IL99647A - Method and apparatus for detection of nucleic acid sequences - Google Patents

Abstract

A method for concentration of molecules, including nucleic acid sequences, in a liquid sample comprising the steps of: providing a dry bibulous carrier defining a capillary transport path which supports the transport of the molecules when contacted with a solution containing the molecules wherein the molecules are target molecules including target nucleic acid sequences and wherein the molecules are transported within the bibulous carrier by capillary action when a portion of the dry bibulous carrier contacts the liquid sample containing the molecules; contacting a portion of the dry bibulous carrier with the liquid sample containing the target molecules wherein the dry bibulous carrier, when wet, defines a liquid transport path which supports the transport of molecules including nucleic aid sequences; transporting the target molecules along the liquid transport path; and capturing the target molecules with a capture agent immobilized in a capture zone on the dry bibulous carrier downstream of the portion of bibulous carrier contacting the liquid sample.