IL94718A0 - Carboxamide non-ionic contrast media and method for the preparation thereof - Google Patents
Carboxamide non-ionic contrast media and method for the preparation thereofInfo
- Publication number
- IL94718A0 IL94718A0 IL94718A IL9471890A IL94718A0 IL 94718 A0 IL94718 A0 IL 94718A0 IL 94718 A IL94718 A IL 94718A IL 9471890 A IL9471890 A IL 9471890A IL 94718 A0 IL94718 A0 IL 94718A0
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- contrast media
- ionic contrast
- carboxamide
- carboxamide non
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Triiodo-5-aminoisophthalamides in which the amino and one of the amide nitrogen groups are substituted are indicated. The compounds have at least two hydroxyl groups and low viscosity and osmolality. Processes for the preparation of the compounds are indicated.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37571489A | 1989-07-05 | 1989-07-05 | |
US43152789A | 1989-11-03 | 1989-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL94718A0 true IL94718A0 (en) | 1991-04-15 |
IL94718A IL94718A (en) | 1994-10-21 |
Family
ID=27007168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL9471890A IL94718A (en) | 1989-07-05 | 1990-06-13 | Carboxamide non-ionic contrast media and method for the preparation thereof |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0406992B1 (en) |
JP (1) | JP3249112B2 (en) |
AT (1) | ATE119783T1 (en) |
AU (1) | AU643447B2 (en) |
CA (1) | CA2020489C (en) |
CS (1) | CS277109B6 (en) |
DE (1) | DE59008695D1 (en) |
DK (1) | DK0406992T3 (en) |
ES (1) | ES2069677T3 (en) |
GR (1) | GR3015580T3 (en) |
HU (1) | HU219585B (en) |
IE (1) | IE65719B1 (en) |
IL (1) | IL94718A (en) |
NO (1) | NO179247C (en) |
PT (1) | PT94595B (en) |
RU (1) | RU2060246C1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4109169A1 (en) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF |
DE4341472A1 (en) * | 1993-12-02 | 1995-06-08 | Schering Ag | A method for increasing the stability of liposome suspensions containing hydrophilic drugs |
GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
DE19731591C2 (en) * | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology |
ITMI20010773A1 (en) * | 2001-04-11 | 2002-10-11 | Chemi Spa | PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO |
CN103980154B (en) * | 2007-07-12 | 2015-02-25 | 通用电气医疗集团股份有限公司 | Contrast agents |
JP2011509943A (en) * | 2008-01-14 | 2011-03-31 | マリンクロッド・インコーポレイテッド | Process for preparing iosimenol |
EP2093206A1 (en) * | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
US9157156B2 (en) | 2009-07-07 | 2015-10-13 | Bracco Imaging S.P.A. | Process for the preparation of a iodinating agent |
JP6325547B2 (en) | 2012-09-27 | 2018-05-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Preparation of X-ray contrast agent ioforminol |
CN110573493A (en) * | 2017-05-01 | 2019-12-13 | 大塚制药株式会社 | Method for preparing iomesol |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
GB1538076A (en) * | 1974-11-15 | 1979-01-10 | Addressograph Multigraph | Apparatus for electrostatic reprography |
CH608189A5 (en) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
FI760068A (en) * | 1975-02-03 | 1976-08-04 | Schering Ag | |
NZ190907A (en) * | 1978-07-04 | 1981-10-19 | Nyegaard & Co As | Preparation of x-ray contrast agent by autoclaving a meta-carboxamido-ortho-iodo-n-(betahydroxyalkyl)-aniline |
DE2909439A1 (en) * | 1979-03-08 | 1980-09-18 | Schering Ag | NEW NON-ionic x-ray contrast agents |
NL7905021A (en) * | 1979-06-27 | 1980-12-30 | Pielkenrood Vinitex Bv | DEVICE FOR SEPARATING SUSPENDED COMPONENTS FROM A LIQUID. |
DE3001292A1 (en) * | 1980-01-11 | 1981-07-16 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES |
DE3150916A1 (en) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS " |
DE3731542A1 (en) * | 1987-09-17 | 1989-03-30 | Schering Ag | NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS |
DE3739098A1 (en) * | 1987-11-16 | 1989-05-24 | Schering Ag | NEW SUBSTITUTED DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIYOD ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING X-RAY CONTRASTING AGENTS |
JPH03506023A (en) * | 1988-07-20 | 1991-12-26 | ノボ ノルデイスク アクツイエセルスカプ | polypeptide |
-
1990
- 1990-06-13 IL IL9471890A patent/IL94718A/en unknown
- 1990-06-28 IE IE234090A patent/IE65719B1/en not_active IP Right Cessation
- 1990-06-29 EP EP90250167A patent/EP0406992B1/en not_active Expired - Lifetime
- 1990-06-29 DE DE59008695T patent/DE59008695D1/en not_active Expired - Lifetime
- 1990-06-29 AT AT90250167T patent/ATE119783T1/en not_active IP Right Cessation
- 1990-06-29 DK DK90250167.5T patent/DK0406992T3/en active
- 1990-06-29 ES ES90250167T patent/ES2069677T3/en not_active Expired - Lifetime
- 1990-07-04 PT PT94595A patent/PT94595B/en not_active IP Right Cessation
- 1990-07-04 NO NO902986A patent/NO179247C/en not_active IP Right Cessation
- 1990-07-04 RU SU904830459A patent/RU2060246C1/en active
- 1990-07-04 CS CS903353A patent/CS277109B6/en not_active IP Right Cessation
- 1990-07-04 AU AU58694/90A patent/AU643447B2/en not_active Expired
- 1990-07-05 CA CA002020489A patent/CA2020489C/en not_active Expired - Lifetime
- 1990-07-05 JP JP17650590A patent/JP3249112B2/en not_active Expired - Lifetime
- 1990-07-05 HU HU104/90A patent/HU219585B/en unknown
-
1995
- 1995-03-30 GR GR950400758T patent/GR3015580T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
PT94595B (en) | 1997-02-28 |
CA2020489C (en) | 2005-01-11 |
AU5869490A (en) | 1991-01-10 |
EP0406992A3 (en) | 1991-09-18 |
IE902340A1 (en) | 1991-01-16 |
JP3249112B2 (en) | 2002-01-21 |
DK0406992T3 (en) | 1995-07-24 |
IE65719B1 (en) | 1995-11-15 |
NO902986L (en) | 1991-01-07 |
NO179247C (en) | 1996-09-04 |
AU643447B2 (en) | 1993-11-18 |
ES2069677T3 (en) | 1995-05-16 |
HU219585B (en) | 2001-05-28 |
CA2020489A1 (en) | 1991-01-06 |
GR3015580T3 (en) | 1995-06-30 |
RU2060246C1 (en) | 1996-05-20 |
HUT57708A (en) | 1991-12-30 |
HU904104D0 (en) | 1990-12-28 |
CS335390A3 (en) | 1992-01-15 |
JPH03115232A (en) | 1991-05-16 |
EP0406992A2 (en) | 1991-01-09 |
PT94595A (en) | 1991-03-20 |
NO902986D0 (en) | 1990-07-04 |
DE59008695D1 (en) | 1995-04-20 |
EP0406992B1 (en) | 1995-03-15 |
CS277109B6 (en) | 1992-11-18 |
IL94718A (en) | 1994-10-21 |
ATE119783T1 (en) | 1995-04-15 |
NO179247B (en) | 1996-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed |