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IL98300A0 - Oxa-and thiazolidinedione hypoglycemic and hypocholesterolemic agents - Google Patents

Oxa-and thiazolidinedione hypoglycemic and hypocholesterolemic agents

Info

Publication number
IL98300A0
IL98300A0 IL98300A IL9830091A IL98300A0 IL 98300 A0 IL98300 A0 IL 98300A0 IL 98300 A IL98300 A IL 98300A IL 9830091 A IL9830091 A IL 9830091A IL 98300 A0 IL98300 A0 IL 98300A0
Authority
IL
Israel
Prior art keywords
oxa
hypocholesterolemic agents
thiazolidinedione
hypoglycemic
thiazolidinedione hypoglycemic
Prior art date
Application number
IL98300A
Other versions
IL98300A (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL98300A0 publication Critical patent/IL98300A0/en
Publication of IL98300A publication Critical patent/IL98300A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Paints Or Removers (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

A series of 5-(4-[2-substituted benzoxazolylmethoxy]benzyl)oxa- and thiazolidine-2,4-diones as antidiabetic and cholesterol lowering agents.
IL9830091A 1990-06-05 1991-05-29 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic compounds and pharmaceutical preparations containing them IL98300A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/533,615 US5037842A (en) 1990-06-05 1990-06-05 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents

Publications (2)

Publication Number Publication Date
IL98300A0 true IL98300A0 (en) 1992-06-21
IL98300A IL98300A (en) 1996-01-31

Family

ID=24126737

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9830091A IL98300A (en) 1990-06-05 1991-05-29 Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic compounds and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US5037842A (en)
EP (1) EP0537300B1 (en)
JP (1) JPH0714924B2 (en)
AT (1) ATE121736T1 (en)
AU (1) AU640284B2 (en)
CA (1) CA2084195A1 (en)
DE (1) DE69109291T2 (en)
DK (1) DK0537300T3 (en)
ES (1) ES2071339T3 (en)
FI (1) FI94756C (en)
HU (1) HUT65676A (en)
IE (1) IE65628B1 (en)
IL (1) IL98300A (en)
MY (1) MY135758A (en)
NO (1) NO924696L (en)
NZ (1) NZ238382A (en)
PT (1) PT97856A (en)
TW (1) TW200481B (en)
WO (1) WO1991019704A2 (en)
ZA (1) ZA914188B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
GB9017218D0 (en) * 1990-08-06 1990-09-19 Beecham Group Plc Novel compounds
NO179246C (en) * 1991-11-20 1996-09-04 Sankyo Co Aromatic amino-alcohol derivatives and intermediates for their preparation
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
DK0590793T3 (en) * 1992-08-31 2000-01-31 Sankyo Co Oxazolidine derivatives with anti-diabetic and anti-obesity properties, their preparation and their therapeutic use
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
TW268952B (en) * 1993-02-26 1996-01-21 Takeda Pharm Industry Co Ltd
US5521202A (en) * 1993-04-07 1996-05-28 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivatives and pharmaceutical compositions containing the same
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5985884A (en) * 1996-07-01 1999-11-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6313113B1 (en) 1997-04-15 2001-11-06 Reddy-Cheminor, Inc. Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
JP2001518068A (en) * 1997-05-02 2001-10-09 ドクター・レディーズ・リサーチ・ファウンデーション Novel heterocyclic compounds having anti-diabetic, hyperlipidemic and anti-hypertensive properties, a process for their preparation and pharmaceutical compositions containing them
WO1997041119A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
AU7595298A (en) * 1997-12-02 1998-12-11 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hy pertension
JP2003040877A (en) * 2001-07-24 2003-02-13 Sumika Fine Chemicals Co Ltd Method for producing 5-[6-(2-fluorobenzyloxy)-2- naphthyl]methyl-2,4-thiazolidinedione and method for refining the same
CA2510455C (en) * 2002-12-19 2013-03-12 The Scripps Research Institute Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding
CA2566688A1 (en) * 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
WO2008034016A2 (en) * 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
US8580832B2 (en) 2007-03-07 2013-11-12 Janssen Pharmaceutica N.V. Substituted phenoxy aminothiazolones as estrogen related receptor-α modulators
EA200970837A1 (en) 2007-03-07 2010-04-30 Янссен Фармацевтика Н.В. SUBSTITUTED PHENOXYIAZOLIDINDIONES AS ESTROGEN α-RECEPTOR MODULATORS
EP2132188B1 (en) * 2007-03-07 2011-12-14 Janssen Pharmaceutica N.V. Substituted phenoxy n-alkylated thiazoledinedione as estrogen related receptor-alpha modulators
US8362268B2 (en) 2008-05-30 2013-01-29 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
CN102770429A (en) 2009-12-18 2012-11-07 詹森药业有限公司 Substituted aminothiazolone indazoles as estrogen related receptor-alpha modulators
RU2586330C2 (en) 2011-09-16 2016-06-10 Пфайзер Инк. Solid forms of transthyretin dissociation inhibitor
CN107001267A (en) * 2014-08-08 2017-08-01 马合伙人株式会社 Condensed heterocyclic compouds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430171A (en) * 1977-08-10 1979-03-06 Taiho Pharmaceutical Co Ltd Isooxazole derivative and production
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4689336A (en) * 1981-01-02 1987-08-25 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine 2,4-diones
US4550172A (en) * 1984-09-21 1985-10-29 American Home Products Corporation Novel heterocyclic compounds as antiallergic agents
CN1003445B (en) * 1984-10-03 1989-03-01 武田药品工业株式会社 thiazolidinedione derivatives, their preparation and use
US4703052A (en) * 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
JPH06779B2 (en) * 1985-06-10 1994-01-05 武田薬品工業株式会社 Thiazolidione derivative and pharmaceutical composition comprising the same
JPS62234085A (en) * 1985-12-18 1987-10-14 Sankyo Co Ltd Remedy for diabetic complication comprising thiazolidine derivative as active ingredient
FI91869C (en) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Process for the preparation of benzoxazole derivatives as antidiabetic agents
ATE186724T1 (en) * 1987-09-04 1999-12-15 Beecham Group Plc SUBSTITUTED THIAZOLIDINEDIONE DERIVATIVES
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
WO1989008650A1 (en) * 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents

Also Published As

Publication number Publication date
WO1991019704A3 (en) 1992-03-19
CA2084195A1 (en) 1991-12-06
DK0537300T3 (en) 1995-07-03
NO924696D0 (en) 1992-12-04
ATE121736T1 (en) 1995-05-15
EP0537300B1 (en) 1995-04-26
FI94756B (en) 1995-07-14
HUT65676A (en) 1994-07-28
IE911885A1 (en) 1991-12-18
NO924696L (en) 1992-12-04
FI925522A0 (en) 1992-12-04
MY135758A (en) 2008-06-30
WO1991019704A2 (en) 1991-12-26
HU9203837D0 (en) 1993-03-29
IL98300A (en) 1996-01-31
ES2071339T3 (en) 1995-06-16
AU640284B2 (en) 1993-08-19
DE69109291D1 (en) 1995-06-01
ZA914188B (en) 1993-01-27
JPH0714924B2 (en) 1995-02-22
AU8753191A (en) 1992-01-07
JPH05506456A (en) 1993-09-22
PT97856A (en) 1992-03-31
NZ238382A (en) 1995-12-21
EP0537300A1 (en) 1993-04-21
FI925522A (en) 1992-12-04
DE69109291T2 (en) 1995-08-31
US5037842A (en) 1991-08-06
IE65628B1 (en) 1995-11-01
TW200481B (en) 1993-02-21
FI94756C (en) 1995-10-25

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Legal Events

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FF Patent granted
RH Patent void