CN113307744A (en) * 2021-05-29 2021-08-27 弘健制药(上海)有限公司 Preparation method of oseltamivir phosphate
CN114478290A (en) * 2022-01-24 2022-05-13 广东中润药物研发有限公司 Synthetic method of oseltamivir intermediate
CN116396306A (en) * 2023-04-13 2023-07-07 华东理工大学 A kind of preparation method of D-biotin key intermediate thiolactone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486328B1 (en) * 2000-10-12 2002-11-26 Council Of Scientific And Industrial Research Substituted 2-[-6-benzyl-5-oxo-3-phenyl-(3s,7s, 7aR)-perhydroimidazol[1,5-c][1,3]thiazol-7yl] compounds
JPWO2007099843A1 (en) * 2006-02-23 2009-07-16 国立大学法人 東京大学 α, β-Unsaturated cyclohexanone derivative, method for producing the same, and method for producing the intermediate
JP2008081489A (en) * 2006-08-31 2008-04-10 Univ Of Tokyo Cyclic urethane compound and method for producing the same

Also Published As

Publication number Publication date
JP2016537315A (en) 2016-12-01
EP3052473A1 (en) 2016-08-10
EP3052473B1 (en) 2018-01-17
JP6474392B2 (en) 2019-02-27
US20160222029A1 (en) 2016-08-04
US9522922B2 (en) 2016-12-20
WO2015049700A1 (en) 2015-04-09

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